Gene Symbol: Nqo1
Description: NAD(P)H quinone dehydrogenase 1
Alias: Dia4, NAD(P)H dehydrogenase [quinone] 1, DT-diaphorase, DTD, Diaphorase (NADH/NADPH), NAD(P)H dehydrogenase, quinone 1, NAD(P)H:menadione oxidoreductase, NAD(P)H:quinone oxidoreductase 1, QR1, azoreductase, menadione reductase, phylloquinone reductase, quinone reductase 1
Species: rat
Products:     Nqo1

Top Publications

  1. Chen G, Fang Q, Zhang J, Zhou D, Wang Z. Role of the Nrf2-ARE pathway in early brain injury after experimental subarachnoid hemorrhage. J Neurosci Res. 2011;89:515-23 pubmed publisher
    ..the elevated expression of Nrf2-ARE-related factors such as Nrf2, HO-1, NAD(P)H:quinone oxidoreductase 1 (NQO1), and glutathione S-transferase-?1 (GST-?1) was detected in the cortex at 48 hr following blood injection...
  2. Racekova E, Martončíková M, Mitrusková B, Cizkova D, Orendacova J. Age-related changes of NADPH-diaphorase positivity in the rat rostral migratory stream. Cell Mol Neurobiol. 2005;25:1093-105 pubmed
    ..The presence of NO producing cells in the RMS of neonatal adult and aging rats indicates, that this proliferating and migratory area is under the influence of NO throughout the entire life of the animals. ..
  3. Wu J, Jin Z, Yan L. Redox imbalance and mitochondrial abnormalities in the diabetic lung. Redox Biol. 2017;11:51-59 pubmed publisher
    ..content of NAD+ dependent enzymes such as sirtuin3 (sirt3) and NAD(P)H: quinone oxidoreductase 1 (NQO1). Our results demonstrate that NADH/NAD+ redox imbalance occurs in the diabetic lung...
  4. Kolesar J, Dahlberg S, Marsh S, McLeod H, Johnson D, Keller S, et al. The NQO1*2/*2 polymorphism is associated with poor overall survival in patients following resection of stages II and IIIa non-small cell lung cancer. Oncol Rep. 2011;25:1765-72 pubmed publisher
    NAD(P)H:quinone oxidoreductase 1 (NQO1), is a cytosolic flavoenzyme that catalyzes the two-electron reduction of quinones into hydroquinones. A polymorphism (NQO1*2) alters enzymatic activity of NQO1 resulting in diminished NQO1 activity...
  5. Dyuizen I, Motavkin P, Shorin V. Dynamics of NADPH diaphorase activity in raphe neurons during chronic treatment with opiates. Bull Exp Biol Med. 2001;132:918-20 pubmed
    ..This effect was blocked by naloxone. In animals with the withdrawal syndrome NO-ergic activity in raphe neurons increased and surpassed the normal. ..
  6. Dear T, McDonald D, Kefford R. Transcriptional down-regulation of a rat gene, WDNM2, in metastatic DMBA-8 cells. Cancer Res. 1989;49:5323-8 pubmed
    ..Homologous sequences in the human genome have been identified. The function of this new gene may relate to regulation of the metastatic phenotype in this tumor. ..
  7. Kodavanti P, Royland J, Richards J, Besas J, MacPhail R. Toluene effects on oxidative stress in brain regions of young-adult, middle-age, and senescent Brown Norway rats. Toxicol Appl Pharmacol. 2011;256:386-98 pubmed publisher
    ..OS parameters were selected to measure the production of reactive oxygen species (NADPH Quinone oxidoreductase 1 (NQO1), NADH Ubiquinone reductase (UBIQ-RD)), antioxidant homeostasis (total antioxidant substances (TAS), superoxide ..
  8. Munday R, Zhang Y, Munday C, Bapardekar M, Paonessa J. Structure-activity relationships and organ specificity in the induction of GST and NQO1 by alkyl-aryl isothiocyanates. Pharm Res. 2008;25:2164-70 pubmed publisher
    ..ITCs) to increase the activities of the Phase 2 detoxification enzymes NAD[P]H:quinone acceptor oxidoreductase 1 (NQO1) and glutathione S-transferases (GST) in rat tissues in vivo and in cells in vitro...
  9. Zachaki S, Stavropoulou C, Koromila T, Manola K, Kalomoiraki M, Daraki A, et al. High frequency of NAD(P)H:quinone oxidoreductase 1 (NQO1) C(609)T germline polymorphism in MDS/AML with trisomy 8. Leuk Res. 2013;37:742-6 pubmed publisher
    The NQO1 C(609)T germline polymorphism resulting in a lowering of enzyme activity may confer susceptibility to MDS...

More Information


  1. Lewis S, Cherry N, Niven R, Barber P, Povey A. Polymorphisms in the NAD(P)H: quinone oxidoreductase gene and small cell lung cancer risk in a UK population. Lung Cancer. 2001;34:177-83 pubmed
    NAD(P)H: quinone oxidoreductase (NQO1) protects the cell against cytotoxicity by reducing the concentration of free quinone available for single electron reduction...
  2. Jiang Z, Wen Y. [Expressions of c-Fos and NADPH-d in the related brainstem during vestibular compensation]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2008;30:655-8 pubmed
    ..In the ipsilesional MVN and the contralesional PrH, c-Fos plays an important role in vestibular compensation, in which nitric oxide acts as a key neurotransmitter. ..
  3. Goodrich G, Goodman P, Budhecha S, Pritsos C. Functional polymorphism of detoxification gene NQO1 predicts intensity of empirical treatment of childhood asthma. Mutat Res. 2009;674:55-61 pubmed publisher
    ..transferase (GST) M1 and T1, ile105val variant of GSTP1, and pro187ser variant of NAD(P)H:quinone oxidoreductase 1 (NQO1)...
  4. Chen Y, Sun C, Lin Y, Chang L, Chen Y, Tsai T, et al. Adipose-derived mesenchymal stem cell protects kidneys against ischemia-reperfusion injury through suppressing oxidative stress and inflammatory reaction. J Transl Med. 2011;9:51 pubmed publisher
    ..02) ADMSC therapy minimized kidney damage after IR injury through suppressing oxidative stress and inflammatory response. ..
  5. Synowiec E, Sliwinski T, Danisz K, Blasiak J, Sklodowska A, Romaniuk D, et al. Association between polymorphism of the NQO1, NOS3 and NFE2L2 genes and AMD. Front Biosci (Landmark Ed). 2013;18:80-90 pubmed
    ..and polymorphisms of genes encoding enzymes involved in the generation and removal of iron-mediated oxidation: NQO1 (609C> T, rs1800566), NOS3 (894G>T, rs1799983) and NFE2L2 (28312647A>G, rs6726395)...
  6. Guo Y, Li J, Wang Y, Mao T, Chen C, Xie T, et al. Yinchen Linggui Zhugan Decoction Ameliorates Nonalcoholic Fatty Liver Disease in Rats by Regulating the Nrf2/ARE Signaling Pathway. Evid Based Complement Alternat Med. 2017;2017:6178358 pubmed publisher
    ..polymerase chain reaction were, respectively, used to determine hepatic protein and gene expression of Keap1, Nrf2, NQO1, and HO-1. Oral YCLGZGD ameliorated HFD-induced NAFLD...
  7. Manzanares M, de Miguel C, Ruíz de Villa M, Santella R, Escrich E, Solanas M. Dietary lipids differentially modulate the initiation of experimental breast carcinogenesis through their influence on hepatic xenobiotic metabolism and DNA damage in the mammary gland. J Nutr Biochem. 2017;43:68-77 pubmed publisher
    ..activity of CYP1s in the hours immediately after induction, while reducing the activity of Phase II enzymes, mainly NQO1. The levels of reactive metabolites measured in plasma by GC-MS and DMBA-DNA adducts in the mammary gland of the ..
  8. Sutariya B, Taneja N, Saraf M. Betulinic acid, isolated from the leaves of Syzygium cumini (L.) Skeels, ameliorates the proteinuria in experimental membranous nephropathy through regulating Nrf2/NF-?B pathways. Chem Biol Interact. 2017;274:124-137 pubmed publisher
    ..Furthermore, BA ameliorated mRNA and protein expression of NF-?B, iNOS, TNF-?, Nrf2, HO-1 and NQO1 in the kidney. BA also restored malondialdehyde level and antioxidant enzyme activities in the kidney...
  9. Wang Y, Lee Y, Tseng P, Shen C, Chiou H. Human NAD(P)H:quinone oxidoreductase 1 (NQO1) and sulfotransferase 1A1 (SULT1A1) polymorphisms and urothelial cancer risk in Taiwan. J Cancer Res Clin Oncol. 2008;134:203-9 pubmed
    To investigate whether the NAD(P)H:quinone oxidoreductase 1 (NQO1) and sulfotransferase 1A1 (SULT1A1) polymorphisms are associated with urothelial cancer (UC) risk in Taiwan...
  10. Koike E, Hirano S, Shimojo N, Kobayashi T. cDNA microarray analysis of gene expression in rat alveolar macrophages in response to organic extract of diesel exhaust particles. Toxicol Sci. 2002;67:241-6 pubmed
    ..Our results suggest that cDNA microarray analysis is a useful tool to investigate the biological responses to pulmonary toxicants. ..
  11. Kang Y, Yan W, Fang H, Zhang G, Du Y, Wang L, et al. Alleviation of Oxidative Damage and Involvement of Nrf2-ARE Pathway in Mesodopaminergic System and Hippocampus of Status Epilepticus Rats Pretreated by Intranasal Pentoxifylline. Oxid Med Cell Longev. 2017;2017:7908072 pubmed publisher
    ..Intranasal administration of Ptx may hopefully become a noninvasive, painless, and easily administered option for epileptic patients. ..
  12. Hartmann R, Licks F, Schemitt E, Colares J, do Couto Soares M, Zabot G, et al. Protective effect of glutamine on the main and adjacent organs damaged by ischemia-reperfusion in rats. Protoplasma. 2017;254:2155-2168 pubmed publisher
    ..reactive substance (TBARS) and nitric oxide, Nrf2/keap1, superoxide dismutase (SOD), NADPH quinone oxidoreductase1 (NQO1), inducible nitric oxide synthase (iNOS), heat shock protein (HSP70), glucose-regulated protein 78 (GRP78), and ..
  13. Li Q, Zemel E, Miller B, Perlman I. NADPH diaphorase activity in the rat retina during the early stages of experimental diabetes. Graefes Arch Clin Exp Ophthalmol. 2003;241:747-56 pubmed
    ..Our findings are consistent with the hypothesis that high glucose levels are deleterious to the rat retina and that excessive synthesis of NO may contribute to the development of diabetic retinopathy. ..
  14. Li J, Yu J, Ma H, Yang N, Li L, Zheng D, et al. Intranasal Pretreatment with Z-Ligustilide, the Main Volatile Component of Rhizoma Chuanxiong, Confers Prophylaxis against Cerebral Ischemia via Nrf2 and HSP70 Signaling Pathways. J Agric Food Chem. 2017;65:1533-1542 pubmed publisher
    ..05) and decreased MMP-2 and -9 levels (p < 0.01). Meanwhile, Z-LIG up-regulated NQO1 and HSP70...
  15. Sameer A, Shah Z, Syeed N, Rasool R, Afroze D, Siddiqi M. NAD(P)H:quinone oxidoreductase 1 (NQO1) Pro187Ser polymorphism and colorectal cancer predisposition in the ethnic Kashmiri population. Asian Pac J Cancer Prev. 2010;11:209-13 pubmed
    The C609T single nucleotide polymorphism of the NAD(P)H:quinone oxidoreductase 1 (NQO1) gene has been identified as an important risk parameter for the susceptibility to colorectal cancer...
  16. Wei I, Huang C, Chang H, Tseng C, Tu H, Wen C, et al. Neuronal NADPH-d/NOS expression in the nodose ganglion of severe hypoxic rats with or without mild hypoxic preconditioning. J Chem Neuroanat. 2005;29:149-56 pubmed
    ..In addition, neuronal survival was markedly increased by MHPC. These results suggested that MHPC might have a neuroprotective effect that reduces the susceptibility of the nodose neurons to NOS mediated neuropathy subsequent to SHE. ..
  17. Bolekova A, Kluchova D, Špakovská T, Dorko F, Lovasova K. Postnatal development of nitrergic and cholinergic structures in rat spinal cord. Arch Ital Biol. 2011;149:293-302 pubmed publisher
    ..Our results confirmed the presence of nitrergic and cholinergic neurons in investigated areas of the SC and indicated their fully functioning of NADPH-d and AChE positive structures in SC from the third postnatal week. ..
  18. Zhang H, Tan X, Yang D, Lu J, Liu B, Baiyun R, et al. Dietary luteolin attenuates chronic liver injury induced by mercuric chloride via the Nrf2/NF-κB/P53 signaling pathway in rats. Oncotarget. 2017;8:40982-40993 pubmed publisher
    ..Taken together, our data suggested that decreasing oxidative stress is a protective mechanism of luteolin against development of HgCl2-induced liver injury, through the Nrf2/NF-κB/P53 signaling pathway in rats. ..
  19. Kumar U. Colocalization of somatostatin receptor subtypes (SSTR1-5) with somatostatin, NADPH-diaphorase (NADPH-d), and tyrosine hydroxylase in the rat hypothalamus. J Comp Neurol. 2007;504:185-205 pubmed
    ..Taken together, these data suggest that SSTRs may interact with NADPH-d and TH to exert a physiological role in concert within the hypothalamus. ..
  20. Li X, Li C, Xiang Z, Hu J, Lu J, Tian R, et al. Allicin ameliorates cardiac hypertrophy and fibrosis through enhancing of Nrf2 antioxidant signaling pathways. Cardiovasc Drugs Ther. 2012;26:457-65 pubmed publisher
    ..To evaluate the protective effects of allicin on Ang II-induced cardiac hypertrophy...
  21. Li R, Bianchet M, Talalay P, Amzel L. The three-dimensional structure of NAD(P)H:quinone reductase, a flavoprotein involved in cancer chemoprotection and chemotherapy: mechanism of the two-electron reduction. Proc Natl Acad Sci U S A. 1995;92:8846-50 pubmed
    Quinone reductase [NAD(P)H:(quinone acceptor) oxidoreductase, EC], also called DT diaphorase, is a homodimeric FAD-containing enzyme that catalyzes obligatory NAD(P)H-dependent two-electron reductions of quinones and protects ..
  22. Maia L, Frazão M, Souza T, Silva M, Rocha de Melo A, Picanço Diniz C, et al. L-arginine treatment early in life influences NADPH-diaphorase neurons in visual cortex of normal and early-malnourished adult rats. Brain Res. 2006;1072:19-25 pubmed
    ..Data are considered of interest for studies of synaptic plasticity during neural development and its relationships to aggressive agents like malnutrition. ..
  23. Kim Y, Hwang J, Noh J, Gang G, Tadi S, Yim Y, et al. Prevention of salt-induced renal injury by activation of NAD(P)H:quinone oxidoreductase 1, associated with NADPH oxidase. Free Radic Biol Med. 2012;52:880-8 pubmed publisher
    ..Lapachone (?L), a well-known substrate of NAD(P)H:quinone oxidoreductase 1 (NQO1), decreases the cellular NAD(P)H/NAD(P)(+) ratio via activation of NQO1...
  24. Guo H, Li M, Liu Q, Guo L, Ma M, Wang S, et al. Danhong injection attenuates ischemia/reperfusion-induced brain damage which is associating with Nrf2 levels in vivo and in vitro. Neurochem Res. 2014;39:1817-24 pubmed publisher
    ..of nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), NAD(P)H: quinone oxidoreductase 1 (NQO1) were analysed by real-time polymerase chain reaction...
  25. Rinaldi Tosi M, Bocanegra V, Manucha W, Gil Lorenzo A, Valles P. The Nrf2-Keap1 cellular defense pathway and heat shock protein 70 (Hsp70) response. Role in protection against oxidative stress in early neonatal unilateral ureteral obstruction (UUO). Cell Stress Chaperones. 2011;16:57-68 pubmed publisher
    ..nuclear Nrf2 and its target gene products glutathione S-transferase A2 (GSTA2) and NADPH/quinone oxidoreductase 1 (NQO1), whereas the Nrf2 repressor Kelch-like ECH-associated protein-1 (Keap1) was upregulated...
  26. Peng S, Hou Y, Yao J, Fang J. Activation of Nrf2-driven antioxidant enzymes by cardamonin confers neuroprotection of PC12 cells against oxidative damage. Food Funct. 2017;8:997-1007 pubmed publisher
    ..Our results demonstrate that CD is a novel small molecule activator of Nrf2 in PC12 cells, and suggest that CD may be a potential candidate for the prevention of oxidative stress-mediated neurodegenerative disorders. ..
  27. Goven D, Boutten A, Lecon Malas V, Marchal Somme J, Amara N, Crestani B, et al. Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema. Thorax. 2008;63:916-24 pubmed publisher
    ..proteins, such as heme oxygenase-1 (HO-1), glutathione peroxidase 2 (GPX2) and NAD(P)H:quinone oxidoreductase 1 (NQO1), results from an equilibrium created by positive or negative regulation by the transcription factors Nrf2, Keap1 ..
  28. Zhu X, Jiang X, Li A, Zhao Z, Li S. S-Allylmercaptocysteine Attenuates  Cisplatin-Induced Nephrotoxicity through  Suppression of Apoptosis, Oxidative Stress, and  Inflammation. Nutrients. 2017;9: pubmed publisher
    ..activity, expression of nuclear factor erythroid 2-related factor 2 (Nrf2), NAD(P)H:quinone oxidoreductase 1 (NQO1) and inflammatory cytokines were also examined...
  29. Zhang J, Zhu Y, Zhou D, Wang Z, Chen G. Recombinant human erythropoietin (rhEPO) alleviates early brain injury following subarachnoid hemorrhage in rats: possible involvement of Nrf2-ARE pathway. Cytokine. 2010;52:252-7 pubmed publisher
    ..of Nrf2-ARE pathway related agents, such as Nrf2, heme oxygenase-1 (HO-1), NAD(P)H:quinone oxidoreductase-1 (NQO1), and glutathione S-transferase ?-1 (GST-?1)...
  30. Yeligar S, Machida K, Kalra V. Ethanol-induced HO-1 and NQO1 are differentially regulated by HIF-1alpha and Nrf2 to attenuate inflammatory cytokine expression. J Biol Chem. 2010;285:35359-73 pubmed publisher
    ..cells respond to oxidative stress-induced expression of heme oxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase (NQO1) to blunt inflammation and liver injury...
  31. Wang H, Lee E, Han S, Kim S, Lee B, Ahn C, et al. Dual pathways of p53 mediated glucolipotoxicity-induced apoptosis of rat cardiomyoblast cell: activation of p53 proapoptosis and inhibition of Nrf2-NQO1 antiapoptosis. Metabolism. 2012;61:496-503 pubmed publisher
    ..NF-E2-related factor 2 (Nrf2) showed increased tendency while the expression of NAD(P)H: quinone oxidoreductase-1 (NQO1) was decreased...
  32. Yan W, Wang H, Zhu L, Feng X, Qiao L, Jin W, et al. Traumatic brain injury induces the activation of the Nrf2-ARE pathway in the lung in rats. Brain Inj. 2008;22:802-10 pubmed publisher
    ..was detected by Western blot and the mRNA levels of heme oxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase-1 (NQO1), two Nrf2-regulated gene products, were determined by RT-PCR at 24 hours after TBI...
  33. Sanchez R, Mesia Vela S, Kauffman F. Induction of NAD(P)H quinone oxidoreductase and glutathione S-transferase activities in livers of female August-Copenhagen Irish rats treated chronically with estradiol: comparison with the Sprague-Dawley rat. J Steroid Biochem Mol Biol. 2003;87:199-206 pubmed
    ..of female ACI and Sprague-Dawley rats for 6 weeks with E2 on activities of NAD(P)H quinone oxidoreductase 1 (NQO1), glutathione peroxidase, glutathione S-transferase (GST), phenol sulfotransferase (SULT1A1), cytochrome P450 (..
  34. Smith M, Wang Y, Kane E, Rollinson S, Wiemels J, Roman E, et al. Low NAD(P)H:quinone oxidoreductase 1 activity is associated with increased risk of acute leukemia in adults. Blood. 2001;97:1422-6 pubmed
    NAD(P)H:quinone oxidoreductase 1 (NQO1) is an enzyme that detoxifies quinones and reduces oxidative stress...
  35. Tanuma J, Shisa H, Hiai H, Higashi S, Yamada Y, Kamoto T, et al. Quantitative trait loci affecting 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in the rat. Cancer Res. 1998;58:1660-4 pubmed
    ..The final incidence of TC in DA, WF, F1, and backcross rats seemed to be explained by combinations of genotype at these two loci. Possible candidate genes for Stc1 and Rtc1 are discussed. ..
  36. Tanaka S, Tamura K, Mizuno Y. [Clinical consideration with special reference to autopsy cases of malignant tumor in the oral cavity, treated with Bleomycin (author's transl)]. Hiroshima Daigaku Shigaku Zasshi. 1975;8:168-75 pubmed
  37. Liu B, Zhang H, Tan X, Yang D, Lv Z, Jiang H, et al. GSPE reduces lead-induced oxidative stress by activating the Nrf2 pathway and suppressing miR153 and GSK-3β in rat kidney. Oncotarget. 2017;8:42226-42237 pubmed publisher
    ..Nrf2 signaling provides a new therapeutic target for renal injury induced by Pb, and GSPE could be a potential natural agent to protect against Pb-induced nephrotoxicity. ..
  38. Han J, Kim S, Ko I, Kim J, Kim K. Afferent Pathway-Mediated Effect of ?1 Adrenergic Antagonist, Tamsulosin, on the Neurogenic Bladder After Spinal Cord Injury. Int Neurourol J. 2017;21:178-188 pubmed publisher
    ..However, further studies are needed to elucidate the exact mechanism and effects of tamsulosin on the afferent pathways of micturition. ..
  39. Jin W, Ming X, Hou X, Zhu T, Yuan B, Wang J, et al. Protective effects of erythropoietin in traumatic spinal cord injury by inducing the Nrf2 signaling pathway activation. J Trauma Acute Care Surg. 2014;76:1228-34 pubmed publisher
    ..and activities of Nrf2 signaling pathway-related agents, including Nrf2, NAD(P)H:quinone oxidoreductase 1(NQO1), and glutathione S-transferase...
  40. Segawa R, Hayashi H, Morita R, Ogawa T, Takimoto N, Hara S, et al. Modifying effects of liver tumor promotion in rats subjected to co-administration of indole-3-carbinol and phenobarbital. J Toxicol Sci. 2014;39:129-40 pubmed
    ..On the contrary, the mRNA levels of Cyp2b1/2 and Nqo1 were suppressed and enhanced, respectively, in the PB+I3C group in the isoadditive model, but there was no ..
  41. Oh C, Kim J, Choi Y, Kim H, Jeong J, Bae K, et al. Dimethylfumarate attenuates renal fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-?/Smad signaling. PLoS ONE. 2012;7:e45870 pubmed publisher
    ..However, downregulation of the antioxidant response element (ARE)-driven Nrf2 target genes such as NQO1, HO-1 and glutathione S-transferase (GST) did not reverse the inhibitory effect of DMF on TGF-?-induced ..
  42. Tsai C, Lin C, Wang Y. Carnosic acid induces the NAD(P)H: quinone oxidoreductase 1 expression in rat clone 9 cells through the p38/nuclear factor erythroid-2 related factor 2 pathway. J Nutr. 2011;141:2119-25 pubmed publisher
    ..compared the effects of phenolic diterpenes from rosemary on the expression of NAD(P)H: quinone oxidoreductase 1 (NQO1) in rat Clone 9 liver cells. Cells were treated with 1-20 ?mol/L of carnosic acid (CA) or carnosol (CS) for 24 h...
  43. Sun C, Yen C, Lin Y, Tsai T, Chang L, Kao Y, et al. Autologous transplantation of adipose-derived mesenchymal stem cells markedly reduced acute ischemia-reperfusion lung injury in a rodent model. J Transl Med. 2011;9:118 pubmed publisher
    ..ADMSC therapy minimized lung damage after IR injury in a rodent model through suppressing oxidative stress and inflammatory reaction. ..
  44. Kapinya K, Harms U, Harms C, Blei K, Katchanov J, Dirnagl U, et al. Role of NAD(P)H:quinone oxidoreductase in the progression of neuronal cell death in vitro and following cerebral ischaemia in vivo. J Neurochem. 2003;84:1028-39 pubmed
    A direct involvement of the antioxidant enzyme NAD(P)H:quinone oxidoreductase (NQO1) in neuroprotection has not yet been shown...
  45. Krajinovic M, Sinnett H, Richer C, Labuda D, Sinnett D. Role of NQO1, MPO and CYP2E1 genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia. Int J Cancer. 2002;97:230-6 pubmed
    ..The genetic factors underlying the susceptibility to this disease remain elusive. The enzymes CYP2E1, MPO and NQO1 are involved in the biotransformation of a variety of xenobiotics present in organic solvents, tobacco smoke, drugs,..
  46. Forrest G, Qian J, Ma J, Kaplan W, Akman S, Doroshow J, et al. Rat liver NAD(P)H:quinone oxidoreductase: cDNA expression and site-directed mutagenesis. Biochem Biophys Res Commun. 1990;169:1087-93 pubmed
    ..Site-directed mutagenesis experiments carried out using this expression system revealed possible regions involved in NAD(P)H binding. ..
  47. Manzanares M, Solanas M, Moral R, Escrich R, Vela E, Escrich E. Ontogeny of the major xenobiotic-metabolizing enzymes expression and the dietary lipids modulatory effect in the rat dimethylbenz(a)anthracene-induced breast cancer model. J Biochem Mol Toxicol. 2014;28:539-48 pubmed publisher
    ..High corn oil and olive oil diets differentially influenced the expression of age-related changes, suggesting that the different susceptibility to xenobiotic exposure depending upon the age may be modulated by dietary factors. ..
  48. Park J, Lee Y, Kim J, Seo H, Kim H. ?-Lapachone increases phase II antioxidant enzyme expression via NQO1-AMPK/PI3K-Nrf2/ARE signaling in rat primary astrocytes. Free Radic Biol Med. 2016;97:168-178 pubmed publisher
    ..expression of phase II antioxidant enzymes such as heme oxygenase-1 (HO-1), NAD(P)H:quinone oxidoreductase 1 (NQO1), manganese superoxide dismutase (MnSOD), and catalase...
  49. Lagoa R, Gañán C, Lopez Sanchez C, Garcia Martinez V, Gutierrez Merino C. The decrease of NAD(P)H:quinone oxidoreductase 1 activity and increase of ROS production by NADPH oxidases are early biomarkers in doxorubicin cardiotoxicity. Biomarkers. 2014;19:142-53 pubmed publisher
    ..quinone oxidoreductase-1 activity and increase of hydrogen peroxide production by NADPH oxidases are early biomarkers in doxorubicin cardiotoxicity. ..
  50. Begleiter A, Sivananthan K, Lefas G, Maksymiuk A, Bird R. Inhibition of colon carcinogenesis by post-initiation induction of NQO1 in Sprague-Dawley rats. Oncol Rep. 2009;21:1559-65 pubmed
    ..cancer at the initiation and post-initiation stage, but the contribution of NAD(P) H:quinone oxidoreductase 1 (NQO1) to this effect remains unclear...
  51. Kim S, Jeoung N, Oh C, Choi Y, Lee H, Kim H, et al. Activation of NAD(P)H:quinone oxidoreductase 1 prevents arterial restenosis by suppressing vascular smooth muscle cell proliferation. Circ Res. 2009;104:842-50 pubmed publisher
    ..The activation of AMPK in VSMCs by betaL is mediated by LKB1 in the presence of NQO1. Taken together, these results show that betaL inhibits VSMCs proliferation via the NQO1 and LKB1-dependent ..
  52. Qiu Y, Ai P, Song J, Liu C, Li Z. Total Flavonoid Extract from Abelmoschus manihot (L.) Medic Flowers Attenuates d-Galactose-Induced Oxidative Stress in Mouse Liver Through the Nrf2 Pathway. J Med Food. 2017;20:557-567 pubmed publisher
    ..Expression of Nrf2 and its target antioxidants (HO-1 and NQO1) was manifestly increased by TFAE treatment...
  53. Robertson J, Chen H, Nebert D. NAD(P)H:menadione oxidoreductase. Novel purification of enzyme cDNA and complete amino acid sequence, and gene regulation. J Biol Chem. 1986;261:15794-9 pubmed
    ..Polyclonal antiserum to menadione reductase was raised in rabbits...