Gene Symbol: Pak4
Description: p21 (RAC1) activated kinase 4
Alias: serine/threonine-protein kinase PAK 4, p21 (CDKN1A)-activated kinase 4, p21 protein (Cdc42/Rac)-activated kinase 4, p21-activated kinase 4
Liu Y, Chen N, Cui X, Zheng X, Deng L, Price S, et al
. The protein kinase Pak4 disrupts mammary acinar architecture and promotes mammary tumorigenesis. Oncogene. 2010;29:5883-94 pubmed publisher
The Pak4 serine/threonine kinase is highly expressed in many cancer cell lines and human tumors. Although several studies have addressed the role for Pak4 in transformation of fibroblasts, most human cancers are epithelial in origin...
Baskaran Y, Ang K, Anekal P, Chan W, Grimes J, Manser E, et al
. An in cellulo-derived structure of PAK4 in complex with its inhibitor Inka1. Nat Commun. 2015;6:8681 pubmed publisher
b>PAK4 is a metazoan-specific kinase acting downstream of Cdc42. Here we describe the structure of human PAK4 in complex with Inka1, a potent endogenous kinase inhibitor...
Belmonte M, Santos M, Kihara A, Yan C, Hamassaki D. Light-Induced photoreceptor degeneration in the mouse involves activation of the small GTPase Rac1. Invest Ophthalmol Vis Sci. 2006;47:1193-200 pubmed
..However, there was a marked increase in PAK3 and PAK4 gene expression, whereas that of PAK5 mRNA remained the same...
Fiedler J, Jazbutyte V, Kirchmaier B, Gupta S, Lorenzen J, Hartmann D, et al
. MicroRNA-24 regulates vascularity after myocardial infarction. Circulation. 2011;124:720-30 pubmed publisher
..are mediated through targeting of the endothelium-enriched transcription factor GATA2 and the p21-activated kinase PAK4, which were identified by bioinformatic predictions and validated by luciferase gene reporter assays...
Dolan B, Duron S, Campbell D, Vollrath B, Shankaranarayana Rao B, Ko H, et al
. Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486. Proc Natl Acad Sci U S A. 2013;110:5671-6 pubmed publisher
..Finally, a single administration of FRAX486 is sufficient to rescue all of these phenotypes in adult Fmr1 KO mice, demonstrating the potential for rapid, postdiagnostic therapy in adults with FXS. ..
Liu W, Yang Y, Liu Y, Liu H, Zhang W, Xu L, et al
. p21-Activated kinase 4 predicts early recurrence and poor survival in patients with nonmetastatic clear cell renal cell carcinoma. Urol Oncol. 2015;33:205.e13-21 pubmed publisher
p21-Activated kinase 4 (PAK4), a serine/threonine kinase implicated in the cytoskeleton organization to orchestrate cell morphology, adhesion, and motility, is associated with angiogenesis and vessel branching, which are important events ..
Won S, Park M, You S, Choi S, Kim H, McLean C, et al
. Nigral dopaminergic PAK4 prevents neurodegeneration in rat models of Parkinson's disease. Sci Transl Med. 2016;8:367ra170 pubmed
..We report that p21-activated kinase 4 (PAK4) is a key survival factor for DA neurons...