Genomes and Genes
Gene Symbol: Nrxn2
Description: neurexin 2
Alias: neurexin-2-beta, neurexin II-alpha, neurexin II-beta, neurexin-2-alpha
- Rozic Kotliroff G, Zisapel N. Ca2+ -dependent splicing of neurexin IIalpha. Biochem Biophys Res Commun. 2007;352:226-30 pubmedNeurexins are synaptic adhesion proteins encoded by 3 genes (NRXN1, NRXN2, and NRXN3) each transcribed from 2 promoters to yield longer (alpha) and shorter (beta) forms...
- Koehnke J, Jin X, Trbovic N, Katsamba P, Brasch J, Ahlsen G, et al. Crystal structures of beta-neurexin 1 and beta-neurexin 2 ectodomains and dynamics of splice insertion sequence 4. Structure. 2008;16:410-21 pubmed publisher..These results raise the possibility that beta-NRX insertion sequence 4 may function in roles independent of neuroligin binding. ..
- Suckow A, Comoletti D, Waldrop M, Mosedale M, Egodage S, Taylor P, et al. Expression of neurexin, neuroligin, and their cytoplasmic binding partners in the pancreatic beta-cells and the involvement of neuroligin in insulin secretion. Endocrinology. 2008;149:6006-17 pubmed publisher..Analogous to their role in synaptic neurotransmission, neurexin-neuroligin interactions may play a role in the formation of the submembrane insulin secretory apparatus...
- Gauthier J, Siddiqui T, Huashan P, Yokomaku D, Hamdan F, Champagne N, et al. Truncating mutations in NRXN2 and NRXN1 in autism spectrum disorders and schizophrenia. Hum Genet. 2011;130:563-73 pubmed publisher..have been associated with these neurodevelopmental disorders, but no such associations have been reported for NRXN2 or NRXN3...