Orai1

Summary

Gene Symbol: Orai1
Description: ORAI calcium release-activated calcium modulator 1
Alias: RGD1311873, calcium release-activated calcium channel protein 1, calcium release-activated calcium modulator 1, protein orai-1, transmembrane protein 142A
Species: rat
Products:     Orai1

Top Publications

  1. Muik M, Fahrner M, Derler I, Schindl R, Bergsmann J, Frischauf I, et al. A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels. J Biol Chem. 2009;284:8421-6 pubmed publisher
    ..the stromal interaction molecule 1 (STIM1) that functions as a Ca(2+) sensor in the endoplasmic reticulum and ORAI1 located in the plasma membrane...
  2. Peinelt C, Vig M, Koomoa D, Beck A, Nadler M, Koblan Huberson M, et al. Amplification of CRAC current by STIM1 and CRACM1 (Orai1). Nat Cell Biol. 2006;8:771-3 pubmed
    ..in the endoplasmic reticulum, and the calcium release-activated calcium (CRAC) modulator CRACM1 (also known as Orai1) in the plasma membrane have recently been shown to be essential for controlling the store-operated CRAC current (..
  3. Gemes G, Bangaru M, Wu H, Tang Q, Weihrauch D, Koopmeiners A, et al. Store-operated Ca2+ entry in sensory neurons: functional role and the effect of painful nerve injury. J Neurosci. 2011;31:3536-49 pubmed publisher
    ..Molecular components of SOCE, specifically STIM1 and Orai1, were confirmed in sensory neurons at both the transcript and protein levels...
  4. Park C, Hoover P, Mullins F, Bachhawat P, Covington E, Raunser S, et al. STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1. Cell. 2009;136:876-90 pubmed publisher
    ..After store depletion, the ER Ca(2+) sensor STIM1 and the CRAC channel protein Orai1 redistribute to ER-plasma membrane (PM) junctions, but the fundamental issue of how STIM1 activates the CRAC ..
  5. Vig M, Peinelt C, Beck A, Koomoa D, Rabah D, Koblan Huberson M, et al. CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry. Science. 2006;312:1220-3 pubmed
    ..Although overexpression of CRACM1 did not affect CRAC currents, RNAi-mediated knockdown disrupted its activation. CRACM1 could be the CRAC channel itself, a subunit of it, or a component of the CRAC signaling machinery. ..
  6. Prakriya M, Feske S, Gwack Y, Srikanth S, Rao A, Hogan P. Orai1 is an essential pore subunit of the CRAC channel. Nature. 2006;443:230-3 pubmed
    ..We and others recently identified Drosophila Orai and human Orai1 (also called TMEM142A) as critical components of store-operated Ca2+ entry downstream of STIM...
  7. Mercer J, Dehaven W, Smyth J, Wedel B, Boyles R, Bird G, et al. Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1. J Biol Chem. 2006;281:24979-90 pubmed
    ..Recent findings have implicated two proteins, Stim1 and Orai1, as having essential roles in store-operated Ca(2+) entry across the plasma membrane...
  8. Soboloff J, Spassova M, Tang X, Hewavitharana T, Xu W, Gill D. Orai1 and STIM reconstitute store-operated calcium channel function. J Biol Chem. 2006;281:20661-5 pubmed
    The two membrane proteins, STIM1 and Orai1, have each been shown to be essential for the activation of store-operated channels (SOC). Yet, how these proteins functionally interact is not known...
  9. Cross B, Hack A, Reinhardt T, Rao R. SPCA2 regulates Orai1 trafficking and store independent Ca2+ entry in a model of lactation. PLoS ONE. 2013;8:e67348 pubmed publisher
    ..interaction between SPCA2, an isoform of the Golgi secretory pathway Ca(2+)-ATPase, and the Ca(2+) influx channel Orai1, has previously been shown to contribute to elevated Ca(2+) influx in breast cancer derived cells...

More Information

Publications65

  1. Zhang X, Gonzalez Cobos J, Schindl R, Muik M, Ruhle B, Motiani R, et al. Mechanisms of STIM1 activation of store-independent leukotriene C4-regulated Ca2+ channels. Mol Cell Biol. 2013;33:3715-23 pubmed publisher
    ..factor activates canonical store-operated Ca(2+) entry and Ca(2+) release-activated Ca(2+) currents encoded by Orai1 and STIM1 genes...
  2. Giachini F, Chiao C, Carneiro F, Lima V, Carneiro Z, Dorrance A, et al. Increased activation of stromal interaction molecule-1/Orai-1 in aorta from hypertensive rats: a novel insight into vascular dysfunction. Hypertension. 2009;53:409-16 pubmed publisher
    ..Augmented activation of STIM-1/Orai-1 may represent the mechanism that leads to impaired control of intracellular Ca(2+) levels in hypertension. ..
  3. Soboloff J, Rothberg B, Madesh M, Gill D. STIM proteins: dynamic calcium signal transducers. Nat Rev Mol Cell Biol. 2012;13:549-65 pubmed publisher
    ..Details are emerging on the remarkable organization within these STIM-induced junctional microdomains and the identification of new regulators and alternative target proteins for STIM. ..
  4. Gonzalez Cobos J, Zhang X, Zhang W, Ruhle B, Motiani R, Schindl R, et al. Store-independent Orai1/3 channels activated by intracrine leukotriene C4: role in neointimal hyperplasia. Circ Res. 2013;112:1013-25 pubmed publisher
    ..b>Orai1-encoded store-operated Ca(2+) entry has recently emerged as an important player in VSMC remodeling...
  5. Bisaillon J, Motiani R, Gonzalez Cobos J, Potier M, Halligan K, Alzawahra W, et al. Essential role for STIM1/Orai1-mediated calcium influx in PDGF-induced smooth muscle migration. Am J Physiol Cell Physiol. 2010;298:C993-1005 pubmed publisher
    ..activates Ca(2+) entry in vascular smooth muscle cells (VSMC) through stromal interaction molecule 1 (STIM1)/Orai1, independently of transient receptor potential canonical (TRPC) channels...
  6. Calvo Rodríguez M, García Durillo M, Villalobos C, Núñez L. In vitro aging promotes endoplasmic reticulum (ER)-mitochondria Ca2+ cross talk and loss of store-operated Ca2+ entry (SOCE) in rat hippocampal neurons. Biochim Biophys Acta. 2016;1863:2637-2649 pubmed publisher
    ..In contrast, in long-term cultures reflecting aging neurons, SOCE is essentially lost, Stim1 and Orai1 are downregulated, Ca2+ stores become overloaded, Ca2+ release is enhanced, expression of ..
  7. Liu H, Hughes J, Rollins S, Chen B, Perkins E. Calcium entry via ORAI1 regulates glioblastoma cell proliferation and apoptosis. Exp Mol Pathol. 2011;91:753-60 pubmed publisher
    ..b>ORAI1 and stromal interaction molecule1 (STIM1) are essential protein components of CRAC channels...
  8. Zhang L, Wang L, Li S, Xue J, Luo D. Calsequestrin-1 Regulates Store-Operated Ca2+ Entry by Inhibiting STIM1 Aggregation. Cell Physiol Biochem. 2016;38:2183-93 pubmed publisher
    Stromal interacting molecule-1 (STIM1) aggregation and redistribution to plasma membrane to interact with Orai1 constitute the core mechanism of store-operated Ca2+ entry (SOCE)...
  9. Gruszczynska Biegala J, Kuznicki J. Native STIM2 and ORAI1 proteins form a calcium-sensitive and thapsigargin-insensitive complex in cortical neurons. J Neurochem. 2013;126:727-38 pubmed publisher
    ..stromal interaction molecule 1 (STIM1) and STIM2 mediate store-operated calcium entry via an interaction with ORAI1 calcium channels...
  10. Ferreira R, Schlichter L. Selective activation of KCa3.1 and CRAC channels by P2Y2 receptors promotes Ca(2+) signaling, store refilling and migration of rat microglial cells. PLoS ONE. 2013;8:e62345 pubmed publisher
    ..KCa3.1 current is activated by Ca(2+) entry through Ca(2+)-release-activated Ca(2+) (CRAC/Orai1) channels, and both CRAC/Orai1 and KCa3.1 channels facilitate refilling of Ca(2+) stores...
  11. Srikanth S, Jung H, Kim K, Souda P, Whitelegge J, Gwack Y. A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells. Nat Cell Biol. 2010;12:436-46 pubmed publisher
    b>Orai1 and STIM1 are critical components of Ca(2+) release-activated Ca(2+) (CRAC) channels that mediate store-operated Ca(2+) entry (SOCE) in immune cells...
  12. Sabourin J, Bartoli F, Antigny F, Gomez A, Benitah J. Transient Receptor Potential Canonical (TRPC)/Orai1-dependent Store-operated Ca2+ Channels: NEW TARGETS OF ALDOSTERONE IN CARDIOMYOCYTES. J Biol Chem. 2016;291:13394-409 pubmed publisher
    ..We thus assessed whether and how SOCE involving transient receptor potential canonical (TRPC) and Orai1 channels are regulated by aldosterone/MR in neonatal rat ventricular cardiomyocytes...
  13. Lee J, Veatch S, Baird B, Holowka D. Molecular mechanisms of spontaneous and directed mast cell motility. J Leukoc Biol. 2012;92:1029-41 pubmed publisher
    ..Here, we show that Ca(2+) influx via Orai1 plays an important role in regulating spontaneous motility and directional migration of mast cells toward antigen ..
  14. Calloway N, Owens T, Corwith K, Rodgers W, Holowka D, Baird B. Stimulated association of STIM1 and Orai1 is regulated by the balance of PtdIns(4,5)P? between distinct membrane pools. J Cell Sci. 2011;124:2602-10 pubmed publisher
    ..that association of the endoplasmic reticulum (ER) Ca(2+) sensor, STIM1, and the store-operated Ca(2+) channel, Orai1, stimulated by thapsigargin-mediated ER store depletion, is enhanced by overexpression of PIP5KI? and inhibited by ..
  15. Zhang M, Song J, Wu Y, Zhao Y, Pang H, Fu Z, et al. Suppression of STIM1 in the early stage after global ischemia attenuates the injury of delayed neuronal death by inhibiting store-operated calcium entry-induced apoptosis in rats. Neuroreport. 2014;25:507-13 pubmed publisher
    ..We found that STIM1 and ORAI1 expression in the hippocampus increased continuously after global ischemia and peaked on day 4...
  16. Wang G, Zhang J, Xu C, Han X, Gao Y, Chen H. Inhibition of SOCs Attenuates Acute Lung Injury Induced by Severe Acute Pancreatitis in Rats and PMVECs Injury Induced by Lipopolysaccharide. Inflammation. 2016;39:1049-58 pubmed publisher
    ..with or without small interfering RNA (siRNA) against calcium release-activated calcium channel protein1 (Orai1) and stromal interaction molecule1 (STIM1), the two main molecular constituents of SOCs, then exposed to LPS...
  17. Ben Kasus Nissim T, Zhang X, Elazar A, Roy S, Stolwijk J, Zhou Y, et al. Mitochondria control store-operated Ca2+ entry through Na+ and redox signals. EMBO J. 2017;36:797-815 pubmed publisher
    Mitochondria exert important control over plasma membrane (PM) Orai1 channels mediating store-operated Ca2+ entry (SOCE)...
  18. Potier M, Gonzalez J, Motiani R, Abdullaev I, Bisaillon J, Singer H, et al. Evidence for STIM1- and Orai1-dependent store-operated calcium influx through ICRAC in vascular smooth muscle cells: role in proliferation and migration. FASEB J. 2009;23:2425-37 pubmed publisher
    ..by the nonselective transient receptor potential canonical (TRPC) 1 protein, the identification of STIM1 and Orai1 as essential components of I(CRAC), a highly Ca(2+)-selective SOCE current in leukocytes, has challenged that view...
  19. McNally B, Yamashita M, Engh A, Prakriya M. Structural determinants of ion permeation in CRAC channels. Proc Natl Acad Sci U S A. 2009;106:22516-21 pubmed publisher
    ..bases of these permeation characteristics, we introduced cysteine residues in the CRAC channel pore subunit, Orai1, and probed their accessibility to various thiol-reactive reagents...
  20. Zou J, Gao Y, Geng S, Yang J. Role of STIM1/Orai1-mediated store-operated Ca²? entry in airway smooth muscle cell proliferation. J Appl Physiol (1985). 2011;110:1256-63 pubmed publisher
    ..to the ER underneath the plasma membrane upon depletion of the ER Ca(2+) store, where it interacts with Orai1, the molecular component of SOC channels, and brings about SOCE...
  21. Gusarova G, Trejo H, Dada L, Briva A, Welch L, Hamanaka R, et al. Hypoxia leads to Na,K-ATPase downregulation via Ca(2+) release-activated Ca(2+) channels and AMPK activation. Mol Cell Biol. 2011;31:3546-56 pubmed publisher
    ..These data suggest that during hypoxia, calcium entry via CRAC channels leads to AMPK activation, Na,K-ATPase downregulation, and alveolar epithelial dysfunction. ..
  22. Szteyn K, Gomez R, Berg K, Jeske N. Divergence in endothelin-1- and bradykinin-activated store-operated calcium entry in afferent sensory neurons. ASN Neuro. 2015;7: pubmed publisher
    ..On the other hand, BK treatment stimulated Orai1 activation, with only minor input from TRPC3...
  23. Guo R, Yang L, Li M, Pan X, Liu B, Deng Y. Stim1- and Orai1-mediated store-operated calcium entry is critical for angiotensin II-induced vascular smooth muscle cell proliferation. Cardiovasc Res. 2012;93:360-70 pubmed publisher
    ..In this study, we determined whether Stim1- and Orai1-mediated store-operated calcium (Ca(2+)) entry (SOCE) plays a critical role in Ang II-induced VSMC proliferation ..
  24. Cioffi D, Wu S, Chen H, Alexeyev M, St Croix C, Pitt B, et al. Orai1 determines calcium selectivity of an endogenous TRPC heterotetramer channel. Circ Res. 2012;110:1435-44 pubmed publisher
    ..to the molecular composition of a channel encoding for a calcium selective store-operated current, I(SOC), whereas Orai1 critically comprises a channel encoding for the highly selective calcium release activated calcium current, I(CRAC)..
  25. Ji W, Xu P, Li Z, Lu J, Liu L, Zhan Y, et al. Functional stoichiometry of the unitary calcium-release-activated calcium channel. Proc Natl Acad Sci U S A. 2008;105:13668-73 pubmed publisher
    Two proteins, STIM1 in the endoplasmic reticulum and Orai1 in the plasma membrane, are required for the activation of Ca(2+) release-activated Ca(2+) (CRAC) channels at the cell surface...
  26. Zhang W, Zhang X, González Cobos J, Stolwijk J, Matrougui K, Trebak M. Leukotriene-C4 synthase, a critical enzyme in the activation of store-independent Orai1/Orai3 channels, is required for neointimal hyperplasia. J Biol Chem. 2015;290:5015-27 pubmed publisher
    ..also a cytosolic second messenger that activated store-independent LTC4-regulated Ca(2+) (LRC) channels encoded by Orai1/Orai3 heteromultimers in vascular smooth muscle cells (VSMCs)...
  27. Nonato A, Olivon V, Dela Justina V, Zanotto C, Webb R, Tostes R, et al. Impaired Ca(2+) Homeostasis and Decreased Orai1 Expression Modulates Arterial Hyporeactivity to Vasoconstrictors During Endotoxemia. Inflammation. 2016;39:1188-97 pubmed publisher
    ..Decreased Orai1, but not STIM1, expression was found in resistance mesenteric arteries from LPS-treated rats...
  28. Voelkers M, Salz M, Herzog N, Frank D, Dolatabadi N, Frey N, et al. Orai1 and Stim1 regulate normal and hypertrophic growth in cardiomyocytes. J Mol Cell Cardiol. 2010;48:1329-34 pubmed publisher
    ..The objective of the present study is to determine the role of the Ca(2+) release-activated Ca(2+) (CRAC) channel Orai1 and stromal interaction molecule 1 (Stim1) in postnatal cardiomyocyte store operated Ca(2+) entry (SOCE) and ..
  29. Zhou Y, Ramachandran S, Oh Hora M, Rao A, Hogan P. Pore architecture of the ORAI1 store-operated calcium channel. Proc Natl Acad Sci U S A. 2010;107:4896-901 pubmed publisher
    b>ORAI1 is the pore-forming subunit of the calcium release-activated calcium (CRAC) channel, a store-operated channel that is central to Ca(2+) signaling in mammalian cells...
  30. Almirza W, Peters P, van Zoelen E, Theuvenet A. Role of Trpc channels, Stim1 and Orai1 in PGF(2?)-induced calcium signaling in NRK fibroblasts. Cell Calcium. 2012;51:12-21 pubmed publisher
    ..This coincides with modulation of the expression of the genes encoding the calcium channels Trpc1, Trpc6 and Orai1, and of the intracellular calcium sensor Stim1...
  31. Zarayskiy V, Monje F, Peter K, Csutora P, Khodorov B, Bolotina V. Store-operated Orai1 and IP3 receptor-operated TRPC1 channel. Channels (Austin). 2007;1:246-52 pubmed
    ..may be responsible for creating a complex and sometimes controversial SOC image: one being a real SOC encoded by Orai1 and activated exclusively upon depletion of Ca2+ stores (via iPLA2beta -dependent pathway), while the second one ..
  32. Gao Y, Zou J, Geng S, Zheng J, Yang J. Role of protein kinase C in the activation of store-operated Ca(2+) entry in airway smooth muscle cells. J Huazhong Univ Sci Technolog Med Sci. 2012;32:303-310 pubmed publisher
    ..In addition, PKC down-regulation did not influence the expression of stromal interaction molecule 1 (STIM1) and Orai1, two elementary molecules in the regulation and activation of SOCs...
  33. Tshuva R, Korkotian E, Segal M. ORAI1-dependent synaptic plasticity in rat hippocampal neurons. Neurobiol Learn Mem. 2017;140:1-10 pubmed publisher
    ..entities involved in plastic processes were already described, the role of a store-operated calcium channel ORAI1 in neuronal plasticity is not known as yet...
  34. Chen M, Li J, Jiang F, Fu J, Xia X, Du J, et al. Orai1 forms a signal complex with BKCa channel in mesenteric artery smooth muscle cells. Physiol Rep. 2016;4: pubmed publisher
    b>Orai1, a specific nonvoltage-gated Ca(2+) channel, has been found to be one of key molecules involved in store-operated Ca(2+) entry (SOCE)...
  35. Wang Y, Deng X, Mancarella S, Hendron E, Eguchi S, Soboloff J, et al. The calcium store sensor, STIM1, reciprocally controls Orai and CaV1.2 channels. Science. 2010;330:105-9 pubmed publisher
    ..2 and Orai1 channels...
  36. Simo Cheyou E, Tan J, Grygorczyk R, Srivastava A. STIM-1 and ORAI-1 channel mediate angiotensin-II-induced expression of Egr-1 in vascular smooth muscle cells. J Cell Physiol. 2017;232:3496-3509 pubmed publisher
    ..In summary, our data demonstrate that Ang-II-induced Egr-1 expression is mediated by STIM-1/Orai-1/Ca2+ -dependent signaling pathways in A-10 VSMC. ..
  37. Korkotian E, Oni Biton E, Segal M. The role of the store-operated calcium entry channel Orai1 in cultured rat hippocampal synapse formation and plasticity. J Physiol. 2017;595:125-140 pubmed publisher
    ..b>Orai1, a store-operated calcium channel, is found in dendritic spines...
  38. Moreno C, Sampieri A, Vivas O, Peña Segura C, Vaca L. STIM1 and Orai1 mediate thrombin-induced Ca(2+) influx in rat cortical astrocytes. Cell Calcium. 2012;52:457-67 pubmed publisher
    ..In many cell types, STIM1 and Orai1 have been demonstrated to be central components of SOCE...
  39. Gruszczynska Biegala J, Pomorski P, Wisniewska M, Kuznicki J. Differential roles for STIM1 and STIM2 in store-operated calcium entry in rat neurons. PLoS ONE. 2011;6:e19285 pubmed publisher
    The interaction between Ca(2+) sensors STIM1 and STIM2 and Ca(2+) channel-forming protein ORAI1 is a crucial element of store-operated calcium entry (SOCE) in non-excitable cells...
  40. Gwozdz T, Dutko Gwozdz J, Zarayskiy V, Peter K, Bolotina V. How strict is the correlation between STIM1 and Orai1 expression, puncta formation, and ICRAC activation?. Am J Physiol Cell Physiol. 2008;295:C1133-40 pubmed publisher
    Stromal interaction molecule 1 (STIM1) and Orai1 have been identified as crucial elements of the store-operated Ca(2+) entry (SOCE) pathway, but the mechanism of their functional interaction remains controversial...
  41. Ong H, Cheng K, Liu X, Bandyopadhyay B, Paria B, Soboloff J, et al. Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx. Evidence for similarities in store-operated and calcium release-activated calcium channel components. J Biol Chem. 2007;282:9105-16 pubmed
    ..Recently, Orai1 and STIM1 have been suggested to be sufficient for generating CRAC channels...
  42. Xu N, Cioffi D, Alexeyev M, Rich T, Stevens T. Sodium entry through endothelial store-operated calcium entry channels: regulation by Orai1. Am J Physiol Cell Physiol. 2015;308:C277-88 pubmed publisher
    b>Orai1 interacts with transient receptor potential protein of the canonical subfamily (TRPC4) and contributes to calcium selectivity of the endothelial cell store-operated calcium entry current (ISOC)...
  43. Cui R, Yan L, Luo Z, Guo X, Yan M. Blockade of store-operated calcium entry alleviates ethanol-induced hepatotoxicity via inhibiting apoptosis. Toxicol Appl Pharmacol. 2015;287:52-66 pubmed publisher
    ..Blockade of SOCE by pharmacological inhibitors and sh-RNA knockdown of STIM1 and Orai1 attenuated intracellular Ca(2+) overload, restored the mitochondrial membrane potential (MMP), decreased ..
  44. Sabourin J, Le Gal L, Saurwein L, Haefliger J, Raddatz E, Allagnat F. Store-operated Ca2+ Entry Mediated by Orai1 and TRPC1 Participates to Insulin Secretion in Rat β-Cells. J Biol Chem. 2015;290:30530-9 pubmed publisher
    ..triggered by acetylcholine (ACh) or thapsigargin stimulated the formation of a ternary complex composed of Orai1, TRPC1, and STIM1, the key proteins involved in the formation of SOCs...
  45. Abdullaev I, Bisaillon J, Potier M, Gonzalez J, Motiani R, Trebak M. Stim1 and Orai1 mediate CRAC currents and store-operated calcium entry important for endothelial cell proliferation. Circ Res. 2008;103:1289-99 pubmed publisher
    ..calcium (Ca(2+)) entry (SOCE) pathway have identified Stim1 as the endoplasmic reticulum Ca(2+) sensor and Orai1 as the pore forming subunit of the highly Ca(2+)-selective CRAC channel expressed in hematopoietic cells...
  46. Shen B, Zhu J, Zhang J, Jiang F, Wang Z, Zhang Y, et al. Attenuated mesangial cell proliferation related to store-operated Ca2+ entry in aged rat: the role of STIM 1 and Orai 1. Age (Dordr). 2013;35:2193-202 pubmed publisher
    ..We conclude that the attenuation of GMCs proliferation can be attributed to the decreased SOCE partially caused by reduced expression of STIM 1 and Orai 1. ..
  47. Giachini F, Lima V, Filgueira F, Dorrance A, Carvalho M, Fortes Z, et al. STIM1/Orai1 contributes to sex differences in vascular responses to calcium in spontaneously hypertensive rats. Clin Sci (Lond). 2012;122:215-26 pubmed publisher
    ..protection in females, compared with males, reflects decreased Ca2+ mobilization due to diminished activation of Orai1/STIM1 (stromal interaction molecule 1)...
  48. Zhang W, Halligan K, Zhang X, Bisaillon J, Gonzalez Cobos J, Motiani R, et al. Orai1-mediated I (CRAC) is essential for neointima formation after vascular injury. Circ Res. 2011;109:534-42 pubmed publisher
    The molecular correlate of the calcium release-activated calcium current (I(CRAC)), the channel protein Orai1, is upregulated in proliferative vascular smooth muscle cells (VSMC)...
  49. Takahashi Y, Murakami M, Watanabe H, Hasegawa H, Ohba T, Munehisa Y, et al. Essential role of the N-terminus of murine Orai1 in store-operated Ca2+ entry. Biochem Biophys Res Commun. 2007;356:45-52 pubmed
    ..Recently, human Orai1 (the channel-forming subunit) and STIM1 (the calcium sensor) were identified as essential molecules for SOCE...
  50. Mitchell C, Gasperini R, Small D, Foa L. STIM1 is necessary for store-operated calcium entry in turning growth cones. J Neurochem. 2012;122:1155-66 pubmed publisher
    ..We hypothesize that STIM1- and Orai1/2-mediated SOCE are necessary for growth cone turning responses to extracellular guidance cues...
  51. Piron M, Villereal M. Chronic exposure to stress hormones alters the subtype of store-operated channels expressed in H19-7 hippocampal neuronal cells. J Cell Physiol. 2013;228:1332-43 pubmed publisher
    ..observation that corticosterone treatment of H19-7 cells increases the expression of the I(CRAC) channel subunit Orai1. Thus, the subtype of SOCs expressed in H19-7 hippocampal neurons can be altered from I(SOC) to I(CRAC) by chronic ..
  52. Balasuriya D, Srivats S, Murrell Lagnado R, Edwardson J. Atomic force microscopy (AFM) imaging suggests that stromal interaction molecule 1 (STIM1) binds to Orai1 with sixfold symmetry. FEBS Lett. 2014;588:2874-80 pubmed publisher
    ..interaction molecule 1 (STIM1), an ER resident protein that senses Ca(2+) store depletion and interacts with Orai1, the pore-forming subunit of the channel. The subunit stoichiometry of the CRAC channel is controversial...
  53. Calloway N, Vig M, Kinet J, Holowka D, Baird B. Molecular clustering of STIM1 with Orai1/CRACM1 at the plasma membrane depends dynamically on depletion of Ca2+ stores and on electrostatic interactions. Mol Biol Cell. 2009;20:389-99 pubmed publisher
    ..stromal interaction molecule 1 (STIM1), localized to the endoplasmic reticulum (ER), and calcium channel subunit (Orai1/CRACM1), localized to the plasma membrane...
  54. Yang Y, Zhu J, Wang X, Xue N, Du J, Meng X, et al. Contrasting Patterns of Agonist-induced Store-operated Ca2+ Entry and Vasoconstriction in Mesenteric Arteries and Aorta With Aging. J Cardiovasc Pharmacol. 2015;65:571-8 pubmed publisher
    ..The results of Western blot and immunofluorescence staining show that the expression levels of Orai1, a store-operated Ca channel, were increased in VSMCs of mesenteric arteries but were reduced in VSMCs of aorta ..
  55. Lee J, Jeon I, Han N, Song H, Kim E, Choi J, et al. Ubiquilin 1 interacts with Orai1 to regulate calcium mobilization. Mol Cells. 2013;35:41-6 pubmed publisher
    ..Through screening of Orai1 interaction partner(s) that might have an effect on SOCE, ubiquilin 1 was identified as a target of Orai1...
  56. Souza Bomfim G, Méndez López I, Arranz Tagarro J, Ferraz Carbonel A, Roman Campos D, Padín J, et al. Functional Upregulation of STIM-1/Orai-1-Mediated Store-Operated Ca2+ Contributing to the Hypertension Development Elicited by Chronic EtOH Consumption. Curr Vasc Pharmacol. 2017;15:265-281 pubmed publisher
    ..These findings suggest that hypertrophic aortic remodeling and abnormal contraction triggered mainly by Ca2+ overload via STIM-1/Orai-1-mediated SOCE through SOCCs are involved hypertension developed by EtOH consumption. ..