Gene Symbol: Pam16
Description: presequence translocase associated motor 16
Alias: Magmas, mitochondrial import inner membrane translocase subunit TIM16, mitochondria-associated granulocyte macrophage CSF signaling molecule, mitochondria-associated protein involved in granulocyte-macrophage colony-stimulating factor signal transduction, presequence translocase associated motor 16 homolog
Species: rat
Products:     Pam16

Top Publications

  1. Elsner S, Simian D, Iosefson O, Marom M, Azem A. The mitochondrial protein translocation motor: structural conservation between the human and yeast Tim14/Pam18-Tim16/Pam16 co-chaperones. Int J Mol Sci. 2009;10:2041-53 pubmed publisher
    ..Of particular interest for us is the human Tim14/Pam18-Tim16/Pam16 complex...
  2. Tagliati F, Gentilin E, Buratto M, Molè D, degli Uberti E, Zatelli M. Magmas, a gene newly identified as overexpressed in human and mouse ACTH-secreting pituitary adenomas, protects pituitary cells from apoptotic stimuli. Endocrinology. 2010;151:4635-42 pubmed publisher
    ..We here report the identification of a cDNA, corresponding to Magmas gene (mitochondria-associated protein involved in granulocyte-macrophage colony-stimulating factor signal ..
  3. Jubinsky P, Short M, Mutema G, Witte D. Developmental expression of Magmas in murine tissues and its co-expression with the GM-CSF receptor. J Histochem Cytochem. 2003;51:585-96 pubmed
    b>Magmas is a protein that is involved in GM-CSF signaling in a myeloid cell line. Its precise role in the signal transduction process is unclear...
  4. Peng J, Huang C, Short M, Jubinsky P. Magmas gene structure and evolution. In Silico Biol. 2005;5:251-63 pubmed
    b>Magmas is a nuclear encoded protein found in the mitochondria of mammalian cells...
  5. Sinha D, Joshi N, Chittoor B, Samji P, D Silva P. Role of Magmas in protein transport and human mitochondria biogenesis. Hum Mol Genet. 2010;19:1248-62 pubmed publisher
    b>Magmas, a conserved mammalian protein essential for eukaryotic development, is overexpressed in prostate carcinomas and cells exposed to granulocyte-macrophage colony-stimulating factor (GM-CSF)...
  6. Tagliati F, Gagliano T, Gentilin E, Minoia M, Molè D, Delgi Uberti E, et al. Magmas overexpression inhibits staurosporine induced apoptosis in rat pituitary adenoma cell lines. PLoS ONE. 2013;8:e75194 pubmed publisher
    Magmas is a nuclear gene that encodes for the mitochondrial import inner membrane translocase subunit Tim16. Magmas is overexpressed in the majority of human pituitary adenomas and in a mouse ACTH-secreting pituitary adenoma cell line...
  7. Mehawej C, Delahodde A, Legeai Mallet L, Delague V, Kaci N, Desvignes J, et al. The impairment of MAGMAS function in human is responsible for a severe skeletal dysplasia. PLoS Genet. 2014;10:e1004311 pubmed publisher
    ..mutation in the mitochondria-associated granulocyte macrophage colony stimulating factor-signaling gene (MAGMAS) in a novel and severe spondylodysplastic dysplasia...
  8. Schulz C, Schendzielorz A, Rehling P. Unlocking the presequence import pathway. Trends Cell Biol. 2015;25:265-75 pubmed publisher
    ..Here, we review recent advances in understanding of the mechanisms underlying protein transport along the presequence pathway. ..