Gene Symbol: Oxtr
Description: oxytocin receptor
Alias: OT-R, OTR, OTR1, oxytocin receptor, oxcytocin receptor
Species: rat
Products:     Oxtr

Top Publications

  1. Lukas M, Bredewold R, Neumann I, Veenema A. Maternal separation interferes with developmental changes in brain vasopressin and oxytocin receptor binding in male rats. Neuropharmacology. 2010;58:78-87 pubmed publisher
  2. Strakova Z, Soloff M. Coupling of oxytocin receptor to G proteins in rat myometrium during labor: Gi receptor interaction. Am J Physiol. 1997;272:E870-6 pubmed
    Occupancy of oxytocin receptor (OTR) binding sites in pregnant rat myometrial membranes with iodinated oxytocin antagonist (OTA), followed by detergent solubilization and size selection, showed that radioactivity eluted in two distinct ..
  3. Martins A, Crescenzi A, Stern J, Bordin S, Michelini L. Hypertension and exercise training differentially affect oxytocin and oxytocin receptor expression in the brain. Hypertension. 2005;46:1004-9 pubmed
    ..In contrast, training increased OT mRNA expression in sedentary and hypertensive rats, which may facilitate training-induced cardiac performance. ..
  4. Beyer C, Dwyer J, Platt B, Neal S, Luo B, Ling H, et al. Angiotensin IV elevates oxytocin levels in the rat amygdala and produces anxiolytic-like activity through subsequent oxytocin receptor activation. Psychopharmacology (Berl). 2010;209:303-11 pubmed publisher
    ..Cotreatment with either the AT(4) receptor antagonist, divalinal, or the selective oxytocin receptor antagonist, WAY-162720, reversed the anxiolytic-like effects of Nle-Ang IV, while combining ineffective ..
  5. Khazipov R, Tyzio R, Ben Ari Y. Effects of oxytocin on GABA signalling in the foetal brain during delivery. Prog Brain Res. 2008;170:243-57 pubmed publisher
    ..Neuronal death caused by anoxic-aglycaemic episodes was substantially delayed in the foetal hippocampus by endogenous OXT. These findings suggest that OXT plays important role in the preparation of the foetal brain to delivery. ..
  6. Bosch O, Meddle S, Beiderbeck D, Douglas A, Neumann I. Brain oxytocin correlates with maternal aggression: link to anxiety. J Neurosci. 2005;25:6807-15 pubmed
    ..Using retrodialysis, blockade of endogenous oxytocin action by infusion of an oxytocin receptor antagonist (des-Gly-NH2,d(CH2)5[Tyr(Me)2,Thr4]OVT) into the PVN or CeA reduced maternal aggression of HAB ..
  7. Matsuzaki T, Iwasa T, Munkhzaya M, Tungalagsuvd A, Kawami T, Murakami M, et al. Developmental changes in hypothalamic oxytocin and oxytocin receptor mRNA expression and their sensitivity to fasting in male and female rats. Int J Dev Neurosci. 2015;41:105-9 pubmed publisher
    ..In this study, the developmental changes in the hypothalamic mRNA levels of OT, the OT receptor (OTR), and ER-α were evaluated in male and female rats...
  8. Ho J, Anekonda V, Thompson B, Zhu M, Curry R, Hwang B, et al. Hindbrain oxytocin receptors contribute to the effects of circulating oxytocin on food intake in male rats. Endocrinology. 2014;155:2845-57 pubmed publisher
    ..determine whether circulating OT inhibits food intake by acting at hindbrain OTRs, we pretreated rats with an OTR antagonist administered into the fourth ventricle (4V) followed by either central or systemic OT administration...
  9. Murata T, Narita K, Honda K, Higuchi T. Changes of receptor mRNAs for oxytocin and estrogen during the estrous cycle in rat uterus. J Vet Med Sci. 2003;65:707-12 pubmed
    b>Oxytocin receptor (OTR) mRNA levels increase dramatically near term and is potently stimulated by estrogen because increased OTR mRNA levels result from estrogen treatment in ovariectomized rat uterus...

Scientific Experts

More Information


  1. Gupta J, RUSSELL R, Wayman C, Hurley D, Jackson V. Oxytocin-induced contractions within rat and rabbit ejaculatory tissues are mediated by vasopressin V1A receptors and not oxytocin receptors. Br J Pharmacol. 2008;155:118-26 pubmed publisher
    ..Endothelin-1-induced contractions are not due to endogenous oxytocin or AVP release. V1A receptor antagonists may have a therapeutic role in both erectile dysfunction and premature ejaculation. ..
  2. Suzuki M, Honda Y, Li M, Masuko S, Murata Y. The localization of oxytocin receptors in the islets of Langerhans in the rat pancreas. Regul Pept. 2013;183:42-5 pubmed publisher
    ..Indeed, OTR mRNA was expressed in the rat pancreas...
  3. Holmes C, Landry D, Granton J. Science review: Vasopressin and the cardiovascular system part 1--receptor physiology. Crit Care. 2003;7:427-34 pubmed
    ..In part 2 of the review we discuss the effects of vasopressin on vascular smooth muscle and the heart, and we summarize clinical studies of vasopressin in shock states. ..
  4. Smith C, Poehlmann M, LI S, Ratnaseelan A, Bredewold R, Veenema A. Age and sex differences in oxytocin and vasopressin V1a receptor binding densities in the rat brain: focus on the social decision-making network. Brain Struct Funct. 2017;222:981-1006 pubmed publisher
    Oxytocin (OT) and vasopressin (AVP) regulate various social behaviors via activation of the OT receptor (OTR) and the AVP V1a receptor (V1aR) in the brain...
  5. Morel G, Pechoux C, Raccurt M, Zingg H. Intrauterine oxytocin system. Compartmental distribution of oxytocin and oxytocin receptors in rat endometrial epithelium. Cell Tissue Res. 2001;304:377-82 pubmed
    At term, uterine epithelial cells express oxytocin (OT) as well as the OT receptor (OTR)...
  6. Fang X, Wong S, Mitchell B. Effects of LPS and IL-6 on oxytocin receptor in non-pregnant and pregnant rat uterus. Am J Reprod Immunol. 2000;44:65-72 pubmed
    ..were incubated in vitro to determine the effects of IL-6 on uterine synthesis of oxytocin (OT) and its receptor (OTR). LPS injection was quite toxic to pregnant rats and gave extremely variable results...
  7. Han Y, Yu L. Involvement of oxytocin and its receptor in nociceptive modulation in the central nucleus of amygdala of rats. Neurosci Lett. 2009;454:101-4 pubmed publisher
    ..The present study demonstrated that oxytocin and its receptors are involved in nociceptive modulation in the CeA of rats. ..
  8. Murata T, Narita K, Higuchi T. Changes in uterine receptor mRNAs for oxytocin and estrogen in the pseudopregnant rat. J Vet Med Sci. 2008;70:1253-6 pubmed
    This study examined the uterine oxytocin- (OTR) and estrogen- (ER) receptor mRNA levels during and after pseudopregnancy (PSP) in rats...
  9. Murata Y, Li M, Masuko S. Developmental expression of oxytocin receptors in the neonatal medulla oblongata and pons. Neurosci Lett. 2011;502:157-61 pubmed publisher
    ..Fibrous or rounded shaped OTR-immunoreactive structures were distributed densely in sensory nuclei, such as the gracile nucleus, the solitary ..
  10. Verty A, McFarlane J, McGregor I, Mallet P. Evidence for an interaction between CB1 cannabinoid and oxytocin receptors in food and water intake. Neuropharmacology. 2004;47:593-603 pubmed
    ..procedure, and then received intracerebroventricular (ICV) injections of various combinations of the oxytocin receptor antagonist tocinoic acid, the cannabionid receptor agonist delta(9)-tetrahydrocannabinol (THC), oxytocin, or ..
  11. Bale T, Davis A, Auger A, Dorsa D, McCarthy M. CNS region-specific oxytocin receptor expression: importance in regulation of anxiety and sex behavior. J Neurosci. 2001;21:2546-52 pubmed
    The oxytocin receptor (OTR) is differentially expressed in the CNS...
  12. Zhao D, Ai H. Oxytocin and vasopressin involved in restraint water-immersion stress mediated by oxytocin receptor and vasopressin 1b receptor in rat brain. PLoS ONE. 2011;6:e23362 pubmed publisher
    ..and 40% of AVP-IR neurons in the PVN, while in the SON it represented 28%, 53% respectively; (3) V(1b)R-IR and OTR-IR neurons occupied all portions of the NTS and DMV...
  13. Jankowski M, Danalache B, Wang D, Bhat P, Hajjar F, Marcinkiewicz M, et al. Oxytocin in cardiac ontogeny. Proc Natl Acad Sci U S A. 2004;101:13074-9 pubmed
    ..Here, we show a maximal OT and OTR protein level in the developing rat heart at day 21 of gestation and postnatal days 1-4, when cardiac myocytes are ..
  14. Grund T, Goyon S, Li Y, Eliava M, Liu H, Charlet A, et al. Neuropeptide S Activates Paraventricular Oxytocin Neurons to Induce Anxiolysis. J Neurosci. 2017;37:12214-12225 pubmed publisher
    ..Thereby, oxytocin neurons seem essential for neuropeptide S-induced anxiolysis, as this effect was blocked by pharmacological and chemogenetic inhibition of the oxytocin system. ..
  15. Jarrett T, McMurray M, Walker C, Johns J. Cocaine treatment alters oxytocin receptor binding but not mRNA production in postpartum rat dams. Neuropeptides. 2006;40:161-7 pubmed
    Gestational cocaine treatment in rat dams results in decreased oxytocin (OT) levels, up-regulated oxytocin receptor (OTR) binding density and decreased receptor affinity in the whole amygdala, all concomitant with a significant increase ..
  16. Yang X, Xi T, Li Y, Wang H, Qin Y, Zhang J, et al. Oxytocin decreases colonic motility of cold water stressed rats via oxytocin receptors. World J Gastroenterol. 2014;20:10886-94 pubmed publisher
    ..whether cold water intake into the stomach affects colonic motility and the involvement of the oxytocin-oxytocin receptor pathway in rats. Female Sprague Dawley rats were used and some of them were ovariectomized...
  17. Hoare S, Copland J, Strakova Z, Ives K, Jeng Y, Hellmich M, et al. The proximal portion of the COOH terminus of the oxytocin receptor is required for coupling to g(q), but not g(i). Independent mechanisms for elevating intracellular calcium concentrations from intracellular stores. J Biol Chem. 1999;274:28682-9 pubmed
    As the oxytocin receptor plays a key role in parturition and lactation, there is considerable interest in defining its structure/functional relationships...
  18. Caligioni C, Oliver C, Jamur M, Franci C. Presence of oxytocin receptors in the gonadotrophin-releasing hormone (GnRH) neurones in female rats: a possible direct action of oxytocin on GnRH neurones. J Neuroendocrinol. 2007;19:439-48 pubmed
    ..Moreover, both oxytocin neuronal activity and the oxytocin receptor expression on GnRH cells are not influenced by oestrogen.
  19. Mitchell J, Ting T, Wong S, Mitchell B, Lye S. Parathyroid hormone-related protein treatment of pregnant rats delays the increase in connexin 43 and oxytocin receptor expression in the myometrium. Biol Reprod. 2003;69:556-62 pubmed
    ..progesterone, which suppresses the expression of labor-associated genes such as connexin 43 (Cx43) and the oxytocin receptor (OTR)...
  20. Ong Z, Alhadeff A, Grill H. Medial nucleus tractus solitarius oxytocin receptor signaling and food intake control: the role of gastrointestinal satiation signal processing. Am J Physiol Regul Integr Comp Physiol. 2015;308:R800-6 pubmed publisher
    Central oxytocin (OT) administration reduces food intake and its effects are mediated, in part, by hindbrain oxytocin receptor (OT-R) signaling...
  21. Breton J, Veinante P, Uhl Bronner S, Vergnano A, Freund Mercier M, Schlichter R, et al. Oxytocin-induced antinociception in the spinal cord is mediated by a subpopulation of glutamatergic neurons in lamina I-II which amplify GABAergic inhibition. Mol Pain. 2008;4:19 pubmed publisher
    ..This OT-specific pathway might represent a novel and interesting therapeutic target for the management of neuropathic and inflammatory pain. ..
  22. Ong Z, Bongiorno D, Hernando M, Grill H. Effects of Endogenous Oxytocin Receptor Signaling in Nucleus Tractus Solitarius on Satiation-Mediated Feeding and Thermogenic Control in Male Rats. Endocrinology. 2017;158:2826-2836 pubmed publisher
    Central oxytocin receptor (OT-R) signaling reduces food intake and increases energy expenditure, but the central sites and mechanisms mediating these effects are unresolved...
  23. Larrazolo López A, Kendrick K, Aburto Arciniega M, Arriaga Avila V, Morimoto S, Frias M, et al. Vaginocervical stimulation enhances social recognition memory in rats via oxytocin release in the olfactory bulb. Neuroscience. 2008;152:585-93 pubmed publisher
    ..The vagus and pelvic nerves are responsible for carrying the information from the pelvic area to the CNS. ..
  24. Jankowski M, Wang D, Danalache B, Gangal M, Gutkowska J. Cardiac oxytocin receptor blockade stimulates adverse cardiac remodeling in ovariectomized spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol. 2010;299:H265-74 pubmed publisher
    ..with genistein improves heart structure and heart work through a mechanism involving the specific OT receptor (OTR)...
  25. Meddle S, Bishop V, Gkoumassi E, van Leeuwen F, Douglas A. Dynamic changes in oxytocin receptor expression and activation at parturition in the rat brain. Endocrinology. 2007;148:5095-104 pubmed
    ..We investigated oxytocin receptor (OTR) expression and activation perinatally...
  26. Kennett J, Poletini M, Fitch C, Freeman M. Antagonism of oxytocin prevents suckling- and estradiol-induced, but not progesterone-induced, secretion of prolactin. Endocrinology. 2009;150:2292-9 pubmed publisher
    ..These data demonstrate the role of OT in the control of suckling and steroid-induced PRL secretion. ..
  27. Klenerova V, Chottová Dvoráková M, Skopek P, Sida P, Mistrova E, Slavikova J, et al. Expression of heart oxytocin receptor and its mRNA in two rat strains with different activity of HPA axis. Neuro Endocrinol Lett. 2011;32:805-10 pubmed
    ..The aim of this study was to investigate the expression of mRNA of OT receptors (OTR) in rat hearts by real-time quantitative PCR (qPCR)...
  28. Moreno López Y, Martínez Lorenzana G, Condes Lara M, Rojas Piloni G. Identification of oxytocin receptor in the dorsal horn and nociceptive dorsal root ganglion neurons. Neuropeptides. 2013;47:117-23 pubmed publisher
    ..Electrophysiological evidence indicates that OT could exert these effects by activating OT receptors (OTR) directly on dorsal horn neurons and/or primary nociceptive afferents in the dorsal root ganglia (DRG)...
  29. Arthur P, Taggart M, Zielnik B, Wong S, Mitchell B. Relationship between gene expression and function of uterotonic systems in the rat during gestation, uterine activation and both term and preterm labour. J Physiol. 2008;586:6063-76 pubmed publisher
    ..Significant increases in expression of oxytocin (OT), its receptor (OTR), prostaglandin (PG) H synthase isoform 1 (PGHS-1) and PGF(2alpha) receptor (FP) occurred first, followed by ..
  30. Tzabazis A, MECHANIC J, Miller J, Klukinov M, Pascual C, Manering N, et al. Oxytocin receptor: Expression in the trigeminal nociceptive system and potential role in the treatment of headache disorders. Cephalalgia. 2016;36:943-50 pubmed publisher
    ..b>Oxytocin receptor expression and co-localization with calcitonin gene-related peptide was investigated in rat trigeminal ..
  31. Lipschitz D, Crowley W, Bealer S. Central blockade of oxytocin receptors during late gestation disrupts systemic release of oxytocin during suckling in rats. J Neuroendocrinol. 2003;15:743-8 pubmed
    ..The present study was designed to determine the effects of central oxytocin receptor blockade during late gestation on parturition, pup growth, and oxytocin release during suckling...
  32. Cesen Cummings K, Houston K, Copland J, Moorman V, Walker C, Davis B. Uterine leiomyomas express myometrial contractile-associated proteins involved in pregnancy-related hormone signaling. J Soc Gynecol Investig. 2003;10:11-20 pubmed
    ..used to assess pregnancy-related changes in gene expression and to determine the impact of signaling by the oxytocin receptor. Eker rat leiomyomas expressed several pregnancy-related genes, including connexin 43, oxytocin receptor (..
  33. Uhrig S, Hirth N, Broccoli L, von Wilmsdorff M, Bauer M, Sommer C, et al. Reduced oxytocin receptor gene expression and binding sites in different brain regions in schizophrenia: A post-mortem study. Schizophr Res. 2016;177:59-66 pubmed publisher
    ..However, it is unknown whether the oxytocin receptor is altered in the brain...
  34. Beery A, McEwen L, Macisaac J, Francis D, Kobor M. Natural variation in maternal care and cross-tissue patterns of oxytocin receptor gene methylation in rats. Horm Behav. 2016;77:42-52 pubmed publisher
    ..b>Oxytocin receptor expression varies in response to early experience, and both oxytocin signaling and methylation status of the ..
  35. Hill K, Warren M, Roth T. The influence of infant-caregiver experiences on amygdala Bdnf, OXTr, and NPY expression in developing and adult male and female rats. Behav Brain Res. 2014;272:175-80 pubmed publisher
    ..a candidate gene approach, we examined fold mRNA changes for the Brain-derived neurotrophic factor (Bdnf), Oxytocin receptor (OXTr), and Neuropeptide Y (NPY) genes, which are all highly expressed in the amygdala and play important ..
  36. Rozen F, Russo C, Banville D, Zingg H. Structure, characterization, and expression of the rat oxytocin receptor gene. Proc Natl Acad Sci U S A. 1995;92:200-4 pubmed
    ..In most target tissues, the number of OTRs is strongly regulated. Specifically, in the uterus, a dramatic OTR upregulation precedes the onset of parturition...
  37. Zingg H, Laporte S. The oxytocin receptor. Trends Endocrinol Metab. 2003;14:222-7 pubmed
    Novel sites of oxytocin receptor expression have recently been detected, including breast cancer cells, bone cells, myoblasts, cardiomyocytes and endothelial cells...
  38. Zaninetti M, Raggenbass M. Oxytocin receptor agonists enhance inhibitory synaptic transmission in the rat hippocampus by activating interneurons in stratum pyramidale. Eur J Neurosci. 2000;12:3975-84 pubmed
    ..The selective oxytocin receptor agonist, [Thr4,Gly7]-oxytocin (TGOT), caused an increase in the frequency and amplitude of spontaneous ..
  39. Qin J, Feng M, Wang C, Ye Y, Wang P, Liu C. Oxytocin receptor expressed on the smooth muscle mediates the excitatory effect of oxytocin on gastric motility in rats. Neurogastroenterol Motil. 2009;21:430-8 pubmed publisher
    The aim of this study was to localize oxytocin receptor (OTR) in the stomach and to investigate the effect of OT on gastric motility in rats. Western blot and immunohistochemistry methods were used to localize OTR in stomach...
  40. Kuo J, Hariri O, Micevych P. An interaction of oxytocin receptors with metabotropic glutamate receptors in hypothalamic astrocytes. J Neuroendocrinol. 2009;21:1001-6 pubmed publisher
    ..These results suggest that the OTR signals through the mGluR1a to release Ca(2+) from intracellular stores and rapid, nongenomic oestradiol ..
  41. Gajdosechova L, Krskova K, Olszanecki R, Zorad S. Differential regulation of oxytocin receptor in various adipose tissue depots and skeletal muscle types in obese Zucker rats. Horm Metab Res. 2015;47:600-4 pubmed publisher
    ..Until now, little is known about regulation of oxytocin receptor in metabolically active tissues in obesity...
  42. Wu C, Hung C, Chang F, Pau K, Wang P. Pharmacological effects of oxytocin on gastric emptying and intestinal transit of a non-nutritive liquid meal in female rats. Naunyn Schmiedebergs Arch Pharmacol. 2003;367:406-13 pubmed
    ..Atosiban, an oxytocin receptor antagonist, effectively attenuated the OT- induced inhibition of gastric emptying and gastrointestinal ..
  43. Huber D, Veinante P, Stoop R. Vasopressin and oxytocin excite distinct neuronal populations in the central amygdala. Science. 2005;308:245-8 pubmed
    ..Through this network, the expression and endogenous activation of vasopressin and oxytocin receptors may regulate the autonomic expression of fear. ..
  44. Chen Q, Schreiber S, Brinton R. Vasopressin and oxytocin receptor mRNA expression during rat telencephalon development. Neuropeptides. 2000;34:173-80 pubmed
    We investigated the developmental expression of vasopressin and oxytocin receptor and peptide mRNA using semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) and Southern blot hybridization...
  45. Dumais K, Alonso A, Bredewold R, Veenema A. Role of the oxytocin system in amygdala subregions in the regulation of social interest in male and female rats. Neuroscience. 2016;330:138-49 pubmed publisher
    We previously found that oxytocin (OT) receptor (OTR) binding density in the medial amygdala (MeA) correlated positively with social interest (i.e...
  46. Wang D, Gutkowska J, Marcinkiewicz M, Rachelska G, Jankowski M. Genistein supplementation stimulates the oxytocin system in the aorta of ovariectomized rats. Cardiovasc Res. 2003;57:186-94 pubmed
    In the present study, we localized oxytocin (OT) and its receptor (OTR) in the rat aorta, and investigated whether genistein, an isoflavonic phytoestrogen, influences their expression in ovariectomized (OVX) rats deficient in estrogen...
  47. Strakova Z, Copland J, Lolait S, Soloff M. ERK2 mediates oxytocin-stimulated PGE2 synthesis. Am J Physiol. 1998;274:E634-41 pubmed
    ..We showed previously that CHO cells stably transfected with the rat oxytocin receptor (CHO-OTR cells) also synthesize PGE2 in response to OT...
  48. Magalhaes J, Carvalho J, Parkes R, Kingdom J, Li Y, Balki M. Oxytocin pretreatment decreases oxytocin-induced myometrial contractions in pregnant rats in a concentration-dependent but not time-dependent manner. Reprod Sci. 2009;16:501-8 pubmed publisher
  49. Lee P, Brady D, Shapiro R, Dorsa D, Koenig J. Prenatal stress generates deficits in rat social behavior: Reversal by oxytocin. Brain Res. 2007;1156:152-67 pubmed
    ..stressed male rats revealed significantly less oxytocin mRNA in the paraventricular nucleus and increased oxytocin receptor binding in the central amygdala...
  50. Lancel M, Krömer S, Neumann I. Intracerebral oxytocin modulates sleep-wake behaviour in male rats. Regul Pept. 2003;114:145-52 pubmed
    ..In the present vehicle-controlled study, we assessed the influence of a selective oxytocin receptor antagonist (des-Gly-NH2d(CH2)5 [Tyr(Me)2,Thr4] OVT; 0.75 microg/5 microl) or of synthetic oxytocin (0...
  51. Asad M, Shewade D, Koumaravelou K, Abraham B, Vasu S, Ramaswamy S. Gastric antisecretory and antiulcer activity of oxytocin in rats and guinea pigs. Life Sci. 2001;70:17-24 pubmed
    ..The reversal of oxytocin effect by atosiban, an oxytocin receptor antagonist indicates a role for oxytocin receptors...
  52. Thompson M, Callaghan P, Hunt G, Cornish J, McGregor I. A role for oxytocin and 5-HT(1A) receptors in the prosocial effects of 3,4 methylenedioxymethamphetamine ("ecstasy"). Neuroscience. 2007;146:509-14 pubmed
    ..p.). The oxytocin receptor antagonist tocinoic acid (20 microg, i.c.v...
  53. Wsol A, Cudnoch Jedrzejewska A, Szczepanska Sadowska E, Kowalewski S, Puchalska L. Oxytocin in the cardiovascular responses to stress. J Physiol Pharmacol. 2008;59 Suppl 8:123-7 pubmed
    ..The study provides evidence that stimulation of the brain oxytocin receptors by endogenous oxytocin plays significant role in inhibition of cardiovascular responses to stress. ..