Gene Symbol: Pak6
Description: p21 (RAC1) activated kinase 6
Alias: serine/threonine-protein kinase PAK 6, p21 (CDKN1A)-activated kinase 6, p21 protein (Cdc42/Rac)-activated kinase 6, p21-activated kinase 6
Nekrasova T, Jobes M, Ting J, Wagner G, Minden A. Targeted disruption of the Pak5 and Pak6 genes in mice leads to deficits in learning and locomotion. Dev Biol. 2008;322:95-108 pubmed publisher
b>PAK6 is a member of the group B family of PAK serine/threonine kinases, and is highly expressed in the brain. The group B PAKs, including PAK4, PAK5, and PAK6, were first identified as effector proteins for the Rho GTPase Cdc42...
Zhao W, Yang J, Shi W, Wu X, Shao B, Wu Q, et al
. Upregulation of p21-activated Kinase 6 in rat brain cortex after traumatic brain injury. J Mol Histol. 2011;42:195-203 pubmed publisher
p21-activated Kinase 6 (PAK6) is a serine/threonine kinase belonging to the p21-activated kinase (PAK) family...
Furnari M, Jobes M, Nekrasova T, Minden A, Wagner G. Functional deficits in PAK5, PAK6 and PAK5/PAK6 knockout mice. PLoS ONE. 2013;8:e61321 pubmed publisher
The p21-activated kinases are effector proteins for Rho-family GTPases. PAK4, PAK5, and PAK6 are the group II PAKs associated with neurite outgrowth, filopodia formation, and cell survival...
Liu W, Liu H, Liu Y, Xu L, Zhang W, Zhu Y, et al
. Prognostic significance of p21-activated kinase 6 expression in patients with clear cell renal cell carcinoma. Ann Surg Oncol. 2014;21 Suppl 4:S575-83 pubmed publisher
To investigate prognostic values of intratumoral p21-activated kinase 6 (PAK6) expression in patients with clear cell renal cell carcinoma (ccRCC)...