Pak7

Summary

Gene Symbol: Pak7
Description: p21 (RAC1) activated kinase 7
Alias: PAK-5, PAK-7, Pak5, serine/threonine-protein kinase PAK 5, serine/threonine-protein kinase PAK 7, p21 (CDKN1A)-activated kinase 7, p21 protein (Cdc42/Rac)-activated kinase 7, p21-activated kinase 5, p21-activated kinase 7
Species: rat
Products:     Pak7

Top Publications

  1. Nekrasova T, Jobes M, Ting J, Wagner G, Minden A. Targeted disruption of the Pak5 and Pak6 genes in mice leads to deficits in learning and locomotion. Dev Biol. 2008;322:95-108 pubmed publisher
    ..The group B PAKs, including PAK4, PAK5, and PAK6, were first identified as effector proteins for the Rho GTPase Cdc42...
  2. Furnari M, Jobes M, Nekrasova T, Minden A, Wagner G. Functional deficits in PAK5, PAK6 and PAK5/PAK6 knockout mice. PLoS ONE. 2013;8:e61321 pubmed publisher
    The p21-activated kinases are effector proteins for Rho-family GTPases. PAK4, PAK5, and PAK6 are the group II PAKs associated with neurite outgrowth, filopodia formation, and cell survival...
  3. Cotteret S, Jaffer Z, Beeser A, Chernoff J. p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD. Mol Cell Biol. 2003;23:5526-39 pubmed
    b>Pak5 is the most recently identified and least understood member of the p21-activated kinase (Pak) family...