Genomes and Genes
Gene Symbol: Pak2
Description: p21 protein (Cdc42/Rac)-activated kinase 2
Alias: PAK-2, gamma-PAK, serine/threonine-protein kinase PAK 2, p21 (CDKN1A)-activated kinase 2, p21-activated kinase 2
- Pirruccello M, Sondermann H, Pelton J, Pellicena P, Hoelz A, Chernoff J, et al. A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases. J Mol Biol. 2006;361:312-26 pubmed..We show that the phosphorylated kinase domain of PAK2 dimerizes in solution and that this association is prevented by addition of a substrate peptide...
- Chang J, Ni Y, Han L, Sinnett Smith J, Jacamo R, Rey O, et al. Protein kinase D1 (PKD1) phosphorylation on Ser203 by type I p21-activated kinase (PAK) regulates PKD1 localization. J Biol Chem. 2017;292:9523-9539 pubmed publisher..different mechanisms abrogated PKD1 phosphorylation at Ser203, 2) siRNA-mediated knockdown of PAK1 and PAK2 in IEC-18 and Swiss 3T3 cells blunted PKD1 phosphorylation at Ser203, 3) phosphorylation of Ser203Shin E, Shim E, Lee C, Kim H, Kim E. Phosphorylation of RhoGDI1 by p21-activated kinase 2 mediates basic fibroblast growth factor-stimulated neurite outgrowth in PC12 cells. Biochem Biophys Res Commun. 2009;379:384-9 pubmed publisherWe previously showed that p21-activated kinase 2 (PAK2), a major PAK isoform expressed in PC12 cells, mediates neurite outgrowth via Rac1 GTPase. RhoGDI1 forms a complex with Rac1, resulting in its inhibition...Dolan B, Duron S, Campbell D, Vollrath B, Shankaranarayana Rao B, Ko H, et al. Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486. Proc Natl Acad Sci U S A. 2013;110:5671-6 pubmed publisher..Finally, a single administration of FRAX486 is sufficient to rescue all of these phenotypes in adult Fmr1 KO mice, demonstrating the potential for rapid, postdiagnostic therapy in adults with FXS. ..Kim S, Irwin P, Katz S, Pelech S. Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart. J Cell Biochem. 1998;71:286-301 pubmed..be involved in the regulation of cytoskeleton as well as in stress signaling, was downregulated with age, but the Pak2 isoform increased only after 50 days...Li X, Wen W, Liu K, Zhu F, Malakhova M, Peng C, et al. Phosphorylation of caspase-7 by p21-activated protein kinase (PAK) 2 inhibits chemotherapeutic drug-induced apoptosis of breast cancer cell lines. J Biol Chem. 2011;286:22291-9 pubmed publisher..However, the role of PAK2 in resistance to chemotherapy is unclear...Wang S, Wilkes M, Leof E, Hirschberg R. Imatinib mesylate blocks a non-Smad TGF-beta pathway and reduces renal fibrogenesis in vivo. FASEB J. 2005;19:1-11 pubmed..p21-activated kinase-2 (PAK2) and activation of abelson nonreceptor tyrosine kinase (c-abl) have been shown recently to be smad-independent, ..Vettel C, Wittig K, Vogt A, Wuertz C, El Armouche A, Lutz S, et al. A novel player in cellular hypertrophy: Gi??/PI3K-dependent activation of the RacGEF TIAM-1 is required for ??-adrenoceptor induced hypertrophy in neonatal rat cardiomyocytes. J Mol Cell Cardiol. 2012;53:165-75 pubmed publisher..We identified the p21-activated kinase 2 (PAK2) as a downstream effector of Rac1 and were able to link this cascade to the activation of the pro-hypertrophic ..Lacombe J, Mangé A, Jarlier M, Bascoul Mollevi C, Rouanet P, Lamy P, et al. Identification and validation of new autoantibodies for the diagnosis of DCIS and node negative early-stage breast cancers. Int J Cancer. 2013;132:1105-13 pubmed publisher..antigens that elicited a specific humoral response in breast cancer were identified and five antigens (GAL3, PAK2, PHB2, RACK1 and RUVBL1) were selected for validation...Symons M, Derry J, Karlak B, Jiang S, Lemahieu V, McCormick F, et al. Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization. Cell. 1996;84:723-34 pubmed..The WASP sequence contains two novel domains that are homologous to other proteins involved in action organization. ..Tuazon P, Lorenson M, Walker A, Traugh J. p21-activated protein kinase gamma-PAK in pituitary secretory granules phosphorylates prolactin. FEBS Lett. 2002;515:84-8 pubmedLee K, Yonehara S. Phosphorylation and dimerization regulate nucleocytoplasmic shuttling of mammalian STE20-like kinase (MST). J Biol Chem. 2002;277:12351-8 pubmedRoig J, Tuazon P, Zipfel P, Pendergast A, Traugh J. Functional interaction between c-Abl and the p21-activated protein kinase gamma-PAK. Proc Natl Acad Sci U S A. 2000;97:14346-51 pubmed