Gene Symbol: Parl
Description: presenilin associated, rhomboid-like
Alias: Psarl, presenilins-associated rhomboid-like protein, mitochondrial, mitochondrial intramembrane-cleaving protease PARL
Species: rat
Products:     Parl

Top Publications

  1. Cipolat S, Rudka T, Hartmann D, Costa V, Serneels L, Craessaerts K, et al. Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling. Cell. 2006;126:163-75 pubmed
    ..Presenilin-associated rhomboid-like (PARL) is an inner mitochondrial membrane rhomboid of unknown function, whose yeast ortholog is involved in mitochondrial ..
  2. Sik A, Passer B, Koonin E, Pellegrini L. Self-regulated cleavage of the mitochondrial intramembrane-cleaving protease PARL yields Pbeta, a nuclear-targeted peptide. J Biol Chem. 2004;279:15323-9 pubmed
    ..Although this ancient function is conserved in PARL (Presenilins-associated Rhomboid-like protein), the mammalian ortholog of Pcp1p/Rbd1p, the two proteins show a ..
  3. Wu H, Chen Q. Hypoxia activation of mitophagy and its role in disease pathogenesis. Antioxid Redox Signal. 2015;22:1032-46 pubmed publisher
    ..An improved understanding of the regulation of mitochondrial quality may provide a strategy for treating aging-related diseases by targeting mitochondria and mitophagy pathways. ..
  4. Powell B, Wiltshire S, Arscott G, McCaskie P, Hung J, McQuillan B, et al. Association of PARL rs3732581 genetic variant with insulin levels, metabolic syndrome and coronary artery disease. Hum Genet. 2008;124:263-70 pubmed publisher
    b>PARL (presenilin-associated rhomboid-like) is a mitochondrial protein involved in mitochondrial membrane remodelling, and maps to a quantitative trait locus (3q27) associated with metabolic traits...
  5. Yoshioka H, Katsu M, Sakata H, Okami N, Wakai T, Kinouchi H, et al. The role of PARL and HtrA2 in striatal neuronal injury after transient global cerebral ischemia. J Cereb Blood Flow Metab. 2013;33:1658-65 pubmed publisher
    The presenilin-associated rhomboid-like (PARL) protein and high temperature requirement factor A2 (HtrA2) are key regulators of mitochondrial integrity and play pivotal roles in apoptosis...
  6. Shi G, Lee J, Grimes D, Racacho L, Ye D, Yang H, et al. Functional alteration of PARL contributes to mitochondrial dysregulation in Parkinson's disease. Hum Mol Genet. 2011;20:1966-74 pubmed publisher
    ..Here we demonstrate that the mitochondrial protease presenilin-associated rhomboid-like (PARL) can affect the proteolytic processing of PINK1 and that normal PINK1 localization and stability requires PARL's ..
  7. Tang H, Liu J, Niu L, He W, Xu Y. Variation in gene expression of presenilins-associated rhomboid-like protein and mitochondrial function in skeletal muscle of insulin-resistant rats. Endocrine. 2009;36:524-9 pubmed publisher
    ..In this study, we evaluated the mRNA levels of presenilins-associated rhomboid-like protein (PARL) and mitochondrial content and enzyme activity from skeletal muscle isolated from insulin-resistant rats...
  8. Civitarese A, MacLean P, Carling S, Kerr Bayles L, McMillan R, Pierce A, et al. Regulation of skeletal muscle oxidative capacity and insulin signaling by the mitochondrial rhomboid protease PARL. Cell Metab. 2010;11:412-26 pubmed publisher
    ..In lower organisms, remodeling by the protease pcp1 (PARL ortholog) maintains the function and lifecycle of mitochondria...
  9. Phasukkijwatana N, Kunhapan B, Stankovich J, Chuenkongkaew W, Thomson R, Thornton T, et al. Genome-wide linkage scan and association study of PARL to the expression of LHON families in Thailand. Hum Genet. 2010;128:39-49 pubmed publisher
    ..2-3q28 covering SLC7A14 (3q26.2), MFN1 (3q26.32), MRPL47 (3q26.33), MCCC1 (3q27.1), PARL (3q27.1) and OPA1 (3q28-q29)...

More Information


  1. Hatunic M, Stapleton M, Hand E, Delong C, Crowley V, Nolan J. The Leu262Val polymorphism of presenilin associated rhomboid like protein (PARL) is associated with earlier onset of type 2 diabetes and increased urinary microalbumin creatinine ratio in an Irish case-control population. Diabetes Res Clin Pract. 2009;83:316-9 pubmed publisher
    ..Presenilin associated rhomboid like protein (PARL) is a mitochondrial protein that has been implicated in T2DM in both the rodent Psammomys obesus and in humans...
  2. Walder K, Kerr Bayles L, Civitarese A, Jowett J, Curran J, Elliott K, et al. The mitochondrial rhomboid protease PSARL is a new candidate gene for type 2 diabetes. Diabetologia. 2005;48:459-68 pubmed
    ..We identified a mitochondrial intramembrane protease, known as presenilins-associated rhomboid-like protein (PSARL) that is associated with insulin resistance and type 2 diabetes...
  3. Deas E, Plun Favreau H, Gandhi S, Desmond H, Kjaer S, Loh S, et al. PINK1 cleavage at position A103 by the mitochondrial protease PARL. Hum Mol Genet. 2011;20:867-79 pubmed publisher
    ..Finally, we show that PINK1 interacts with the mitochondrial protease presenilin-associated rhomboid-like protein (PARL) and that loss of PARL results in aberrant PINK1 cleavage in mammalian cells...
  4. Andrew T, Maniatis N, Carbonaro F, Liew S, Lau W, Spector T, et al. Identification and replication of three novel myopia common susceptibility gene loci on chromosome 3q26 using linkage and linkage disequilibrium mapping. PLoS Genet. 2008;4:e1000220 pubmed publisher
    ..655 kb), approximately 156 kb upstream from alternate-splicing SOX2OT (182,595 kb; 95% CI 182,533-182,688 kb) and PSARL (184,386 kb; 95% CI 184,356-184,411 kb), with the loci showing modest to strong evidence of association for the ..
  5. Canzoneri R, Lacunza E, Isla Larrain M, Croce M, Abba M. Rhomboid family gene expression profiling in breast normal tissue and tumor samples. Tumour Biol. 2014;35:1451-8 pubmed publisher
    ..012). In addition, we found that RHBDL2 and PARL mRNA expression was associated with a low/intermediate histologic tumor grade (p = 0.024 and p = 0...
  6. Zhang A, Jia X, Zhang Q, Yao Y. No association between the SNPs (rs3749446 and rs1402000) in the PARL gene and LHON in Chinese patients with m.11778G>A. Hum Genet. 2010;128:465-8 pubmed publisher
    ..two single nucleotide polymorphisms (SNPs) (rs3749446 and rs1402000) in the presenilins-associated rhomboid-like (PARL) gene were found to be associated with Leber hereditary optic neuropathy (LHON)...
  7. Meissner C, Lorenz H, Weihofen A, Selkoe D, Lemberg M. The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking. J Neurochem. 2011;117:856-67 pubmed publisher
    ..In mitochondria, the inner membrane rhomboid protease PARL has been implicated in the control of life span and apoptosis by a so far uncharacterized mechanism...
  8. Borengasser S, Faske J, Kang P, Blackburn M, Badger T, Shankar K. In utero exposure to prepregnancy maternal obesity and postweaning high-fat diet impair regulators of mitochondrial dynamics in rat placenta and offspring. Physiol Genomics. 2014;46:841-50 pubmed publisher
    ..Our results indicate HFD-fed offspring had reduced mRNA expression of presenilin-associated rhomboid-like (PARL), optic atrophy (OPA)1, mitofusin (Mfn)1, Mfn2, fission (Fis)1, and nuclear respiratory factor (Nrf)1 at PND35, ..