p35

Summary

Gene Symbol: p35
Description: cyclin-dependent kinase 5, regulatory subunit 1 (p35)
Alias: Cdk5r, p35, CDK5 activator 1, TPKII regulatory subunit, cyclin-dependent kinase 5 activator 1, p23, tau protein kinase II 23 kDa subunit
Species: rat

Top Publications

  1. ncbi Influence of phosphorylation of p35, an activator of cyclin-dependent kinase 5 (cdk5), on the proteolysis of p35
    Petri Kerokoski
    Department of Neuroscience and Neurology, University of Kuopio, P O Box 1627, Finland
    Brain Res Mol Brain Res 106:50-6. 2002
  2. doi Elevation of p-NR2A(S1232) by Cdk5/p35 contributes to retinal ganglion cell apoptosis in a rat experimental glaucoma model
    Jie Chen
    Institutes of Brain Science, Institute of Neurobiology and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200032, China
    Neurobiol Dis 43:455-64. 2011
  3. ncbi Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5/p35 pathway
    Rodrigo A Quintanilla
    Millennium Institute for Advanced Studies in Cell Biology and Biotechnology CBB, Nunoa, Santiago, Chile
    Exp Cell Res 295:245-57. 2004
  4. ncbi Glucose-induced expression of the cyclin-dependent protein kinase 5 activator p35 involved in Alzheimer's disease regulates insulin gene transcription in pancreatic beta-cells
    Mariano Ubeda
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, 55 Fruit Street, Wellman 306, Boston, Massachusetts 02114, USA
    Endocrinology 145:3023-31. 2004
  5. ncbi Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism
    Wing Yu Fu
    Department of Biochemistry, Biotechnology Research Institute and Molecular Neuroscience Center, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
    Nat Neurosci 10:67-76. 2007
  6. pmc Involvement of calpain/p35-p25/Cdk5/NMDAR signaling pathway in glutamate-induced neurotoxicity in cultured rat retinal neurons
    Yanying Miao
    Institutes of Brain Science, Institute of Neurobiology and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China
    PLoS ONE 7:e42318. 2012
  7. ncbi [Changes of cdk5, p35 and p53 gene expression levels in arsenic-induced neural cell apoptosis]
    Xin Li
    Department of Radiation Health, Control of Disease Control of Taiyuan Iron Steel Company, Taiyuan 030003, China
    Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 30:85-8. 2012
  8. pmc A novel mechanism for regulating hepatic glycogen synthesis involving serotonin and cyclin-dependent kinase-5
    Susan J Tudhope
    Institute of Cellular Medicine, The Medical School, Newcastle University, Newcastle upon Tyne, UK
    Diabetes 61:49-60. 2012
  9. ncbi [Expression changes of cyclin dependent kinase 5/p35 in nerve tissues of 2, 5-hexanedione intoxicated rats]
    Qing shan Wang
    Department of Toxicology, School of Occupational Health, Shandong University, Jinan 250012, China
    Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 26:336-40. 2008
  10. ncbi Neuronal loss in primary long-term cortical culture involves neurodegeneration-like cell death via calpain and p35 processing, but not developmental apoptosis or aging
    Min Ju Kim
    Department of Biochemistry, College of Medicine, Hallym University, Chuncheon 200 702, Korea
    Exp Mol Med 39:14-26. 2007

Scientific Experts

  • Xiaochun Chen
  • Yanying Miao
  • K D Pruitt
  • Petri Kerokoski
  • Taro Saito
  • Monica Sharma
  • Fa fa Tian
  • Ryo Endo
  • Wing Yu Fu
  • Xin Li
  • Susan J Tudhope
  • Jie Chen
  • Sashi Kesavapany
  • Mi Young Son
  • Yong Qing Han
  • Chun tao Zhao
  • Nune Darbinian
  • Estela Cecilia Mlewski
  • Qing shan Wang
  • Hirotsugu Kamei
  • Min Ju Kim
  • Shin Ichi Hisanaga
  • Akiko Asada
  • Ya Li Zheng
  • Michael J O'Hare
  • Fumika Sakaue
  • Amy K Y Fu
  • Nancy Y Ip
  • Rodrigo A Quintanilla
  • Mariano Ubeda
  • Harish C Pant
  • L H Tsai
  • Y T Kwon
  • Cecilia M Sahlgren
  • Kai Cheng
  • Rani Dhavan
  • Laura J Hampson
  • Fiona Malcomson
  • S R Floyd
  • Julius Kieswich
  • Muhammad M Yaqoob
  • Qiao Niu
  • Chung Chi Wang
  • A K Fu
  • Catherine Arden
  • M Nikolic
  • Lloyd Potts
  • Loranne Agius
  • John L Petrie
  • Hong Mei Zhang
  • Fu sheng Yuan
  • Xiao Han Wang
  • Zhongfeng Wang
  • Sul Hee Chung
  • R Nath
  • Xiao Bing Yuan
  • Ning Li
  • An qi Geng
  • Jun tao Li
  • Ya Wei Yuan
  • Wang Zheng
  • Long Hua Chen
  • Kun Li
  • Ai Min Sun
  • Xu jun Liang
  • Que Ling Liu
  • Armine Darbinyan
  • Ke Qin Xie
  • Shohreh Amini
  • Francesca Peruzzi
  • Li Yan Hou
  • Gabriela Paglini
  • Jennifer Gordon
  • Tao Zeng
  • Xi Wei Yang
  • Soledad Ferreras
  • Favio Ariel Krapacher
  • Krzysztof Reiss
  • Cui Li Zhang
  • Marta Czernik
  • Kamel Khalili
  • Yuichi Fujita
  • James A Bibb
  • Seong Hoon Park
  • Yu Chen
  • Jaebong Kim
  • Jae Yong Lee
  • Jong Il Kim
  • Xiao su Zhao
  • Jay B Bikoff

Detail Information

Publications35

  1. ncbi Influence of phosphorylation of p35, an activator of cyclin-dependent kinase 5 (cdk5), on the proteolysis of p35
    Petri Kerokoski
    Department of Neuroscience and Neurology, University of Kuopio, P O Box 1627, Finland
    Brain Res Mol Brain Res 106:50-6. 2002
    ..The activity of the kinase is regulated by binding of cdk5 activators (p35, p39, p67)...
  2. doi Elevation of p-NR2A(S1232) by Cdk5/p35 contributes to retinal ganglion cell apoptosis in a rat experimental glaucoma model
    Jie Chen
    Institutes of Brain Science, Institute of Neurobiology and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200032, China
    Neurobiol Dis 43:455-64. 2011
    ..We investigated the possible involvement of cyclin-dependent kinase 5 (Cdk5) and its activator p35, which have been implicated in a variety of neurological disorders, in RGC apoptosis in a rat experimental glaucoma ..
  3. ncbi Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5/p35 pathway
    Rodrigo A Quintanilla
    Millennium Institute for Advanced Studies in Cell Biology and Biotechnology CBB, Nunoa, Santiago, Chile
    Exp Cell Res 295:245-57. 2004
    ..the observed increase of tau epitopes of Alzheimer type is explained by an increase of intraneuronal levels of p35 activator and in the activity of the protein kinase cdk5 in response to this cytokine...
  4. ncbi Glucose-induced expression of the cyclin-dependent protein kinase 5 activator p35 involved in Alzheimer's disease regulates insulin gene transcription in pancreatic beta-cells
    Mariano Ubeda
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, 55 Fruit Street, Wellman 306, Boston, Massachusetts 02114, USA
    Endocrinology 145:3023-31. 2004
    ..Overactivity of CDK5 occurs by proteolytic cleavage and cellular mislocalization of its activator, p35. These alterations in p35/CDK5 signaling pathway may mediate, at least in part, the functional abnormalities ..
  5. ncbi Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism
    Wing Yu Fu
    Department of Biochemistry, Biotechnology Research Institute and Molecular Neuroscience Center, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
    Nat Neurosci 10:67-76. 2007
    ..These findings suggest that ephrin-A1 promotes EphA4-dependent spine retraction through the activation of Cdk5 and ephexin1, which in turn modulates actin cytoskeletal dynamics...
  6. pmc Involvement of calpain/p35-p25/Cdk5/NMDAR signaling pathway in glutamate-induced neurotoxicity in cultured rat retinal neurons
    Yanying Miao
    Institutes of Brain Science, Institute of Neurobiology and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China
    PLoS ONE 7:e42318. 2012
    We investigated possible involvement of a calpain/p35-p25/cyclin-dependent kinase 5 (Cdk5) signaling pathway in modifying NMDA receptors (NMDARs) in glutamate-induced injury of cultured rat retinal neurons...
  7. ncbi [Changes of cdk5, p35 and p53 gene expression levels in arsenic-induced neural cell apoptosis]
    Xin Li
    Department of Radiation Health, Control of Disease Control of Taiyuan Iron Steel Company, Taiyuan 030003, China
    Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 30:85-8. 2012
    To study the expression levels of cdk5, p35 and p53 genes in arsenic trioxide (As2O3O)-induced neuron apoptosis and to explore the potential mechanism.
  8. pmc A novel mechanism for regulating hepatic glycogen synthesis involving serotonin and cyclin-dependent kinase-5
    Susan J Tudhope
    Institute of Cellular Medicine, The Medical School, Newcastle University, Newcastle upon Tyne, UK
    Diabetes 61:49-60. 2012
    ..A role for cdk5 was supported by adaptive changes in the coactivator protein p35 and by elevated glycogen synthesis during overexpression of p35/cdk5...
  9. ncbi [Expression changes of cyclin dependent kinase 5/p35 in nerve tissues of 2, 5-hexanedione intoxicated rats]
    Qing shan Wang
    Department of Toxicology, School of Occupational Health, Shandong University, Jinan 250012, China
    Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 26:336-40. 2008
    ..To explore the role of cyclin dependent kinase 5 (CDK5) in 2, 5-hexanedione (HD)-induced neuropathy...
  10. ncbi Neuronal loss in primary long-term cortical culture involves neurodegeneration-like cell death via calpain and p35 processing, but not developmental apoptosis or aging
    Min Ju Kim
    Department of Biochemistry, College of Medicine, Hallym University, Chuncheon 200 702, Korea
    Exp Mol Med 39:14-26. 2007
    ..This neuronal death exhibited neurodegenerative features, such as conversion of p35 to p25, which is important in the developmental process and in the pathogenesis of Alzheimer's disease...
  11. ncbi Cyclin dependent kinase 5 (Cdk5) mediated inhibition of the MAP kinase pathway results in CREB down regulation and apoptosis in PC12 cells
    Monica Sharma
    Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, India
    Biochem Biophys Res Commun 358:379-84. 2007
    ..We also demonstrate that the activity of transcription factor CREB, which is known to play pro-survival roles in neuronal cells, is attenuated as a result of this cross-talk...
  12. pmc HIV-1 Tat inhibits NGF-induced Egr-1 transcriptional activity and consequent p35 expression in neural cells
    Nune Darbinian
    Department of Neuroscience, Temple University School of Medicine, Philadelphia, Pennsylvania
    J Cell Physiol 216:128-34. 2008
    ..that a decrease in the level of Egr-1, one of the targets for MAPK, by Tat has a negative impact on the level of p35 expression in NGF-treated neural cells...
  13. doi Involvement of calpain and p25 of CDK5 pathway in ginsenoside Rb1's attenuation of beta-amyloid peptide25-35-induced tau hyperphosphorylation in cortical neurons
    Xiaochun Chen
    Department of Neurology, Fujian Institute of Geriatrics, the Affiliated Union Hospital of Fujian Medical University, Fuzhou, Fujian 350001, China
    Brain Res 1200:99-106. 2008
    ..Cyclin-dependent kinase 5 (CDK5) and its activator p35 are required for neurite outgrowth...
  14. doi Transient enhanced expression of Cdk5 activator p25 after acute and chronic d-amphetamine administration
    Estela Cecilia Mlewski
    Instituto de Investigacion Medica Mercedes y Martin Ferreyra, INIMEC CONICET, Cordoba, Argentina
    Ann N Y Acad Sci 1139:89-102. 2008
    ..cocaine has been shown to upregulate the expression of cyclin-dependent kinase 5 (cdk5) and its specific activator, p35, in the striatum, as a downstream target gene of DeltaFosB, and has been implicated in compensatory adaptive ..
  15. doi Expression of p25, an aberrant cyclin-dependent kinase 5 activator, stimulates basal secretion in PC12 cells
    Mi Young Son
    Graduate Program in Neuroscience, Institute for Brain Science and Technology, Inje University, Busan, 614 735, Korea
    Mol Cells 29:51-6. 2010
    ..The amount of p25, an aberrant cleavage product of p35 that activates cyclin-dependent kinase 5 (Cdk5), is elevated in AD brains...
  16. ncbi [Hippocampal mossy fiber sprouting and Cdk5/p35 expressions in the pentylenetetrazole kindling rat model]
    Fa fa Tian
    Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 33:1101-7. 2008
    To observe the expression of cyclin-dependent kinase 5 (Cdk5) and p35 in rat hippocampus during pentetrazole kindling process and their relation with mossy fiber sprouting (MFS), and to investigate the role of Cdk5/p35 in epileptogenesis.
  17. ncbi [p35 and p25 expressions and Cdk5 kinase activity in primary cultured rat hippocampal neurons with X-ray exposure]
    Yong Qing Han
    Department of Radiotherapy, Nanfang Hospital, Southern Medical University, Guangzhou, China
    Nan Fang Yi Ke Da Xue Xue Bao 29:405-7. 2009
    To study the expressions of p35 and p25 and Cdk5 kinase activity in cultured rats hippocampal neurons following X-ray exposure to provide experimental evidence for prevention and treatment of radiation encephalopathy.
  18. pmc Commitment of 1-methyl-4-phenylpyrinidinium ion-induced neuronal cell death by proteasome-mediated degradation of p35 cyclin-dependent kinase 5 activator
    Ryo Endo
    Laboratory of Molecular Neuroscience, Department of Biological Sciences, Graduate School of Science, Tokyo Metropolitan University, Hachioji, Tokyo 192 0397, Japan
    J Biol Chem 284:26029-39. 2009
    ..We studied the role of cyclin-dependent kinase 5 (Cdk5)-p35 in the neuronal cell death induced by 1-methyl-4-phenylpyrinidinium ion (MPP+), which has been used as an in vitro ..
  19. pmc PKCdelta regulates cortical radial migration by stabilizing the Cdk5 activator p35
    Chun tao Zhao
    State Key Laboratory of Neurobiology, Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Proc Natl Acad Sci U S A 106:21353-8. 2009
    Cyclin-dependent kinase 5 (Cdk5) and its activator p35 are critical for radial migration and lamination of cortical neurons...
  20. ncbi Suppression of calpain-dependent cleavage of the CDK5 activator p35 to p25 by site-specific phosphorylation
    Hirotsugu Kamei
    Department of Biological Sciences, Graduate School of Science, Tokyo Metropolitan University, 1 1 Minami Osawa, Hachiohji, Tokyo 192 0397, Japan
    J Biol Chem 282:1687-94. 2007
    ..proline-directed Ser/Thr protein kinase predominantly expressed in postmitotic neurons together with its activator, p35. N-terminal truncation of p35 to p25 by calpain results in deregulation of Cdk5 and contributes to neuronal cell ..
  21. ncbi The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation
    M Nikolic
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 10:816-25. 1996
    ..b>p35 is a neuronal-specific cdk5 regulator that activates cdk5 kinase activity upon association...
  22. ncbi Regulation of N-cadherin-mediated adhesion by the p35-Cdk5 kinase
    Y T Kwon
    Health Advances, Inc, Wellesley, Massachusetts 02181, USA
    Curr Biol 10:363-72. 2000
    The p35-Cdk5 kinase has been implicated in a variety of functions in the central nervous system (CNS), including axon outgrowth, axon guidance, fasciculation, and neuronal migration during cortical development...
  23. ncbi Processing of cdk5 activator p35 to its truncated form (p25) by calpain in acutely injured neuronal cells
    R Nath
    Department of Neuroscience Therapeutics, Parke Davis Pharmaceutical Research, Division of Warner Lambert Company, 2800 Plymouth Road, Ann Arbor, Michigan 48105, USA
    Biochem Biophys Res Commun 274:16-21. 2000
    Recently, it was shown that conversion of cdk5 activator protein p35 to a C-terminal fragment p25 promotes a deregulation of cdk5 activity, which may contribute to neurodegeneration in Alzheimer's disease...
  24. ncbi Amphiphysin 1 binds the cyclin-dependent kinase (cdk) 5 regulatory subunit p35 and is phosphorylated by cdk5 and cdc2
    S R Floyd
    Howard Hughes Medical Institute and Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 276:8104-10. 2001
    ..We show here that amphiphysin 1 interacts with the cdk5-activating subunit p35 and that this interaction is mediated by the conserved NH2-terminal region of amphiphysin...
  25. pmc RefSeq and LocusLink: NCBI gene-centered resources
    K D Pruitt
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A Room 6N605, 8600 Rockville Pike, Bethesda, MD 20894 USA
    Nucleic Acids Res 29:137-40. 2001
    ..Additional information about LocusLink and RefSeq is available at http://www.ncbi.nlm.nih.gov/LocusLink/...
  26. ncbi Cdk5 is involved in neuregulin-induced AChR expression at the neuromuscular junction
    A K Fu
    Department of Biochemistry, Biotechnology Research Institute, Molecular Neuroscience Center, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
    Nat Neurosci 4:374-81. 2001
    Here we describe an important involvement of Cdk5/p35 in regulating the gene expression of acetylcholine receptor (AChR) at the neuromuscular synapse...
  27. ncbi Pctaire1 interacts with p35 and is a novel substrate for Cdk5/p35
    Kai Cheng
    Department of Biochemistry, Biotechnology Research Institute and Molecular Neuroscience Center, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
    J Biol Chem 277:31988-93. 2002
    ..Cdk5 kinase activity depends on its regulatory partners, p35 or p39, which are prominently expressed in the central nervous system...
  28. ncbi The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner
    Rani Dhavan
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 22:7879-91. 2002
    ..Activation of Cdk5 requires its association with a regulatory subunit, and two Cdk5 activators, p35 and p39, have been identified...
  29. ncbi Developmental regulation of the proteolysis of the p35 cyclin-dependent kinase 5 activator by phosphorylation
    Taro Saito
    Department of Biological Sciences, Graduate School of Science, Tokyo Metropolitan University, Minami Osawa, Hachiohji, Tokyo 192 0397, Japan
    J Neurosci 23:1189-97. 2003
    ..cdc2-related kinase expressed in postmitotic neurons, is activated by association with a brain-specific activator, p35. It has been suggested that the conversion of p35 to p25 by the protease calpain is involved in neuronal cell death...
  30. pmc Cdk5 regulates the organization of Nestin and its association with p35
    Cecilia M Sahlgren
    Department of Biology, Abo Akademi University, BioCity, Finland
    Mol Cell Biol 23:5090-106. 2003
    ..We identify nestin as a novel in vivo target for cdk5 and p35 kinase, a critical signaling determinant in development...
  31. ncbi Identification of a novel, membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinase
    Sashi Kesavapany
    Departments of Neuroscience and Neurology, The Institute of Psychiatry, Kings College London, London SE5 8AF, United Kingdom
    J Neurosci 23:4975-83. 2003
    Here we characterize a novel neuronal kinase, cyclin-dependent kinase 5 (cdk5)/p35-regulated kinase (cprk)...
  32. pmc A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neurons
    Ya Li Zheng
    Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 4130, USA
    EMBO J 24:209-20. 2005
    ..p25 is a truncated activator, which is produced from the physiological Cdk5 activator p35 upon exposure to Abeta peptides...
  33. ncbi Phosphorylation of FTDP-17 mutant tau by cyclin-dependent kinase 5 complexed with p35, p25, or p39
    Fumika Sakaue
    Department of Biological Sciences, Graduate School of Science, Tokyo Metropolitan University, Hachiohji, Tokyo 192 039, Japan
    J Biol Chem 280:31522-9. 2005
    ..the phosphorylation of FTDP-17 mutant tau proteins, K257T, P301L, P301S, and R406W, by Cdk5 complexed with p35, p25, or p39 in vitro and in cultured cells...
  34. ncbi Differential roles of nuclear and cytoplasmic cyclin-dependent kinase 5 in apoptotic and excitotoxic neuronal death
    Michael J O'Hare
    Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa Health Research Institute, Ottawa, Ontario, K1H 8M5, Canada
    J Neurosci 25:8954-66. 2005
    ..is localized mainly to postmitotic neurons attributable to the selective expression of its activating partners p35 and p39...
  35. ncbi Phosphorylation of the high molecular weight neurofilament protein (NF-H) by Cdk5 and p35
    D Sun
    Department of Pathology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Biol Chem 271:14245-51. 1996
    ..In vitro phosphorylation studies have shown that Cdk5 in conjunction with its activator, p35, is able to phosphorylate histone H1, dephosphorylated NF-H, as well as a synthetic peptide with the repetitive KSP ..