Gene Symbol: Oxa1l
Description: OXA1L, mitochondrial inner membrane protein
Alias: mitochondrial inner membrane protein OXA1L, oxidase (cytochrome c) assembly 1-like, oxidase assembly 1-like
Haque M, Spremulli L, Fecko C. Identification of protein-protein and protein-ribosome interacting regions of the C-terminal tail of human mitochondrial inner membrane protein Oxa1L. J Biol Chem. 2010;285:34991-8 pubmed publisher
The mammalian mitochondrial inner membrane protein Oxa1L is involved in the insertion of a number of mitochondrial translation products into the inner membrane...
Bonnefoy N, Kermorgant M, Groudinsky O, Minet M, Slonimski P, Dujardin G. Cloning of a human gene involved in cytochrome oxidase assembly by functional complementation of an oxa1- mutation in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 1994;91:11978-82 pubmed
Stiburek L, Fornuskova D, Wenchich L, Pejznochova M, Hansikova H, Zeman J. Knockdown of human Oxa1l impairs the biogenesis of F1Fo-ATP synthase and NADH:ubiquinone oxidoreductase. J Mol Biol. 2007;374:506-16 pubmed
..The predicted human homologue, Oxa1l, was originally identified by partial functional complementation of the respiratory growth defect of the yeast ..
Haque M, Elmore K, Tripathy A, Koc H, Koc E, Spremulli L. Properties of the C-terminal tail of human mitochondrial inner membrane protein Oxa1L and its interactions with mammalian mitochondrial ribosomes. J Biol Chem. 2010;285:28353-62 pubmed publisher
In humans the mitochondrial inner membrane protein Oxa1L is involved in the biogenesis of membrane proteins and facilitates the insertion of both mitochondrial- and nuclear-encoded proteins from the mitochondrial matrix into the inner ..
Wenz L, OpaliÅ„ski Å, Wiedemann N, Becker T. Cooperation of protein machineries in mitochondrial protein sorting. Biochim Biophys Acta. 2015;1853:1119-29 pubmed publisher
..Therefore, we propose that the protein transport systems are part of a complicated protein network for mitochondrial biogenesis. ..
Sato T, Mihara K. Topogenesis of mammalian Oxa1, a component of the mitochondrial inner membrane protein export machinery. J Biol Chem. 2009;284:14819-27 pubmed publisher
..Together, these results demonstrated that topogenesis of Oxa1 is a cooperative event of all five TMs, and GLPWWG followed immediately by TM1 is essential for correct Oxa1 topogenesis...