Gene Symbol: Nrxn3
Description: neurexin 3
Alias: neurexin-3, neurexin III
Ullrich B, Ushkaryov Y, Sudhof T. Cartography of neurexins: more than 1000 isoforms generated by alternative splicing and expressed in distinct subsets of neurons. Neuron. 1995;14:497-507 pubmed
Ichtchenko K, Nguyen T, Sudhof T. Structures, alternative splicing, and neurexin binding of multiple neuroligins. J Biol Chem. 1996;271:2676-82 pubmed
..Thus, neuroligins constitute a multigene family of brain-specific proteins with distinct isoforms that may have overlapping functions in mediating recognition processes between neurons. ..
Ushkaryov Y, Sudhof T. Neurexin III alpha: extensive alternative splicing generates membrane-bound and soluble forms. Proc Natl Acad Sci U S A. 1993;90:6410-4 pubmed
The structure of neurexin III alpha was elucidated from overlapping cDNA clones...
Missler M, Hammer R, Sudhof T. Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit. J Biol Chem. 1998;273:34716-23 pubmed
..The results support the notion that neurexophilins represent a family of extracellular signaling molecules that interact with multiple receptors including all three alpha-neurexins. ..
Vaags A, Lionel A, Sato D, Goodenberger M, Stein Q, Curran S, et al
. Rare deletions at the neurexin 3 locus in autism spectrum disorder. Am J Hum Genet. 2012;90:133-41 pubmed publisher
The three members of the human neurexin gene family, neurexin 1 (NRXN1), neurexin 2 (NRXN2), and neurexin 3 (NRXN3), encode neuronal adhesion proteins that have important roles in synapse development and function...
Hata Y, Butz S, Sudhof T. CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins. J Neurosci. 1996;16:2488-94 pubmed
Suckow A, Comoletti D, Waldrop M, Mosedale M, Egodage S, Taylor P, et al
. Expression of neurexin, neuroligin, and their cytoplasmic binding partners in the pancreatic beta-cells and the involvement of neuroligin in insulin secretion. Endocrinology. 2008;149:6006-17 pubmed publisher
..Analogous to their role in synaptic neurotransmission, neurexin-neuroligin interactions may play a role in the formation of the submembrane insulin secretory apparatus...
Sugita S, Saito F, Tang J, Satz J, Campbell K, Sudhof T. A stoichiometric complex of neurexins and dystroglycan in brain. J Cell Biol. 2001;154:435-45 pubmed
..Our data indicate that dystroglycan is a physiological ligand for neurexins and that neurexins' tightly regulated interaction could mediate cell adhesion between brain cells. ..
Hock B, Böhme B, Karn T, Yamamoto T, Kaibuchi K, Holtrich U, et al
. PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor. Proc Natl Acad Sci U S A. 1998;95:9779-84 pubmed