Genomes and Genes
Gene Symbol: Pask
Description: PAS domain containing serine/threonine kinase
Alias: PAS domain-containing serine/threonine-protein kinase
- Semplici F, Vaxillaire M, Fogarty S, Semache M, Bonnefond A, Fontes G, et al. Human mutation within Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK) causes basal insulin hypersecretion. J Biol Chem. 2011;286:44005-14 pubmed publisherPAS kinase (PASK) is a glucose-regulated protein kinase involved in the control of pancreatic islet hormone release and insulin sensitivity...
- Semache M, Zarrouki B, Fontes G, Fogarty S, Kikani C, Chawki M, et al. Per-Arnt-Sim kinase regulates pancreatic duodenal homeobox-1 protein stability via phosphorylation of glycogen synthase kinase 3? in pancreatic ?-cells. J Biol Chem. 2013;288:24825-33 pubmed publisher..We previously showed that the serine/threonine Per-Arnt-Sim domain-containing kinase (PASK) regulates insulin gene transcription via PDX-1. However, the mechanisms underlying this regulation are unknown...
- Vorontsova I, Lam L, Delpire E, Lim J, Donaldson P. Identification of the WNK-SPAK/OSR1 signaling pathway in rodent and human lenses. Invest Ophthalmol Vis Sci. 2014;56:310-21 pubmed publisher..The increased susceptibility of SPAK lenses to opacification suggests that disruption of this signaling pathway may compromise the ability of the lens to control its volume, and its ability to maintain its transparency. ..
- Liu Y, Liu Y, Ma X, Xiao Y, Wang Y, Zhang M, et al. Hydrogen-rich saline attenuates skin ischemia/reperfusion induced apoptosis via regulating Bax/Bcl-2 ratio and ASK-1/JNK pathway. J Plast Reconstr Aesthet Surg. 2015;68:e147-56 pubmed publisher..b>pASK-1, pJNK, Bcl-2 and Bax were examined by immunodetection. In addition Bcl-2, Bax and caspase-3 were detected by qPCR...