Genomes and Genes
Gene Symbol: Nrcam
Description: neuronal cell adhesion molecule
Alias: neuronal cell adhesion molecule, ankyrin-binding cell adhesion molecule NrCAM, neuron-glia-CAM-related cell adhesion molecule, neuronal surface protein Bravo, ng-CAM-related, ngCAM-related cell adhesion molecule, nr-CAM, rBravo
- Dirks P, Thomas U, Montag D. The cytoplasmic domain of NrCAM binds to PDZ domains of synapse-associated proteins SAP90/PSD95 and SAP97. Eur J Neurosci. 2006;24:25-31 pubmedb>NrCAM, a member of the L1 family of cell adhesion molecules, serves important functions during the development of the nervous system, e.g. in adhesion-dependent processes such as neurite outgrowth and axonal pathfinding...
- Davey F, Hill M, Falk J, Sans N, Gunn Moore F. Synapse associated protein 102 is a novel binding partner to the cytoplasmic terminus of neurone-glial related cell adhesion molecule. J Neurochem. 2005;94:1243-53 pubmedNeurone glial-related cell adhesion molecule (NrCAM) is a member of the L1 family of transmembrane cell adhesion receptors which are involved in the development and function of the mammalian nervous system...
- Feinberg K, Eshed Eisenbach Y, Frechter S, Amor V, Salomon D, Sabanay H, et al. A glial signal consisting of gliomedin and NrCAM clusters axonal Na+ channels during the formation of nodes of Ranvier. Neuron. 2010;65:490-502 pubmed publisher..Here, we show that initial clustering of Na(+) channels at heminodes requires glial NrCAM and gliomedin, as well as their axonal receptor neurofascin 186 (NF186)...
- Eshed Y, Feinberg K, Poliak S, Sabanay H, Sarig Nadir O, Spiegel I, et al. Gliomedin mediates Schwann cell-axon interaction and the molecular assembly of the nodes of Ranvier. Neuron. 2005;47:215-29 pubmed..We report the identification of gliomedin, a glial ligand for neurofascin and NrCAM, two axonal immunoglobulin cell adhesion molecules that are associated with Na+ channels at the nodes of Ranvier...