Gene Symbol: occludin
Description: occludin
Alias: occludin
Species: rat
Products:     occludin

Top Publications

  1. Traweger A, Fang D, Liu Y, Stelzhammer W, Krizbai I, Fresser F, et al. The tight junction-specific protein occludin is a functional target of the E3 ubiquitin-protein ligase itch. J Biol Chem. 2002;277:10201-8 pubmed
    ..Recent evidence confirms the notion that occludin, a four-pass integral plasma-membrane protein, is a functional component of the paracellular barrier...
  2. Ikenouchi J, Furuse M, Furuse K, Sasaki H, Tsukita S, Tsukita S. Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells. J Cell Biol. 2005;171:939-45 pubmed
    ..These findings indicate the critical function of tricellulin for formation of the epithelial barrier. ..
  3. Lui W, Lee W. cAMP perturbs inter-Sertoli tight junction permeability barrier in vitro via its effect on proteasome-sensitive ubiquitination of occludin. J Cell Physiol. 2005;203:564-72 pubmed
    ..Using Sertoli cell culture, it was shown that there was an increase in occludin level, concomitant with a reduction of an E3 ubiquitin ligase, Itch, at the time when inter-Sertoli TJs were ..
  4. Steed E, Rodrigues N, Balda M, Matter K. Identification of MarvelD3 as a tight junction-associated transmembrane protein of the occludin family. BMC Cell Biol. 2009;10:95 pubmed publisher
    ..discovered in proteins involved in membrane apposition and fusion events, such as the tight junction proteins occludin and tricellulin. In mammals, MarvelD3 is expressed as two alternatively spliced isoforms...
  5. Raleigh D, Marchiando A, Zhang Y, Shen L, Sasaki H, Wang Y, et al. Tight junction-associated MARVEL proteins marveld3, tricellulin, and occludin have distinct but overlapping functions. Mol Biol Cell. 2010;21:1200-13 pubmed publisher
    In vitro studies have demonstrated that occludin and tricellulin are important for tight junction barrier function, but in vivo data suggest that loss of these proteins can be overcome...
  6. Zhang G, Tian Y, Huang J, Tao R, Liao M, Lu Y, et al. The ?-secretase blocker DAPT reduces the permeability of the blood-brain barrier by decreasing the ubiquitination and degradation of occludin during permanent brain ischemia. CNS Neurosci Ther. 2013;19:53-60 pubmed publisher
    ..We investigated the mechanisms of occludin degradation that underlie permanent middle cerebral artery occlusion (pMCAO) in rats...
  7. Liu J, Jin X, LIU K, Liu W. Matrix metalloproteinase-2-mediated occludin degradation and caveolin-1-mediated claudin-5 redistribution contribute to blood-brain barrier damage in early ischemic stroke stage. J Neurosci. 2012;32:3044-57 pubmed publisher
    ..This same OGD treatment also led to rapid degradation of tight junction protein occludin and dissociation of claudin-5 from the cytoskeleton, which contributed to OGD-induced endothelial barrier ..
  8. Furuse M, Fujita K, Hiiragi T, Fujimoto K, Tsukita S. Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J Cell Biol. 1998;141:1539-50 pubmed
    b>Occludin is the only known integral membrane protein localizing at tight junctions (TJ), but recent targeted disruption analysis of the occludin gene indicated the existence of as yet unidentified integral membrane proteins in TJ...
  9. McCaffrey G, Willis C, Staatz W, Nametz N, Quigley C, Hom S, et al. Occludin oligomeric assemblies at tight junctions of the blood-brain barrier are altered by hypoxia and reoxygenation stress. J Neurochem. 2009;110:58-71 pubmed publisher
    ..investigate the effect of hypoxia (Hx) and reoxygenation on oligomeric assemblies of the transmembrane TJ protein occludin, rats were subjected to either normoxia (Nx, 21% O(2), 60 min), Hx (6% O(2), 60 min), or hypoxia/reoxygenation (H/..

More Information


  1. Hu J, Shao C, Wang P, Liu Y, Hao W, Feng Y, et al. [High temperature reduces the proliferation of and occludin expression in rat Sertoli cells in vitro]. Zhonghua Nan Ke Xue. 2012;18:920-4 pubmed
    ..male infertility or subfertility by observing the effects of different temperatures on the proliferation of and occludin (OCLN) expression in rat Sertoli cells in vitro...
  2. Wu L, Yin F, Peng J, Wang W, Gan N. [The tight junction proteins ZO-1, occludin and actin participate in the permeability increasing of blood-brain barrier induced by hypoxia-ischemia]. Zhongguo Dang Dai Er Ke Za Zhi. 2008;10:513-6 pubmed
    To study the changes of blood-brain barrier-tight junction (BBB-TJ) proteins ZO-1, occludin and actin following hypoxia-ischemia (HI) in order to explore the possible mechanism of permeability increasing of blood-brain barrier (BBB) ..
  3. Takakuwa Y, Kokai Y, Sasaki K, Chiba H, Tobioka H, Mori M, et al. Bile canalicular barrier function and expression of tight-junctional molecules in rat hepatocytes during common bile duct ligation. Cell Tissue Res. 2002;307:181-9 pubmed
    ..An apparent increase of occludin mRNA expression was detected in livers after 6 h ligation, whereas the expression of claudin-1, -2, and -3 was ..
  4. Park M, Kim H, Lim B, Wylegala A, Toborek M. Methamphetamine-induced occludin endocytosis is mediated by the Arp2/3 complex-regulated actin rearrangement. J Biol Chem. 2013;288:33324-34 pubmed publisher
    ..on the actin cytoskeletal rearrangement as a modulator of METH-induced redistribution of tight junction protein occludin in brain endothelial cells...
  5. Adamson R, Sarai R, Altangerel A, Clark J, Weinbaum S, Curry F. Microvascular permeability to water is independent of shear stress, but dependent on flow direction. Am J Physiol Heart Circ Physiol. 2013;304:H1077-84 pubmed publisher
    ..Increased Lp in reverse-perfused vessels was associated with numerous discontinuities of VE-cadherin and occludin, while both proteins were continuous around the periphery of forward-perfused vessels...
  6. Lee D, Kim D. S-methylation of 2-mercaptopyrazine in rat liver microsomes and cytosol. Xenobiotica. 1999;29:909-16 pubmed
    ..Both activities were inhibited by S-adenosyl-L-homocysteine (Met-Hcy). 4. These results suggest that both TMT and TPMT may be involved in the in vivo methylation of 2-MP. ..
  7. Sandoval K, Witt K. Age and 17?-estradiol effects on blood-brain barrier tight junction and estrogen receptor proteins in ovariectomized rats. Microvasc Res. 2011;81:198-205 pubmed publisher
    ..Middle-aged rats showed decreased protein expression of occludin with 17?-estradiol (55 kDa band) or placebo (45, 55, 60 kDa bands) treatment compared to respective young...
  8. Reijerkerk A, Kooij G, van der Pol S, Khazen S, Dijkstra C, de Vries H. Diapedesis of monocytes is associated with MMP-mediated occludin disappearance in brain endothelial cells. FASEB J. 2006;20:2550-2 pubmed
    ..we retrovirally expressed green fluorescent protein (GFP) fused to the N-terminus of the tight junction protein occludin in the rat brain endothelial cell line GP8/3.9...
  9. Faropoulos K, Chroni E, Assimakopoulos S, Mavrakis A, Stamatopoulou V, Toumpeki C, et al. Altered occludin expression in brain capillaries induced by obstructive jaundice in rats. Brain Res. 2010;1325:121-7 pubmed publisher
    ..The present study aimed to detect alterations of tight junction-associated occludin in rat brain capillaries after bile duct ligation (BDL)...
  10. Jiao H, Wang Z, Liu Y, Wang P, Xue Y. Specific role of tight junction proteins claudin-5, occludin, and ZO-1 of the blood-brain barrier in a focal cerebral ischemic insult. J Mol Neurosci. 2011;44:130-9 pubmed publisher
    ..120 h following reperfusion and evaluate the specific role of tight junction (TJ) associated proteins claudin-5, occludin, and ZO-1 as well as protein kinase C delta (PKC?) pathway in BBB leakage induced by reperfusion injury...
  11. João S, Arana Chavez V. Tight junctions in differentiating ameloblasts and odontoblasts differentially express ZO-1, occludin, and claudin-1 in early odontogenesis of rat molars. Anat Rec A Discov Mol Cell Evol Biol. 2004;277:338-43 pubmed
    ..We studied the distribution of ZO-1, occludin, and claudin-1 between differentiating ameloblasts and odontoblasts in molar tooth germs from 1- to 3-day-old ..
  12. Li X, Akhtar S, Choudhry M. Alteration in intestine tight junction protein phosphorylation and apoptosis is associated with increase in IL-18 levels following alcohol intoxication and burn injury. Biochim Biophys Acta. 2012;1822:196-203 pubmed publisher
    ..One day after injury, EtOH combined with burn injury resulted in a significant decrease in total occludin protein and its phosphorylation in small intestine compared to either EtOH or burn injury alone...
  13. Fujita H, Chiba H, Yokozaki H, Sakai N, Sugimoto K, Wada T, et al. Differential expression and subcellular localization of claudin-7, -8, -12, -13, and -15 along the mouse intestine. J Histochem Cytochem. 2006;54:933-44 pubmed
    ..This manuscript contains online supplemental material available at http://www.jhc.org. Please visit this article online to view these materials. ..
  14. Steed E, Elbediwy A, Vacca B, Dupasquier S, Hemkemeyer S, Suddason T, et al. MarvelD3 couples tight junctions to the MEKK1-JNK pathway to regulate cell behavior and survival. J Cell Biol. 2014;204:821-38 pubmed publisher
    ..MarvelD3 thus couples tight junctions to the MEKK1-JNK pathway to regulate cell behavior and survival. ..
  15. Cong X, Zhang Y, Yang N, Li J, Ding C, Ding Q, et al. Occludin is required for TRPV1-modulated paracellular permeability in the submandibular gland. J Cell Sci. 2013;126:1109-21 pubmed publisher
    b>Occludin plays an important role in maintaining tight junction barrier function in many types of epithelia...
  16. Sheth B, Fontaine J, Ponza E, McCallum A, Page A, Citi S, et al. Differentiation of the epithelial apical junctional complex during mouse preimplantation development: a role for rab13 in the early maturation of the tight junction. Mech Dev. 2000;97:93-104 pubmed
    ..However, following assembly of the TJ transmembrane protein, occludin, from the early 32-cell stage when blastocoel formation begins, ZO-1alpha- and other TJ proteins (ZO-1alpha+ ..
  17. Kluger M, Clark P, Tellides G, Gerke V, Pober J. Claudin-5 controls intercellular barriers of human dermal microvascular but not human umbilical vein endothelial cells. Arterioscler Thromb Vasc Biol. 2013;33:489-500 pubmed publisher
    ..Claudin-5 expression and junctional organization control HDMEC and arteriolar-capillary paracellular barriers, whereas HUVEC and venular junctions use vascular endothelial-cadherin. ..
  18. Plante I, Wallis A, Shao Q, Laird D. Milk secretion and ejection are impaired in the mammary gland of mice harboring a Cx43 mutant while expression and localization of tight and adherens junction proteins remain unchanged. Biol Reprod. 2010;82:837-47 pubmed publisher
    ..localization of Cx26 (Gjb2), Cx30 (Gjb6), Cx32 (Gjb1), E-cadherin, P-cadherin, beta-catenin, claudin-1, and occludin were all unaffected by the decreased levels of Cx43 at parturition, suggesting no cross-talk to other connexins ..
  19. Patibandla P, Tyagi N, Dean W, Tyagi S, Roberts A, Lominadze D. Fibrinogen induces alterations of endothelial cell tight junction proteins. J Cell Physiol. 2009;221:195-203 pubmed publisher
    ..Western blot analysis and RT-PCR data showed that the higher dose of Fg decreased the contents of TJPs, occludin, zona occluden-1 (ZO-1), and zona occluden-2 (ZO-2) in ECs...
  20. Elias B, Suzuki T, Seth A, Giorgianni F, Kale G, Shen L, et al. Phosphorylation of Tyr-398 and Tyr-402 in occludin prevents its interaction with ZO-1 and destabilizes its assembly at the tight junctions. J Biol Chem. 2009;284:1559-69 pubmed publisher
    b>Occludin is phosphorylated on tyrosine residues during the oxidative stress-induced disruption of tight junction, and in vitro phosphorylation of occludin by c-Src attenuates its binding to ZO-1...
  21. Morimoto S, Nishimura N, Terai T, Manabe S, Yamamoto Y, Shinahara W, et al. Rab13 mediates the continuous endocytic recycling of occludin to the cell surface. J Biol Chem. 2005;280:2220-8 pubmed
    ..b>Occludin and claudins are integral membrane proteins comprising TJ strands and are thought to be responsible for ..
  22. Unda F, Perez Nanclares G, Le Morvan V, Hernandez C, Vilaxa A, de la Fuente M, et al. Dynamic assembly of tight junction-associated proteins ZO-1, ZO-2, ZO-3 and occludin during mouse tooth development. Histol Histopathol. 2003;18:27-38 pubmed publisher
    ..we have studied the distribution pattern of the tight junction-associated proteins ZO-1, ZO-2, ZO-3 and occludin in the developing mouse tooth as a model...
  23. You K, Xu X, Fu J, Xu S, Yue X, Yu Z, et al. Hyperoxia disrupts pulmonary epithelial barrier in newborn rats via the deterioration of occludin and ZO-1. Respir Res. 2012;13:36 pubmed publisher
    ..This study determines whether changes in tight junctions play an important role in disruption of the pulmonary epithelial barrier during hyperoxic acute lung injury...
  24. Gu Y, Xue Y, Wei X, Zhang H, Li Y. Calcium-activated potassium channel activator down-regulated the expression of tight junction protein in brain tumor model in rats. Neurosci Lett. 2011;493:140-4 pubmed publisher
    ..Using a rat brain glioma (C6) model, we exam the expression of ZO-1 and occludin in mRNA and protein level at different time point after intracarotid infusion of NS1619 (30 ?g/kg/min) to tumor ..
  25. Hussar P, Tserentsoodol N, Koyama H, Yokoo Sugawara M, Matsuzaki T, Takami S, et al. The glucose transporter GLUT1 and the tight junction protein occludin in nasal olfactory mucosa. Chem Senses. 2002;27:7-11 pubmed
    ..Immunohistochemical examination showed that the tight junction protein occludin was present in the junctions of the olfactory epithelium...
  26. Ohta H, Adachi H, Inaba M. Developmental changes in the expression of tight junction protein claudins in murine metanephroi and embryonic kidneys. J Vet Med Sci. 2006;68:149-55 pubmed
    ..chain reaction for the claudins examined, including claudins 1-4, 8, 10, 11, and 16, and the TJ proteins occludin and ZO-1...
  27. Siu E, Wong E, Mruk D, Porto C, Cheng C. Focal adhesion kinase is a blood-testis barrier regulator. Proc Natl Acad Sci U S A. 2009;106:9298-303 pubmed publisher
    ..focal adhesion kinase (FAK), a nonreceptor protein tyrosine kinase, is shown to structurally interact with occludin and ZO-1 to form a functional protein complex at the BTB...
  28. Sun Y, Chen W, Zhang T, Cao H, Zhou J. Effects of cardiopulmonary bypass on tight junction protein expressions in intestinal mucosa of rats. World J Gastroenterol. 2008;14:5868-75 pubmed
    ..Expression of occludin and zonula occludens-1 (ZO-1) were determined by Western blotting and immunotochemistry, respectively...
  29. Martinez C, de Campos F, de Carvalho V, de Castro Ferreira C, Rodrigues M, Sato D, et al. Claudin-3 and occludin tissue content in the glands of colonic mucosa with and without a fecal stream. J Mol Histol. 2015;46:183-94 pubmed publisher
    ..To evaluate the contents of claudin-3 and occludin in the glands of colonic mucosa devoid of a fecal stream...
  30. Caraballo J, Yshii C, Butti M, Westphal W, Borcherding J, Allamargot C, et al. Hypoxia increases transepithelial electrical conductance and reduces occludin at the plasma membrane in alveolar epithelial cells via PKC-? and PP2A pathway. Am J Physiol Lung Cell Mol Physiol. 2011;300:L569-78 pubmed publisher
    ..Alveolar epithelial cells (AEC) exposed to mild hypoxia (Po(2) = 50 mmHg) for 30 and 60 min decreased occludin abundance at the plasma membrane and significantly increased G(t)...
  31. Muthusamy A, Lin C, Shanmugam S, Lindner H, ABCOUWER S, Antonetti D. Ischemia-reperfusion injury induces occludin phosphorylation/ubiquitination and retinal vascular permeability in a VEGFR-2-dependent manner. J Cereb Blood Flow Metab. 2014;34:522-31 pubmed publisher
    ..The results demonstrate that IR injury induced occludin Ser490 phosphorylation and ubiquitination within 15?minutes of reperfusion with subsequent vascular permeability...
  32. Atsumi Si S, Kokai Y, Tobioka H, Kuwahara K, Kuwabara H, Takakuwa Y, et al. Occludin modulates organization of perijunctional circumferential actin in rat endothelial cells. Med Electron Microsc. 1999;32:11-19 pubmed
    ..b>Occludin is an integral membrane component of tight junctions, but the role of occludin in the endothelial cell function ..
  33. Zhao T, Liu M, Gu C, Wang X, Wang Y. Activation of c-Src tyrosine kinase mediated the degradation of occludin in ventilator-induced lung injury. Respir Res. 2014;15:158 pubmed publisher
    ..This study examined the relationship between c-Src activation and occludin levels in VILI both in vitro and in vivo...
  34. Siu E, Wong E, Mruk D, Sze K, Porto C, Cheng C. An occludin-focal adhesion kinase protein complex at the blood-testis barrier: a study using the cadmium model. Endocrinology. 2009;150:3336-44 pubmed publisher
    ..These include tight junction (TJ) proteins (e.g. occludin, junctional adhesion molecule-A, claudins), basal ectoplasmic specialization proteins (e.g...
  35. Andras I, Deli M, Veszelka S, Hayashi K, Hennig B, Toborek M. The NMDA and AMPA/KA receptors are involved in glutamate-induced alterations of occludin expression and phosphorylation in brain endothelial cells. J Cereb Blood Flow Metab. 2007;27:1431-43 pubmed
    ..of this study was to investigate the mechanisms of glutamate-induced alterations of the tight-junction protein occludin in cultured brain microvascular endothelial cells (BMECs)...
  36. Nunes F, Lopez L, Lin H, Davies C, Azevedo R, Gow A, et al. Distinct subdomain organization and molecular composition of a tight junction with adherens junction features. J Cell Sci. 2006;119:4819-27 pubmed
  37. Altay B, Turna B, Oktem G, Aktug H, Semerci B, Bilir A. Immunohistochemical expression of connexin 43 and occludin in the rat testis after epididymal and vasal ligation. Fertil Steril. 2008;90:141-7 pubmed
    To describe the effects of epididymal and vasal ligation, in an experimental rat model, by using connexin 43 and occludin immunohistochemistry as well as transmission electron microscopy...
  38. Liu L, Xue Y, Liu Y, Wang Y. Bradykinin increases blood-tumor barrier permeability by down-regulating the expression levels of ZO-1, occludin, and claudin-5 and rearranging actin cytoskeleton. J Neurosci Res. 2008;86:1153-68 pubmed publisher
    ..whether BK opens the BTB by affecting the tight junction (TJ)-associated proteins zonula occluden-1 (ZO-1), occludin, and caludin-5 and cytoskeleton protein filamentous actin (F-actin)...
  39. Zhang Y, Zhang P, Shen X, Tian S, Wu Y, Zhu Y, et al. Early exercise protects the blood-brain barrier from ischemic brain injury via the regulation of MMP-9 and occludin in rats. Int J Mol Sci. 2013;14:11096-112 pubmed publisher
    ..cerebral infarct volume and the expression of MMP-9, the tissue inhibitors of metalloproteinase-1 (TIMP-1), and occludin were determined...
  40. Adachi M, Inoko A, Hata M, Furuse K, Umeda K, Itoh M, et al. Normal establishment of epithelial tight junctions in mice and cultured cells lacking expression of ZO-3, a tight-junction MAGUK protein. Mol Cell Biol. 2006;26:9003-15 pubmed
    ..These findings indicate that ZO-3 is dispensable in vivo in terms of individual viability, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment. ..
  41. Volpert O, Pili R, Sikder H, Nelius T, Zaichuk T, Morris C, et al. Id1 regulates angiogenesis through transcriptional repression of thrombospondin-1. Cancer Cell. 2002;2:473-83 pubmed
    ..This decrease was completely reversed by a TSP-1 neutralizing antibody. We conclude that TSP-1 is a major target for Id1 effects on angiogenesis. ..
  42. Morita K, Furuse M, Yoshida Y, Itoh M, Sasaki H, Tsukita S, et al. Molecular architecture of tight junctions of periderm differs from that of the maculae occludentes of epidermis. J Invest Dermatol. 2002;118:1073-9 pubmed
    b>Occludin and claudins are tetraspan-transmembrane proteins in tight junctions. Maculae occludentes, which are less-developed tight junctions, occur in the granular cell layer of the epidermis...
  43. Yu Z, Gong C, Lu B, Yang L, Sheng Y, Ji L, et al. Dendrobium chrysotoxum Lindl. alleviates diabetic retinopathy by preventing retinal inflammation and tight junction protein decrease. J Diabetes Res. 2015;2015:518317 pubmed publisher
    ..Decreased retinal mRNA expression of tight junction proteins (including occludin and claudin-1) in diabetic rats was also reversed by DC...
  44. Pérez C, Sobarzo C, Jacobo P, Pellizzari E, Cigorraga S, Denduchis B, et al. Loss of occludin expression and impairment of blood-testis barrier permeability in rats with autoimmune orchitis: effect of interleukin 6 on Sertoli cell tight junctions. Biol Reprod. 2012;87:122 pubmed publisher
    ..attack, the aim of this study was to analyze BTB permeability and the expression of tight junction proteins (occludin, claudin 11, and tight junction protein 1 [TJP1]) in rats during development of autoimmune orchitis...
  45. Jin D, Wang F, Qu L, Li Z, Jin L, Liu P, et al. The distribution and expression of claudin-5 and occludin at the rat blood-optic nerve barrier after borneol treatment. Mol Biol Rep. 2011;38:913-20 pubmed publisher
    ..study is to investigate the distribution and expression of the tight junction membrane proteins, claudin-5 and occludin, in rat blood-optic nerve barrier after borneol treatment...
  46. Nakatsu D, Kano F, Taguchi Y, Sugawara T, Nishizono T, Nishikawa K, et al. JNK1/2-dependent phosphorylation of angulin-1/LSR is required for the exclusive localization of angulin-1/LSR and tricellulin at tricellular contacts in EpH4 epithelial sheet. Genes Cells. 2014;19:565-81 pubmed publisher
  47. Zhang Y, Li Q, Guo W, Huang Y, Yang J. [Effects of chronic ethanol ingestion on intercellular junction proteins and barrier function of airway epithelium in the endotoxemic rat]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2008;20:95-9 pubmed
    ..and lipopolysaccharide (LPS) on airway epithelium barrier function and the expression of tight junction protein occludin and adherens junction protein E-cadherin...
  48. Szabo S, Wögenstein K, Österreicher C, Guldiken N, Chen Y, Doler C, et al. Epiplakin attenuates experimental mouse liver injury by chaperoning keratin reorganization. J Hepatol. 2015;62:1357-66 pubmed publisher
    ..Our data indicate that epiplakin plays a protective role during experimental liver injuries by chaperoning disease-induced keratin reorganization. ..
  49. Chen D, Li L, Yan J, Yang X, You Y, Zhou Y, et al. The loss of αSNAP downregulates the expression of occludin in the intestinal epithelial cell of acute pancreatitis model. Pancreatology. 2014;14:347-55 pubmed publisher
    ..The expression of occludin, one of the main components of the intestinal barrier proteins, is regulated by various factors related to ..
  50. McCabe M, Foo C, Dinger M, Smooker P, Stanton P. Claudin-11 and occludin are major contributors to Sertoli cell tight junction function, in vitro. Asian J Androl. 2016;18:620-6 pubmed publisher
    ..We also conducted an analysis of the contribution of occludin, another intrinsic transmembrane protein of the TJ...
  51. Tien T, Barrette K, Chronopoulos A, Roy S. Effects of high glucose-induced Cx43 downregulation on occludin and ZO-1 expression and tight junction barrier function in retinal endothelial cells. Invest Ophthalmol Vis Sci. 2013;54:6518-25 pubmed publisher
    ..whether high glucose (HG)-induced downregulation of connexin 43 (Cx43), a gap junction protein, alters ZO-1 and occludin expression and cell monolayer permeability...
  52. Hou Q, Huang Y, Zhu S, Li P, Chen X, Hou Z, et al. MiR-144 Increases Intestinal Permeability in IBS-D Rats by Targeting OCLN and ZO1. Cell Physiol Biochem. 2017;44:2256-2268 pubmed publisher
    ..expression of miRNAs and their targets in the distal colon of IBS-D rats; (ii) verify in vitro whether occludin (OCLN) and zonula occludens 1 (ZO1/TJP1) were direct targets of miR-144 and were down-regulated in IBS-D rats; ..
  53. Su L, Mruk D, Lui W, Lee W, Cheng C. P-glycoprotein regulates blood-testis barrier dynamics via its effects on the occludin/zonula occludens 1 (ZO-1) protein complex mediated by focal adhesion kinase (FAK). Proc Natl Acad Sci U S A. 2011;108:19623-8 pubmed publisher
    ..report findings that P-glycoprotein, an ATP-dependent efflux drug transporter and an integrated component of the occludin/zonula occludens 1 (ZO-1) adhesion complex at the BTB, structurally interacted with focal adhesion kinase (FAK), ..
  54. Gao X, Wang S, Peng R, Zuo H, Wang L, Gao Y, et al. [Microwave radiation decreases the expressions of occludin and JAM-1 in rats]. Zhonghua Nan Ke Xue. 2010;16:10-3 pubmed
    To explore the changes in the expressions of the tight junction related protein occludin and junctional adhesion molecule-1 (JAM-1) of the blood-testis barrier and their significance in rats after microwave radiation.
  55. Hori S, Ohtsuki S, Hosoya K, Nakashima E, Terasaki T. A pericyte-derived angiopoietin-1 multimeric complex induces occludin gene expression in brain capillary endothelial cells through Tie-2 activation in vitro. J Neurochem. 2004;89:503-13 pubmed
    ..The purpose of this study was therefore to identify molecules, which regulate occludin expression, derived from astrocytes and pericytes that ensheathe brain microvessels by using conditionally ..
  56. Balbuena P, Li W, Ehrich M. Assessments of tight junction proteins occludin, claudin 5 and scaffold proteins ZO1 and ZO2 in endothelial cells of the rat blood-brain barrier: cellular responses to neurotoxicants malathion and lead acetate. Neurotoxicology. 2011;32:58-67 pubmed publisher
    ..Immunoblotting assessments demonstrated that protein levels of tight junction proteins occludin and claudin 5, and scaffold proteins ZO1 and ZO2 were decreased after treatments...
  57. Oltulu F, Aktug H, Uysal A, Turgan N, Oktem G, Erbaş O, et al. Immunoexpressions of embryonic and nonembryonic stem cell markers (Nanog, Thy-1, c-kit) and cellular connections (connexin 43 and occludin) on testicular tissue in thyrotoxicosis rat model. Hum Exp Toxicol. 2015;34:601-11 pubmed publisher
    ..Similarly, connexin 43 and occludin expressions were also found to be significantly lower in the thyrotoxicosis group...
  58. Takenaga Y, Takagi N, Murotomi K, Tanonaka K, Takeo S. Inhibition of Src activity decreases tyrosine phosphorylation of occludin in brain capillaries and attenuates increase in permeability of the blood-brain barrier after transient focal cerebral ischemia. J Cereb Blood Flow Metab. 2009;29:1099-108 pubmed publisher
    ..It is likely that tyrosine phosphorylation of a membrane-associated tight junctional protein, occludin, is important for the interaction of occludin with intracellular proteins, ZO-1 to ZO-3, and it regulates ..
  59. Etournay R, Zwaenepoel I, Perfettini I, Legrain P, Petit C, El Amraoui A. Shroom2, a myosin-VIIa- and actin-binding protein, directly interacts with ZO-1 at tight junctions. J Cell Sci. 2007;120:2838-50 pubmed
  60. Parkinson S, Le Good J, Whelan R, Whitehead P, Parker P. Identification of PKCzetaII: an endogenous inhibitor of cell polarity. EMBO J. 2004;23:77-88 pubmed
    ..The data demonstrate a regulatory role for PKCzetaII in the maintenance of cell transformation and the development of cell polarity. ..
  61. Guillemot L, Schneider Y, Brun P, Castagliuolo I, Pizzuti D, Martines D, et al. Cingulin is dispensable for epithelial barrier function and tight junction structure, and plays a role in the control of claudin-2 expression and response to duodenal mucosa injury. J Cell Sci. 2012;125:5005-14 pubmed publisher
  62. Nicholson M, Lindsay L, Murphy C. Ovarian hormones control the changing expression of claudins and occludin in rat uterine epithelial cells during early pregnancy. Acta Histochem. 2010;112:42-52 pubmed publisher
    ..microscopy, protein and RNA analysis, the cellular distributions of tight junction components claudins and occludin were observed during early pregnancy and under various hormonal regimens...
  63. Sallee J, Burridge K. Density-enhanced phosphatase 1 regulates phosphorylation of tight junction proteins and enhances barrier function of epithelial cells. J Biol Chem. 2009;284:14997-5006 pubmed publisher
    ..We have shown that in epithelial cells the trapping mutant of DEP-1 interacts with the tight junction proteins occludin and ZO-1 in a tyrosine phosphorylation-dependent manner...
  64. McCaffrey G, Seelbach M, Staatz W, Nametz N, Quigley C, Campos C, et al. Occludin oligomeric assembly at tight junctions of the blood-brain barrier is disrupted by peripheral inflammatory hyperalgesia. J Neurochem. 2008;106:2395-409 pubmed publisher
    ..e., hyperalgesia) on the oligomeric assembly of the key TJ transmembrane protein, occludin. Oligomerization of integral membrane proteins is a critical step in TJ complex assembly that enables the ..
  65. Chehade J, Haas M, Mooradian A. Diabetes-related changes in rat cerebral occludin and zonula occludens-1 (ZO-1) expression. Neurochem Res. 2002;27:249-52 pubmed
    ..To test this hypothesis, Western and Northern blot analysis were carried out to measure the steady-state level of occludin and zonula occludens-one (ZO-1) proteins and mRNA levels in cerebral tissue of streptozotocin-induced diabetic ..