Gene Symbol: p54
Description: nucleobindin 2
Alias: Nefa, p54, nucleobindin-2, DNA-binding protein NEFA, nesfatin-1, prepronefastin, prepronesfatin
Species: rat
Products:     p54

Top Publications

  1. Morel Huaux V, Pypaert M, Wouters S, Tartakoff A, Jurgan U, Gevaert K, et al. The calcium-binding protein p54/NEFA is a novel luminal resident of medial Golgi cisternae that traffics independently of mannosidase II. Eur J Cell Biol. 2002;81:87-100 pubmed
    ..and identified by matrix-assisted laser desorption ionization/time-of-flight (MALDI-TOF) mass spectrometry as NEFA, a calcium-binding protein (Barnikol-Watanabe et al., 1994, Biol. Chem. Hoppe Seyler, 375, 497-512)...
  2. Brailoiu G, Dun S, Brailoiu E, Inan S, Yang J, Chang J, et al. Nesfatin-1: distribution and interaction with a G protein-coupled receptor in the rat brain. Endocrinology. 2007;148:5088-94 pubmed
  3. Noetzel S, Stengel A, Inhoff T, Goebel M, Wisser A, Bannert N, et al. CCK-8S activates c-Fos in a dose-dependent manner in nesfatin-1 immunoreactive neurons in the paraventricular nucleus of the hypothalamus and in the nucleus of the solitary tract of the brainstem. Regul Pept. 2009;157:84-91 pubmed publisher
    ..No effect on the number of c-Fos-ir neurons was observed in the ARC. These results suggest that the effects of CCK on the HPA axis and on food intake may, at least in part, be mediated by nesfatin-1-ir neurons in the PVN. ..
  4. Shimizu H, Oh I S, Okada S, Mori M. Nesfatin-1: an overview and future clinical application. Endocr J. 2009;56:537-43 pubmed
    Nesfatin/nucleobindin 2 (NUCB2) is expressed in the appetite-control hypothalamic nuclei and brainstem nuclei. Nesfatin/NUCB2 expression in the paraventricular nucleus of the hypothalamus was modulated by starvation and refeeding...
  5. Goebel M, Stengel A, Wang L, Lambrecht N, TACHE Y. Nesfatin-1 immunoreactivity in rat brain and spinal cord autonomic nuclei. Neurosci Lett. 2009;452:241-6 pubmed publisher
    ..The features and distributions of nesfatin-1 IR and mRNA expression in the brain and spinal cord suggest that NUCB2/nesfatin-1 could play a wider role in autonomic regulation of visceral-endocrine functions besides food intake. ..
  6. Foo K, Brauner H, Ostenson C, Broberger C. Nucleobindin-2/nesfatin in the endocrine pancreas: distribution and relationship to glycaemic state. J Endocrinol. 2010;204:255-63 pubmed publisher
    ..However, our findings, together with previous reports, appear more compatible with intracellular actions rather than with endocrine/paracrine communication, and suggest that NUCB2 in serum derives primarily from non-islet sources. ..
  7. Goebel M, Stengel A, Wang L, TACHE Y. Restraint stress activates nesfatin-1-immunoreactive brain nuclei in rats. Brain Res. 2009;1300:114-24 pubmed publisher
    ..These data demonstrate that nesfatin-1 neurons are part of the hypothalamic and hindbrain neuronal cell groups activated by restraint suggesting a possible role of nesfatin-1 in the response to stress. ..
  8. Taniguchi N, Taniura H, Niinobe M, Takayama C, Tominaga Yoshino K, Ogura A, et al. The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm. J Biol Chem. 2000;275:31674-81 pubmed
    ..We isolated cDNAs encoding partial sequences of mouse NEFA and rat nucleobindin (CALNUC), which are Ca(2+)-binding proteins possessing similar domain structures...
  9. Gonzalez R, Tiwari A, Unniappan S. Pancreatic beta cells colocalize insulin and pronesfatin immunoreactivity in rodents. Biochem Biophys Res Commun. 2009;381:643-8 pubmed publisher
    Nesfatin-1 is a recently discovered feeding inhibitory peptide encoded in the precursor protein, nucleobindin 2 (pronesfatin). Previous studies have shown pronesfatin expression in the brain, stomach and pancreas...

More Information


  1. Maejima Y, Sedbazar U, Suyama S, Kohno D, Onaka T, Takano E, et al. Nesfatin-1-regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin-independent melanocortin pathway. Cell Metab. 2009;10:355-65 pubmed publisher
    ..The present results reveal the nesfatin-1-operative oxytocinergic signaling in the PVN that triggers leptin-independent melanocortin-mediated anorexia. ..
  2. Yoshida N, Maejima Y, Sedbazar U, Ando A, Kurita H, Damdindorj B, et al. Stressor-responsive central nesfatin-1 activates corticotropin-releasing hormone, noradrenaline and serotonin neurons and evokes hypothalamic-pituitary-adrenal axis. Aging (Albany NY). 2010;2:775-84 pubmed
    ..These results indicate that the central nesfatin-1 system is stimulated by stress and activates CRH, NA and 5-HT neurons and hypothalamic-pituitary-adrenal axis, evoking both central and peripheral stress responses. ..
  3. Yosten G, Samson W. Nesfatin-1 exerts cardiovascular actions in brain: possible interaction with the central melanocortin system. Am J Physiol Regul Integr Comp Physiol. 2009;297:R330-6 pubmed publisher
    ..Thus we have identified a novel action of nesfatin-1, in addition to its anorexigenic effects, to stimulate autonomic nervous system activity. ..
  4. Kohno D, Nakata M, Maejima Y, Shimizu H, Sedbazar U, Yoshida N, et al. Nesfatin-1 neurons in paraventricular and supraoptic nuclei of the rat hypothalamus coexpress oxytocin and vasopressin and are activated by refeeding. Endocrinology. 2008;149:1295-301 pubmed
    ..Feeding-activated nesfatin-1 neurons in the PVN and SON could play a role in the postprandial regulation of feeding behavior and energy homeostasis. ..
  5. Oh I S, Shimizu H, Satoh T, Okada S, Adachi S, Inoue K, et al. Identification of nesfatin-1 as a satiety molecule in the hypothalamus. Nature. 2006;443:709-12 pubmed
    ..Here we show that nesfatin, corresponding to NEFA/nucleobindin2 (NUCB2), a secreted protein of unknown function, is expressed in the appetite-control hypothalamic ..
  6. Stengel A, Goebel M, Wang L, Rivier J, Kobelt P, Monnikes H, et al. Central nesfatin-1 reduces dark-phase food intake and gastric emptying in rats: differential role of corticotropin-releasing factor2 receptor. Endocrinology. 2009;150:4911-9 pubmed publisher
    ..Activation of nesfatin-1 neurons by cholecystokinin at sites regulating food intake may suggest a role in gut peptide satiation effect. ..
  7. Könczöl K, Bodnar I, Zelena D, Pintér O, Papp R, Palkovits M, et al. Nesfatin-1/NUCB2 may participate in the activation of the hypothalamic-pituitary-adrenal axis in rats. Neurochem Int. 2010;57:189-97 pubmed publisher
    ..These data provide the first evidence for possible participation of nesfatin-1/NUCB2 in the stress-axis regulation, both at the level of the brainstem and in the hypothalamus. ..
  8. Iwasa T, Matsuzaki T, Tungalagsuvd A, Munkhzaya M, Yiliyasi M, Kuwahara A, et al. Developmental changes in the hypothalamic mRNA levels of nucleobindin-2 (NUCB2) and their sensitivity to fasting in male and female rats. Int J Dev Neurosci. 2016;49:46-9 pubmed publisher
    ..However, hypothalamic NUCB2 mRNA expression does not become sensitive to a negative energy balance during the neonatal to pre-pubertal period. ..
  9. Brodeur J, Larkin H, Boucher R, Thériault C, St Louis S, Gagnon H, et al. Calnuc binds to LRP9 and affects its endosomal sorting. Traffic. 2009;10:1098-114 pubmed publisher
    ..This is the first report showing that Calnuc plays a role in receptor trafficking. ..
  10. Dore R, Levata L, Gachkar S, Jöhren O, Mittag J, Lehnert H, et al. The thermogenic effect of nesfatin-1 requires recruitment of the melanocortin system. J Endocrinol. 2017;235:111-122 pubmed publisher
    ..Overall, we clearly demonstrate that nesfatin-1 requires the activation of the central melanocortin system to increase iBAT thermogenesis and, in turn, overall energy expenditure. ..
  11. Yoshimura M, Matsuura T, Ohkubo J, Maruyama T, Ishikura T, Hashimoto H, et al. A role of nesfatin-1/NucB2 in dehydration-induced anorexia. Am J Physiol Regul Integr Comp Physiol. 2014;307:R225-36 pubmed publisher
    ..These results suggested that nesfatin-1/NucB2 is a crucial peptide in dehydration-induced anorexia. ..
  12. Stengel A, Taché Y. Role of NUCB2/Nesfatin-1 in the hypothalamic control of energy homeostasis. Horm Metab Res. 2013;45:975-9 pubmed publisher
    ..The present review describes the current state-of-knowledge on central nesfatin-1's effects on food intake and body weight and highlights important missing links regarding cellular signaling mechanisms involved in nesfatin-1's action. ..
  13. Ying J, Zhang Y, Gong S, Chang Z, Zhou X, Li H, et al. Nesfatin-1 Suppresses Cardiac L-type Ca²⁺ Channels Through Melanocortin Type 4 Receptor and the Novel Protein Kinase C Theta Isoform Pathway. Cell Physiol Biochem. 2015;36:555-68 pubmed
    ..These data suggest that NF-1 suppresses L-type Ca2+ channels via the MC4-R that couples sequentially to the βγ subunits of Gi/o-protein and the novel PKCθ isoform in adult ventricular myocytes. ..
  14. Szlachcic A, Majka J, Strzalka M, Szmyd J, Pajdo R, Ptak Belowska A, et al. Experimental healing of preexisting gastric ulcers induced by hormones controlling food intake ghrelin, orexin-A and nesfatin-1 is impaired under diabetic conditions. A key to understanding the diabetic gastropathy?. J Physiol Pharmacol. 2013;64:625-37 pubmed
  15. Bonnet M, Pecchi E, Trouslard J, Jean A, Dallaporta M, Troadec J. Central nesfatin-1-expressing neurons are sensitive to peripheral inflammatory stimulus. J Neuroinflammation. 2009;6:27 pubmed publisher
  16. Gonzalez R, Perry R, Gao X, Gaidhu M, Tsushima R, Ceddia R, et al. Nutrient responsive nesfatin-1 regulates energy balance and induces glucose-stimulated insulin secretion in rats. Endocrinology. 2011;152:3628-37 pubmed publisher
    ..6 mM) and high (16.7 mM), but not at low (2 mM), glucose concentrations. Furthermore, nesfatin-1/nucleobindin 2 release from rat pancreatic islets was stimulated by glucose...
  17. Tanida M, Mori M. Nesfatin-1 stimulates renal sympathetic nerve activity in rats. Neuroreport. 2011;22:309-12 pubmed publisher
    ..Thus, the stimulating effects of nesfatin-1 administration on the sympathetic nerve activity of the kidney may depend on the central melanocortin system. ..
  18. Akcılar R, Ayada C, Turgut G, Turgut S. Supplementation of apelin increase plasma levels of nesfatin-1 in normal and DOCA-salt hypertensive rats. Bratisl Lek Listy. 2015;116:104-8 pubmed
    ..This is the first report to investigate the effect of apelin administration on plasma nesfatin levels of normal and hypertensive rats (Fig. 2, Ref. 44). ..
  19. Garcia Galiano D, Pineda R, Ilhan T, Castellano J, Ruiz Pino F, Sanchez Garrido M, et al. Cellular distribution, regulated expression, and functional role of the anorexigenic peptide, NUCB2/nesfatin-1, in the testis. Endocrinology. 2012;153:1959-71 pubmed publisher
    Nesfatin-1, product of the precursor NEFA/nucleobindin2 (NUCB2), was initially identified as anorectic hypothalamic neuropeptide, acting in a leptin-independent manner...
  20. Xu Y, Ge J, Qin G, Peng Y, Zhang C, Liu X, et al. Acute, but not chronic, stress increased the plasma concentration and hypothalamic mRNA expression of NUCB2/nesfatin-1 in rats. Neuropeptides. 2015;54:47-53 pubmed publisher
    ..These results indicated that acute stress, but not chronic stress, increased the plasma concentration and hypothalamic mRNA expression of NUCB2/nesfatin-1 in rats. ..
  21. Jia F, Li X, Li T, Wu J, Xie B, Lin L. Role of nesfatin-1 in a rat model of visceral hypersensitivity. World J Gastroenterol. 2013;19:3487-93 pubmed publisher
    ..05). Nesfatin-1 may be associated with IBS-like visceral hypersensitivity, which may be implicated in brain CRF/CRF1 signaling pathways. ..
  22. Yang M, Zhang Z, Wang C, Li K, Li S, Boden G, et al. Nesfatin-1 action in the brain increases insulin sensitivity through Akt/AMPK/TORC2 pathway in diet-induced insulin resistance. Diabetes. 2012;61:1959-68 pubmed publisher
    Nesfatin-1, derived from nucleobindin 2, was recently identified as an anorexigenic signal peptide. However, its neural role in glucose homeostasis and insulin sensitivity is unknown...
  23. Vas S, Adori C, Könczöl K, Katai Z, Pap D, Papp R, et al. Nesfatin-1/NUCB2 as a potential new element of sleep regulation in rats. PLoS ONE. 2013;8:e59809 pubmed publisher
    ..The data designate nesfatin as a potential new factor in sleep regulation, which fact can also be relevant in the better understanding of the role of nesfatin in the pathomechanism of depression. ..
  24. Jego S, Salvert D, Renouard L, Mori M, Goutagny R, Luppi P, et al. Tuberal hypothalamic neurons secreting the satiety molecule Nesfatin-1 are critically involved in paradoxical (REM) sleep homeostasis. PLoS ONE. 2012;7:e52525 pubmed publisher
    ..This could be done through the inhibition of downstream targets comprised primarily of the local hypothalamic wake-active orexin- and histamine-containing neurons. ..
  25. Garcia Marcos M, Kietrsunthorn P, Wang H, Ghosh P, Farquhar M. G Protein binding sites on Calnuc (nucleobindin 1) and NUCB2 (nucleobindin 2) define a new class of G(alpha)i-regulatory motifs. J Biol Chem. 2011;286:28138-49 pubmed publisher
    ..These findings provide the structural basis for the properties of Calnuc and NUCB2 binding to G? subunits and its regulation by calcium ions. ..
  26. Stengel A, Goebel Stengel M, Jawien J, Kobelt P, TACHE Y, Lambrecht N. Lipopolysaccharide increases gastric and circulating NUCB2/nesfatin-1 concentrations in rats. Peptides. 2011;32:1942-7 pubmed publisher
    ..These changes are opposite to those of ghrelin in response to LPS supporting a differential gastric regulation of NUCB2/nesfatin-1 and ghrelin expression derived from the same cell by immune challenge. ..
  27. Chen Z, Xu Y, Wu R, Han Y, Yu Y, Ge J, et al. Impaired learning and memory in rats induced by a high-fat diet: Involvement with the imbalance of nesfatin-1 abundance and copine 6 expression. J Neuroendocrinol. 2017;29: pubmed publisher
  28. Osaki A, Shimizu H, Ishizuka N, Suzuki Y, Mori M, Inoue S. Enhanced expression of nesfatin/nucleobindin-2 in white adipose tissue of ventromedial hypothalamus-lesioned rats. Neurosci Lett. 2012;521:46-51 pubmed publisher
    ..Further, this action may be mediated via inhibition of the sympathetic nerve activity. ..
  29. Maejima Y, Kumamoto K, Takenoshita S, Shimomura K. Projections from a single NUCB2/nesfatin-1 neuron in the paraventricular nucleus to different brain regions involved in feeding. Brain Struct Funct. 2016;221:4723-4731 pubmed
    The anorexigenic neuropeptide NEFA/nucleobindin 2 (NUCB2)/nesfatin-1-containing neurons are distributed in the brain regions involved in feeding regulation, including the hypothalamic paraventricular nucleus (PVN)...
  30. Xu L, Bloem B, Gaszner B, Roubos E, Kozicz T. Sex-specific effects of fasting on urocortin 1, cocaine- and amphetamine-regulated transcript peptide and nesfatin-1 expression in the rat Edinger-Westphal nucleus. Neuroscience. 2009;162:1141-9 pubmed publisher
    ..The peptide level and mRNA of nesfatin-1 were unaffected by fasting. We conclude that npEW-neurons containing Ucn1, CART and nesfatin-1 co-express ObR, and may be involved in leptin-mediated feeding control in male rats only. ..
  31. Bonnet M, Djelloul M, Tillement V, Tardivel C, Mounien L, Trouslard J, et al. Central NUCB2/Nesfatin-1-expressing neurones belong to the hypothalamic-brainstem circuitry activated by hypoglycaemia. J Neuroendocrinol. 2013;25:1-13 pubmed publisher
  32. Saito R, So M, Motojima Y, Matsuura T, Yoshimura M, Hashimoto H, et al. Activation of Nesfatin-1-Containing Neurones in the Hypothalamus and Brainstem by Peripheral Administration of Anorectic Hormones and Suppression of Feeding via Central Nesfatin-1 in Rats. J Neuroendocrinol. 2016;28: pubmed publisher
    ..These results indicate that nesfatin-1-expressing neurones in the brainstem may play an important role in sensing peripheral levels of GLP-1 and leptin in addition to CCK-8, and also suppress food intake in rats. ..
  33. Feng H, Wang Q, Guo F, Han X, Pang M, Sun X, et al. Nesfatin-1 influences the excitability of gastric distension-responsive neurons in the ventromedial hypothalamic nucleus of rats. Physiol Res. 2017;66:335-344 pubmed
    ..The hippocampus may participate in the modulation of nesfatin-1-mediated effects in VMH. ..
  34. Yosten G, Redlinger L, Samson W. Evidence for a role of endogenous nesfatin-1 in the control of water drinking. J Neuroendocrinol. 2012;24:1078-84 pubmed publisher
    ..The results obtained in the present study suggest that locally produced nesfatin-1 may be an important component of the hypothalamic mechanisms controlling fluid and electrolyte homeostasis. ..
  35. Prinz P, Goebel Stengel M, Teuffel P, Rose M, Klapp B, Stengel A. Peripheral and central localization of the nesfatin-1 receptor using autoradiography in rats. Biochem Biophys Res Commun. 2016;470:521-527 pubmed publisher
    ..Based on the distribution of nesfatin-1 autoradiography, nesfatin-1 is a pleiotropic hormone that is involved in the regulation of several homeostatic functions. ..
  36. Riva M, Nitert M, Voss U, Sathanoori R, Lindqvist A, Ling C, et al. Nesfatin-1 stimulates glucagon and insulin secretion and beta cell NUCB2 is reduced in human type 2 diabetic subjects. Cell Tissue Res. 2011;346:393-405 pubmed publisher
    Nesfatin-1 is a novel anorexigenic regulatory peptide. The peptide is the N-terminal part of nucleobindin 2 (NUCB2) and is expressed in brain areas regulating feeding...
  37. Tian Z, Deng R, Sun G, Wei L, Kong X, Ding X, et al. Expression of gastrointestinal nesfatin-1 and gastric emptying in ventromedial hypothalamic nucleus- and ventrolateral hypothalamic nucleus-lesioned rats. World J Gastroenterol. 2014;20:6897-905 pubmed publisher
    ..Additionally, there is a positive relationship between gastric emptying and body mass. The results of this study indicate that gastrointestinal nesfatin-1 may play a significant role in gastric mobility and energy homeostasis. ..
  38. García Galiano D, Navarro V, Roa J, Ruiz Pino F, Sánchez Garrido M, Pineda R, et al. The anorexigenic neuropeptide, nesfatin-1, is indispensable for normal puberty onset in the female rat. J Neurosci. 2010;30:7783-92 pubmed publisher
    The hypothalamic peptide, nesfatin-1, derived from the precursor NEFA/nucleobindin 2 (NUCB2), was recently identified as anorexigenic signal, acting in a leptin-independent manner...
  39. Tagaya Y, Osaki A, Miura A, Okada S, Ohshima K, Hashimoto K, et al. Secreted nucleobindin-2 inhibits 3T3-L1 adipocyte differentiation. Protein Pept Lett. 2012;19:997-1004 pubmed
    ..Taken together, these data indicate that secreted Nucleobindin-2 is a suppressor of adipocyte differentiation through inhibition of cAMP production and insulin signal. ..
  40. Xu Y, Zhang H, Li Q, Lao K, Wang Y. The role of nesfatin-1 expression in letrozole-induced polycystic ovaries in the rat. Gynecol Endocrinol. 2017;33:438-441 pubmed publisher
    ..05). When taken together, these data indicated that the decrease in nesfatin-1 may contribute to the mechanism governing PCOS, and might provide a new potential target for therapies aimed at treating PCOS. ..
  41. Xu L, Wang Q, Guo F, Pang M, Sun X, Gao S, et al. Nesfatin-1 signaling in the basom edial amygdala modulates the gastric distension-sensitive neurons discharge and decreases gastric motility via melanocortin 3/4 receptors and modified by the arcuate nucleus. Eur J Pharmacol. 2015;764:164-72 pubmed publisher
    ..It is suggested that nesfatin-1 in the BMA plays an important role in decreasing gastric motility and the Arc may be involved in this regulation process. ..
  42. Garcés M, Poveda N, Sanchez E, Sánchez A, Bravo S, Vazquez M, et al. Regulation of NucB2/Nesfatin-1 throughout rat pregnancy. Physiol Behav. 2014;133:216-22 pubmed publisher
    ..by post-translational cleavage from the N-terminus region DNA binding/EF-hand/acidic amino acid rich region (NEFA)/nucleobindin2 (NucB2) protein through proteolytic prohormone convertases...
  43. Katsurada K, Maejima Y, Nakata M, Kodaira M, Suyama S, Iwasaki Y, et al. Endogenous GLP-1 acts on paraventricular nucleus to suppress feeding: projection from nucleus tractus solitarius and activation of corticotropin-releasing hormone, nesfatin-1 and oxytocin neurons. Biochem Biophys Res Commun. 2014;451:276-81 pubmed publisher
    ..This study reveals a neuronal basis for the anorexigenic effect of endogenous GLP-1 in the brain. ..
  44. Stengel A, Goebel M, Wang L, TACHE Y. Abdominal surgery activates nesfatin-1 immunoreactive brain nuclei in rats. Peptides. 2010;31:263-70 pubmed publisher
  45. Roy D, Mandal S, Sen G, Mukhopadhyay S, Biswas T. 14-Deoxyandrographolide desensitizes hepatocytes to tumour necrosis factor-alpha-induced apoptosis through calcium-dependent tumour necrosis factor receptor superfamily member 1A release via the NO/cGMP pathway. Br J Pharmacol. 2010;160:1823-43 pubmed publisher
    ..This can be used as a strategy against cytokine-mediated hepatocyte apoptosis in liver dysfunctions. ..
  46. Inhoff T, Stengel A, Peter L, Goebel M, TACHE Y, Bannert N, et al. Novel insight in distribution of nesfatin-1 and phospho-mTOR in the arcuate nucleus of the hypothalamus of rats. Peptides. 2010;31:257-62 pubmed publisher
  47. Angelone T, Filice E, Pasqua T, Amodio N, Galluccio M, Montesanti G, et al. Nesfatin-1 as a novel cardiac peptide: identification, functional characterization, and protection against ischemia/reperfusion injury. Cell Mol Life Sci. 2013;70:495-509 pubmed publisher
  48. Yamawaki H, Takahashi M, Mukohda M, Morita T, Okada M, Hara Y. A novel adipocytokine, nesfatin-1 modulates peripheral arterial contractility and blood pressure in rats. Biochem Biophys Res Commun. 2012;418:676-81 pubmed publisher
    ..The results are the first to demonstrate that nesfatin-1 modulates blood pressure through directly acting on peripheral arterial resistance. ..
  49. Senín L, Al Massadi O, Barja Fernandez S, Folgueira C, Castelao C, Tovar S, et al. Regulation of NUCB2/nesfatin-1 production in rat's stomach and adipose tissue is dependent on age, testosterone levels and lactating status. Mol Cell Endocrinol. 2015;411:105-12 pubmed publisher
    Nesfatin-1, which is derived from the NEFA/nucleobindin 2 (NUCB2) precursor, was recently identified as an anorexigenic peptide that is produced in several tissues including the hypothalamus...
  50. Cheng Y, Lv H, Wang X, Song G. [Expression of nesfatin-1/NUCB2 and ghrelin in gastric mucosa of rats with intrauterine growth retardation]. Zhongguo Dang Dai Er Ke Za Zhi. 2014;16:1051-6 pubmed
    ..Nesfatin-1 and ghrelin are co-expressed in the gastric mucosa of rats with IUGR after birth and interact with each other to produce long-term nutritional regulation. ..
  51. Yosten G, Samson W. Neural circuitry underlying the central hypertensive action of nesfatin-1: melanocortins, corticotropin-releasing hormone, and oxytocin. Am J Physiol Regul Integr Comp Physiol. 2014;306:R722-7 pubmed publisher
  52. Bonnet M, Ouelaa W, Tillement V, Trouslard J, Jean A, Gonzalez B, et al. Gastric distension activates NUCB2/nesfatin-1-expressing neurons in the nucleus of the solitary tract. Regul Pept. 2013;187:17-23 pubmed publisher
    ..Nesfatin-1 was recently identified as a neuropeptide cleaved from the N-terminal part of NEFA/nucleobindin 2 precursor (NUCB2)...
  53. Dettlaff Pokora A, Sledzinski T, Swierczynski J. Upregulation of Pnpla2 and Abhd5 and downregulation of G0s2 gene expression in mesenteric white adipose tissue as a potential reason for elevated concentration of circulating NEFA after removal of retroperitoneal, epididymal, and inguinal adipose tis. Mol Cell Biochem. 2016;422:21-29 pubmed
    Elevated concentrations of circulating non-esterified fatty acids (NEFA) were reported in (a) humans with lipodystrophy, (b) humans following bariatric surgery, and (c) transgenic mice with reduced amounts of adipose tissue...
  54. Tagaya Y, Miura A, Okada S, Ohshima K, Mori M. Nucleobindin-2 is a positive modulator of EGF-dependent signals leading to enhancement of cell growth and suppression of adipocyte differentiation. Endocrinology. 2012;153:3308-19 pubmed publisher
    ..Taken together, these data indicate that nucleobindin-2 regulates EGF-stimulated MAPK kinase/Erk signaling, cell proliferation, and adipocyte differentiation. ..
  55. Sarac M, Bakal U, Tartar T, Kuloglu T, Yardim M, Artaş G, et al. Ghrelin and NUCB2/Nesfatin-1 expression in unilateral testicular torsion-induced rats with and without N-acetylcysteine. Cell Mol Biol (Noisy-le-grand). 2017;63:40-45 pubmed publisher
    ..determines the degree of testicular damage; however, its effects on the expression of octanoylated ghrelin and nucleobindin 2 (NUCB2) /nesfatin-1 synthetized from testicular tissue remain unclear...
  56. Zhang A, Li X, Jiang C, Lin L, Shi R, Chen J, et al. Expression of nesfatin-1/NUCB2 in rodent digestive system. World J Gastroenterol. 2010;16:1735-41 pubmed
    ..To observe the regional distributions and morphological features of nesfatin-1/nucleobindin-2 (NUCB2) immunoreactive (IR) cells in the rodent digestive system...
  57. Cao X, Zhou X, Cao Y, Liu X, Zhou L. Expression of NUCB2/nesfatin-1 in the taste buds of rats. Endocr J. 2016;63:37-45 pubmed publisher
    Nesfatin-1, an anorexigenic peptide derived from nucleobindin 2 (NUCB2), is closely involved in feeding behavior, glycometabolism, and satiety regulation...
  58. Liu Z, Wang F, Li Z, Qi J, Xu W, Zhang P, et al. [Expression of neuropeptides ghrelin and Nesfatin-1 in kainic acid kindling rats]. Zhonghua Yi Xue Za Zhi. 2011;91:496-500 pubmed
    ..It may offer a simple, sensitive and noninvasive method of diagnosing and treating epilepsy. ..