Gene Symbol: Pam
Description: MYC binding protein 2, E3 ubiquitin protein ligase
Alias: Pam, Phr1, pam, highwire, rpm 1, protein associated with Myc
Scholich K, Pierre S, Patel T. Protein associated with Myc (PAM) is a potent inhibitor of adenylyl cyclases. J Biol Chem. 2001;276:47583-9 pubmed
..of type V adenylyl cyclase (ACV) as bait, we identified a small region (amino acids 1028-1231) in the protein associated with Myc (PAM) as an interaction site for ACV...
Etournay R, El Amraoui A, Bahloul A, Blanchard S, Roux I, Pezeron G, et al
. PHR1, an integral membrane protein of the inner ear sensory cells, directly interacts with myosin 1c and myosin VIIa. J Cell Sci. 2005;118:2891-9 pubmed
By using the yeast two-hybrid technique, we identified a candidate protein ligand of the myosin 1c tail, PHR1, and found that this protein can also bind to the myosin VIIa tail...
Lewcock J, Genoud N, Lettieri K, Pfaff S. The ubiquitin ligase Phr1 regulates axon outgrowth through modulation of microtubule dynamics. Neuron. 2007;56:604-20 pubmed
..We mapped the Magellan mutation to the Phr1 gene encoding a large multidomain E3 ubiquitin ligase...
Pierre S, Maeurer C, Coste O, Becker W, Schmidtko A, Holland S, et al
. Toponomics analysis of functional interactions of the ubiquitin ligase PAM (Protein Associated with Myc) during spinal nociceptive processing. Mol Cell Proteomics. 2008;7:2475-85 pubmed publisher
b>Protein associated with Myc (PAM) is a giant E3 ubiquitin ligase of 510 kDa. Although the role of PAM during neuronal development is well established, very little is known about its function in the regulation of synaptic strength...
Murthy V, Han S, Beauchamp R, Smith N, Haddad L, Ito N, et al
. Pam and its ortholog highwire interact with and may negatively regulate the TSC1.TSC2 complex. J Biol Chem. 2004;279:1351-8 pubmed
..Tuberin and hamartin function together as a complex in mammals and Drosophila. We report here the association of Pam, a protein identified as an interactor of Myc, with the tuberin-hamartin complex in the brain...
Paemka L, Mahajan V, Ehaideb S, Skeie J, Tan M, Wu S, et al
. Seizures are regulated by ubiquitin-specific peptidase 9 X-linked (USP9X), a de-ubiquitinase. PLoS Genet. 2015;11:e1005022 pubmed publisher
..These studies point to a new target for anti-seizure therapy and illustrate the translational power of studying diseases in species across the evolutionary spectrum. ..