Gene Symbol: P2X2
Description: purinergic receptor P2X 2
Alias: P2X2, P2X purinoceptor 2, ATP receptor, purinergic receptor P2X, ligand-gated ion channel, 2
Species: rat
Products:     P2X2

Top Publications

  1. Li Z, Migita K, Samways D, Voigt M, Egan T. Gain and loss of channel function by alanine substitutions in the transmembrane segments of the rat ATP-gated P2X2 receptor. J Neurosci. 2004;24:7378-86 pubmed
    ATP opens ionotropic P2X channels through a process that is poorly understood. We made an array of mutant rat P2X2 channels containing unique alanine substitutions in the transmembrane segments with the goal of identifying possible ..
  2. Fujiwara Y, Kubo Y. Regulation of the desensitization and ion selectivity of ATP-gated P2X2 channels by phosphoinositides. J Physiol. 2006;576:135-49 pubmed
  3. Clyne J, Brown T, Hume R. Expression level dependent changes in the properties of P2X2 receptors. Neuropharmacology. 2003;44:403-12 pubmed
    ..Thus, the interactions that cause expression-dependent changes in P2X(2) receptor properties must involve domains proximal to position H397. ..
  4. Ishida Y, Ugawa S, Ueda T, Yamada T, Shibata Y, Hondoh A, et al. P2X(2)- and P2X(3)-positive fibers in fungiform papillae originate from the chorda tympani but not the trigeminal nerve in rats and mice. J Comp Neurol. 2009;514:131-44 pubmed publisher
    ..Taken together, these findings suggest that most P2X(2) and P2X(3) receptors in fungiform papillae are used for gustation rather than somatosensation...
  5. Fujiwara Y, Kubo Y. Density-dependent changes of the pore properties of the P2X2 receptor channel. J Physiol. 2004;558:31-43 pubmed
    ..One exception is the P2X ATP-gated channel. After application of ATP, the ion selectivity of the P2X2 channel time-dependently changes, i.e...
  6. Ren J, Bian X, DeVries M, Schnegelsberg B, Cockayne D, Ford A, et al. P2X2 subunits contribute to fast synaptic excitation in myenteric neurons of the mouse small intestine. J Physiol. 2003;552:809-21 pubmed
    ..These studies used tissues from P2X2 wild-type (P2X2+/+) and P2X2 gene knockout (P2X2-/-) mice to investigate the role of this subunit in enteric ..
  7. Samways D, Migita K, Li Z, Egan T. On the role of the first transmembrane domain in cation permeability and flux of the ATP-gated P2X2 receptor. J Biol Chem. 2008;283:5110-7 pubmed
    ..mutagenesis and patch clamp photometry to study the role of the first transmembrane domain of the rat P2X2 receptor in cation permeability and flux...
  8. Jiang R, Martz A, Gonin S, Taly A, de Carvalho L, Grutter T. A putative extracellular salt bridge at the subunit interface contributes to the ion channel function of the ATP-gated P2X2 receptor. J Biol Chem. 2010;285:15805-15 pubmed publisher
    ..By using a P2X2 model based on the x-ray structure, we sought salt bridges formed between charged residues located in a region that ..
  9. Kubo Y, Fujiwara Y, Keceli B, Nakajo K. Dynamic aspects of functional regulation of the ATP receptor channel P2X2. J Physiol. 2009;587:5317-24 pubmed publisher
    ..Complete elucidation of these regulatory mechanisms awaits dynamic imaging of functioning P2X(2) channels. ..

More Information


  1. Brake A, Wagenbach M, Julius D. New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor. Nature. 1994;371:519-23 pubmed
    ..There is sequence similarity between the ATP receptor and RP-2, a gene activated in thymocytes undergoing programmed cell death...
  2. Cockayne D, Dunn P, Zhong Y, Rong W, Hamilton S, Knight G, et al. P2X2 knockout mice and P2X2/P2X3 double knockout mice reveal a role for the P2X2 receptor subunit in mediating multiple sensory effects of ATP. J Physiol. 2005;567:621-39 pubmed
    ..signalling and sensory regulation of visceral function through ionotropic receptors variably composed of P2X2 and P2X3 subunits...
  3. Finger T, Danilova V, Barrows J, Bartel D, Vigers A, Stone L, et al. ATP signaling is crucial for communication from taste buds to gustatory nerves. Science. 2005;310:1495-9 pubmed
    ..Genetic elimination of ionotropic purinergic receptors (P2X2 and P2X3) eliminates taste responses in the taste nerves, although the nerves remain responsive to touch, ..
  4. Khakh B, Gittermann D, Cockayne D, Jones A. ATP modulation of excitatory synapses onto interneurons. J Neurosci. 2003;23:7426-37 pubmed
    ..We show that ATP-gated presynaptic P2X2 channels facilitate excitatory transmission onto stratum radiatum interneurons but not onto CA1 pyramidal neurons...
  5. Cao L, Broomhead H, Young M, North R. Polar residues in the second transmembrane domain of the rat P2X2 receptor that affect spontaneous gating, unitary conductance, and rectification. J Neurosci. 2009;29:14257-64 pubmed publisher
    ..We have measured single-channel currents, spontaneous gating, and rectification of rat P2X2 receptor in which polar and charged residues of the second transmembrane domain (TM2) were systematically probed by ..
  6. Rubio M, Soto F. Distinct Localization of P2X receptors at excitatory postsynaptic specializations. J Neurosci. 2001;21:641-53 pubmed
    ..The present study shows for the first time qualitatively and quantitatively the precise localization of P2X receptors in brain. Moreover, our data indicate that P2X receptors may play a significant role at glutamatergic synapses. ..
  7. Nagaya N, Tittle R, Saar N, Dellal S, Hume R. An intersubunit zinc binding site in rat P2X2 receptors. J Biol Chem. 2005;280:25982-93 pubmed
    ..Zinc binds to rat P2X2 receptors and acts as an allosteric modulator, potentiating channel opening...
  8. Gourine A, Atkinson L, Deuchars J, Spyer K. Purinergic signalling in the medullary mechanisms of respiratory control in the rat: respiratory neurones express the P2X2 receptor subunit. J Physiol. 2003;552:197-211 pubmed
    ..In particular we determined whether respiratory neurones in the rostral ventrolateral medulla (VLM) express P2X2 receptor subunits of the ATP-gated ion channel, since ATP currents evoked at recombinant P2X2 receptors are ..
  9. Keceli B, Kubo Y. Signal transmission within the P2X2 trimeric receptor. J Gen Physiol. 2014;143:761-82 pubmed publisher
    b>P2X2 receptor channel, a homotrimer activated by the binding of extracellular adenosine triphosphate (ATP) to three intersubunit ATP-binding sites (each located ?50 Å from the ion permeation pore), also shows voltage-dependent activation ..
  10. De Roo M, Rodeau J, Schlichter R. Dehydroepiandrosterone potentiates native ionotropic ATP receptors containing the P2X2 subunit in rat sensory neurones. J Physiol. 2003;552:59-71 pubmed
    ..3) and by ivermectin (IVM, 3 microM), indicating the presence heteromeric P2X2-containing receptors and possibly of functional native P2X4/6 receptors...
  11. Lavado A, Olivares C, García Borrón J, Montoliu L. Molecular basis of the extreme dilution mottled mouse mutation: a combination of coding and noncoding genomic alterations. J Biol Chem. 2005;280:4817-24 pubmed
  12. Atkinson L, Batten T, Deuchars J. P2X(2) receptor immunoreactivity in the dorsal vagal complex and area postrema of the rat. Neuroscience. 2000;99:683-96 pubmed
  13. Ito K, Iwami A, Katsura H, Ikeda M. Therapeutic effects of the putative P2X3/P2X2/3 antagonist A-317491 on cyclophosphamide-induced cystitis in rats. Naunyn Schmiedebergs Arch Pharmacol. 2008;377:483-90 pubmed
    ..In this study, we investigated the effect of the recently developed P2X3 and P2X2/3 receptor antagonist A-317491 on cyclophosphamide (CYP)-induced cystitis to determine whether a P2X receptor ..
  14. Wang Y, Li G, Yu K, Liang S, Wan F, Xu C, et al. Expressions of P2X2 and P2X3 receptors in rat nodose neurons after myocardial ischemia injury. Auton Neurosci. 2009;145:71-5 pubmed publisher
    ..It suggests that P2X(2) receptor subtype in company with P2X(3) receptor subtype plays the important role in cardiac vagal sensory nociceptors with a sensitivity to ATP. ..
  15. Ryten M, Koshi R, Knight G, Turmaine M, Dunn P, Cockayne D, et al. Abnormalities in neuromuscular junction structure and skeletal muscle function in mice lacking the P2X2 nucleotide receptor. Neuroscience. 2007;148:700-11 pubmed
    ..However, the role of this neurotransmitter in muscle function remains unclear. The P2X2 ion channel receptor subunit is expressed during development of the skeletal NMJ, but not in adult muscle fibers, ..
  16. Masin M, Kerschensteiner D, Dümke K, Rubio M, Soto F. Fe65 interacts with P2X2 subunits at excitatory synapses and modulates receptor function. J Biol Chem. 2006;281:4100-8 pubmed
    ..Thus, the time- and activation-dependent change in ionic selectivity of P2X(2) receptors was inhibited by coexpression of Fe65, suggesting a novel role for Fe65 in regulating P2X receptor function and ATP-mediated synaptic transmission. ..
  17. Mio K, Kubo Y, Ogura T, Yamamoto T, Sato C. Visualization of the trimeric P2X2 receptor with a crown-capped extracellular domain. Biochem Biophys Res Commun. 2005;337:998-1005 pubmed
    The P2X2 purinergic receptor permeates cationic ions in response to stimulation by ATP and mediates fast synaptic transmission...
  18. Schwindt T, Trujillo C, Negraes P, Lameu C, Ulrich H. Directed differentiation of neural progenitors into neurons is accompanied by altered expression of P2X purinergic receptors. J Mol Neurosci. 2011;44:141-6 pubmed publisher
    ..rat neurospheres cultured in suspension under mitogen-free condition presented significant higher expression of P2X2 and P2X6 receptor subunits, when compared to cells cultured in the presence of growth factors, suggesting a direct ..
  19. Trujillo C, Nery A, Martins A, Majumder P, Gonzalez F, Ulrich H. Inhibition mechanism of the recombinant rat P2X(2) receptor in glial cells by suramin and TNP-ATP. Biochemistry. 2006;45:224-33 pubmed
  20. de Oliveira Fusaro M, Pelegrini da Silva A, Araldi D, Parada C, Tambeli C. P2X3 and P2X2/3 receptors mediate mechanical hyperalgesia induced by bradykinin, but not by pro-inflammatory cytokines, PGE? or dopamine. Eur J Pharmacol. 2010;649:177-82 pubmed publisher
    Activation of peripheral P2X3 and P2X2/3 receptors by endogenous ATP is essential to the development of inflammatory hyperalgesia...
  21. Barrera N, Henderson R, Murrell Lagnado R, Edwardson J. The stoichiometry of P2X2/6 receptor heteromers depends on relative subunit expression levels. Biophys J. 2007;93:505-12 pubmed
    ..We suggest that this property of receptor assembly might introduce an additional layer of subtlety into P2X receptor signaling. ..
  22. Yan D, Zhu Y, Walsh T, Xie D, Yuan H, Sirmaci A, et al. Mutation of the ATP-gated P2X(2) receptor leads to progressive hearing loss and increased susceptibility to noise. Proc Natl Acad Sci U S A. 2013;110:2228-33 pubmed publisher
    ..V60L, noise exposure exacerbated high-frequency hearing loss in young adulthood. Our results suggest that P2X(2) function is required for life-long normal hearing and for protection from exposure to noise. ..
  23. Lin J, Li G, Den X, Xu C, Liu S, Gao Y, et al. VEGF and its receptor-2 involved in neuropathic pain transmission mediated by P2X?(/)? receptor of primary sensory neurons. Brain Res Bull. 2010;83:284-91 pubmed publisher
    ..Anti-rVEGF treatment in CCI rats may alleviate chronic neuropathic pain by decreasing the expressions of VEGFR2 and P2X?(/)? receptors on DRG neurons to inhibit the transmission of neuropathic pain signaling. ..
  24. Dunn P, Gever J, Ruan H, Burnstock G. Developmental changes in heteromeric P2X(2/3) receptor expression in rat sympathetic ganglion neurons. Dev Dyn. 2005;234:505-11 pubmed
  25. Yang R, Montoya A, Bond A, Walton J, Kinnamon J. Immunocytochemical analysis of P2X2 in rat circumvallate taste buds. BMC Neurosci. 2012;13:51 pubmed publisher
    ..Recent studies indicate that the ionotropic purinergic receptors P2X2/P2X3 are present in rodent taste buds...
  26. Habermacher C, Martz A, Calimet N, Lemoine D, Peverini L, Specht A, et al. Photo-switchable tweezers illuminate pore-opening motions of an ATP-gated P2X ion channel. elife. 2016;5:e11050 pubmed publisher
    ..as 'molecular tweezers' to monitor a series of inter-residue distances in the transmembrane domain of the P2X2 receptor during activation...
  27. Mangano C, Colldén G, Meister B. Chemical phenotypes of P2X2 purinoreceptor immunoreactive cell bodies in the area postrema. Purinergic Signal. 2012;8:223-34 pubmed publisher
    ..The purinergic receptor subunit P2X2 is a ligand-gated ion channel that is widely expressed by neurons in the CNS...
  28. Studeny S, Torabi A, Vizzard M. P2X2 and P2X3 receptor expression in postnatal and adult rat urinary bladder and lumbosacral spinal cord. Am J Physiol Regul Integr Comp Physiol. 2005;289:R1155-68 pubmed
    ..This may involve changes in neuroactive compounds and receptors in bladder reflex pathways. We examined P2X2 and P2X3 receptors in bladder and spinal cord from postnatal (P0-P36, indicating number of days) and adult Wistar ..
  29. Aschrafi A, Sadtler S, Niculescu C, Rettinger J, Schmalzing G. Trimeric architecture of homomeric P2X2 and heteromeric P2X1+2 receptor subtypes. J Mol Biol. 2004;342:333-43 pubmed
    ..evidence that in addition to the rapidly desensitising P2X1 and P2X3 receptors, the slowly desensitising subtypes P2X2, P2X4, and P2X5 are trimers of identical subunits...
  30. Wolf C, Rosefort C, Fallah G, Kassack M, Hamacher A, Bodnar M, et al. Molecular determinants of potent P2X2 antagonism identified by functional analysis, mutagenesis, and homology docking. Mol Pharmacol. 2011;79:649-61 pubmed publisher
    b>P2X2 receptors are members of the ATP-gated P2X family of cation channels, and they participate in neurotransmission in sympathetic ganglia and interneurons...
  31. Liu Y, Tian X, Wu Y, Chen L, Yi C, Li Z, et al. Phenotypes of ATP-activated current associated with their genotypes of P2X1-6 subunits in neurons innervating tooth-pulp. Biochem Biophys Res Commun. 2015;458:596-600 pubmed publisher
    ..to ATP with the type F current mainly showed positive staining for P2X3 and P2X5, but negative staining for P2X2; cells responsive to ATP with the type I current showed positive staining for P2X1-3 and P2X5, but negative ..
  32. Misawa R, Girotti P, Mizuno M, Liberti E, Furness J, Castelucci P. Effects of protein deprivation and re-feeding on P2X2 receptors in enteric neurons. World J Gastroenterol. 2010;16:3651-63 pubmed
    ..Undernutrition affected P2X(2) receptor expression in the submucosal plexus, and neuronal and size. These changes were rescued in the re-fed rats. ..
  33. Fukui M, Nakagawa T, Minami M, Satoh M, Kaneko S. Inhibitory role of supraspinal P2X3/P2X2/3 subtypes on nociception in rats. Mol Pain. 2006;2:19 pubmed
    ..c.v.) pretreatment with A-317491 (1 nmol), the novel non-nucleotide antagonist selective for P2X3 and P2X2/3 receptors, attenuated the antinociceptive effect produced by i.c.v...
  34. Dang K, Lamb K, Cohen M, Bielefeldt K, Gebhart G. Cyclophosphamide-induced bladder inflammation sensitizes and enhances P2X receptor function in rat bladder sensory neurons. J Neurophysiol. 2008;99:49-59 pubmed
  35. Liang X, Xu H, Li C, Yin S, Xu T, Liu J, et al. Functional identification of close proximity amino acid side chains within the transmembrane-spanning helixes of the P2X2 receptor. PLoS ONE. 2013;8:e70629 pubmed publisher
    ..The relative movement between the first transmembrane and the second transmembrane in the intra-subunit is likely important for transmitting the action of ATP binding to the opening of the channel. ..
  36. Barrera N, Ormond S, Henderson R, Murrell Lagnado R, Edwardson J. Atomic force microscopy imaging demonstrates that P2X2 receptors are trimers but that P2X6 receptor subunits do not oligomerize. J Biol Chem. 2005;280:10759-65 pubmed
    ..We conclude that P2X(2) receptors are trimers, whereas the P2X(6) receptor subunits do not form stable oligomers. ..
  37. Wang J, Raybould N, Luo L, Ryan A, Cannell M, Thorne P, et al. Noise induces up-regulation of P2X2 receptor subunit of ATP-gated ion channels in the rat cochlea. Neuroreport. 2003;14:817-23 pubmed
  38. Coutinho Silva R, Parsons M, Robson T, Lincoln J, Burnstock G. P2X and P2Y purinoceptor expression in pancreas from streptozotocin-diabetic rats. Mol Cell Endocrinol. 2003;204:141-54 pubmed
    The expression of the nucleotide receptors P2X1, P2X2, P2X7, P2Y1, P2Y2 and P2Y4, in the pancreas of the streptozotocin-induced diabetic rat was investigated using immunohistochemistry...
  39. Gomes D, Song Z, Stevens W, Sladek C. Sustained stimulation of vasopressin and oxytocin release by ATP and phenylephrine requires recruitment of desensitization-resistant P2X purinergic receptors. Am J Physiol Regul Integr Comp Physiol. 2009;297:R940-9 pubmed publisher
    ..by recruitment of desensitization-resistant ionotropic purinergic receptor subtypes (P2X-Rs): 1) Antagonists of the P2X2/3 and P2X7-Rs truncated the sustained VP/OT release induced by ATP+PE but did not alter the transient response to ..
  40. Luo J, Yin G, Gu Y, Liu Y, Dai J, Li C, et al. Characterization of three types of ATP-activated current in relation to P2X subunits in rat trigeminal ganglion neurons. Brain Res. 2006;1115:9-15 pubmed
    ..current was associated with cell size and P2X receptor subunits: small-sized cells with type F of I(ATP) express only P2X1 and/or P2X3 subunits, while cells with types S and I of I(ATP) express P2X2 or P2X4 in addition to P2X1 and P2X3.
  41. Florenzano F, Viscomi M, Cavaliere F, Volonte C, Molinari M. Cerebellar lesion up-regulates P2X1 and P2X2 purinergic receptors in precerebellar nuclei. Neuroscience. 2002;115:425-34 pubmed
    ..They provide in vivo evidence of a correlation between purinergic receptor subunit up-regulation and survival of injured neurons. ..
  42. Rodrigues R, Almeida T, Richardson P, Oliveira C, Cunha R. Dual presynaptic control by ATP of glutamate release via facilitatory P2X1, P2X2/3, and P2X3 and inhibitory P2Y1, P2Y2, and/or P2Y4 receptors in the rat hippocampus. J Neurosci. 2005;25:6286-95 pubmed
    ..release of glutamate from purified nerve terminals of the rat hippocampus, the facilitation being mediated by P2X1, P2X2/3, and P2X3 [antagonized by 8-(benzamido)naphthalene-1,3,5-trisulfonate and 2',3'-O-(2,4,6-trinitrophenyl)-ATP] and ..
  43. Salih S, Housley G, Burton L, Greenwood D. P2X2 receptor subunit expression in a subpopulation of cochlear type I spiral ganglion neurones. Neuroreport. 1998;9:279-82 pubmed
    Spiral ganglion neurones in rat cochlea express three different isoforms of the P2X2 receptor subunit which assemble into ATP-gated ion channels. Two of these P2X2R subunit isoforms have previously been detected in other auditory tissues...
  44. Stelmashenko O, Compan V, Browne L, North R. Ectodomain movements of an ATP-gated ion channel (P2X2 receptor) probed by disulfide locking. J Biol Chem. 2014;289:9909-17 pubmed publisher
    ..In the present work, we examined this opening model by introducing pairs of cysteines into the rat P2X2 receptor that might form disulfide bonds within or between subunits...
  45. Emerit M, Baranowski C, Diaz J, Martinez A, Areias J, Alterio J, et al. A New Mechanism of Receptor Targeting by Interaction between Two Classes of Ligand-Gated Ion Channels. J Neurosci. 2016;36:1456-70 pubmed publisher
    The 5-HT3 receptors are serotonin-gated ion channels that physically couple with purinergic P2X2 receptors to trigger a functional cross-inhibition leading to reciprocal channel occlusion...
  46. Li G, Liu S, Zhang J, Yu K, Xu C, Lin J, et al. Increased sympathoexcitatory reflex induced by myocardial ischemic nociceptive signaling via P2X2/3 receptor in rat superior cervical ganglia. Neurochem Int. 2010;56:984-90 pubmed publisher
    ..The myocardial ischemic injury induced an increase in the expression of P2X(2/3) receptor colocalization with TH and a hypersensitivity state of SCG neurons to ATP, which led to the increased sympathoexcitatory reflex. ..
  47. Lorca R, Coddou C, Gazitúa M, Bull P, Arredondo C, Huidobro Toro J. Extracellular histidine residues identify common structural determinants in the copper/zinc P2X2 receptor modulation. J Neurochem. 2005;95:499-512 pubmed
    To assess the mechanism of P2X2 receptor modulation by transition metals, the cDNA for the wild-type receptor was injected to Xenopus laevis oocytes and examined 48-72 h later by the two-electrode voltage-clamp technique...
  48. Khakh B, Fisher J, Nashmi R, Bowser D, Lester H. An angstrom scale interaction between plasma membrane ATP-gated P2X2 and alpha4beta2 nicotinic channels measured with fluorescence resonance energy transfer and total internal reflection fluorescence microscopy. J Neurosci. 2005;25:6911-20 pubmed
    ..Here, we show that plasma membrane alpha4beta2 nicotinic and P2X2 channels form a molecular scale partnership and also influence each other when coactivated, resulting in ..
  49. Paulino A, Palombit K, Cavriani G, Tavares de Lima W, Mizuno M, Marosti A, et al. Effects of ischemia and reperfusion on P2X2 receptor expressing neurons of the rat ileum enteric nervous system. Dig Dis Sci. 2011;56:2262-75 pubmed publisher
    We investigated the effects of ischemia/reperfusion in the intestine (I/R-i) on purine receptor P2X2-immunoreactive (IR) neurons of the rat ileum...
  50. Wang L, Feng D, Yan H, Wang Z, Pei L. Comparative analysis of P2X1, P2X2, P2X3, and P2X4 receptor subunits in rat nodose ganglion neurons. PLoS ONE. 2014;9:e96699 pubmed publisher
    ..immunocytochemistry, and whole cell patch clamp techniques to compare the expression and function of P2X1, P2X2, P2X3, and P2X4 receptor subunits in adult rat NG neurons...
  51. Antonio L, Stewart A, Varanda W, Edwardson J. Identification of P2X2/P2X4/P2X6 heterotrimeric receptors using atomic force microscopy (AFM) imaging. FEBS Lett. 2014;588:2125-8 pubmed publisher
    Seven P2X purinergic receptor subunits have been identified: P2X1-P2X7. The overlapping expression of P2X2, P2X4 and P2X6 subunits has been shown in different cell types, and functional analysis of P2X receptors in Leydig cells suggests ..
  52. Mio K, Ogura T, Yamamoto T, Hiroaki Y, Fujiyoshi Y, Kubo Y, et al. Reconstruction of the P2X(2) receptor reveals a vase-shaped structure with lateral tunnels above the membrane. Structure. 2009;17:266-75 pubmed publisher
    ..The sparse, extended structure of the P2X(2) receptor indicates a loose assembly of subunits, which could be a basis for the activation-dependent pore dilation of P2X receptors. ..
  53. Keceli B, Kubo Y. Voltage- and ATP-dependent structural rearrangements of the P2X2 receptor associated with the gating of the pore. J Physiol. 2014;592:4657-76 pubmed publisher
    b>P2X2 is an extracellular ATP-gated cation channel which has a voltage-dependent gating property even though it lacks a canonical voltage sensor...
  54. Niane L, Donnelly D, Joseph V, Bairam A. Ventilatory and carotid body chemoreceptor responses to purinergic P2X receptor antagonists in newborn rats. J Appl Physiol (1985). 2011;110:83-94 pubmed publisher
    ..However, these effects are not age dependent within the age range studied. ..
  55. Gao Y, Liu H, Deng L, Zhu G, Xu C, Li G, et al. Effect of emodin on neuropathic pain transmission mediated by P2X2/3 receptor of primary sensory neurons. Brain Res Bull. 2011;84:406-13 pubmed publisher
    ..The results showed that emodin can inhibit the transmission of neuropathic pain mediated by P2X(2/3) receptor of primary sensory neurons to alleviate chronic neuropathic pain. ..
  56. Housley G, Greenwood D, Bennett T, Ryan A. Identification of a short form of the P2xR1-purinoceptor subunit produced by alternative splicing in the pituitary and cochlea. Biochem Biophys Res Commun. 1995;212:501-8 pubmed
    ..The region of the receptor lost in the truncated version coded for a number of serine/proline rich regions which may act as potential intracellular regulatory sites. ..
  57. Li S, Tomić M, Stojilkovic S. Characterization of novel Pannexin 1 isoforms from rat pituitary cells and their association with ATP-gated P2X channels. Gen Comp Endocrinol. 2011;174:202-10 pubmed publisher
    ..These splice forms can also physically associate with ATP-gated P2X2, P2X3, P2X4, and P2X7 receptor channels...
  58. Moffatt L, Hume R. Responses of rat P2X2 receptors to ultrashort pulses of ATP provide insights into ATP binding and channel gating. J Gen Physiol. 2007;130:183-201 pubmed
    ..Like NMDA receptors, P2X(2) receptors provide the potential for complex patterns of synaptic integration over a time scale of hundreds of milliseconds. ..
  59. Allgaier C, Reinhardt R, Schädlich H, Rubini P, Bauer S, Reichenbach A, et al. Somatic and axonal effects of ATP via P2X2 but not P2X7 receptors in rat thoracolumbar sympathetic neurones. J Neurochem. 2004;90:359-67 pubmed
    ..However, the functional significance of axonal and (peri)-nuclear P2X(7) receptors has still to be proven. ..
  60. Richler E, Shigetomi E, Khakh B. Neuronal P2X2 receptors are mobile ATP sensors that explore the plasma membrane when activated. J Neurosci. 2011;31:16716-30 pubmed publisher
    ATP-gated ionotropic P2X2 receptors are widely expressed in neurons...
  61. Xu J, Chu K, Brederson J, Jarvis M, McGaraughty S. Spontaneous firing and evoked responses of spinal nociceptive neurons are attenuated by blockade of P2X3 and P2X2/3 receptors in inflamed rats. J Neurosci Res. 2012;90:1597-606 pubmed publisher
    P2X3 and P2X2/3 receptors are selectively expressed on primary afferent nociceptors and have been implicated in modulating nociception in different models of pathological pain, including inflammatory pain...
  62. Rong W, Gourine A, Cockayne D, Xiang Z, Ford A, Spyer K, et al. Pivotal role of nucleotide P2X2 receptor subunit of the ATP-gated ion channel mediating ventilatory responses to hypoxia. J Neurosci. 2003;23:11315-21 pubmed
    ..Mice deficient in P2X2 receptor subunit showed a markedly attenuated ventilatory response to hypoxia, whereas the response to hypoxia in ..
  63. Atkinson L, Shigetomi E, Kato F, Deuchars J. Differential increases in P2X receptor levels in rat vagal efferent neurones following a vagal nerve section. Brain Res. 2003;977:112-8 pubmed
    ..Thus the increase in P2XR levels in DVN cells ipsilateral to a nerve section are likely to reflect an increase in expression of functional P2XRs on the cell surface. ..
  64. Colldén G, Mangano C, Meister B. P2X2 purinoreceptor protein in hypothalamic neurons associated with the regulation of food intake. Neuroscience. 2010;171:62-78 pubmed publisher
    ..The purinergic receptor subunit P2X2 is a ligand-gated ion channel that is widely expressed by neurons in the central nervous system...
  65. Kakimoto S, Nagakura Y, Tamura S, Watabiki T, Shibasaki K, Tanaka S, et al. Minodronic acid, a third-generation bisphosphonate, antagonizes purinergic P2X(2/3) receptor function and exerts an analgesic effect in pain models. Eur J Pharmacol. 2008;589:98-101 pubmed publisher
    ..These unique effects of minodronic acid would be beneficial for the treatment of accelerated bone turnover diseases accompanied by bone pain, including bone metastases. ..
  66. Tittle R, Power J, Hume R. A histidine scan to probe the flexibility of the rat P2X2 receptor zinc-binding site. J Biol Chem. 2007;282:19526-33 pubmed
    ..Our data are consistent with a moderately flexible zinc-binding site and inconsistent with parallel and anti-parallel orientations of the regions surrounding histidines 120 and 213. ..
  67. Greenwood D, Jagger D, Huang L, Hoya N, Thorne P, Wildman S, et al. P2X receptor signaling inhibits BDNF-mediated spiral ganglion neuron development in the neonatal rat cochlea. Development. 2007;134:1407-17 pubmed
    ..These findings indicate that P2X receptor signaling provides a mechanism for inhibiting neurotrophin support of SGN neurites when synaptic reorganization is occurring in the cochlea. ..
  68. Chaumont S, Jiang L, Penna A, North R, Rassendren F. Identification of a trafficking motif involved in the stabilization and polarization of P2X receptors. J Biol Chem. 2004;279:29628-38 pubmed
  69. Brandle U, Spielmanns P, Osteroth R, Sim J, Surprenant A, Buell G, et al. Desensitization of the P2X(2) receptor controlled by alternative splicing. FEBS Lett. 1997;404:294-8 pubmed
    ..These results imply functional differences between cells differentially expressing these P2X(2) isoforms. ..