Gene Symbol: Odc1
Description: ornithine decarboxylase 1
Alias: Odc, ornithine decarboxylase, Ornitine decarboxylase
Species: rat
Products:     Odc1

Top Publications

  1. Eloranta T, Khomutov A, Khomutov R, Hyvonen T. Aminooxy analogues of spermidine as inhibitors of spermine synthase and substrates of hepatic polyamine acetylating activity. J Biochem. 1990;108:593-8 pubmed
    ..polyamine acetyltransferase, inactivators of S-adenosylmethionine decarboxylase and inhibitors of ornithine decarboxylase. AP-APA and AOE-PU showed K1-values of 1...
  2. Brenner C, Deplus R, Didelot C, Loriot A, Viré E, De Smet C, et al. Myc represses transcription through recruitment of DNA methyltransferase corepressor. EMBO J. 2005;24:336-46 pubmed
    ..Furthermore, these findings suggest that targeting of DNA methyltransferases by transcription factors is a wide and general mechanism for the generation of specific DNA methylation patterns within a cell. ..
  3. Ning Q, Li C, Wei K, He J, Xu C, Shao Q. Regulatory effects of corticosterone on ornithine decarboxylase activity during liver regeneration in rats. J Gastroenterol Hepatol. 2007;22:1978-82 pubmed
    The regulation of ornithine decarboxylase (ODC) gene expression and enzyme activity by corticosterone during rat liver regeneration induced by partial hepatectomy (PH) was evaluated...
  4. Liu W, Wu Y, Zhang L, Liu X, Wang Y, Xue B, et al. Effects of lentivirus-mediated ornithine decarboxylase gene on the proliferation and apoptosis of fibroblast-like synoviocytes in rats with arthritis. Life Sci. 2018;194:224-230 pubmed publisher
    This study aimed to explore the effects of lentivirus-mediated ornithine decarboxylase (ODC) gene on the proliferation and apoptosis of fibroblast-like synoviocytes (FLSs) in rats with rheumatoid arthritis (RA)...
  5. López Contreras A, Sánchez Laorden B, Ramos Molina B, de la Morena M, Cremades A, Peñafiel R. Subcellular localization of antizyme inhibitor 2 in mammalian cells: Influence of intrinsic sequences and interaction with antizymes. J Cell Biochem. 2009;107:732-40 pubmed publisher
    b>Ornithine decarboxylase (ODC) and the antizyme inhibitors (AZIN1 and AZIN2), regulatory proteins of polyamine levels, are antizyme-binding proteins...
  6. Mäkitie L, Kanerva K, Andersson L. Ornithine decarboxylase regulates the activity and localization of rhoA via polyamination. Exp Cell Res. 2009;315:1008-14 pubmed publisher
    b>Ornithine decarboxylase (ODC) is the rate-limiting enzyme of polyamine synthesis. Polyamines and ODC are connected to cell proliferation and transformation...
  7. Miracle C, Rieg T, Mansoury H, Vallon V, Thomson S. Ornithine decarboxylase inhibitor eliminates hyperresponsiveness of the early diabetic proximal tubule to dietary salt. Am J Physiol Renal Physiol. 2008;295:F995-F1002 pubmed publisher
    ..Kidney growth was suppressed with ornithine decarboxylase (ODC) inhibitor, DFMO (200 mg.kg(-1).day(-1)), or placebo...
  8. Wild G, Searles L, Koski K, Drozdowski L, Begum Hasan J, Thomson A. Oral polyamine administration modifies the ontogeny of hexose transporter gene expression in the postnatal rat intestine. Am J Physiol Gastrointest Liver Physiol. 2007;293:G453-60 pubmed
    ..Studies in postnatal rats have shown that ornithine decarboxylase (ODC) protein and mRNA peak before the maximal expression of brush-border membrane (BBM) sucrase-..
  9. Babal P, Ruchko M, Ault Ziel K, Cronenberg L, Olson J, Gillespie M. Regulation of ornithine decarboxylase and polyamine import by hypoxia in pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2002;282:L840-6 pubmed
    In rat lung and cultured lung vascular cells, hypoxia decreases ornithine decarboxylase (ODC) activity and increases polyamine import...

More Information


  1. Pendeville H, Carpino N, Marine J, Takahashi Y, Muller M, Martial J, et al. The ornithine decarboxylase gene is essential for cell survival during early murine development. Mol Cell Biol. 2001;21:6549-58 pubmed
    Overexpression and inhibitor studies have suggested that the c-Myc target gene for ornithine decarboxylase (ODC), the enzyme which converts ornithine to putrescine, plays an important role in diverse biological processes, including cell ..
  2. Zhang H, Xue G, Zhang W, Wang L, Li H, Zhang L, et al. Akt and Erk1/2 activate the ornithine decarboxylase/polyamine system in cardioprotective ischemic preconditioning in rats: the role of mitochondrial permeability transition pores. Mol Cell Biochem. 2014;390:133-42 pubmed publisher
    b>Ornithine decarboxylase (ODC) is the first rate-limiting enzyme in polyamine biosynthesis, which is essential for cell survival...
  3. van Steeg H, van Oostrom C, Hodemaekers H, Peters L, Thomas A. The translation in vitro of rat ornithine decarboxylase mRNA is blocked by its 5' untranslated region in a polyamine-independent way. Biochem J. 1991;274 ( Pt 2):521-6 pubmed
    The enzyme ornithine decarboxylase (ODC, EC is believed to play an essential role in the growth and differentiation of cells by regulating the biosynthesis of polyamines...
  4. Kanerva K, Mäkitie L, Pelander A, Heiskala M, Andersson L. Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase. Biochem J. 2008;409:187-92 pubmed
    ODC (ornithine decarboxylase), the rate-limiting enzyme in polyamine biosynthesis, is regulated by specific inhibitors, AZs (antizymes), which in turn are inhibited by AZI (AZ inhibitor)...
  5. Tsirka S, Turck C, Coffino P. Multiple active conformers of mouse ornithine decarboxylase. Biochem J. 1993;293 ( Pt 1):289-95 pubmed
    Purified recombinant mouse ornithine decarboxylase (ODC) was denatured with urea or with guanidinium chloride. Enzymic activity was efficiently recovered upon dilution of the denaturing agent...
  6. Schipper R, Romain N, Otten A, Tan J, Lange W, Verhofstad A. Immunocytochemical detection of ornithine decarboxylase. J Histochem Cytochem. 1999;47:1395-404 pubmed
    b>Ornithine decarboxylase (ODC), a regulatory enzyme of polyamine biosynthesis, is involved in cell growth and differentiation...
  7. Hillary R, Pegg A. Decarboxylases involved in polyamine biosynthesis and their inactivation by nitric oxide. Biochim Biophys Acta. 2003;1647:161-6 pubmed
    ..b>Ornithine decarboxylase is a PLP-requiring decarboxylase, whereas S-adenosylmethionine decarboxylase (AdoMetDC) contains a ..
  8. Higaki I, Matsui Yuasa I, Hirohashi K, Kinoshita H, Otani S. The role of polyamines in growth factor induced DNA synthesis in cultured rat hepatocytes. Hepatogastroenterology. 1999;46:1874-9 pubmed
    ..Hepatocytes were isolated from rats by the collagenase perfusion method. Ornithine decarboxylase and S-adenosylmethionine decarboxylase activities were measured as the release of 14CO2 from L-[-14C]..
  9. Hayashi T, Tsujino T, Iwata S, Nonaka H, Emoto N, Yano Y, et al. Decreased ornithine decarboxylase activity in the kidneys of Dahl salt-sensitive rats. Hypertens Res. 2002;25:787-95 pubmed
    To assess the roles of polyamines (putrescine, spermidine, and spermine) and ornithine decarboxylase (ODC), the rate-limiting enzyme of polyamine synthesis, in the development of salt-sensitive hypertension, we evaluated activity and ..
  10. van Steeg H, van Oostrom T, van Kranen H, van Kreijl C. Nucleotide sequence of the rat ornithine decarboxylase gene. Nucleic Acids Res. 1988;16:8173-4 pubmed
  11. Aksenova G, Logvinovich O, Fialkovskaya L, Afanasyev V, Ignat ev D, Kolomiytseva I, et al. The effect of hypothermia on the ornithine decarboxylase activity in tissues of rats. Dokl Biochem Biophys. 2009;428:249-51 pubmed
  12. Govoni M, Bonavita F, Shantz L, Guarnieri C, Giordano E. Overexpression of ornithine decarboxylase increases myogenic potential of H9c2 rat myoblasts. Amino Acids. 2010;38:541-7 pubmed publisher
    ..Cell cultures were committed via a 7-day treatment with insulin which induced increase in the activity of ornithine decarboxylase, the first enzyme in the polyamine biosynthetic pathway, consistent with myogenic differentiation...
  13. Wen L, Huang J, Blackshear P. Rat ornithine decarboxylase gene. Nucleotide sequence, potential regulatory elements, and comparison to the mouse gene. J Biol Chem. 1989;264:9016-21 pubmed
    Expression of ornithine decarboxylase is regulated by a variety of hormonal and other stimuli in rat cells and tissues...
  14. Deng A, Munger K, Valdivielso J, Satriano J, Lortie M, Blantz R, et al. Increased expression of ornithine decarboxylase in distal tubules of early diabetic rat kidneys: are polyamines paracrine hypertrophic factors?. Diabetes. 2003;52:1235-9 pubmed
    ..They can also contribute to hypertrophy. The activity of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis, increases in the early diabetic kidney to ..
  15. Loikkanen I, Lin Y, Railo A, Pajunen A, Vainio S. Polyamines are involved in murine kidney development controlling expression of c-ret, E-cadherin, and Pax2/8 genes. Differentiation. 2005;73:303-12 pubmed
    ..the polyamine pools with alpha-difluoromethylornithine (DFMO), an irreversible suicide inhibitor of ornithine decarboxylase (ODC)...
  16. van Kranen H, van de Zande L, van Kreijl C, Bisschop A, Wieringa B. Cloning and nucleotide sequence of rat ornithine decarboxylase cDNA. Gene. 1987;60:145-55 pubmed
    The enzyme ornithine decarboxylase (ODC; EC catalyses the first and rate-limiting step in polyamine biosynthesis...
  17. Ramos Molina B, Lambertos A, López Contreras A, Kasprzak J, Czerwoniec A, Bujnicki J, et al. Structural and degradative aspects of ornithine decarboxylase antizyme inhibitor 2. FEBS Open Bio. 2014;4:510-21 pubmed publisher
    b>Ornithine decarboxylase (ODC) is the key enzyme in the polyamine biosynthetic pathway...
  18. López Contreras A, Lopez Garcia C, Jimenez Cervantes C, Cremades A, Peñafiel R. Mouse ornithine decarboxylase-like gene encodes an antizyme inhibitor devoid of ornithine and arginine decarboxylating activity. J Biol Chem. 2006;281:30896-906 pubmed
    b>Ornithine decarboxylase (ODC), a key enzyme in the biosynthesis of polyamines, is a labile protein that is regulated by interacting with antizymes (AZs), a family of polyamine-induced proteins...
  19. Meng M, Gu L, Zhang Q, Xie H, Wang Q. [The study on the relationship between the tumor-like proliferation of synoviocytes and the expression of c-myc and ODC genes in adjuvant arthritis rats]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2005;21:411-4 pubmed
    ..The proliferation of cultured synoviocytes was measured by MTT colorimetry. Meanwhile, the mRNAs of C-myc and ODC genes in synovial tissues of the rats were detected by semi-quantitative RT-PCR...
  20. Passariello C, Gottardi D, Cetrullo S, Zini M, Campana G, Tantini B, et al. Evidence that AMP-activated protein kinase can negatively modulate ornithine decarboxylase activity in cardiac myoblasts. Biochim Biophys Acta. 2012;1823:800-7 pubmed publisher
    The responses of AMP-activated protein kinase (AMPK) and Ornithine decarboxylase (ODC) to isoproterenol have been examined in H9c2 cardiomyoblasts, AMPK represents the link between cell growth and energy availability whereas ODC, the key ..
  21. Wang J, Viar M, McCormack S, Johnson L. Effect of putrescine on S-adenosylmethionine decarboxylase in a small intestinal crypt cell line. Am J Physiol. 1992;263:G494-501 pubmed
    Two key enzymes in polyamine biosynthesis are ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (SAMDC)...
  22. Ohtake Y, Maruko A, Ohishi N, Kawaguchi M, Satoh T, Ohkubo Y. Effect of retinoic acid on transglutaminase and ornithine decarboxylase activities during liver regeneration. Cell Biochem Funct. 2008;26:359-65 pubmed
    ..It is suggested that transglutaminase 2 (TG2) and ornithine decarboxylase (ODC) are involved in liver regeneration...
  23. Manzella J, Blackshear P. Regulation of rat ornithine decarboxylase mRNA translation by its 5'-untranslated region. J Biol Chem. 1990;265:11817-22 pubmed
    b>Ornithine decarboxylase (ODC), a key enzyme in polyamine biosynthesis, is a highly inducible protein whose expression involves a complex and variable array of regulatory mechanisms...
  24. Wallace H, Fraser A, Hughes A. A perspective of polyamine metabolism. Biochem J. 2003;376:1-14 pubmed
    ..The future will be in adopting a functional genomics approach to identifying polyamine-regulated genes linked to either carcinogenesis or apoptosis. ..