Npy

Summary

Gene Symbol: Npy
Description: neuropeptide Y
Alias: NPY02, RATNPY, RATNPY02, pro-neuropeptide Y
Species: rat
Products:     Npy

Top Publications

  1. Melas P, Mannervik M, Mathe A, Lavebratt C. Neuropeptide Y: identification of a novel rat mRNA splice-variant that is downregulated in the hippocampus and the prefrontal cortex of a depression-like model. Peptides. 2012;35:49-55 pubmed publisher
    Neuropeptide Y (NPY) is known to influence emotional processing and decreased NPY levels have been associated with mood and anxiety disorders...
  2. Thorsell A, Michalkiewicz M, Dumont Y, Quirion R, Caberlotto L, Rimondini R, et al. Behavioral insensitivity to restraint stress, absent fear suppression of behavior and impaired spatial learning in transgenic rats with hippocampal neuropeptide Y overexpression. Proc Natl Acad Sci U S A. 2000;97:12852-7 pubmed
    Exogenous neuropeptide Y (NPY) reduces experimental anxiety in a wide range of animal models...
  3. Holliday N, Lam C, Tough I, Cox H. Role of the C terminus in neuropeptide Y Y1 receptor desensitization and internalization. Mol Pharmacol. 2005;67:655-64 pubmed
    We have studied truncation mutants of the rat neuropeptide Y (NPY) Y1 receptor lacking four (Thr361stop, Y1T361*) or eight (Ser352stop, Y1S352*) potential serine/threonine C-terminal phosphorylation sites...
  4. Bjørnebekk A, Mathe A, Brene S. The antidepressant effects of running and escitalopram are associated with levels of hippocampal NPY and Y1 receptor but not cell proliferation in a rat model of depression. Hippocampus. 2010;20:820-8 pubmed publisher
    ..treatments: escitalopram, voluntary running, and their combination on hippocampal cell proliferation, NPY and the NPY-Y1 receptor mRNAs, targets assumed to be important for hippocampal plasticity and mood disorders...
  5. Tiesjema B, la Fleur S, Luijendijk M, Adan R. Sustained NPY overexpression in the PVN results in obesity via temporarily increasing food intake. Obesity (Silver Spring). 2009;17:1448-50 pubmed publisher
    Increasing neuropeptide Y (NPY) signaling in the paraventricular nucleus (PVN) by recombinant adeno-associated virus (rAAV)-mediated overexpression of NPY in rats, results in hyperphagia and obesity in rats...
  6. Heilig M, Zachrisson O, Thorsell A, Ehnvall A, Mottagui Tabar S, Sjogren M, et al. Decreased cerebrospinal fluid neuropeptide Y (NPY) in patients with treatment refractory unipolar major depression: preliminary evidence for association with preproNPY gene polymorphism. J Psychiatr Res. 2004;38:113-21 pubmed
    Extensive animal studies suggest neuropeptide Y (NPY) to be involved in coping with a wide range of stressors, and that impaired central NPY signalling could be involved in the pathophysiology of anxiety and depression...
  7. Garcia M, Lopez M, Gualillo O, Seoane L, Dieguez C, Señarís R. Hypothalamic levels of NPY, MCH, and prepro-orexin mRNA during pregnancy and lactation in the rat: role of prolactin. FASEB J. 2003;17:1392-400 pubmed
    ..the increased feeding in these situations, we measured hypothalamic mRNA levels of three orexigenic neuropeptides--NPY, MCH, and orexins--in nonpregnant, pregnant, and lactating rats by in situ hybridization...
  8. Tiesjema B, Adan R, Luijendijk M, Kalsbeek A, la Fleur S. Differential effects of recombinant adeno-associated virus-mediated neuropeptide Y overexpression in the hypothalamic paraventricular nucleus and lateral hypothalamus on feeding behavior. J Neurosci. 2007;27:14139-46 pubmed
    It is well known that neuropeptide Y (NPY) increases food intake. The hypothalamic paraventricular nucleus (PVN) and the lateral hypothalamus (LH) are both involved in the acute, hyperphagic effects of NPY...
  9. Sanchez E, Singru P, Acharya R, Bodria M, Fekete C, Zavacki A, et al. Differential effects of refeeding on melanocortin-responsive neurons in the hypothalamic paraventricular nucleus. Endocrinology. 2008;149:4329-35 pubmed publisher
    ..ARC), c-fos immunoreactivity (IR) in the PVN and ARC 2 h after refeeding and hypothalamic TRH, neuropeptide Y (NPY) and agouti-related protein (AGRP) mRNA levels 4, 12, and 24 h after refeeding were studied in Sprague-Dawley rats ..

More Information

Publications62

  1. Gardiner J, Kong W, Ward H, Murphy K, Dhillo W, Bloom S. AAV mediated expression of anti-sense neuropeptide Y cRNA in the arcuate nucleus of rats results in decreased weight gain and food intake. Biochem Biophys Res Commun. 2005;327:1088-93 pubmed
    Neuropeptide Y (NPY) is the most potent stimulant of feeding when administered by intracerebroventricular injection...
  2. Bi S, Robinson B, Moran T. Acute food deprivation and chronic food restriction differentially affect hypothalamic NPY mRNA expression. Am J Physiol Regul Integr Comp Physiol. 2003;285:R1030-6 pubmed
    ..hypothalamic peptide systems involved in energy homeostasis, we compared patterns of hypothalamic neuropeptide Y (NPY), agouti-related protein (AgRP), proopiomelanocotin (POMC), and leptin receptor gene expression in acutely food-..
  3. Raposinho P, Pierroz D, Broqua P, White R, Pedrazzini T, Aubert M. Chronic administration of neuropeptide Y into the lateral ventricle of C57BL/6J male mice produces an obesity syndrome including hyperphagia, hyperleptinemia, insulin resistance, and hypogonadism. Mol Cell Endocrinol. 2001;185:195-204 pubmed
    Neuropeptide Y (NPY) is involved in the central regulation of appetite, sexual behavior, and reproductive function...
  4. Donner J, Sipilä T, Ripatti S, Kananen L, Chen X, Kendler K, et al. Support for involvement of glutamate decarboxylase 1 and neuropeptide Y in anxiety susceptibility. Am J Med Genet B Neuropsychiatr Genet. 2012;159B:316-27 pubmed publisher
    ..0009). We additionally found that SNPs and haplotypes in neuropeptide Y (NPY) modified the effect of childhood adversities on anxiety susceptibility (P?=?0.003)...
  5. van den Hoek A, Van Heijningen C, Schröder van der Elst J, Ouwens D, Havekes L, Romijn J, et al. Intracerebroventricular administration of neuropeptide Y induces hepatic insulin resistance via sympathetic innervation. Diabetes. 2008;57:2304-10 pubmed publisher
    We recently showed that intracerebroventricular infusion of neuropeptide Y (NPY) hampers inhibition of endogenous glucose production (EGP) by insulin in mice...
  6. Kristensen P, Judge M, Thim L, Ribel U, Christjansen K, Wulff B, et al. Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature. 1998;393:72-6 pubmed
    ..An antiserum against CART increases feeding in normal rats, indicating that CART may be an endogenous inhibitor of food intake in normal animals. ..
  7. Bundzikova J, Pirnik Z, Zelena D, Mikkelsen J, Kiss A. The ?2-adrenoceptors do not modify the activity of tyrosine hydroxylase, corticoliberine, and neuropeptide Y producing hypothalamic magnocellular neurons ion the Long Evans and Brattleboro rats. J Physiol Pharmacol. 2010;61:391-8 pubmed
    ..In this study, tyrosine hydroxylase (TH), corticoliberine (CRH), and neuropeptide Y(NPY) magnocellular phenotypes, were analysed in response to alpha(2)-adrenoceptor manipulations and sustained ..
  8. Goto M, Arima H, Hiroi M, Shimizu H, Watanabe M, Hayashi M, et al. Insulin is not a prerequisite for rapid regulation of neuropeptide Y gene transcription in the arcuate nucleus in food-restricted rats. Neurosci Lett. 2007;420:61-5 pubmed
    Neuropeptide Y (NPY), synthesized in the arcuate nucleus of the hypothalamus, is one of the most potent orexigenic neuropeptides in the brain...
  9. Oh S, D Angelo I, Lee E, Chun M, Brecha N. Distribution and synaptic connectivity of neuropeptide Y-immunoreactive amacrine cells in the rat retina. J Comp Neurol. 2002;446:219-34 pubmed
    Neuropeptide Y (NPY) is a potent bioactive peptide that is widely expressed in the nervous system, including the retina...
  10. Zhiguo W, Long L, Xiao B, Chen S, Yi F. [Number changes and axonal sprouting of neuropeptide Y interneurons in the hippocampus of pilocarpine-induced rats]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2009;34:93-8 pubmed
    To investigate the role of neuropeptide Y(NPY) positive interneurons in the generation and compensation of temporal lobe epilepsy. Pilocarpine-induced rat model was founded...
  11. Tsai Y, Lin C, Huang C, Wang H, Tien L, Chen S, et al. Neuropeptide Y modulates c-Fos protein expression in the cuneate nucleus and contributes to mechanical hypersensitivity following rat median nerve injury. J Neurotrauma. 2009;26:1609-21 pubmed publisher
    This study sought to investigate the effects of injury-induced neuropeptide Y (NPY) on c-Fos expression in the cuneate neurons and neuropathic pain after median nerve injury...
  12. Melhorn S, Krause E, Scott K, Mooney M, Johnson J, Woods S, et al. Meal patterns and hypothalamic NPY expression during chronic social stress and recovery. Am J Physiol Regul Integr Comp Physiol. 2010;299:R813-22 pubmed publisher
    ..Hypothalamic neuropeptide Y (NPY) mRNA levels were not different between these groups during the experimental period...
  13. Leitermann R, Rostkowski A, Urban J. Neuropeptide Y input to the rat basolateral amygdala complex and modulation by conditioned fear. J Comp Neurol. 2016;524:2418-39 pubmed publisher
    Within the basolateral amygdaloid complex (BLA), neuropeptide Y (NPY) buffers against protracted anxiety and fear...
  14. Ross A, Johnson C, Bell L, Reilly L, Duncan J, Barrett P, et al. Divergent regulation of hypothalamic neuropeptide Y and agouti-related protein by photoperiod in F344 rats with differential food intake and growth. J Neuroendocrinol. 2009;21:610-9 pubmed publisher
    ..In F344/N rats, marked, but opposite, changes in the genes for neuropeptide Y (NPY) (+97.5%) and agouti-related protein (AgRP) (-39...
  15. Primeaux S, York D, Bray G. Neuropeptide Y administration into the amygdala alters high fat food intake. Peptides. 2006;27:1644-51 pubmed
    The orexigenic effects of neuropeptide Y (NPY) are mediated through the hypothalamus, while the anxiolytic effects of NPY appear to be mediated through the amygdala...
  16. Masliukov P, Moiseev K, Emanuilov A, Anikina T, Zverev A, Nozdrachev A. Development of neuropeptide Y-mediated heart innervation in rats. Neuropeptides. 2016;55:47-54 pubmed publisher
    Neuropeptide Y (NPY) plays a trophic role in the nervous and vascular systems and in cardiac hypertrophy. However, there is no report concerning the expression of NPY and its receptors in the heart during postnatal development...
  17. Palou M, SANCHEZ J, Rodriguez A, Priego T, Pico C, Palou A. Induction of NPY/AgRP orexigenic peptide expression in rat hypothalamus is an early event in fasting: relationship with circulating leptin, insulin and glucose. Cell Physiol Biochem. 2009;23:115-24 pubmed publisher
    ..energy intake and expenditure in mammals, presenting two interconnected populations of neurons producing orexigenic NPY/AgRP (neuropeptide Y; agouti related peptide) and anorexigenic POMC/CART (pro-opiomelanocortin; cocaine and ..
  18. Briski K, Parihar M. Effects of orchidectomy on adaptation of arcuate neuropeptide Y, proopiomelanocortin, and cocaine- and amphetamine-related transcript gene profiles to recurring insulin-induced hypoglycemia in the male rat. Neuropeptides. 2008;42:585-91 pubmed publisher
    ..regulates the expression of ARH neuropeptide genes of characterized metabolic relevance, including neuropeptide Y (NPY) and proopiomelanocortin (POMC)...
  19. Jang M, Shin M, Kim K, Cho S, Bahn G, Kim E, et al. Nicotine administration decreases neuropeptide Y expression and increases leptin receptor expression in the hypothalamus of food-deprived rats. Brain Res. 2003;964:311-5 pubmed
    The effects of nicotine on the expressions of neuropeptide Y (NPY) and leptin receptor in the rat hypothalamus were investigated via immunohistochemistry...
  20. Caminos J, Bravo S, González C, Garcés M, Cepeda L, González A, et al. Food-intake-regulating-neuropeptides are expressed and regulated through pregnancy and following food restriction in rat placenta. Reprod Biol Endocrinol. 2008;6:14 pubmed publisher
    Neuropeptide Y (NPY), agouti related peptide (AgRP), cocaine and amphetamine-regulated transcript (CART) and melanocortins, the products of the proopiomelanocortin (POMC), are hypothalamic peptides involved in feeding regulation and ..
  21. Gelfo F, De Bartolo P, Tirassa P, Croce N, Caltagirone C, Petrosini L, et al. Intraperitoneal injection of neuropeptide Y (NPY) alters neurotrophin rat hypothalamic levels: Implications for NPY potential role in stress-related disorders. Peptides. 2011;32:1320-3 pubmed publisher
    Neuropeptide Y (NPY) is a 36-amino acid peptide which exerts several regulatory actions within peripheral and central nervous systems...
  22. Coronel M, Villar M, Brumovsky P, Gonzalez S. Spinal neuropeptide expression and neuropathic behavior in the acute and chronic phases after spinal cord injury: Effects of progesterone administration. Peptides. 2017;88:189-195 pubmed publisher
    ..In the present study, we explored temporal changes in the expression of the neuropeptides galanin and tyrosine (NPY) and their receptors (GalR1 and GalR2; Y1R and Y2R, respectively) in the injured spinal cord and evaluated the ..
  23. Tu B, Timofeeva O, Jiao Y, Nadler J. Spontaneous release of neuropeptide Y tonically inhibits recurrent mossy fiber synaptic transmission in epileptic brain. J Neurosci. 2005;25:1718-29 pubmed
    ..In the pilocarpine model of temporal lobe epilepsy, mossy fibers coexpress the inhibitory transmitter neuropeptide Y (NPY) with glutamate...
  24. Morrison J, Dhanasekaran S, Howarth F. Neuropeptide Y and CGRP concentrations in the rat tail artery: Effects of age and two types of diabetes. Peptides. 2009;30:710-4 pubmed publisher
    The changes in concentrations of two neuropeptides, neuropeptide Y (NPY) and calcitonin gene-related peptide (CGRP) in different segments of the rat tail artery have been investigated (a) after 12 and 16 weeks of streptozotocin (STZ)-..
  25. Rocha A, Guerra Sa R, Silveira N, Anselmo Franci J, Franci C. Neuropeptide Y in the medial basal hypothalamus and medial preoptic area during the induction of LH surge may be controlled by locus coeruleus. Neuropeptides. 2006;40:57-63 pubmed
    ..releasing hormone (GnRH)/luteinizing hormone (LH) secretion involves locus coeruleus (LC) and neuropeptide Y (NPY)...
  26. Zeng C, Wang X, Liu G, Yang C. Effects of ACE inhibitor and beta-adrenergic blocker on plasma NPY and NPY receptors in aortic vascular smooth muscle cells from SHR and WKY rats. Neuropeptides. 2002;36:353-61 pubmed
    ..enzyme (ACE) inhibitor, peridopril, and the beta-adrenergic blocker, metoprolol, on plasma neuropeptide Y (NPY), and NPY receptors in aortic vascular smooth muscle cells (VSMCs) from normotensive Wistar-Kyoto (WKY) rats and ..
  27. Nergårdh R, Ammar A, Brodin U, Bergstrom J, Scheurink A, Södersten P. Neuropeptide Y facilitates activity-based-anorexia. Psychoneuroendocrinology. 2007;32:493-502 pubmed
    The hypothesis that treatment with neuropeptide Y (NPY) can increase running activity and decrease food intake and body weight was tested...
  28. Larhammar D, Ericsson A, Persson H. Structure and expression of the rat neuropeptide Y gene. Proc Natl Acad Sci U S A. 1987;84:2068-72 pubmed
    ..The level of neuropeptide Y mRNA was also studied in several rat peripheral organs. Unexpectedly high levels were observed in heart and spleen. This mRNA may be synthesized in intrinsic ganglia and non-neuronal cells, respectively. ..
  29. Wang J, Chen C, Wang R. Influence of short- and long-term treadmill exercises on levels of ghrelin, obestatin and NPY in plasma and brain extraction of obese rats. Endocrine. 2008;33:77-83 pubmed publisher
    ..Concentrations of ghrelin, obestatin, and neuropeptide Y (NPY) were measured using radio immuno-assay...
  30. Duan H, Hao C, Fan Y, Wang H, Liu Y, Hao J, et al. The role of neuropeptide Y and aquaporin 4 in the pathogenesis of intestinal dysfunction caused by traumatic brain injury. J Surg Res. 2013;184:1006-12 pubmed publisher
    ..Experiments were designed to study the roles of neuropeptide Y (NPY) and aquaporin 4 (AQP4) in the pathogenesis of intestinal dysfunction caused by TBI and to find some new solutions ..
  31. Fujisawa A, Matsuwaki T, Yamanouchi K, Nishihara M. Possible involvement of neuropeptide Y in photo-induced suppression of growth hormone pulses. J Vet Med Sci. 2013;75:275-81 pubmed
    ..the GH pulse-generating mechanism is not fully understood, we have previously reported that neuropeptide Y (NPY) profiles in the cerebrospinal fluid were negatively correlated with serum GH pulses...
  32. Corder R, Gaillard R, Bohlen P. Isolation and sequence of rat peptide YY and neuropeptide Y. Regul Pept. 1988;21:253-61 pubmed
    ..Immunoreactivity was identified using a combination of 3 NPY immunoassays which exhibit differing cross-reactivities for PYY (90%, less than 0.01% and 30% respectively)...
  33. Fekete C, Sarkar S, Rand W, Harney J, Emerson C, Bianco A, et al. Neuropeptide Y1 and Y5 receptors mediate the effects of neuropeptide Y on the hypothalamic-pituitary-thyroid axis. Endocrinology. 2002;143:4513-9 pubmed
    Neuropeptide Y (NPY) is one of the most important hypothalamic-derived neuropeptides mediating the effects of leptin on energy homeostasis...
  34. Cifani C, Durocher Y, Pathak A, Penicaud L, Smih F, Massi M, et al. Possible common central pathway for resistin and insulin in regulating food intake. Acta Physiol (Oxf). 2009;196:395-400 pubmed publisher
    ..In addition, we examined how RSTN might affect neuropeptide Y (NPY)-induced feeding, as studies have shown that rat RSTN can interfere with the NPY system...
  35. Yalamuri S, Brennan T, Spofford C. Neuropeptide Y is analgesic in rats after plantar incision. Eur J Pharmacol. 2013;698:206-12 pubmed publisher
    Previous work has demonstrated that neuropeptide tyrosine (NPY), Y(1) receptor and Y(2) receptor are critical in modulation of pain after nerve injury. We hypothesized that NPY was important for nociception after surgical incision...
  36. Evanson K, Stone A, Hammond A, Kluess H. Neuropeptide Y overflow and metabolism in skeletal muscle arterioles. J Physiol. 2011;589:3309-18 pubmed publisher
    The purpose of this study was to characterize neuropeptide Y (NPY) overflow and metabolism from isolated skeletal muscle arterioles of female rats...
  37. Sucajtys Szulc E, Goyke E, Korczynska J, Stelmanska E, Rutkowski B, Swierczynski J. Chronic food restriction differentially affects NPY mRNA level in neurons of the hypothalamus and in neurons that innervate liver. Neurosci Lett. 2008;433:174-7 pubmed publisher
    Neuropeptide Y (NPY) is found in neurons of the brain and in the neurons that innervate abdominal organs including liver. Major biological function of hypothalamic NPY is regulation of appetite and body weight homeostasis...
  38. Byku M, Macarthur H, Westfall T. Nerve stimulation induced overflow of neuropeptide Y and modulation by angiotensin II in spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol. 2008;295:H2188-97 pubmed publisher
    ..We demonstrated that periarterial nerve stimulation (NS) increased the perfusion pressure (PP) and neuropeptide Y (NPY) overflow from perfused mesenteric arterial beds of SHRs at 4-6, 10-12, and 18-20 wk of age, which correspond to ..
  39. Melas P, Lennartsson A, Vakifahmetoglu Norberg H, Wei Y, Aberg E, Werme M, et al. Allele-specific programming of Npy and epigenetic effects of physical activity in a genetic model of depression. Transl Psychiatry. 2013;3:e255 pubmed publisher
    Neuropeptide Y (NPY) has been implicated in depression, emotional processing and stress response. Part of this evidence originates from human single-nucleotide polymorphism (SNP) studies...
  40. Crnkovic S, Egemnazarov B, Jain P, Seay U, Gattinger N, Marsh L, et al. NPY/Y? receptor-mediated vasoconstrictory and proliferative effects in pulmonary hypertension. Br J Pharmacol. 2014;171:3895-907 pubmed publisher
    ..Here, we have examined the role of the neuropeptide Y (NPY) and its Y? receptor in PH pathogenesis. NPY was localized by immunofluorescence...
  41. Li L, Jonsson Rylander A, Abe K, Zukowska Z. Chronic stress induces rapid occlusion of angioplasty-injured rat carotid artery by activating neuropeptide Y and its Y1 receptors. Arterioscler Thromb Vasc Biol. 2005;25:2075-80 pubmed
    We reported previously that neuropeptide Y (NPY) induces an atherosclerotic-like lesion that is significantly reduced by NPY-Y1 and NPY-Y5 receptor (R) inhibitors...
  42. Shi J, Yan J, Lei Q, Zhao J, Chen K, Yang D, et al. Intragastric administration of evodiamine suppresses NPY and AgRP gene expression in the hypothalamus and decreases food intake in rats. Brain Res. 2009;1247:71-8 pubmed publisher
    ..decreased rate of food intake and body weight increase following rat growth, reduced orexigenic neuropeptide Y (NPY) and agouti-gene related protein (AgRP) mRNA levels and NPY peptide level in the arcuate nucleus (ARC) of the ..
  43. Treesukosol Y, Bi S, Moran T. Overexpression of neuropeptide Y in the dorsomedial hypothalamus increases trial initiation but does not significantly alter concentration-dependent licking to sucrose in a brief-access taste test. Physiol Behav. 2013;110-111:109-14 pubmed publisher
    Evidence in the literature raises the possibility that alterations in neuropeptide Y (NPY) in the dorsomedial hypothalamus (DMH) may contribute to hyperphagia leading to body weight gain...
  44. Kas M, Bruijnzeel A, Haanstra J, Wiegant V, Adan R. Differential regulation of agouti-related protein and neuropeptide Y in hypothalamic neurons following a stressful event. J Mol Endocrinol. 2005;35:159-64 pubmed
    ..Neuropeptide Y (NPY) and agouti-related protein (AgRP) are potent food-stimulating neuropeptides that are highly co-localised in ..
  45. Saderi N, Cázarez Márquez F, Buijs F, Salgado Delgado R, Guzman Ruiz M, del Carmen Basualdo M, et al. The NPY intergeniculate leaflet projections to the suprachiasmatic nucleus transmit metabolic conditions. Neuroscience. 2013;246:291-300 pubmed publisher
    ..The following groups of male Wistar rats were used for analysis of neuropeptide Y (NPY) and c-Fos in the IGL and SCN. (1) Fed ad libitum. (2) Fasted for 48 h...
  46. Di Yorio M, Bilbao M, Faletti A. Neuropeptide Y regulates the leptin receptors in rat hypothalamic and pituitary explant cultures. Regul Pept. 2014;188:13-20 pubmed publisher
    ..of leptin receptors (OBR) in the hypothalamic-pituitary (HP) axis is regulated by the orexigenic neuropeptide Y (NPY) during ovulation...
  47. Jia C, Hegg C. Effect of IP3R3 and NPY on age-related declines in olfactory stem cell proliferation. Neurobiol Aging. 2015;36:1045-56 pubmed publisher
    ..expresses both inositol trisphosphate receptor type 3 (IP3R3) and the neuroproliferative factor neuropeptide Y (NPY) is critical for regulation of homeostasis, yet its role in aging is undefined...
  48. Bundzikova J, Pirnik Z, Lackovicova L, Mravec B, Kiss A. Activation of different neuronal phenotypes in the rat brain induced by liver ischemia–reperfusion injury: dual Fos/neuropeptide immunohistochemistry. Cell Mol Neurobiol. 2011;31:293-301 pubmed publisher
    ..hydroxylase (TH), phenylethanolamine N-methyltransferase (PNMT), corticoliberine (CRH), and neuropeptide Y (NPY) immunohistochemistry...
  49. Konno J, Yoshida S, Ina A, Ohmomo H, Shutoh F, Nogami H, et al. Upregulated expression of neuropeptide Y in hypothalamic-pituitary system of rats by chronic dexamethasone administration. Neurosci Res. 2008;60:259-65 pubmed publisher
    To study the effect of adrenal steroids on neuropeptide Y (NPY) synthesis in the hypothalamic-pituitary system, we examined NPY expression in rats treated with dexamethasone (a synthetic glucocorticoid) by in situ hybridization and ..
  50. Kuo D. Involvement of hypothalamic neuropeptide Y in regulating the amphetamine-induced appetite suppression in streptozotocin diabetic rats. Regul Pept. 2005;127:19-26 pubmed
    ..In normal rats, AMPH-induced anorexia has been attributed to its inhibitory action on hypothalamic neuropeptide Y (NPY), an appetite stimulant in the brain...
  51. Fodor M, van Elk E, Huizinga C, Prins T, Delemarre van de Waal H. NPY neurons express somatostatin receptor subtype 1 in the arcuate nucleus. Neuroreport. 2005;16:29-32 pubmed
    ..Neuropeptide Y (NPY)-containing neurons function as direct transducers for GH feedback...
  52. Wieronska J, Branski P, Pałvcha A, Śmiałowska M. The effect of competitive and non-competitive NMDA receptor antagonists, ACPC and MK-801 on NPY and CRF-like immunoreactivity in the rat brain amygdala. Neuropeptides. 2001;35:219-26 pubmed
    ..for integrating all behavior connected with fear, and in this structure two neuropeptides, neuropeptide Y (NPY), corticoliberin (CRF) and the most abundant excitatory neurotransmitter glutamate seem to take part in the ..
  53. Schmitz J, Zakrzewicz A, Wilker S, Kuncová J, Hecker A, Grau V, et al. Non-neuronal neuropeptide Y and its receptors during acute rejection of rat pulmonary allografts. Transpl Immunol. 2017;43-44:49-53 pubmed publisher
    This study tested the hypothesis that neuropeptide Y (NPY) and NPY receptors 1 (Y1) and 2 (Y2) participate in lung allograft rejection...