Nr3c1

Summary

Gene Symbol: Nr3c1
Description: nuclear receptor subfamily 3, group C, member 1
Alias: Gcr, Grl, glucocorticoid receptor
Species: rat
Products:     Nr3c1

Top Publications

  1. Baumann H, Paulsen K, Kovacs H, Berglund H, Wright A, Gustafsson J, et al. Refined solution structure of the glucocorticoid receptor DNA-binding domain. Biochemistry. 1993;32:13463-71 pubmed
    A refined solution structure of the glucocorticoid receptor DNA-binding domain (GR DBD) has been determined using two- and three-dimensional nuclear magnetic resonance (NMR) spectroscopy on an 15N-labeled GR DBD fragment in conjunction ..
  2. Reimer R, Helmbold H, Szalay B, Hagel C, Hohenberg H, Deppert W, et al. Nestin modulates glucocorticoid receptor function by cytoplasmic anchoring. PLoS ONE. 2009;4:e6084 pubmed publisher
    ..show that a strong nestin expression in mouse embryo tissue coincides with a strong accumulation of the glucocorticoid receptor (GR), a key regulator of growth and differentiation in embryonic development...
  3. Rogatsky I, Waase C, Garabedian M. Phosphorylation and inhibition of rat glucocorticoid receptor transcriptional activation by glycogen synthase kinase-3 (GSK-3). Species-specific differences between human and rat glucocorticoid receptor signaling as revealed through GSK-3 phosphoryla. J Biol Chem. 1998;273:14315-21 pubmed
    Transcriptional activation by the glucocorticoid receptor (GR) is regulated by both glucocorticoid binding and phosphorylation...
  4. Almeida O, Conde G, Crochemore C, Demeneix B, Fischer D, Hassan A, et al. Subtle shifts in the ratio between pro- and antiapoptotic molecules after activation of corticosteroid receptors decide neuronal fate. FASEB J. 2000;14:779-90 pubmed
    b>Glucocorticoid receptor (GR) activation induces apoptosis of granule cells in the hippocampus. In contrast, neuroprotection is seen after mineralocorticoid receptor (MR) activation...
  5. Lyu J, Kim J, Chung S, Kim K, Joo C. Alteration of cadherin in dexamethasone-induced cataract organ-cultured rat lens. Invest Ophthalmol Vis Sci. 2003;44:2034-40 pubmed
    ..The pattern of opacity that developed in cultured rat lenses closely resembled that observed in patients with PSC. The results suggest that the decrease in E-cadherin plays a role in the formation of steroid-induced cataract. ..
  6. Kohda K, Harada K, Kato K, Hoshino A, Motohashi J, Yamaji T, et al. Glucocorticoid receptor activation is involved in producing abnormal phenotypes of single-prolonged stress rats: a putative post-traumatic stress disorder model. Neuroscience. 2007;148:22-33 pubmed
    ..HPA) axis, which has been reliably reproduced in patients with PTSD, and increased expression of glucocorticoid receptor (GR) in the hippocampus...
  7. Ricketson D, Hostick U, Fang L, Yamamoto K, Darimont B. A conformational switch in the ligand-binding domain regulates the dependence of the glucocorticoid receptor on Hsp90. J Mol Biol. 2007;368:729-41 pubmed
    ..In the case of the glucocorticoid receptor (GR), high-affinity ligand binding requires the interaction of the LBD with the heat shock protein 90 (..
  8. Hard T, Kellenbach E, Boelens R, Maler B, Dahlman K, Freedman L, et al. Solution structure of the glucocorticoid receptor DNA-binding domain. Science. 1990;249:157-60 pubmed
    The three-dimensional structure of the DNA-binding domain (DBD) of the glucocorticoid receptor has been determined by nuclear magnetic resonance spectroscopy and distance geometry...
  9. Hong H, Kohli K, Garabedian M, Stallcup M. GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors. Mol Cell Biol. 1997;17:2735-44 pubmed
    ..A search for possible coactivators for steroid hormone receptors resulted in identification of glucocorticoid receptor interacting protein 1 (GRIP1)...

More Information

Publications62

  1. McCormick J, Lyons V, Jacobson M, Noble J, Diorio J, Nyirenda M, et al. 5'-heterogeneity of glucocorticoid receptor messenger RNA is tissue specific: differential regulation of variant transcripts by early-life events. Mol Endocrinol. 2000;14:506-17 pubmed
    b>Glucocorticoid receptor (GR) gene expression is regulated in a complex tissue-specific manner, notably by early-life environmental events that program tissue GR levels. We have identified and characterized several new rat GR mRNAs...
  2. Luisi B, Xu W, Otwinowski Z, Freedman L, Yamamoto K, Sigler P. Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA. Nature. 1991;352:497-505 pubmed
    Two crystal structures of the glucocorticoid receptor DNA-binding domain complexed with DNA are reported. The domain has a globular fold which contains two Zn-nucleated substructures of distinct conformation and function...
  3. Meijsing S, Pufall M, So A, Bates D, Chen L, Yamamoto K. DNA binding site sequence directs glucocorticoid receptor structure and activity. Science. 2009;324:407-10 pubmed publisher
    ..How genes are modulated so precisely is not well understood. The glucocorticoid receptor (GR) regulates target genes by associating with specific DNA binding sites, the sequences of which differ ..
  4. Chakraborti P, Garabedian M, Yamamoto K, Simons S. Creation of "super" glucocorticoid receptors by point mutations in the steroid binding domain. J Biol Chem. 1991;266:22075-8 pubmed
    ..These results indicate that additional modifications of the glucocorticoid receptor, and probably the other steroid receptors, may further increase the binding affinity and/or specificity.
  5. Lindroos J, Husa J, Mitterer G, Haschemi A, Rauscher S, Haas R, et al. Human but not mouse adipogenesis is critically dependent on LMO3. Cell Metab. 2013;18:62-74 pubmed publisher
    ..These results establish LMO3 as a regulator of human adipogenesis and could contribute a mechanism resulting in visceral-fat accumulation in obesity due to excess glucocorticoids. ..
  6. Szymanska M, Budziszewska B, Jaworska Feil L, Basta Kaim A, Kubera M, Leskiewicz M, et al. The effect of antidepressant drugs on the HPA axis activity, glucocorticoid receptor level and FKBP51 concentration in prenatally stressed rats. Psychoneuroendocrinology. 2009;34:822-32 pubmed publisher
    ..the effect of prenatal stress on behavioral changes, blood corticosterone level, concentrations of glucocorticoid receptor (GR) and its cochaperone, FKBP51, in the hippocampus and frontal cortex in adult rats...
  7. Conway Campbell B, McKenna M, Wiles C, Atkinson H, de Kloet E, Lightman S. Proteasome-dependent down-regulation of activated nuclear hippocampal glucocorticoid receptors determines dynamic responses to corticosterone. Endocrinology. 2007;148:5470-7 pubmed
  8. Mor D, Keay K. Differential regulation of glucocorticoid receptor expression in distinct columns of periaqueductal grey in rats with behavioural disability following nerve injury. Cell Mol Neurobiol. 2013;33:953-63 pubmed publisher
    ..CCI increases corticosterone, which through its actions at the glucocorticoid receptor (GR), can trigger cellular adaptation...
  9. Chen J, Yang J, Zhao X, Wang Z, Yue G. [Effects of Chinese herbs on glucocorticoid receptor in rat brain regions with chronic immobilization stress]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2005;21:402-6 pubmed
    To investigate the changes of glucocorticoid receptor (GR) in rat brain regions with chronic immobilization stress and the influence of Chinese herbs...
  10. Liu W, Wang J, Sauter N, Pearce D. Steroid receptor heterodimerization demonstrated in vitro and in vivo. Proc Natl Acad Sci U S A. 1995;92:12480-4 pubmed
    ..We suggest from these findings that heterodimerization may play an important role in steroid receptor transcriptional regulation. ..
  11. Zhang L, Zhang J, Sun H, Zhu H, Liu H, Yang Y. An enriched environment elevates corticosteroid receptor levels in the hippocampus and restores cognitive function in a rat model of chronic cerebral hypoperfusion. Pharmacol Biochem Behav. 2013;103:693-700 pubmed publisher
    ..an EE on serum corticosteroid concentrations and the levels of the mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) in the hippocampus...
  12. Bousquet E, Zhao M, Ly A, Leroux les Jardins G, Goldenberg B, Naud M, et al. The aldosterone-mineralocorticoid receptor pathway exerts anti-inflammatory effects in endotoxin-induced uveitis. PLoS ONE. 2012;7:e49036 pubmed publisher
    ..body and the corticosterone concentration was increased in aqueous humor, altering the normal MR/glucocorticoid receptor (GR) balance. At 24 hours, the GR expression was also decreased...
  13. Ostlund Farrants A, Blomquist P, Kwon H, Wrange O. Glucocorticoid receptor-glucocorticoid response element binding stimulates nucleosome disruption by the SWI/SNF complex. Mol Cell Biol. 1997;17:895-905 pubmed
    ..In this study we show that the glucocorticoid receptor (GR), a hormone-inducible transcription factor, stimulates the nucleosome-disrupting activity of the SWI/..
  14. Pérez H, Soto Moyano R, Ruiz S, Hernandez A, Sierralta W, Olivares R, et al. A putative role for hypothalamic glucocorticoid receptors in hypertension induced by prenatal undernutrition in the rat. Neurosci Lett. 2010;483:41-6 pubmed publisher
    ..Results suggest that the low sensitivity of paraventricular neurons to glucocorticoid receptor ligands observed in prenatally undernourished rats could be due to the already reported glucocorticoid ..
  15. Ordyan N, Galeeva A, Pivina S. Expression of glucocorticoid receptor in the brain of rats during postnatal ontogeny. Bull Exp Biol Med. 2008;146:176-9 pubmed
    Expression of glucocorticoid receptor protein in the hippocampus and frontal cortex of male and female rats during the 1st, 2nd, and 3rd weeks of life was studied by Western blot hybridization...
  16. Vivinetto A, Suárez M, Rivarola M. Neurobiological effects of neonatal maternal separation and post-weaning environmental enrichment. Behav Brain Res. 2013;240:110-8 pubmed publisher
    ..In the dorsal hippocampus, glucocorticoid receptor expression and neuronal activity were examined by immunoreactivity...
  17. Crochemore C, Lu J, Wu Y, Liposits Z, Sousa N, Holsboer F, et al. Direct targeting of hippocampal neurons for apoptosis by glucocorticoids is reversible by mineralocorticoid receptor activation. Mol Psychiatry. 2005;10:790-8 pubmed
    ..These results demonstrate that GRs can act directly to induce hippocampal neuronal death and that demonstration of their full apoptotic potency depends on abolition of survival-promoting actions mediated by MR. ..
  18. Myers B, Greenwood Van Meerveld B. Corticosteroid receptor-mediated mechanisms in the amygdala regulate anxiety and colonic sensitivity. Am J Physiol Gastrointest Liver Physiol. 2007;292:G1622-9 pubmed
    ..Our data suggest that both GR and MR play a critical role in Cort-induced anxiety and colonic hypersensitivity. ..
  19. Zinker B, Mika A, Nguyen P, Wilcox D, Ohman L, von Geldern T, et al. Liver-selective glucocorticoid receptor antagonism decreases glucose production and increases glucose disposal, ameliorating insulin resistance. Metabolism. 2007;56:380-7 pubmed
    It is unclear how hepatic glucocorticoid receptor (GR) function and hypothalamic-pituitary-adrenal axis tone contribute to the diabetic state and in particular whole-body glucose fluxes...
  20. Boscia F, Casamassa A, Secondo A, Esposito A, Pannaccione A, Sirabella R, et al. NCX1 Exchanger Cooperates with Calretinin to Confer Preconditioning-Induced Tolerance Against Cerebral Ischemia in the Striatum. Mol Neurobiol. 2016;53:1365-76 pubmed publisher
    ..Collectively, our results indicate that the Na(+)/Ca(+2) exchanger NCX1 and the calcium binding protein calretinin cooperate within the striatum to confer tolerance against cerebral ischemia. ..
  21. Wong E, Herbert J. Roles of mineralocorticoid and glucocorticoid receptors in the regulation of progenitor proliferation in the adult hippocampus. Eur J Neurosci. 2005;22:785-92 pubmed
    ..Although a small proportion of newly formed cells may express GR and MR, corticosterone probably regulates proliferation indirectly through other local cells. ..
  22. Samtani M, Pyszczynski N, Dubois D, Almon R, Jusko W. Modeling glucocorticoid-mediated fetal lung maturation: II. Temporal patterns of gene expression in fetal rat lung. J Pharmacol Exp Ther. 2006;317:127-38 pubmed
    ..Expression of the glucocorticoid receptor (GR) and surfactant proteins A and B mRNA were chosen as lung maturational markers...
  23. Castillo P, Ibáñez F, Guajardo A, Llanos M, Ronco A. Impact of cadmium exposure during pregnancy on hepatic glucocorticoid receptor methylation and expression in rat fetus. PLoS ONE. 2012;7:e44139 pubmed publisher
    ..effects of maternal exposure to cadmium (Cd, 50 ppm) during pregnancy in the methylation of fetal hepatic glucocorticoid receptor promoter (GR) and the correlation with its expression and that of the DNA methyltransferases (DNMT1a and ..
  24. Yakirevich E, Matoso A, Sabo E, Wang L, Tavares R, Meitner P, et al. Expression of the glucocorticoid receptor in renal cell neoplasms: an immunohistochemical and quantitative reverse transcriptase polymerase chain reaction study. Hum Pathol. 2011;42:1684-92 pubmed publisher
    ..Our goal was to determine the expression pattern and prognostic significance of glucocorticoid receptor in renal cell neoplasms...
  25. Hwang I, Yi S, Yoo K, Park O, Yan B, Song W, et al. Effect of treadmill exercise on blood glucose, serum corticosterone levels and glucocorticoid receptor immunoreactivity in the hippocampus in chronic diabetic rats. Neurochem Res. 2011;36:281-7 pubmed publisher
    ..In the present study, we investigated the effect of treadmill exercise at chronic diabetic stages on glucocorticoid receptor (GR) immunoreactivity in the hippocampal CA1 region and dentate gyrus, which are very vulnerable to ..
  26. Shi K, Wu Y, Xiong B, Yu X. [Effects of medicinal extract for tonifying kidney to relieve asthma on glucocorticoid receptor expression in lung tissues of rats with bronchial asthma]. Zhong Xi Yi Jie He Xue Bao. 2010;8:785-9 pubmed
    To observe the effects of medicinal extract for tonifying kidney to relieve asthma on glucocorticoid receptor (GR) expression in rats with asthma, and to explore its mechanism in treating asthma...
  27. Bo T, Yi L, Wang T, Li J, Li X, Mao D. [Effect of magnesium-free on glucocorticoid receptor expression in primary cultured cortical neurons of fetal rats in vitro]. Zhongguo Dang Dai Er Ke Za Zhi. 2010;12:211-4 pubmed
    To study the changes of glucocorticoid receptor (GR) expression in embryonic rat cortical neurons exposed to transient Mg(2+)-free treatment...
  28. Ogias D, de Andrade Sá E, Kasai A, Moisan M, Alvares E, Gama P. Fasting differentially regulates plasma corticosterone-binding globulin, glucocorticoid receptor, and cell cycle in the gastric mucosa of pups and adult rats. Am J Physiol Gastrointest Liver Physiol. 2010;298:G117-25 pubmed publisher
    ..development, and its effects are regulated in particular by corticosterone-binding globulin (CBG) and glucocorticoid receptor (GR)...
  29. Tao T, Lan J, Lukacs G, Haché R, Kaplan F. Importin 13 regulates nuclear import of the glucocorticoid receptor in airway epithelial cells. Am J Respir Cell Mol Biol. 2006;35:668-80 pubmed
    ..We now report on the identification of the glucocorticoid receptor (GR) as a cargo substrate for IPO13...
  30. Pazirandeh A, Jondal M, Okret S. Conditional expression of a glucocorticoid receptor transgene in thymocytes reveals a role for thymic-derived glucocorticoids in thymopoiesis in vivo. Endocrinology. 2005;146:2501-7 pubmed
    ..These observations further confirmed a role for the thymic-derived GCs in regulating thymocyte homeostasis in vivo. ..
  31. Corvol H, Nathan N, Charlier C, Chadelat K, Le Rouzic P, Tabary O, et al. Glucocorticoid receptor gene polymorphisms associated with progression of lung disease in young patients with cystic fibrosis. Respir Res. 2007;8:88 pubmed
    ..CF) patients together with the variable effect of glucocorticoid treatment led us to hypothesize that glucocorticoid receptor (GR) gene polymorphisms may affect glucocorticoid sensitivity in CF and, consequently, may contribute to ..
  32. Park S, Lee J, Seo M, Ly N, Lee C, Cho H, et al. Epigenetic modification of glucocorticoid receptor promoter I7 in maternally separated and restraint-stressed rats. Neurosci Lett. 2017;650:38-44 pubmed publisher
    b>Glucocorticoid receptor (GR) promoter I7 is susceptible to epigenetic changes induced by environmental influences...
  33. Ke X, McKnight R, Gracey Maniar L, Sun Y, Callaway C, Majnik A, et al. IUGR increases chromatin-remodeling factor Brg1 expression and binding to GR exon 1.7 promoter in newborn male rat hippocampus. Am J Physiol Regul Integr Comp Physiol. 2015;309:R119-27 pubmed publisher
    ..Neuroendocrine reprogramming involves the glucocorticoid receptor (GR) gene that is epigenetically regulated in the hippocampus...
  34. Kovacevic S, Nestorov J, Matić G, Elaković I. Dietary fructose-related adiposity and glucocorticoid receptor function in visceral adipose tissue of female rats. Eur J Nutr. 2014;53:1409-20 pubmed publisher
    ..of fructose might be mediated by glucocorticoid regeneration in adipose tissue only indirectly implicated glucocorticoid receptor (GR) in the phenomenon...
  35. Polman J, de Kloet E, Datson N. Two populations of glucocorticoid receptor-binding sites in the male rat hippocampal genome. Endocrinology. 2013;154:1832-44 pubmed publisher
    ..In conclusion, our results highlight the existence of 2 populations of GBS in the rat hippocampal genome. ..
  36. Tran L, Chaloner A, Sawalha A, Greenwood Van Meerveld B. Importance of epigenetic mechanisms in visceral pain induced by chronic water avoidance stress. Psychoneuroendocrinology. 2013;38:898-906 pubmed publisher
    ..exposed to repeated WAS or SHAM stress, the amygdala was isolated to assess the methylation status of glucocorticoid receptor (GR) and corticotropin releasing-factor (CRF) genes via bisulfite sequencing and verified by ..
  37. Stavreva D, Wiench M, John S, Conway Campbell B, McKenna M, Pooley J, et al. Ultradian hormone stimulation induces glucocorticoid receptor-mediated pulses of gene transcription. Nat Cell Biol. 2009;11:1093-102 pubmed publisher
    Studies on glucocorticoid receptor (GR) action typically assess gene responses by long-term stimulation with synthetic hormones...
  38. Adzic M, Djordjevic J, Djordjevic A, Niciforovic A, Demonacos C, Radojcic M, et al. Acute or chronic stress induce cell compartment-specific phosphorylation of glucocorticoid receptor and alter its transcriptional activity in Wistar rat brain. J Endocrinol. 2009;202:87-97 pubmed publisher
    Chronic stress and impaired glucocorticoid receptor (GR) feedback are important factors for the compromised hypothalamic-pituitary-adrenal (HPA) axis activity...
  39. Ogino H, Yamada K, Yuhara M, Tsuchida S, Maezawa K, Kizu J, et al. Fluoroquinolones reduce carrageenan-induced edema in rats and the involvement of the glucocorticoid receptor system. J Infect Chemother. 2009;15:113-7 pubmed publisher
    ..sparfloxacin, and enoxacin was abolished by pretreatment with mifepristone, an antagonist of the glucocorticoid receptor. These results suggest that FQs with piperazinyl and/or cyclopropyl groups can modify biological ..
  40. Ackermann D, Gresko N, Carrel M, Loffing Cueni D, Habermehl D, Gomez Sanchez C, et al. In vivo nuclear translocation of mineralocorticoid and glucocorticoid receptors in rat kidney: differential effect of corticosteroids along the distal tubule. Am J Physiol Renal Physiol. 2010;299:F1473-85 pubmed publisher
    ..Differential regulation of MR and GR may alter the level of heterodimerization of the receptors and hence may contribute to the complexity of corticosteroid effects on ASDN function. ..
  41. Invitti C, Redaelli G, Baldi G, Cavagnini F. Glucocorticoid receptors in anorexia nervosa and Cushing's disease. Biol Psychiatry. 1999;45:1467-71 pubmed
    ..b>Glucocorticoid receptor characteristics were examined on mononuclear leukocytes by measuring [3H]dexamethasone binding and the ..
  42. Fenoglio K, Brunson K, Avishai Eliner S, Stone B, Kapadia B, Baram T. Enduring, handling-evoked enhancement of hippocampal memory function and glucocorticoid receptor expression involves activation of the corticotropin-releasing factor type 1 receptor. Endocrinology. 2005;146:4090-6 pubmed
    ..corticotropin-releasing factor (CRF) expression and subsequent (by P45) increase in hippocampal glucocorticoid receptor (GR) expression...
  43. Haslbeck V, Eckl J, Drazic A, Rutz D, Lorenz O, Zimmermann K, et al. The activity of protein phosphatase 5 towards native clients is modulated by the middle- and C-terminal domains of Hsp90. Sci Rep. 2015;5:17058 pubmed publisher
    ..of the domains of Hsp90 for turnover of native substrates we find that ternary complexes with the glucocorticoid receptor (GR) are cooperatively formed by full-length Hsp90 and PPH-5...
  44. Roberts L, Fini M, Derkash N, Wright R. PD98059 enhanced insulin, cytokine, and growth factor activation of xanthine oxidoreductase in epithelial cells involves STAT3 and the glucocorticoid receptor. J Cell Biochem. 2007;101:1567-87 pubmed
    ..Activation of the proximal promoter was blocked by inhibitors of the glucocorticoid receptor (GR), p38 MAP kinase, and U0126...
  45. Lu X, Cheng B, Ling C, Yue X, Li B. [Effects of a formula of components from Shengmai Powder on glucocorticoid receptor in rats after thermal injury]. Zhong Xi Yi Jie He Xue Bao. 2009;7:121-4 pubmed
    ..of a formula of components from Shengmai Powder, a compound traditional Chinese herbal medicine, on glucocorticoid receptor (GR) in rats after thermal injury...
  46. Goldbart A, Veling M, Goldman J, Li R, Brittian K, Gozal D. Glucocorticoid receptor subunit expression in adenotonsillar tissue of children with obstructive sleep apnea. Pediatr Res. 2005;57:232-6 pubmed
    ..However, the expression of glucocorticoid receptor (GCR) expression in adenoid and tonsillar tissue is currently unknown...
  47. Zucchi F, Matthies N, Badr N, Metz G. Stress-induced glucocorticoid receptor activation determines functional recovery following ischemic stroke. Exp Transl Stroke Med. 2010;2:18 pubmed publisher
    ..This study investigated if recovery after stroke is related to glucocorticoid receptor (GR) activation in a rat model of stroke...
  48. Chen W, Roeder R. The Mediator subunit MED1/TRAP220 is required for optimal glucocorticoid receptor-mediated transcription activation. Nucleic Acids Res. 2007;35:6161-9 pubmed
    ..The isolated MED1/TRAP220 protein previously was shown to interact with glucocorticoid receptor (GR) in a ligand-dependent manner...
  49. Rivarola M, Suárez M. Early maternal separation and chronic variable stress in adulthood changes the neural activity and the expression of glucocorticoid receptor in limbic structures. Int J Dev Neurosci. 2009;27:567-74 pubmed publisher
    ..Persistent changes were assessed in glucocorticoid receptor density and Fos activity in the anterodorsal thalamic nuclei, mammillary nuclei and retrosplenial cortex...
  50. Ruiz N, Pacheco L, Farrell B, Cox C, Ermolinsky B, Garrido Sanabria E, et al. Metabolic gene expression changes in the hippocampus of obese epileptic male rats in the pilocarpine model of temporal lobe epilepsy. Brain Res. 2011;1426:86-95 pubmed publisher
    ..Nr3c1 (glucocorticoid receptor) mRNA levels on the other hand were down-regulated at 24h, 10 days and 2 months, post SE...
  51. Rossie S, Jayachandran H, Meisel R. Cellular co-localization of protein phosphatase 5 and glucocorticoid receptors in rat brain. Brain Res. 2006;1111:1-11 pubmed
    ..in complexes with heat shock protein 90 and glucocorticoid receptors and may be a negative modulator of glucocorticoid receptor function...
  52. Menconi M, Gonnella P, Petkova V, Lecker S, Hasselgren P. Dexamethasone and corticosterone induce similar, but not identical, muscle wasting responses in cultured L6 and C2C12 myotubes. J Cell Biochem. 2008;105:353-64 pubmed publisher
    ..In addition, the expression of the glucocorticoid receptor (GR) and its role in glucocorticoid-induced metabolic changes were determined...
  53. van der Laan S, Sarabdjitsingh R, Van Batenburg M, Lachize S, Li H, Dijkmans T, et al. Chromatin immunoprecipitation scanning identifies glucocorticoid receptor binding regions in the proximal promoter of a ubiquitously expressed glucocorticoid target gene in brain. J Neurochem. 2008;106:2515-23 pubmed publisher
    ..These findings were corroborated using the glucocorticoid receptor (GR) expressing Ns-1 PC12 rat cell-line...