Nr1h3

Summary

Gene Symbol: Nr1h3
Description: nuclear receptor subfamily 1, group H, member 3
Alias: LXRalpha, oxysterols receptor LXR-alpha, RLD-1, liver X receptor alpha, nuclear orphan receptor LXR-alpha
Species: rat
Products:     Nr1h3

Top Publications

  1. Lehmann J, Kliewer S, Moore L, Smith Oliver T, Oliver B, Su J, et al. Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. J Biol Chem. 1997;272:3137-40 pubmed
    ..Here, we report that LXRalpha and LXRbeta, two orphan members of the nuclear receptor superfamily, are activated by 24(S), 25-epoxycholesterol ..
  2. Bradley M, Hong C, Chen M, Joseph S, Wilpitz D, Wang X, et al. Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE. J Clin Invest. 2007;117:2337-46 pubmed
    ..Previous work has shown that mice lacking LXRalpha accumulate cholesterol in the liver but not in peripheral tissues...
  3. Chiang J, Kimmel R, Stroup D. Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha). Gene. 2001;262:257-65 pubmed
    ..The goal of this study was to investigate the role of LXRalpha on the regulation of rat, human and hamster CYP7A1 transcription in its native promoter and cellular context...
  4. Repa J, Liang G, Ou J, Bashmakov Y, Lobaccaro J, Shimomura I, et al. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. Genes Dev. 2000;14:2819-30 pubmed
    ..Because this active form of SREBP-1c controls the transcription of genes involved in fatty acid biosynthesis, our results reveal a unique regulatory interplay between cholesterol and fatty acid metabolism. ..
  5. Vo T, Revesz A, Sohi G, Ma N, Hardy D. Maternal protein restriction leads to enhanced hepatic gluconeogenic gene expression in adult male rat offspring due to impaired expression of the liver X receptor. J Endocrinol. 2013;218:85-97 pubmed publisher
    ..that the acetylation of histone H3 (K9,14) surrounding the transcriptional start site of hepatic Lxr? (Nr1h3) was decreased in LP offspring, suggesting MPR-induced epigenetic silencing of the Lxr? promoter...
  6. Nedumaran B, Kim G, Hong S, Yoon Y, Kim Y, Lee C, et al. Orphan nuclear receptor DAX-1 acts as a novel corepressor of liver X receptor alpha and inhibits hepatic lipogenesis. J Biol Chem. 2010;285:9221-32 pubmed publisher
    ..assays have demonstrated that DAX-1 can inhibit the transcriptional activity of nuclear receptor liver X receptor alpha (LXRalpha)...
  7. Wang D, Miao C, Gong J. [Effect of the liver X receptor agonist on LPS-induced inflammatory response associated factor IRAK-4 and NF-kappaB]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009;25:293-5, 298 pubmed
    ..LXR agonists can effectively up-regulate the level of LXR gene and protein and down-regulate the levels of IRAK4 and NF-kappaB mRNA and protein expression. They can also inhibit activity of NF-kappaB. ..
  8. Lu R, Ito J, Iwamoto N, Nishimaki Mogami T, Yokoyama S. FGF-1 induces expression of LXRalpha and production of 25-hydroxycholesterol to upregulate the apoE gene in rat astrocytes. J Lipid Res. 2009;50:1156-64 pubmed publisher
    ..We investigated the mechanism for FGF-1 to upregulate apoE transcription. FGF-1 increased apoE and liver X receptor alpha (LXRalpha) mRNAs in rat astrocytes...
  9. Gabbi C, Kim H, Hultenby K, Bouton D, Toresson G, Warner M, et al. Pancreatic exocrine insufficiency in LXRbeta-/- mice is associated with a reduction in aquaporin-1 expression. Proc Natl Acad Sci U S A. 2008;105:15052-7 pubmed publisher
    ..Several genes are known to be involved in the pathogenesis and susceptibility to pancreatic insufficiency. LXRbeta should be included in that list. ..

More Information

Publications73

  1. Hebbachi A, Knight B, Wiggins D, Patel D, Gibbons G. Peroxisome proliferator-activated receptor alpha deficiency abolishes the response of lipogenic gene expression to re-feeding: restoration of the normal response by activation of liver X receptor alpha. J Biol Chem. 2008;283:4866-76 pubmed
    ..genes Scd-1 and Fas is regulated partly by the insulin-sensitive transcription factor SREBP-1c and liver X receptor alpha (LXRalpha)...
  2. Premalatha R, Srikumar K, Vijayalaksmi D, Kumar G, Mathur P. 28-Homobrassinolide: a novel oxysterol transactivating LXR gene expression. Mol Biol Rep. 2014;41:7447-61 pubmed publisher
    ..Conformational differences in 28-HB docking to LXR-? and ? binding domains were also noted through in silico studies, LXR-? adopting lesser specificity. We report that 28-HB transactivates LXR genes in the rat tissues. ..
  3. Asquith D, Miller A, Reilly J, Kerr S, Welsh P, Sattar N, et al. Simultaneous activation of the liver X receptors (LXR? and LXR?) drives murine collagen-induced arthritis disease pathology. Ann Rheum Dis. 2011;70:2225-8 pubmed publisher
    ..The absence of increased disease severity in the LXR?-/- and LXR?-/- GW3965-treated groups shows for the first time that agonism of both LXR? and LXR? is required to drive proinflammatory pathways in vivo. ..
  4. Lee J, Park S, Kim O, Lee C, Woo J, Park S, et al. Differential SUMOylation of LXRalpha and LXRbeta mediates transrepression of STAT1 inflammatory signaling in IFN-gamma-stimulated brain astrocytes. Mol Cell. 2009;35:806-17 pubmed publisher
    ..Immunoprecipitation data revealed that LXRbeta formed a trimer with PIAS1-pSTAT1, whereas LXRalpha formed a trimer with HDAC4-pSTAT1, mediated by direct ligand binding to the LXR proteins...
  5. Kazeminasab F, Marandi M, Ghaedi K, Esfarjani F, Moshtaghian J. Endurance training enhances LXR? gene expression in Wistar male rats. Eur J Appl Physiol. 2013;113:2285-90 pubmed publisher
    ..001). In conclusion, we found that endurance training induced significant elevation in LXR? gene expression, which correlated with enhanced levels of ABCA1 mRNA and plasma HDL-C concentration. ..
  6. Chen J, Zheng R, Xu C, Wu W. [Expression and significance of liver X receptor-alpha in nonalcoholic fatty liver disease in rats]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2009;23:265-8 pubmed
    ..05) . The increase of LXR-alpha and SREBP-1c in liver may be concered with energy disorder and closely associated with the activity of inflammation and the severity of the liver damage in NAFLD rats. ..
  7. Kim T, Kim H, Park J, Im S, Bae J, Kim M, et al. Interrelationship between liver X receptor alpha, sterol regulatory element-binding protein-1c, peroxisome proliferator-activated receptor gamma, and small heterodimer partner in the transcriptional regulation of glucokinase gene expression in liver. J Biol Chem. 2009;284:15071-83 pubmed publisher
    ..liver of liver X receptor (LXR) knockout mice, we have investigated whether LGK might be directly activated by LXRalpha. Furthermore, we have studied interrelationship between transcription factors that control gene expression of LGK...
  8. Green C, Jump D, Olson L. Elevated insulin secretion from liver X receptor-activated pancreatic beta-cells involves increased de novo lipid synthesis and triacylglyceride turnover. Endocrinology. 2009;150:2637-45 pubmed publisher
  9. Howell G, Deng X, Yellaturu C, Park E, Wilcox H, Raghow R, et al. N-3 polyunsaturated fatty acids suppress insulin-induced SREBP-1c transcription via reduced trans-activating capacity of LXRalpha. Biochim Biophys Acta. 2009;1791:1190-6 pubmed publisher
    ..The SREBP-1c promoter contains an insulin response unit consisting of tandem LXRalpha response elements (LXREs) as well as sites for NF-Y, Sp1, and SREBP-1c itself...
  10. Buono C, Li Y, Waldo S, Kruth H. Liver X receptors inhibit human monocyte-derived macrophage foam cell formation by inhibiting fluid-phase pinocytosis of LDL. J Lipid Res. 2007;48:2411-8 pubmed
    ..The findings reveal an additional new mechanism by which LXR agonists may inhibit macrophage cholesterol accumulation and atherosclerosis, namely, by inhibiting macrophage uptake of LDL. ..
  11. Volle D, Repa J, Mazur A, Cummins C, Val P, Henry Berger J, et al. Regulation of the aldo-keto reductase gene akr1b7 by the nuclear oxysterol receptor LXRalpha (liver X receptor-alpha) in the mouse intestine: putative role of LXRs in lipid detoxification processes. Mol Endocrinol. 2004;18:888-98 pubmed
    ..Two of these cis-acting elements are specific for regulation by the LXRalpha isoform...
  12. Ai Z, Zhu C, Min M, Wang J, Lan C, Fan L, et al. The role of hepatic liver X receptor ?- and sterol regulatory element binding protein-1c-mediated lipid disorder in the pathogenesis of non-alcoholic steatohepatitis in rats. J Int Med Res. 2011;39:1219-29 pubmed
    ..In conclusion, a high-fat diet upregulates LXR? which, in turn, upregulates SREBP-1c, increasing the activity of FAS and FFA and accumulation of TG in hepatocytes. Thus, LXR? and SREBP-1c contribute to the development of NASH. ..
  13. Baranowski M, Zabielski P, Błachnio Zabielska A, Harasiuk D, Gorski J. LXR activation prevents exhaustive exercise-induced hypoglycaemia and spares muscle glycogen but does not enhance running endurance in untrained rats. Acta Physiol (Oxf). 2011;201:373-9 pubmed publisher
    ..However, running time to exhaustion was not improved. We conclude that LXR activation increases fatty acid utilization during exercise which, however, does not translate into measurable enhancement of exercise endurance. ..
  14. Yamamoto T, Shimano H, Inoue N, Nakagawa Y, Matsuzaka T, Takahashi A, et al. Protein kinase A suppresses sterol regulatory element-binding protein-1C expression via phosphorylation of liver X receptor in the liver. J Biol Chem. 2007;282:11687-95 pubmed
    ..PKA), a mediator of glucagon/cAMP, a fasting signaling, suppresses SREBP-1c by modulating the activity of liver X receptor alpha (LXRalpha), a dominant activator of SREBP-1c expression...
  15. Hegarty B, Bobard A, Hainault I, Ferre P, Bossard P, Foufelle F. Distinct roles of insulin and liver X receptor in the induction and cleavage of sterol regulatory element-binding protein-1c. Proc Natl Acad Sci U S A. 2005;102:791-6 pubmed
    ..Both insulin and liver X receptor alpha (LXRalpha) induce SREBP-1c transcription; however, the respective roles of these factors and the mechanism ..
  16. Harasiuk D, Baranowski M, Zabielski P, Chabowski A, Gorski J. Liver X Receptor Agonist TO901317 Prevents Diacylglycerols Accumulation in the Heart of Streptozotocin-Diabetic Rats. Cell Physiol Biochem. 2016;39:350-9 pubmed publisher
    ..Activation of LXRs by TO901317 protects cardiomyocytes against DAG accumulation and thus may reverse disturbances in lipid metabolism observed in streptozotocin-diabetic heart. ..
  17. Cho K, Kim H, Kamanna V, Vaziri N. Niacin improves renal lipid metabolism and slows progression in chronic kidney disease. Biochim Biophys Acta. 2010;1800:6-15 pubmed publisher
    ..Present study sought to determine efficacy of niacin supplementation on renal tissue lipid metabolism in CRF...
  18. Rébé C, Raveneau M, Chevriaux A, Lakomy D, Sberna A, Costa A, et al. Induction of transglutaminase 2 by a liver X receptor/retinoic acid receptor alpha pathway increases the clearance of apoptotic cells by human macrophages. Circ Res. 2009;105:393-401 pubmed publisher
    ..A combination of LXR/RARalpha agonists that may operate in atherosclerosis could also constitute a promising strategy to improve the clearance of apoptotic cells by macrophages in other pathological situations. ..
  19. Watanabe Y, Jiang S, Takabe W, Ohashi R, Tanaka T, Uchiyama Y, et al. Expression of the LXRalpha protein in human atherosclerotic lesions. Arterioscler Thromb Vasc Biol. 2005;25:622-7 pubmed
    Liver X-activated receptor alpha (LXRalpha) regulates multiple genes controlling cholesterol metabolism and transport...
  20. Sakurabashi A, Wada Hiraike O, Hirano M, Fu H, Isono W, Fukuda T, et al. CCAR2 negatively regulates nuclear receptor LXRα by competing with SIRT1 deacetylase. J Steroid Biochem Mol Biol. 2015;149:80-8 pubmed publisher
    ..Therefore, these results clearly indicate a novel mechanism in which CCAR2 may regulate the transcriptional activation function of LXRα due to its specific inhibition of SIRT1 and serve to regulate cellular proliferation. ..
  21. Fluhr J, Crumrine D, Mao Qiang M, Moskowitz D, Elias P, Feingold K. Topical liver x receptor activators accelerate postnatal acidification of stratum corneum and improve function in the neonate. J Invest Dermatol. 2005;125:1206-14 pubmed
    ..These results demonstrate that LXR activators stimulate the formation of an acidic SC and improve both permeability barrier homeostasis and SC integrity/cohesion. ..
  22. Beyea M, Heslop C, Sawyez C, Edwards J, Markle J, Hegele R, et al. Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol. J Biol Chem. 2007;282:5207-16 pubmed
    ..In summary, endogenous synthesis of 24(S),25-epoxy selectively up-regulates expression of macrophage LXR-regulated cholesterol efflux genes without stimulating genes linked to fatty acid and triglyceride synthesis...
  23. Lund E, Peterson L, Adams A, Lam M, Burton C, Chin J, et al. Different roles of liver X receptor alpha and beta in lipid metabolism: effects of an alpha-selective and a dual agonist in mice deficient in each subtype. Biochem Pharmacol. 2006;71:453-63 pubmed
    ..of either LXR isoform have been thoroughly studied, as have the effects of simultaneous activation of both LXRalpha and LXRbeta by synthetic compounds...
  24. Weedon Fekjaer M, Dalen K, Solaas K, Staff A, Duttaroy A, Nebb H. Activation of LXR increases acyl-CoA synthetase activity through direct regulation of ACSL3 in human placental trophoblast cells. J Lipid Res. 2010;51:1886-96 pubmed publisher
    ..The nuclear receptors, liver X receptors alpha and beta (LXRalpha and LXRbeta), are key regulators of lipid metabolism in many tissues, but little is known about their role in ..
  25. Fontaine C, Rigamonti E, Pourcet B, Duez H, Duhem C, Fruchart J, et al. The nuclear receptor Rev-erbalpha is a liver X receptor (LXR) target gene driving a negative feedback loop on select LXR-induced pathways in human macrophages. Mol Endocrinol. 2008;22:1797-811 pubmed publisher
    ..b>LXRalpha binds to a specific response element in the human Rev-erbalpha promoter, thus inducing Rev-erbalpha ..
  26. Nakamura K, Kennedy M, Baldán A, Bojanic D, Lyons K, Edwards P. Expression and regulation of multiple murine ATP-binding cassette transporter G1 mRNAs/isoforms that stimulate cellular cholesterol efflux to high density lipoprotein. J Biol Chem. 2004;279:45980-9 pubmed
    ..The relatively high levels of expression in neuronal tissues and the eye suggest that ABCG1-dependent cholesterol efflux may be critical for normal neuronal function in addition to its role in macrophages...
  27. Huang K, Liang X, Zhong Y, He W, Wang Z. 5-Caffeoylquinic acid decreases diet-induced obesity in rats by modulating PPARα and LXRα transcription. J Sci Food Agric. 2015;95:1903-10 pubmed publisher
    ..However, 5-CQA significantly ameliorated this effect. 5-CQA may improve lipid metabolism disorders by altering the expression of PPARα and LXRα, which are involved in multiple intracellular signalling pathways. ..
  28. Meng Z, Yin Y, Lv J, Sha M, Lin Y, Gao L, et al. Aberrant activation of liver X receptors impairs pancreatic beta cell function through upregulation of sterol regulatory element-binding protein 1c in mouse islets and rodent cell lines. Diabetologia. 2012;55:1733-44 pubmed publisher
    ..Upregulation of SREBP1c production and the lipotoxicity mediated by it played a central role in this process. ..
  29. Ren J, Li D, Li Y, Lan X, Zheng J, Wang X, et al. HDAC3 interacts with sumoylated C/EBP? to negatively regulate the LXR? expression in rat hepatocytes. Mol Cell Endocrinol. 2013;374:35-45 pubmed publisher
    The expression changes of liver X receptor alpha (LXR?), histone deacetylase 3 (HDAC3) and CCAAT/enhancer binding protein alpha (C/EBP?) were detected in liver tissues of our high-fat-diet E3 rat model...
  30. Chen G, Liang G, Ou J, Goldstein J, Brown M. Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver. Proc Natl Acad Sci U S A. 2004;101:11245-50 pubmed
    ..Nuclear SREBPs and nuclear factor Y play permissive roles. ..
  31. Hong C, Walczak R, Dhamko H, Bradley M, Marathe C, Boyadjian R, et al. Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target. J Lipid Res. 2011;52:531-9 pubmed publisher
    ..These findings provide further support for an important role of LXRs in the coordinated regulation of lipid metabolic and inflammatory gene programs in macrophages. ..
  32. Yang L, Wang M, Liu T, Song H, Li D, Zheng P, et al. [Effects of Chinese herbal medicine Jiangzhi Granule on expressions of liver X receptor ? and sterol regulatory element-binding protein-1c in a rat model of non-alcoholic fatty liver disease]. Zhong Xi Yi Jie He Xue Bao. 2011;9:998-1004 pubmed
    ..JZG may regulate fatty acid metabolic disorder by decreasing the levels of LXR? and SREBP-1c. ..
  33. Rigamonti E, Helin L, Lestavel S, Mutka A, Lepore M, Fontaine C, et al. Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages. Circ Res. 2005;97:682-9 pubmed
  34. Zhao Y, Li L, Ma J, Chen G, Bai J. LXRalpha gene downregulation by lentiviral-based RNA interference enhances liver function after fatty liver transplantation in rats. Hepatobiliary Pancreat Dis Int. 2015;14:386-93 pubmed
    ..b>Liver X receptor alpha (LXRalpha) is important in fatty acid metabolism and interrelated with the specific ischemia-reperfusion ..
  35. Birrell M, Catley M, Hardaker E, Wong S, Willson T, McCluskie K, et al. Novel role for the liver X nuclear receptor in the suppression of lung inflammatory responses. J Biol Chem. 2007;282:31882-90 pubmed
    The liver X receptors (LXRalpha/beta) are part of the nuclear receptor family and are believed to regulate cholesterol and lipid homeostasis. It has also been suggested that LXR agonists possess anti-inflammatory properties...
  36. Laragione T, Gulko P. Liver X receptor regulates rheumatoid arthritis fibroblast-like synoviocyte invasiveness, matrix metalloproteinase 2 activation, interleukin-6 and CXCL10. Mol Med. 2012;18:1009-17 pubmed publisher
    ..These findings provide a new rationale for considering LXR agonists as therapeutic agents aimed at reducing both inflammation and FLS-mediated invasion and destruction in RA. ..
  37. Koh M, Takitani K, Miyazaki H, Yamaoka S, Tamai H. Liver X receptor up-regulates ?-tocopherol transfer protein expression and ?-tocopherol status. J Nutr Biochem. 2013;24:2158-67 pubmed publisher
    ..Our observations imply that the LXR signaling pathway might be a useful target for antioxidant properties by controlling the vitamin E status. ..
  38. Choe S, Choi A, Lee J, Kim K, Chung J, Park J, et al. Chronic activation of liver X receptor induces beta-cell apoptosis through hyperactivation of lipogenesis: liver X receptor-mediated lipotoxicity in pancreatic beta-cells. Diabetes. 2007;56:1534-43 pubmed
    ..Taken together, we suggest lipid accumulation caused by chronic activation of LXR in beta-cells as a possible cause of beta-cell lipotoxicity, a key step in the development of type 2 diabetes. ..
  39. Hirayama T, Honda A, Matsuzaki Y, Miyazaki T, Ikegami T, Doy M, et al. Hypercholesterolemia in rats with hepatomas: increased oxysterols accelerate efflux but do not inhibit biosynthesis of cholesterol. Hepatology. 2006;44:602-11 pubmed
    ..These increases were associated with activation of liver X receptor alpha (LXRalpha) as a result of the increased tissue oxysterol concentrations...
  40. Pawar A, Botolin D, Mangelsdorf D, Jump D. The role of liver X receptor-alpha in the fatty acid regulation of hepatic gene expression. J Biol Chem. 2003;278:40736-43 pubmed
    ..indicate that unsaturated fatty acids interfere with oxysterols binding to LXR and antagonize oxysterol-induced LXRalpha activity...
  41. Tobin K, Ulven S, Schuster G, Steineger H, Andresen S, Gustafsson J, et al. Liver X receptors as insulin-mediating factors in fatty acid and cholesterol biosynthesis. J Biol Chem. 2002;277:10691-7 pubmed
    ..A time- and dose-dependent increase in LXRalpha steady-state mRNA level was seen after insulin stimulation of primary rat hepatocytes in culture...
  42. Ai Z, Chen D. [The significance and effects of liver X receptor alpha in nonalcoholic fatty liver disease in rats]. Zhonghua Gan Zang Bing Za Zhi. 2007;15:127-30 pubmed
    To explore liver X receptor alpha (LXR alpha) gene changes and their significance in nonalcoholic fatty liver disease (NAFLD) in rats...
  43. Quinet E, Savio D, Halpern A, Chen L, Schuster G, Gustafsson J, et al. Liver X receptor (LXR)-beta regulation in LXRalpha-deficient mice: implications for therapeutic targeting. Mol Pharmacol. 2006;70:1340-9 pubmed
    The nuclear receptors liver X receptor (LXR) LXRalpha and LXRbeta are differentially expressed ligand-activated transcription factors that induce genes controlling cholesterol homeostasis and lipogenesis...
  44. Miyazaki M, Jacobson M, Man W, Cohen P, Asilmaz E, Friedman J, et al. Identification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors. J Biol Chem. 2003;278:33904-11 pubmed
    ..b>Liver X receptor alpha (LXR alpha) agonists and a high carbohydrate fat-free diet induced SCD4 expression, but unlike SCD1, SCD4 ..
  45. Tian J, Goldstein J, Brown M. Insulin induction of SREBP-1c in rodent liver requires LXR?-C/EBP? complex. Proc Natl Acad Sci U S A. 2016;113:8182-7 pubmed publisher
    ..The LXR?-C/EBP? complex is bound to the SREBP-1c promoter in the absence or presence of insulin, indicating that insulin acts not by increasing the formation of this complex, but rather by activating it. ..
  46. Park U, Seong M, Kim E, Hur W, Kim S, Yoon S, et al. Reciprocal regulation of LXR? activity by ASXL1 and ASXL2 in lipogenesis. Biochem Biophys Res Commun. 2014;443:489-94 pubmed publisher
    b>Liver X receptor alpha (LXR?), a member of the nuclear receptor superfamily, plays a pivotal role in hepatic cholesterol and lipid metabolism, regulating the expression of genes associated with hepatic lipogenesis...
  47. A Gonzalez N, Bensinger S, Hong C, Beceiro S, Bradley M, Zelcer N, et al. Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR. Immunity. 2009;31:245-58 pubmed publisher
    ..Thus, activation of LXR by apoptotic cells engages a virtuous cycle that promotes their own clearance and couples engulfment to the suppression of inflammatory pathways. ..
  48. Apfel R, Benbrook D, Lernhardt E, Ortiz M, Salbert G, Pfahl M. A novel orphan receptor specific for a subset of thyroid hormone-responsive elements and its interaction with the retinoid/thyroid hormone receptor subfamily. Mol Cell Biol. 1994;14:7025-35 pubmed
    ..Our data suggest a highly specific role for this novel receptor within the network of gene regulation by the thyroid/retinoid receptor subfamily. ..
  49. Tamehiro N, Shigemoto Mogami Y, Kakeya T, Okuhira K, Suzuki K, Sato R, et al. Sterol regulatory element-binding protein-2- and liver X receptor-driven dual promoter regulation of hepatic ABC transporter A1 gene expression: mechanism underlying the unique response to cellular cholesterol status. J Biol Chem. 2007;282:21090-9 pubmed
    ..We conclude that the dual promoter system driven by SREBP-2 and LXR regulates hepatic ABCA1 expression and may mediate the unique response of hepatic ABCA1 gene expression to cellular cholesterol status...
  50. Li D, Wang X, Ren W, Ren J, Lan X, Wang F, et al. High expression of liver histone deacetylase 3 contributes to high-fat-diet-induced metabolic syndrome by suppressing the PPAR-? and LXR-?-pathways in E3 rats. Mol Cell Endocrinol. 2011;344:69-80 pubmed publisher
    ..The results suggested that a high constitutive expression of Hdac3 inhibiting the expression of PPAR-?, LXR-? and CYP7A1 in liver contributes to HFD-MetS in E3 rats. ..
  51. Imayama I, Ichiki T, Patton D, Inanaga K, Miyazaki R, Ohtsubo H, et al. Liver X receptor activator downregulates angiotensin II type 1 receptor expression through dephosphorylation of Sp1. Hypertension. 2008;51:1631-6 pubmed publisher
    ..These results indicate that the suppression of AT1R may be one of the important mechanisms by which LXR ligands exert antiatherogenic effects. ..
  52. Mencarelli A, Renga B, D Amore C, Santorelli C, Graziosi L, Bruno A, et al. Dissociation of intestinal and hepatic activities of FXR and LXR? supports metabolic effects of terminal ileum interposition in rodents. Diabetes. 2013;62:3384-93 pubmed publisher
    ..Whether confirmed in human settings, these results support the association of pharmacological therapies with bariatric surgeries to exploit the selective activation of intestinal nuclear receptors. ..
  53. Kruse M, Rey M, Vega M, Coirini H. Alterations of LXR? and LXR? expression in the hypothalamus of glucose-intolerant rats. J Endocrinol. 2012;215:51-8 pubmed publisher
  54. Kim Y, Kim Y, Yang Y, Kim T, Hwang S, Lee J, et al. Inhibition of SREBP-1c-mediated hepatic steatosis and oxidative stress by sauchinone, an AMPK-activating lignan in Saururus chinensis. Free Radic Biol Med. 2010;48:567-78 pubmed publisher
    ..Previously, we identified the role of AMPK in liver X receptor-alpha (LXRalpha)-mediated SREBP-1c-dependent lipogenesis...
  55. Dahlman I, Nilsson M, Jiao H, Hoffstedt J, Lindgren C, Humphreys K, et al. Liver X receptor gene polymorphisms and adipose tissue expression levels in obesity. Pharmacogenet Genomics. 2006;16:881-9 pubmed
    ..Our results support a role for LXRA in human adipose tissue. The nominal associations of LXRA and LXRB alleles with obesity are interesting and should be further investigated in independent data sets. ..
  56. Gupta S, Pandak W, Hylemon P. LXR alpha is the dominant regulator of CYP7A1 transcription. Biochem Biophys Res Commun. 2002;293:338-43 pubmed
    ..These results suggest that under conditions of both SHP and LXR alpha activation, stimulatory effect of LXR alpha overrides the inhibitory effect of FXR and results in an induction of rat CYP7A1 mRNA levels. ..
  57. Dang H, Liu Y, Pang W, Li C, Wang N, Shyy J, et al. Suppression of 2,3-oxidosqualene cyclase by high fat diet contributes to liver X receptor-alpha-mediated improvement of hepatic lipid profile. J Biol Chem. 2009;284:6218-26 pubmed publisher
    ..To explore the underlying mechanism, we administered mice normal chow or an HF diet and overexpressed LXRalpha in the liver...
  58. Fernø J, Vik Mo A, Jassim G, Håvik B, Berge K, Skrede S, et al. Acute clozapine exposure in vivo induces lipid accumulation and marked sequential changes in the expression of SREBP, PPAR, and LXR target genes in rat liver. Psychopharmacology (Berl). 2009;203:73-84 pubmed publisher
    ..cholesterol efflux genes, normally controlled by the peroxisome proliferator activated receptor alpha and liver X receptor alpha transcription factors, and also down-regulation of genes encoding major lipases...
  59. Helleboid Chapman A, Helleboid S, Jakel H, Timmerman C, Sergheraert C, Pattou F, et al. Glucose regulates LXRalpha subcellular localization and function in rat pancreatic beta-cells. Cell Res. 2006;16:661-70 pubmed
    ..Here, we show that glucose does not change LXRalpha protein level, but affects its localization in pancreatic beta-cells...
  60. Mohammadi E, Ghaedi K, Esmailie A, Rahgozar S. Gene expression profiling of liver X receptor ? and Bcl-2-associated X protein in experimental transection spinal cord-injured rats. J Spinal Cord Med. 2013;36:66-71 pubmed publisher
    ..Furthermore, an increase in LXR? transcription level was observed first in rostral area and then extended to epicentral and caudal areas, implying that inflammation responses extended from rostral to caudal areas. ..
  61. Wada T, Kang H, Angers M, Gong H, Bhatia S, Khadem S, et al. Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3). Mol Pharmacol. 2008;73:891-9 pubmed
    ..Reporter gene analysis showed that the activation of Cyp7b1 gene promoter by RORalpha was suppressed by LXRalpha (NR1H3), whereas RORalpha inhibited both the constitutive and ligand-dependent activities of LXRalpha...
  62. Cha J, Repa J. The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR. J Biol Chem. 2007;282:743-51 pubmed
    The liver X receptors, LXRalpha (NR1H3) and LXRbeta (NR1H2), are ligand-activated transcription factors that belong to the nuclear hormone receptor superfamily. LXRs play a critical role in cholesterol homeostasis and bile acid metabolism...
  63. Demeure O, Lecerf F, Duby C, Desert C, Ducheix S, Guillou H, et al. Regulation of LPCAT3 by LXR. Gene. 2011;470:7-11 pubmed publisher
    ..Altogether these data evidence for the first time that the chicken LPCAT3 gene is a direct target of LXR and therefore suggest a new role for LXR in phospholipid homeostasis. ..
  64. Jiang W, Miyamoto T, Kakizawa T, Nishio S, Oiwa A, Takeda T, et al. Inhibition of LXRalpha signaling by vitamin D receptor: possible role of VDR in bile acid synthesis. Biochem Biophys Res Commun. 2006;351:176-84 pubmed
    ..rate-limiting enzyme in the catabolism of cholesterol to bile acid, is stimulated by oxysterol receptor, liver X receptor alpha (LXRalpha) and negatively regulated by a bile acid receptor, farnesoid X receptor...