Gene Symbol: Pam16
Description: presequence translocase associated motor 16
Alias: Magmas, mitochondrial import inner membrane translocase subunit TIM16, mitochondria-associated granulocyte macrophage CSF signaling molecule, mitochondria-associated protein involved in granulocyte-macrophage colony-stimulating factor signal transduction, presequence translocase associated motor 16 homolog
Elsner S, Simian D, Iosefson O, Marom M, Azem A. The mitochondrial protein translocation motor: structural conservation between the human and yeast Tim14/Pam18-Tim16/Pam16 co-chaperones. Int J Mol Sci. 2009;10:2041-53 pubmed publisher
..Of particular interest for us is the human Tim14/Pam18-Tim16/Pam16 complex...
Tagliati F, Gentilin E, Buratto M, Molè D, degli Uberti E, Zatelli M. Magmas, a gene newly identified as overexpressed in human and mouse ACTH-secreting pituitary adenomas, protects pituitary cells from apoptotic stimuli. Endocrinology. 2010;151:4635-42 pubmed publisher
..We here report the identification of a cDNA, corresponding to Magmas gene (mitochondria-associated protein involved in granulocyte-macrophage colony-stimulating factor signal ..
Jubinsky P, Short M, Mutema G, Witte D. Developmental expression of Magmas in murine tissues and its co-expression with the GM-CSF receptor. J Histochem Cytochem. 2003;51:585-96 pubmed
b>Magmas is a protein that is involved in GM-CSF signaling in a myeloid cell line. Its precise role in the signal transduction process is unclear...
Peng J, Huang C, Short M, Jubinsky P. Magmas gene structure and evolution. In Silico Biol. 2005;5:251-63 pubmed
b>Magmas is a nuclear encoded protein found in the mitochondria of mammalian cells...
Sinha D, Joshi N, Chittoor B, Samji P, D Silva P. Role of Magmas in protein transport and human mitochondria biogenesis. Hum Mol Genet. 2010;19:1248-62 pubmed publisher
b>Magmas, a conserved mammalian protein essential for eukaryotic development, is overexpressed in prostate carcinomas and cells exposed to granulocyte-macrophage colony-stimulating factor (GM-CSF)...
Tagliati F, Gagliano T, Gentilin E, Minoia M, Molè D, Delgi Uberti E, et al
. Magmas overexpression inhibits staurosporine induced apoptosis in rat pituitary adenoma cell lines. PLoS ONE. 2013;8:e75194 pubmed publisher
Magmas is a nuclear gene that encodes for the mitochondrial import inner membrane translocase subunit Tim16. Magmas is overexpressed in the majority of human pituitary adenomas and in a mouse ACTH-secreting pituitary adenoma cell line...
Mehawej C, Delahodde A, Legeai Mallet L, Delague V, Kaci N, Desvignes J, et al
. The impairment of MAGMAS function in human is responsible for a severe skeletal dysplasia. PLoS Genet. 2014;10:e1004311 pubmed publisher
..mutation in the mitochondria-associated granulocyte macrophage colony stimulating factor-signaling gene (MAGMAS) in a novel and severe spondylodysplastic dysplasia...
Schulz C, Schendzielorz A, Rehling P. Unlocking the presequence import pathway. Trends Cell Biol. 2015;25:265-75 pubmed publisher
..Here, we review recent advances in understanding of the mechanisms underlying protein transport along the presequence pathway. ..