Nrxn2

Summary

Gene Symbol: Nrxn2
Description: neurexin 2
Alias: neurexin-2-beta, neurexin II-alpha, neurexin II-beta, neurexin-2-alpha
Species: rat
Products:     Nrxn2

Top Publications

  1. Ullrich B, Ushkaryov Y, Sudhof T. Cartography of neurexins: more than 1000 isoforms generated by alternative splicing and expressed in distinct subsets of neurons. Neuron. 1995;14:497-507 pubmed
  2. Ushkaryov Y, Petrenko A, Geppert M, Sudhof T. Neurexins: synaptic cell surface proteins related to the alpha-latrotoxin receptor and laminin. Science. 1992;257:50-6 pubmed
    ..The polymorphic structure of the neurexins, their neural localization, and their sequence similarity to proteins associated with neurogenesis suggest a function as cell recognition molecules in the nerve terminal. ..
  3. Ichtchenko K, Nguyen T, Sudhof T. Structures, alternative splicing, and neurexin binding of multiple neuroligins. J Biol Chem. 1996;271:2676-82 pubmed
    ..Thus, neuroligins constitute a multigene family of brain-specific proteins with distinct isoforms that may have overlapping functions in mediating recognition processes between neurons. ..
  4. Missler M, Hammer R, Sudhof T. Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit. J Biol Chem. 1998;273:34716-23 pubmed
    ..The results support the notion that neurexophilins represent a family of extracellular signaling molecules that interact with multiple receptors including all three alpha-neurexins. ..
  5. Ushkaryov Y, Hata Y, Ichtchenko K, Moomaw C, Afendis S, Slaughter C, et al. Conserved domain structure of beta-neurexins. Unusual cleaved signal sequences in receptor-like neuronal cell-surface proteins. J Biol Chem. 1994;269:11987-92 pubmed
    ..Thus, beta-neurexins are essentially N terminally truncated alpha-neurexins. ..
  6. Sugita S, Saito F, Tang J, Satz J, Campbell K, Sudhof T. A stoichiometric complex of neurexins and dystroglycan in brain. J Cell Biol. 2001;154:435-45 pubmed
    ..Our data indicate that dystroglycan is a physiological ligand for neurexins and that neurexins' tightly regulated interaction could mediate cell adhesion between brain cells. ..
  7. Missler M, Zhang W, Rohlmann A, Kattenstroth G, Hammer R, Gottmann K, et al. Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis. Nature. 2003;423:939-48 pubmed
    ..These data suggest that alpha-neurexins organize presynaptic terminals by functionally coupling Ca2+ channels to the presynaptic machinery. ..
  8. Hata Y, Butz S, Sudhof T. CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins. J Neurosci. 1996;16:2488-94 pubmed
  9. Hock B, Böhme B, Karn T, Yamamoto T, Kaibuchi K, Holtrich U, et al. PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor. Proc Natl Acad Sci U S A. 1998;95:9779-84 pubmed

More Information

Publications13

  1. Rozic Kotliroff G, Zisapel N. Ca2+ -dependent splicing of neurexin IIalpha. Biochem Biophys Res Commun. 2007;352:226-30 pubmed
    Neurexins are synaptic adhesion proteins encoded by 3 genes (NRXN1, NRXN2, and NRXN3) each transcribed from 2 promoters to yield longer (alpha) and shorter (beta) forms...
  2. Koehnke J, Jin X, Trbovic N, Katsamba P, Brasch J, Ahlsen G, et al. Crystal structures of beta-neurexin 1 and beta-neurexin 2 ectodomains and dynamics of splice insertion sequence 4. Structure. 2008;16:410-21 pubmed publisher
    ..These results raise the possibility that beta-NRX insertion sequence 4 may function in roles independent of neuroligin binding. ..
  3. Suckow A, Comoletti D, Waldrop M, Mosedale M, Egodage S, Taylor P, et al. Expression of neurexin, neuroligin, and their cytoplasmic binding partners in the pancreatic beta-cells and the involvement of neuroligin in insulin secretion. Endocrinology. 2008;149:6006-17 pubmed publisher
    ..Analogous to their role in synaptic neurotransmission, neurexin-neuroligin interactions may play a role in the formation of the submembrane insulin secretory apparatus...
  4. Gauthier J, Siddiqui T, Huashan P, Yokomaku D, Hamdan F, Champagne N, et al. Truncating mutations in NRXN2 and NRXN1 in autism spectrum disorders and schizophrenia. Hum Genet. 2011;130:563-73 pubmed publisher
    ..have been associated with these neurodevelopmental disorders, but no such associations have been reported for NRXN2 or NRXN3...