Gene Symbol: osteoactivin
Description: glycoprotein nmb
Alias: transmembrane glycoprotein NMB, glycoprotein (transmembrane) nmb, osteoactivin
Species: rat
Products:     osteoactivin

Top Publications

  1. Onaga M, Ido A, Hasuike S, Uto H, Moriuchi A, Nagata K, et al. Osteoactivin expressed during cirrhosis development in rats fed a choline-deficient, L-amino acid-defined diet, accelerates motility of hepatoma cells. J Hepatol. 2003;39:779-85 pubmed
    ..We examined both the expression in the liver and HCC tissues of osteoactivin (OA), isolated in this screen, and its effect on invasiveness and metastasis...
  2. Furochi H, Tamura S, Mameoka M, Yamada C, Ogawa T, Hirasaka K, et al. Osteoactivin fragments produced by ectodomain shedding induce MMP-3 expression via ERK pathway in mouse NIH-3T3 fibroblasts. FEBS Lett. 2007;581:5743-50 pubmed
    Intact osteoactivin, a novel type I membrane glycoprotein, were shed at a dibasic motif in the juxtamembrane region in C2C12 myoblasts. Extracellular fragments were secreted into the culture media by a putative metalloprotease...
  3. Chung J, Bonkobara M, Tomihari M, Cruz P, Ariizumi K. The DC-HIL/syndecan-4 pathway inhibits human allogeneic T-cell responses. Eur J Immunol. 2009;39:965-74 pubmed publisher
    ..Our findings indicate that the DC-HIL/SD-4 pathway can be manipulated to treat T-cell-driven disorders in humans. ..
  4. Rose A, Annis M, Dong Z, Pepin F, Hallett M, Park M, et al. ADAM10 releases a soluble form of the GPNMB/Osteoactivin extracellular domain with angiogenic properties. PLoS ONE. 2010;5:e12093 pubmed publisher
    Glycoprotein non-metastatic melanoma protein B (GPNMB)/Osteoactivin (OA) is a transmembrane protein expressed in approximately 40-75% of breast cancers...
  5. Shikano S, Bonkobara M, Zukas P, Ariizumi K. Molecular cloning of a dendritic cell-associated transmembrane protein, DC-HIL, that promotes RGD-dependent adhesion of endothelial cells through recognition of heparan sulfate proteoglycans. J Biol Chem. 2001;276:8125-34 pubmed
    ..We propose that DC-HIL serves as a DC-associated, heparan sulfate proteoglycan-dependent integrin ligand, which may be involved in transendothelial migration of DC. ..
  6. Ripoll V, Irvine K, Ravasi T, Sweet M, Hume D. Gpnmb is induced in macrophages by IFN-gamma and lipopolysaccharide and acts as a feedback regulator of proinflammatory responses. J Immunol. 2007;178:6557-66 pubmed
    ..Thus, GPNMB acts as a negative regulator of macrophage inflammatory responses. ..
  7. Bächner D, Schröder D, Gross G. mRNA expression of the murine glycoprotein (transmembrane) nmb (Gpnmb) gene is linked to the developing retinal pigment epithelium and iris. Brain Res Gene Expr Patterns. 2002;1:159-65 pubmed
  8. Haralanova Ilieva B, Ramadori G, Armbrust T. Expression of osteoactivin in rat and human liver and isolated rat liver cells. J Hepatol. 2005;42:565-72 pubmed
    The transmembrane glycoprotein osteoactivin is expressed in osteoblasts, dendritic cells and tumor cells. It is suggested to influence osteoblast maturation, cell adhesion and migration. We studied osteoactivin expression within the liver...
  9. Utsunomiya K, Owaki K, Okumura Y, Yano M, Oto T, Suzuki E, et al. An intracellular fragment of osteoactivin formed by ectodomain shedding translocated to the nucleoplasm and bound to RNA binding proteins. Biosci Biotechnol Biochem. 2012;76:2225-9 pubmed
    b>Osteoactivin is a type I transmembrane protein upregulated by unloading stresses, including denervation, prolonged bed rest, and space flight, but the regulatory mechanisms of its expression and activation under these conditions remain ..

More Information


  1. Ye M, Xie X, Peng L, Tan L, Lan G, Yu S. [Expression and mechanism of osteoactivin in the kidney of SD rats after acute cyclosporine A toxicity]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2011;36:881-8 pubmed publisher
    To determine the expression and mechanism of osteoactivin (OA) in the kidney by establishing SD rat model of acute cyclosporine A (CsA) toxicity...
  2. Li B, Castano A, Hudson T, Nowlin B, Lin S, Bonventre J, et al. The melanoma-associated transmembrane glycoprotein Gpnmb controls trafficking of cellular debris for degradation and is essential for tissue repair. FASEB J. 2010;24:4767-81 pubmed publisher
    ..Therefore, Gpnmb is a novel prorepair gene that is necessary for crosstalk between the macroautophagic degradation pathway and phagocytosis. ..
  3. Patel Chamberlin M, Wang Y, Satirapoj B, Phillips L, Nast C, Dai T, et al. Hematopoietic growth factor inducible neurokinin-1 (Gpnmb/Osteoactivin) is a biomarker of progressive renal injury across species. Kidney Int. 2011;79:1138-48 pubmed publisher
    ..kidney disease and tested hematopoietic growth factor inducible neurokinin-1 (HGFIN, also known as Gpnmb/Osteoactivin) as it was found to be a kidney injury biomarker in microarray studies...
  4. Katayama A, Nakatsuka A, Eguchi J, Murakami K, Teshigawara S, Kanzaki M, et al. Beneficial impact of Gpnmb and its significance as a biomarker in nonalcoholic steatohepatitis. Sci Rep. 2015;5:16920 pubmed publisher
    ..The GPNMB is a promising biomarker and therapeutic target for the development and progression of NAFLD in obesity. ..
  5. Nakano Y, Suzuki Y, Takagi T, Kitashoji A, Ono Y, Tsuruma K, et al. Glycoprotein nonmetastatic melanoma protein B (GPNMB) as a novel neuroprotective factor in cerebral ischemia-reperfusion injury. Neuroscience. 2014;277:123-31 pubmed publisher
    ..In conclusion, these findings indicate that GPNMB has neuroprotective effects against IRI, via phosphorylation of ERK1/2 and Akt, suggesting that GPNMB may be a therapeutic target for ischemia-reperfusion injuries...
  6. Tanaka H, Shimazawa M, Kimura M, Takata M, Tsuruma K, Yamada M, et al. The potential of GPNMB as novel neuroprotective factor in amyotrophic lateral sclerosis. Sci Rep. 2012;2:573 pubmed publisher
    ..This study suggests that GPNMB can be a target for therapeutic intervention for suppressing motor neuron degeneration in ALS. ..
  7. Singh M, Del Carpio Cano F, Monroy M, Popoff S, Safadi F. Homeodomain transcription factors regulate BMP-2-induced osteoactivin transcription in osteoblasts. J Cell Physiol. 2012;227:390-9 pubmed publisher
    b>Osteoactivin (OA) is required for the differentiation of osteoblast cells. OA expression is stimulated by bone morphogenetic protein-2 (BMP-2)...
  8. Nakamura A, Ishii A, Ohata C, Komurasaki T. Early induction of osteoactivin expression in rat renal tubular epithelial cells after unilateral ureteral obstruction. Exp Toxicol Pathol. 2007;59:53-9 pubmed
    In this study, we examined the expression of osteoactivin in the rat kidney after unilateral ureteral obstruction. Male Wistar rats were sacrificed at 6h, and on days 1, 2, 3 and 7 after the obstruction...
  9. Abe H, Uto H, Takami Y, Takahama Y, Hasuike S, Kodama M, et al. Transgenic expression of osteoactivin in the liver attenuates hepatic fibrosis in rats. Biochem Biophys Res Commun. 2007;356:610-5 pubmed
    The role of osteoactivin (OA) in liver fibrogenesis remains unclear. After feeding wild-type (WT) and OA transgenic (OA-Tg) rats a choline-deficient, L-amino acid-defined (CDAA) diet for 12 weeks, we evaluated liver fibrosis...
  10. Selim A. Osteoactivin bioinformatic analysis: prediction of novel functions, structural features, and modes of action. Med Sci Monit. 2009;15:MT19-33 pubmed
    The initial identification of osteoactivin (OA) came from studies using an animal model of osteopetrosis in rats...
  11. Frara N, Abdelmagid S, Tytell M, Amin M, Popoff S, Safadi F, et al. Growth and repair factors, osteoactivin, matrix metalloproteinase and heat shock protein 72, increase with resolution of inflammation in musculotendinous tissues in a rat model of repetitive grasping. BMC Musculoskelet Disord. 2016;17:34 pubmed publisher
    Expression of the growth factor osteoactivin (OA) increases during tissue degeneration and regeneration, fracture repair and after denervation-induced disuse atrophy, concomitant with increased matrix metalloproteinases (MMPs)...
  12. Järve A, Mühlstedt S, Qadri F, Nickl B, Schulz H, Hubner N, et al. Adverse left ventricular remodeling by glycoprotein nonmetastatic melanoma protein B in myocardial infarction. FASEB J. 2017;31:556-568 pubmed publisher
    ..Järve, A., Mühlstedt, S., Qadri, F., Nickl, B., Schulz, H., Hübner, N., Özcelik, C., Bader, M. Adverse left ventricular remodeling by glycoprotein nonmetastatic melanoma protein B in myocardial infarction. ..
  13. Ma J, Baker A, Calabro A, Derwin K. Exploratory study on the effect of osteoactivin on muscle regeneration in a rat volumetric muscle loss model. PLoS ONE. 2017;12:e0175853 pubmed publisher
    ..Recent studies have shown evidence that osteoactivin (OA), a transmembrane glycoprotein, has the ability to prevent skeletal muscle atrophy in response to ..
  14. Narasaraju T, Shukla D, More S, Huang C, Zhang L, Xiao X, et al. Role of microRNA-150 and glycoprotein nonmetastatic melanoma protein B in angiogenesis during hyperoxia-induced neonatal lung injury. Am J Respir Cell Mol Biol. 2015;52:253-61 pubmed publisher
    ..GPNMB plays an important role in angiogenesis during hyperoxia injury. Treatment with GPNMB may offer a novel therapeutic approach in reducing pathologic complications in bronchopulmonary dysplasia. ..
  15. Abdelmagid S, Barbe M, Arango Hisijara I, Owen T, Popoff S, Safadi F. Osteoactivin acts as downstream mediator of BMP-2 effects on osteoblast function. J Cell Physiol. 2007;210:26-37 pubmed
    Our laboratory previously showed that osteoactivin (OA) is a novel, osteoblast-related glycoprotein that plays a role in osteoblast differentiation and function...
  16. Bandari P, Qian J, Yehia G, Joshi D, Maloof P, Potian J, et al. Hematopoietic growth factor inducible neurokinin-1 type: a transmembrane protein that is similar to neurokinin 1 interacts with substance P. Regul Pept. 2003;111:169-78 pubmed
    ..This suggests that HGFIN might be involved in the maturation of LHSC. HGFIN was detected in several other tissues, but not in brain where NK-1 is constitutively expressed. ..
  17. Safadi F, Xu J, Smock S, Rico M, Owen T, Popoff S. Cloning and characterization of osteoactivin, a novel cDNA expressed in osteoblasts. J Cell Biochem. 2001;84:12-26 pubmed
    ..This novel cDNA was named osteoactivin. Osteoactivin has an open reading frame of 1716 bp that encodes a protein of 572 amino acids with a predicted ..