Gene Symbol: Paox
Description: polyamine oxidase
Alias: peroxisomal N(1)-acetyl-spermine/spermidine oxidase, GTP-binding protein-like, polyamine oxidase (exo-N4-amino)
Van den Munckhof R, Denyn M, Tigchelaar Gutter W, Schipper R, Verhofstad A, Van Noorden C, et al
. In situ substrate specificity and ultrastructural localization of polyamine oxidase activity in unfixed rat tissues. J Histochem Cytochem. 1995;43:1155-62 pubmed
..Strong intraperoxisomal, interperoxisomal, and intercellular heterogeneity in polyamine oxidase activity was found in all tissues investigated. ..
Vujcic S, Liang P, Diegelman P, Kramer D, Porter C. Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine back-conversion. Biochem J. 2003;370:19-28 pubmed
Wu T, Yankovskaya V, McIntire W. Cloning, sequencing, and heterologous expression of the murine peroxisomal flavoprotein, N1-acetylated polyamine oxidase. J Biol Chem. 2003;278:20514-25 pubmed
..This report provides details of the biochemical, spectral, oxidation-reduction, and steady-state kinetic properties of pure mPAO. ..
Järvinen A, Keinänen T, Grigorenko N, Khomutov A, Uimari A, Vepsalainen J, et al
. Guide molecule-driven stereospecific degradation of alpha-methylpolyamines by polyamine oxidase. J Biol Chem. 2006;281:4589-95 pubmed
..These findings might facilitate the chemical regulation of stereospecificity of the enzymes. ..
Cattaruzza M, Schafer K, Hecker M. Cytokine-induced down-regulation of zfm1/splicing factor-1 promotes smooth muscle cell proliferation. J Biol Chem. 2002;277:6582-9 pubmed
..Therefore, cytokine-induced down-regulation of zfm1 expression may contribute to the pathogenesis of hyperproliferative inflammatory diseases. ..
Wallace H, Fraser A, Hughes A. A perspective of polyamine metabolism. Biochem J. 2003;376:1-14 pubmed
..The future will be in adopting a functional genomics approach to identifying polyamine-regulated genes linked to either carcinogenesis or apoptosis. ..
Ferioli M, Berselli D, Caimi S. Effect of mitoguazone on polyamine oxidase activity in rat liver. Toxicol Appl Pharmacol. 2004;201:105-11 pubmed
..Therefore, we hypothesized that the enzyme involved in mitoguazone response of the liver is the polyamine oxidase, which acts on acetylated polyamines as substrate. ..
Bjelakovic G, Pavlovic D, Kocic G, Stojanovic I, Jevtovic Stoimenov T, Nikolic J, et al
. Dexamethasone decreases the spermidine and spermine concentrations and polyamine oxidase activity in rat thymus. J Basic Clin Physiol Pharmacol. 2013;24:67-72 pubmed publisher
..449±0.121 U/mg prot.; PAO Exp. Group, 0.312±0.096 U/mg prot.). The decrease in polyamine amounts in the rat thymus is not due to the change in PAO activity. ..
Gudkova O, Latyshko N, Shandrenko S. Amine oxidases as important agents of pathological processes of rhabdomyolysis in rats. Ukr Biochem J. 2016;88:79-87 pubmed publisher