Gene Symbol: Pax9
Description: paired box 9
Alias: paired box protein Pax-9, paired box gene 9
Neubüser A, Peters H, Balling R, Martin G. Antagonistic interactions between FGF and BMP signaling pathways: a mechanism for positioning the sites of tooth formation. Cell. 1997;90:247-55 pubmed
..Here we have identified Pax9 as a marker for prospective tooth mesenchyme prior to the first morphological manifestation of odontogenesis...
Hetzer Egger C, Schorpp M, Haas Assenbaum A, Balling R, Peters H, Boehm T. Thymopoiesis requires Pax9 function in thymic epithelial cells. Eur J Immunol. 2002;32:1175-81 pubmed
The epithelial thymic anlage develops from the third pharyngeal pouch. Pax9 is expressed in the entire pharyngeal endoderm, and its function is required for normal development of organs derived from pharyngeal pouches...
Tan K, Shaw A, Madsen B, Jensen K, Taylor Papadimitriou J, Freemont P. Human PLU-1 Has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9. J Biol Chem. 2003;278:20507-13 pubmed
..as bait has identified two unrelated PLU-1 interacting proteins, namely brain factor-1 (BF-1) and paired box 9 (PAX9), both of which are developmental transcription factors...
Rodrigo I, Bovolenta P, Mankoo B, Imai K. Meox homeodomain proteins are required for Bapx1 expression in the sclerotome and activate its transcription by direct binding to its promoter. Mol Cell Biol. 2004;24:2757-66 pubmed
..Genetic analysis has demonstrated that the transcription factors Pax1, Pax9, Meox1, Meox2, and Bapx1 are all required for sclerotomal differentiation...
Sasaki Y, O Kane S, Dixon J, Dixon M, Ferguson M. Temporal and spatial expression of Pax9 and Sonic hedgehog during development of normal mouse palates and cleft palates in TGF-beta3 null embryos. Arch Oral Biol. 2007;52:260-7 pubmed
Transforming growth factor-beta (TGF-beta3) gene disruption causes cleft secondary palate. Pax9 and Sonic hedgehog (Shh) genes are involved in the patterning of vertebrate embryonic tissues, including the facial skeleton...
Suzuki M, Katagiri N, Ueda M, Tanaka S. Functional analysis of Nkx2.1 and Pax9 for calcitonin gene transcription. Gen Comp Endocrinol. 2007;152:259-66 pubmed
..1 induced a significant increase in the promoter transcription. Furthermore, we detected Pax1 and/or Pax9 gene expression in mammalian medullary thyroid carcinoma cell lines, rat rMTC and human TT cells, and in mammalian ..
Nakatomi M, Wang X, Key D, Lund J, Turbe Doan A, Kist R, et al
. Genetic interactions between Pax9 and Msx1 regulate lip development and several stages of tooth morphogenesis. Dev Biol. 2010;340:438-49 pubmed publisher
..b>Pax9 and Msx1 are co-expressed during craniofacial development, and mice that are single homozygous mutant for either ..
Mensah J, Ogawa T, Kapadia H, Cavender A, D Souza R. Functional analysis of a mutation in PAX9 associated with familial tooth agenesis in humans. J Biol Chem. 2004;279:5924-33 pubmed
b>Pax9 is a paired domain-containing transcription factor that plays an essential role in the patterning of murine dentition...