Genomes and Genes
Gene Symbol: Ogdh
Description: oxoglutarate dehydrogenase
Alias: 2-oxoglutarate dehydrogenase, mitochondrial, 2-oxoglutarate dehydrogenase E1 component, mitochondrial, 2-oxoglutarate dehydrogenase complex component E1, OGDC-E1, alpha-ketoglutarate dehydrogenase, oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide), oxoglutarate dehydrogenase (lipoamide)
- Andersson U, Leighton B, Young M, Blomstrand E, Newsholme E. Inactivation of aconitase and oxoglutarate dehydrogenase in skeletal muscle in vitro by superoxide anions and/or nitric oxide. Biochem Biophys Res Commun. 1998;249:512-6 pubmed..It is suggested that these effects may be responsible for some alterations in skeletal muscle metabolism, and these possibilities are discussed. ..
- Sheu K, Blass J. The alpha-ketoglutarate dehydrogenase complex. Ann N Y Acad Sci. 1999;893:61-78 pubmed..We hypothesize that variations in KGDHC that are not deleterious during reproductive life become deleterious with aging, perhaps by predisposing this mitochondrial metabolon to oxidative damage. ..
- Bunik V, Kabysheva M, Klimuk E, Storozhevykh T, Pinelis V. Phosphono analogues of 2-oxoglutarate protect cerebellar granule neurons upon glutamate excitotoxicity. Ann N Y Acad Sci. 2009;1171:521-9 pubmed publisher..We investigated the role in these phenomena of 2-oxoglutarate dehydrogenase (OGDH), the enzyme participating in mitochondrial degradation of glutamate...
- Quinlan C, Goncalves R, Hey Mogensen M, Yadava N, Bunik V, Brand M. The 2-oxoacid dehydrogenase complexes in mitochondria can produce superoxide/hydrogen peroxide at much higher rates than complex I. J Biol Chem. 2014;289:8312-25 pubmed publisher..However, the 2-oxoglutarate dehydrogenase (OGDH), branched-chain 2-oxoacid dehydrogenase (BCKDH), and pyruvate dehydrogenase (PDH) complexes are also capable of ..