Gene Symbol: Nr2f2
Description: nuclear receptor subfamily 2, group F, member 2
Alias: Tfcoup2, COUP transcription factor 2, ARP-1, COUP transcription factor II, COUP-TF II, COUP-TF2, COUPb, apolipoprotein A-I regulatory protein 1, apolipoprotein AI regulatory protein 1, ovalbumin upstream promoter beta nuclear receptor
Species: rat
Products:     Nr2f2

Top Publications

  1. Tripodi M, Filosa A, Armentano M, Studer M. The COUP-TF nuclear receptors regulate cell migration in the mammalian basal forebrain. Development. 2004;131:6119-29 pubmed
    ..Therefore, we propose that COUP-TFs are directly involved in tangential cell migration in the developing brain, through the regulation of short- and long-range guidance cues. ..
  2. You L, Lin F, Lee C, DeMayo F, Tsai M, Tsai S. Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity. Nature. 2005;435:98-104 pubmed
    ..Here, we show that COUP-TFII (also known as Nr2f2), a member of the orphan nuclear receptor superfamily, is specifically expressed in venous but not arterial ..
  3. You L, Takamoto N, Yu C, Tanaka T, Kodama T, DeMayo F, et al. Mouse lacking COUP-TFII as an animal model of Bochdalek-type congenital diaphragmatic hernia. Proc Natl Acad Sci U S A. 2005;102:16351-6 pubmed
    ..Our finding suggests that COUP-TFII is a likely contributor to the formation of CDH in individuals with 15q deletions, and it may also be a potential contributor to some other Bochdalek-type of CDH. ..
  4. Petit F, Jamin S, Kurihara I, Behringer R, DeMayo F, Tsai M, et al. Deletion of the orphan nuclear receptor COUP-TFII in uterus leads to placental deficiency. Proc Natl Acad Sci U S A. 2007;104:6293-8 pubmed
    COUP-TFII (NR2F2), chicken ovalbumin upstream promoter-transcription factor II, is an orphan nuclear receptor of the steroid/thyroid hormone receptor superfamily...
  5. Takamoto N, You L, Moses K, Chiang C, Zimmer W, Schwartz R, et al. COUP-TFII is essential for radial and anteroposterior patterning of the stomach. Development. 2005;132:2179-89 pubmed
    ..Our results are consistent with a functional link between hedgehog proteins and COUP-TFII, factors that are vital for epithelial-mesenchymal interactions. ..
  6. Yamazaki T, Yoshimatsu Y, Morishita Y, Miyazono K, Watabe T. COUP-TFII regulates the functions of Prox1 in lymphatic endothelial cells through direct interaction. Genes Cells. 2009;14:425-34 pubmed publisher
    ..These results suggest that COUP-TFII physically and functionally interact during differentiation and maintenance of lymphatic vessels. ..
  7. Kyrmizi I, Hatzis P, Katrakili N, Tronche F, Gonzalez F, Talianidis I. Plasticity and expanding complexity of the hepatic transcription factor network during liver development. Genes Dev. 2006;20:2293-305 pubmed
    ..The results illustrate the remarkable flexibility of a self-sustaining transcription factor network, built up by complex dominant and redundant regulatory motifs in developing hepatocytes. ..
  8. Katayama S, Ashizawa K, Gohma H, Fukuhara T, Narumi K, Tsuzuki Y, et al. The expression of Hedgehog genes (Ihh, Dhh) and Hedgehog target genes (Ptc1, Gli1, Coup-TfII) is affected by estrogenic stimuli in the uterus of immature female rats. Toxicol Appl Pharmacol. 2006;217:375-83 pubmed
    ..These results suggest that the expression of Hedgehog genes (Ihh, Dhh) and Hedgehog target genes (Ptc1, Gli1, Coup-TfII) is affected by estrogenic stimuli in the uterus of immature female rats. ..
  9. Kumarasamy S, Waghulde H, Gopalakrishnan K, Mell B, Morgan E, Joe B. Mutation within the hinge region of the transcription factor Nr2f2 attenuates salt-sensitive hypertension. Nat Commun. 2015;6:6252 pubmed publisher
    Genome-wide association studies (GWAS) have prioritized a transcription factor, nuclear receptor 2 family 2 (NR2F2), as being associated with essential hypertension in humans...

More Information


  1. Tornari C, Towers E, Gale J, Dawson S. Regulation of the orphan nuclear receptor Nr2f2 by the DFNA15 deafness gene Pou4f3. PLoS ONE. 2014;9:e112247 pubmed publisher
    ..The orphan thyroid nuclear receptor Nr2f2 was identified as a POU4F3 target using a subtractive hybridization strategy and EMSA analysis showed that POU4F3 ..
  2. Howell M, Li R, Zhang R, Li Y, Chen W, Chen G. The expression of Apoc3 mRNA is regulated by HNF4? and COUP-TFII, but not acute retinoid treatments, in primary rat hepatocytes and hepatoma cells. Mol Cell Biochem. 2014;387:241-50 pubmed
    ..We conclude that short-term retinoid treatments could not induce Apoc3 mRNA expression, which is regulated by HNF4? and COUP-TFII in hepatocytes. ..
  3. Dingemann J, Doi T, Ruttenstock E, Gosemann J, Puri P. COUP-TFII gene expression is upregulated in embryonic pleuroperitoneal folds in the nitrofen-induced congenital diaphragmatic hernia rat model. Eur J Pediatr Surg. 2012;22:21-5 pubmed publisher
    ..No difference in immunoreactivity was observed on D18 and D21. Upregulation of COUP-II gene expression in the PPF may contribute to the diaphragmatic defect in the nitrofen CDH model by inhibiting the RSP. ..
  4. Doi T, Sugimoto K, Puri P. Up-regulation of COUP-TFII gene expression in the nitrofen-induced hypoplastic lung. J Pediatr Surg. 2009;44:321-4 pubmed publisher
    ..We speculate that up-regulation of COUP-TFII gene expression during the stage of branching lung morphogenesis may cause pulmonary hypoplasia by repressing RSP. ..
  5. Lee S, Kang J, Yoo J, Ganesan S, Cook S, Aguilar B, et al. Prox1 physically and functionally interacts with COUP-TFII to specify lymphatic endothelial cell fate. Blood. 2009;113:1856-9 pubmed publisher
  6. Zhang Y, Dufau M. Repression of the luteinizing hormone receptor gene promoter by cross talk among EAR3/COUP-TFI, Sp1/Sp3, and TFIIB. Mol Cell Biol. 2003;23:6958-72 pubmed
  7. Kim B, Scott D. Mouse model reveals the role of RERE in cerebellar foliation and the migration and maturation of Purkinje cells. PLoS ONE. 2014;9:e87518 pubmed publisher
  8. Raccurt M, Smallwood S, Mertani H, Devost D, Abbaci K, Boutin J, et al. Cloning, expression and regulation of chicken ovalbumin upstream promoter transcription factors (COUP-TFII and EAR-2) in the rat anterior pituitary gland. Neuroendocrinology. 2005;82:233-44 pubmed
    Chicken ovalbumin upstream promoter transcription factors (COUP-TF)-II (NR2F2) and EAR-2 (NR2F6) are structurally related orphan members of the nuclear receptors superfamily...
  9. Kruse S, Suino Powell K, Zhou X, Kretschman J, Reynolds R, Vonrhein C, et al. Identification of COUP-TFII orphan nuclear receptor as a retinoic acid-activated receptor. PLoS Biol. 2008;6:e227 pubmed publisher
  10. Berenson L, Ota N, Murphy K. Issues in T-helper 1 development--resolved and unresolved. Immunol Rev. 2004;202:157-74 pubmed
    ..None of these areas is static or resolved fully, and they likely will remain topics of rapid progress. ..
  11. Kang S, Spann N, Hui T, Davis R. ARP-1/COUP-TF II determines hepatoma phenotype by acting as both a transcriptional repressor of microsomal triglyceride transfer protein and an inducer of CYP7A1. J Biol Chem. 2003;278:30478-86 pubmed
    ..This dual function of ARP-1/COUP-TFII may play an important role in determining the metabolic phenotype of individual liver cells. ..
  12. Li Y, Xia Y, Wang Y, Mao L, Gao Y, He Q, et al. Sonic hedgehog (Shh) regulates the expression of angiogenic growth factors in oxygen-glucose-deprived astrocytes by mediating the nuclear receptor NR2F2. Mol Neurobiol. 2013;47:967-75 pubmed publisher
    ..The results of silencing Gli-1, or NR2F2, exhibited that exogenous Shh could regulate the expressions of VEGF, Ang-1, and Ang-2 in astrocytes by activating ..
  13. Marcus S, Winrow C, Capone J, Rachubinski R. A p56(lck) ligand serves as a coactivator of an orphan nuclear hormone receptor. J Biol Chem. 1996;271:27197-200 pubmed
    ..This factor is identical to a recently described ligand of the tyrosine kinase signaling molecule p56(lck), suggesting that it mediates cross-talk between mitogenic and nuclear hormone receptor signal transduction pathways. ..
  14. Perilhou A, Tourrel Cuzin C, Kharroubi I, Henique C, Fauveau V, Kitamura T, et al. The transcription factor COUP-TFII is negatively regulated by insulin and glucose via Foxo1- and ChREBP-controlled pathways. Mol Cell Biol. 2008;28:6568-79 pubmed publisher
    ..We demonstrate that this negative glucose effect involves ChREBP expression. We propose that COUP-TFII acts in a coordinate fashion to control insulin secretion and glucose metabolism. ..
  15. Chu K, Zingg H. The nuclear orphan receptors COUP-TFII and Ear-2 act as silencers of the human oxytocin gene promoter. J Mol Endocrinol. 1997;19:163-72 pubmed
  16. Ben Shushan E, Sharir H, Pikarsky E, Bergman Y. A dynamic balance between ARP-1/COUP-TFII, EAR-3/COUP-TFI, and retinoic acid receptor:retinoid X receptor heterodimers regulates Oct-3/4 expression in embryonal carcinoma cells. Mol Cell Biol. 1995;15:1034-48 pubmed
  17. Fuentealba P, Klausberger T, Karayannis T, Suen W, Huck J, Tomioka R, et al. Expression of COUP-TFII nuclear receptor in restricted GABAergic neuronal populations in the adult rat hippocampus. J Neurosci. 2010;30:1595-609 pubmed publisher
    The COUP-TFII nuclear receptor, also known as NR2F2, is expressed in the developing ventral telencephalon and modulates the tangential migration of a set of subpallial neuronal progenitors during forebrain development...