Npm1

Summary

Gene Symbol: Npm1
Description: nucleophosmin 1
Alias: B23NP, nucleophosmin, NPM, nucleolar phosphoprotein B23, nucleolar protein B23.1, nucleolar protein NO38, nucleophosmin (nucleolar phosphoprotein B23, numatrin), numatrin
Species: rat
Products:     Npm1

Top Publications

  1. Falini B, Mecucci C, Tiacci E, Alcalay M, Rosati R, Pasqualucci L, et al. Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype. N Engl J Med. 2005;352:254-66 pubmed
    b>Nucleophosmin (NPM), a nucleocytoplasmic shuttling protein with prominent nucleolar localization, regulates the ARF-p53 tumor-suppressor pathway. Translocations involving the NPM gene cause cytoplasmic dislocation of the NPM protein...
  2. Ahn J, Liu X, Cheng D, Peng J, Chan P, Wade P, et al. Nucleophosmin/B23, a nuclear PI(3,4,5)P(3) receptor, mediates the antiapoptotic actions of NGF by inhibiting CAD. Mol Cell. 2005;18:435-45 pubmed
    ..Here, we describe a nuclear PI(3,4,5)P(3) receptor, nucleophosmin (NPM)/B23, that mediates the antiapoptotic effects of NGF by inhibiting DNA fragmentation activity of caspase-..
  3. Grisendi S, Bernardi R, Rossi M, Cheng K, Khandker L, Manova K, et al. Role of nucleophosmin in embryonic development and tumorigenesis. Nature. 2005;437:147-53 pubmed
    b>Nucleophosmin (also known as NPM, B23, NO38) is a nucleolar protein directly implicated in cancer pathogenesis, as the NPM1 gene is found mutated and rearranged in a number of haematological disorders...
  4. Wang W, Budhu A, Forgues M, Wang X. Temporal and spatial control of nucleophosmin by the Ran-Crm1 complex in centrosome duplication. Nat Cell Biol. 2005;7:823-30 pubmed
    ..Here, we discover that nucleophosmin (NPM) may be a Ran-Crm1 substrate that controls centrosome duplication...
  5. Lee S, Xuan Nguyen T, Choi J, Lee K, Cho S, Liu Z, et al. Nuclear Akt interacts with B23/NPM and protects it from proteolytic cleavage, enhancing cell survival. Proc Natl Acad Sci U S A. 2008;105:16584-9 pubmed publisher
    B23/NPM is a major nucleolar phosphoprotein that has a critical role in cell proliferation and cell death...
  6. Colombo E, Marine J, Danovi D, Falini B, Pelicci P. Nucleophosmin regulates the stability and transcriptional activity of p53. Nat Cell Biol. 2002;4:529-33 pubmed
    b>Nucleophosmin (NPM) is a ubiquitously expressed nucleolar phosphoprotein that continuously shuttles between the nucleus and cytoplasm...
  7. Szebeni A, Olson M. Nucleolar protein B23 has molecular chaperone activities. Protein Sci. 1999;8:905-12 pubmed
    ..Thus, by several criteria, protein B23 behaves like a molecular chaperone; these activities may be related to its role in ribosome biogenesis. ..
  8. Okuda M, Horn H, Tarapore P, Tokuyama Y, Smulian A, Chan P, et al. Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication. Cell. 2000;103:127-40 pubmed
    ..We identified nucleophosmin (NPM/B23) as a substrate of CDK2/cyclin E in centrosome duplication...
  9. Colombo E, Bonetti P, Lazzerini Denchi E, Martinelli P, Zamponi R, Marine J, et al. Nucleophosmin is required for DNA integrity and p19Arf protein stability. Mol Cell Biol. 2005;25:8874-86 pubmed
    b>Nucleophosmin (NPM) is a nucleolar phosphoprotein that binds the tumor suppressors p53 and p19(Arf) and is thought to be indispensable for ribogenesis, cell proliferation, and survival after DNA damage...

More Information

Publications62

  1. Vassiliou G, Cooper J, Rad R, Li J, Rice S, Uren A, et al. Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice. Nat Genet. 2011;43:470-5 pubmed publisher
    ..with a poor prognosis whose largest subgroup is characterized by somatic mutations in NPM1, which encodes nucleophosmin. These mutations, termed NPM1c, result in cytoplasmic dislocation of nucleophosmin and are associated with ..
  2. Nishimura Y, Ohkubo T, Furuichi Y, Umekawa H. Tryptophans 286 and 288 in the C-terminal region of protein B23.1 are important for its nucleolar localization. Biosci Biotechnol Biochem. 2002;66:2239-42 pubmed
    ..1 mutant proteins fused with green fluorescent protein in HeLa cells. The results suggested that the two C-terminal tryptophan residues (Trp-286 and Trp-288) of protein B23.1 were important in this phenomenon. ..
  3. Wu M, Yung B. UV stimulation of nucleophosmin/B23 expression is an immediate-early gene response induced by damaged DNA. J Biol Chem. 2002;277:48234-40 pubmed
    b>Nucleophosmin/B23 (NPM/B23), a nucleolar protein, was rapidly up-regulated after UV irradiation (at 254 nm; 30 J/m(2)) in NIH 3T3 cells and HeLa/S3 cells...
  4. Okuwaki M, Matsumoto K, Tsujimoto M, Nagata K. Function of nucleophosmin/B23, a nucleolar acidic protein, as a histone chaperone. FEBS Lett. 2001;506:272-6 pubmed
    We previously identified and purified a nucleolar phosphoprotein, nucleophosmin/B23, as a stimulatory factor for replication from the adenovirus chromatin...
  5. Umekawa H, Sato K, Takemura M, Watanabe Y, Usui S, Takahashi T, et al. The carboxyl terminal sequence of nucleolar protein B23.1 is important in its DNA polymerase alpha-stimulatory activity. J Biochem. 2001;130:199-205 pubmed
    ..1, which are absent in B23.2, may be essential for the full stimulation of the DNA polymerase alpha. ..
  6. Li Y. Protein B23 is an important human factor for the nucleolar localization of the human immunodeficiency virus protein Tat. J Virol. 1997;71:4098-102 pubmed
    ..These data suggest that B23 is a human factor necessary for the nucleolar localization of Tat...
  7. Bonetti P, Davoli T, Sironi C, Amati B, Pelicci P, Colombo E. Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7 gamma. J Cell Biol. 2008;182:19-26 pubmed publisher
    Mutations leading to aberrant cytoplasmic localization of nucleophosmin (NPM) are the most frequent genetic alteration in acute myelogenous leukemia (AML). NPM binds the Arf tumor suppressor and protects it from degradation...
  8. Krause A, Hoffmann I. Polo-like kinase 2-dependent phosphorylation of NPM/B23 on serine 4 triggers centriole duplication. PLoS ONE. 2010;5:e9849 pubmed publisher
    ..In search for Plk2 interacting proteins we have identified NPM/B23 (Nucleophosmin) as a novel Plk2 binding partner...
  9. Chang J, Olson M. A single gene codes for two forms of rat nucleolar protein B23 mRNA. J Biol Chem. 1989;264:11732-7 pubmed
    ..1. Exons X and Z each contain distinct 3'-untranslated sequences in which are found polyadenylation signals. These data suggest that two different mRNAs are formed by alternative splicing of separate 3' segments onto a common 5' region. ..
  10. Mekhail K, Khacho M, Carrigan A, Hache R, Gunaratnam L, Lee S. Regulation of ubiquitin ligase dynamics by the nucleolus. J Cell Biol. 2005;170:733-44 pubmed
    ..Data shown here provide the first evidence that cells have evolved a mechanism to regulate molecular networks by reversibly switching proteins between a mobile and static state. ..
  11. Tarapore P, Shinmura K, Suzuki H, Tokuyama Y, Kim S, Mayeda A, et al. Thr199 phosphorylation targets nucleophosmin to nuclear speckles and represses pre-mRNA processing. FEBS Lett. 2006;580:399-409 pubmed
    b>Nucleophosmin (NPM) is a multifunctional phosphoprotein, being involved in ribosome assembly, pre-ribosomal RNA processing, DNA duplication, nucleocytoplasmic protein trafficking, and centrosome duplication...
  12. Takemura M, Ohta N, Furuichi Y, Takahashi T, Yoshida S, Olson M, et al. Stimulation of calf thymus DNA polymerase alpha activity by nucleolar protein B23. Biochem Biophys Res Commun. 1994;199:46-51 pubmed
    ..1 from Novikoff cells. In contrast, isoform B23.2 showed no effect on the activity of DNA polymerase alpha, suggesting that C-terminal region of B23.1 is important in its activity in the stimulation of DNA polymerase alpha. ..
  13. Okada M, Jang S, Ye K. Ebp1 association with nucleophosmin/B23 is essential for regulating cell proliferation and suppressing apoptosis. J Biol Chem. 2007;282:36744-54 pubmed
    Ebp1 and NPM/B23 are essential for cell proliferation and survival. Ebp1 possesses p42 and p48 isoforms. Whereas p42 exclusively resides in the cytoplasm, p48 localizes in both the cytoplasm and the nucleolus...
  14. Chen H, Li Z, Haruna K, Li Z, Li Z, Semba K, et al. Early pre-implantation lethality in mice carrying truncated mutation in the RNA polymerase 1-2 gene. Biochem Biophys Res Commun. 2008;365:636-42 pubmed
    ..These results indicate that the loss of rDNA transcription induced nucleolar structure disorganization and apoptosis in preimplantation embryos. ..
  15. Yun J, Chew E, Liew C, Chan J, Jin M, Ding M, et al. Nucleophosmin/B23 is a proliferate shuttle protein associated with nuclear matrix. J Cell Biochem. 2003;90:1140-8 pubmed
    It has become obvious that a better understanding and potential elucidation of the nucleolar phosphoprotein B23 involving in functional interrelationship between nuclear organization and gene expression...
  16. Shinmura K, Tarapore P, Tokuyama Y, George K, Fukasawa K. Characterization of centrosomal association of nucleophosmin/B23 linked to Crm1 activity. FEBS Lett. 2005;579:6621-34 pubmed
    b>Nucleophosmin (NPM)/B23 is a multifunctional protein, involving in a wide variety of basic cellular processes, including ribosome assembly, DNA duplication, nucleocytoplasmic trafficking, and centrosome duplication...
  17. Lindström M, Zhang Y. Ribosomal protein S9 is a novel B23/NPM-binding protein required for normal cell proliferation. J Biol Chem. 2008;283:15568-76 pubmed publisher
    B23 (NPM/nucleophosmin) is a multifunctional nucleolar protein and a member of the nucleoplasmin superfamily of acidic histone chaperones...
  18. Liu X, Liu D, Qian D, Dai J, An Y, Jiang S, et al. Nucleophosmin (NPM1/B23) interacts with activating transcription factor 5 (ATF5) protein and promotes proteasome- and caspase-dependent ATF5 degradation in hepatocellular carcinoma cells. J Biol Chem. 2012;287:19599-609 pubmed publisher
    b>Nucleophosmin (NPM1/B23) and the activating transcription factor 5 (ATF5) are both known to subject to cell type-dependent regulation...
  19. Mitrea D, Grace C, Buljan M, Yun M, Pytel N, Satumba J, et al. Structural polymorphism in the N-terminal oligomerization domain of NPM1. Proc Natl Acad Sci U S A. 2014;111:4466-71 pubmed publisher
    b>Nucleophosmin (NPM1) is a multifunctional phospho-protein with critical roles in ribosome biogenesis, tumor suppression, and nucleolar stress response...
  20. Chang J, Dumbar T, Olson M. cDNA and deduced primary structure of rat protein B23, a nucleolar protein containing highly conserved sequences. J Biol Chem. 1988;263:12824-7 pubmed
    ..S., Hügle-Dörr, B., and Franke, W. (1987) EMBO J. 6, 1881-1890). Except for the presence of highly acidic regions no significant similarities were found with protein C23 (nucleolin), the other major nucleolar protein. ..
  21. Chou S, Ko B, Chiou J, Hsu Y, Tsai M, Chiu Y, et al. A knock-in Npm1 mutation in mice results in myeloproliferation and implies a perturbation in hematopoietic microenvironment. PLoS ONE. 2012;7:e49769 pubmed publisher
    Somatic Nucleophosmin (NPM1) mutation frequently occurs in acute myeloid leukemia (AML), but its role in leukemogenesis remains unclear...
  22. Lee S, Kim C, Lee K, Ahn J. S-nitrosylation of B23/nucleophosmin by GAPDH protects cells from the SIAH1-GAPDH death cascade. J Cell Biol. 2012;199:65-76 pubmed publisher
    B23/nucleophosmin is a multifunctional protein that participates in cell survival signaling by shuttling between the nucleolus/nucleoplasm and nucleus/cytoplasm...
  23. Choi J, Lee S, Ahn J, Lee K. Disruption of ATP binding destabilizes NPM/B23 and inhibits anti-apoptotic function. BMB Rep. 2008;41:840-5 pubmed
    b>Nucleophosmin/B23, a major nucleolar phosphoprotein, is overexpressed in actively proliferating cells...
  24. Okuwaki M, Tsujimoto M, Nagata K. The RNA binding activity of a ribosome biogenesis factor, nucleophosmin/B23, is modulated by phosphorylation with a cell cycle-dependent kinase and by association with its subtype. Mol Biol Cell. 2002;13:2016-30 pubmed
    b>Nucleophosmin/B23 is a nucleolar phosphoprotein. It has been shown that B23 binds to nucleic acids, digests RNA, and is localized in nucleolar granular components from which preribosomal particles are transported to cytoplasm...
  25. Huang N, Negi S, Szebeni A, Olson M. Protein NPM3 interacts with the multifunctional nucleolar protein B23/nucleophosmin and inhibits ribosome biogenesis. J Biol Chem. 2005;280:5496-502 pubmed
    Protein B23/nucleophosmin is a multifunctional protein that plays roles in ribosome biogenesis, control of centrosome duplication, and regulation of p53 expression...
  26. Takemura M, Sato K, Nishio M, Akiyama T, Umekawa H, Yoshida S. Nucleolar protein B23.1 binds to retinoblastoma protein and synergistically stimulates DNA polymerase alpha activity. J Biochem. 1999;125:904-9 pubmed
    ..1 = 1:1:12. Since B23 exists as a hexamer in solution, it may act as a stimulator of DNA polymerase alpha in a form of double-hexamer, in concert with the phosphorylated retinoblastoma protein. ..
  27. Wanzel M, Russ A, Kleine Kohlbrecher D, Colombo E, Pelicci P, Eilers M. A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth. Nat Cell Biol. 2008;10:1051-61 pubmed
    ..L23 exerts this function by retaining nucleophosmin, an essential co-activator of Miz1 required for Miz1-induced cell-cycle arrest, in the nucleolus...
  28. Tawfic S, Goueli S, Olson M, Ahmed K. Androgenic regulation of the expression and phosphorylation of prostatic nucleolar protein B23. Cell Mol Biol Res. 1993;39:43-51 pubmed
    ..Thus, androgenic regulation of the amount and phosphorylation of prostatic protein B23 may be related to the early changes associated with androgen mediated growth of the gland. ..
  29. Ma Z, Kanai M, Kawamura K, Kaibuchi K, Ye K, Fukasawa K. Interaction between ROCK II and nucleophosmin/B23 in the regulation of centrosome duplication. Mol Cell Biol. 2006;26:9016-34 pubmed
    b>Nucleophosmin (NPM)/B23 has been implicated in the regulation of centrosome duplication. NPM/B23 localizes between two centrioles in the unduplicated centrosome...
  30. Avitabile D, Bailey B, Cottage C, Sundararaman B, Joyo A, McGregor M, et al. Nucleolar stress is an early response to myocardial damage involving nucleolar proteins nucleostemin and nucleophosmin. Proc Natl Acad Sci U S A. 2011;108:6145-50 pubmed publisher
    ..NS interacts with nucleophosmin (NPM), a marker of nucleolar stress with cytoprotective properties...
  31. Marquez Lona E, Tan Z, Schreiber S. Nucleolar stress characterized by downregulation of nucleophosmin: a novel cause of neuronal degeneration. Biochem Biophys Res Commun. 2012;417:514-20 pubmed publisher
    b>Nucleophosmin (NPM) is a multifunctional nucleolar protein that has been linked with nucleolar stress. In non-neuronal cell lines, NPM may enhance or inhibit the activity of tumor suppressor p53, a major apoptotic protein...
  32. Kuželová K, Brodská B, Fuchs O, Dobrovolná M, Soukup P, Cetkovský P. Altered HLA Class I Profile Associated with Type A/D Nucleophosmin Mutation Points to Possible Anti-Nucleophosmin Immune Response in Acute Myeloid Leukemia. PLoS ONE. 2015;10:e0127637 pubmed publisher
    b>Nucleophosmin 1 (NPM1) mutations are frequently found in patients with acute myeloid leukemia (AML) and the newly generated sequences were suggested to induce immune response contributing to the relatively favorable outcome of patients ..
  33. Rau R, Magoon D, Greenblatt S, Li L, Annesley C, Duffield A, et al. NPMc+ cooperates with Flt3/ITD mutations to cause acute leukemia recapitulating human disease. Exp Hematol. 2014;42:101-13.e5 pubmed publisher
    Cytoplasmic nucleophosmin (NPMc(+)) mutations and FMS-like tyrosine kinase 3 (FLT3) internal tandem duplication (ITD) mutations are two of the most common known molecular alterations in acute myeloid leukemia (AML); they frequently occur ..
  34. Vascotto C, Fantini D, Romanello M, Cesaratto L, Deganuto M, Leonardi A, et al. APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process. Mol Cell Biol. 2009;29:1834-54 pubmed publisher
    ..In particular, a novel interaction between nucleophosmin (NPM1) and APE1 was characterized...
  35. Chang J, Olson M. Structure of the gene for rat nucleolar protein B23. J Biol Chem. 1990;265:18227-33 pubmed
    ..The latter feature suggests that the B23 gene has some properties of tissue-specific genes in addition to the predominant characteristics of housekeeping genes. ..
  36. Herrera J, Correia J, Jones A, Olson M. Sedimentation analyses of the salt- and divalent metal ion-induced oligomerization of nucleolar protein B23. Biochemistry. 1996;35:2668-73 pubmed
    ..These studies suggest that protein B23 exists in an equilibrium between monomer and oligomer and that the quaternary structure of the protein may regulate its DNA binding properties. ..
  37. Weng J, Yung B. Nucleophosmin/B23 regulates PCNA promoter through YY1. Biochem Biophys Res Commun. 2005;335:826-31 pubmed
    Ectopic over-expression of nucleophosmin/B23 caused a marked up-regulation in the amounts of Yin Yang 1 (YY1) and proliferating cellular nuclear antigen (PCNA) proteins...
  38. Bischof D, Pulford K, Mason D, Morris S. Role of the nucleophosmin (NPM) portion of the non-Hodgkin's lymphoma-associated NPM-anaplastic lymphoma kinase fusion protein in oncogenesis. Mol Cell Biol. 1997;17:2312-25 pubmed
    ..75-kDa hybrid protein that contains the amino-terminal 117 amino acid residues of the nucleolar phosphoprotein nucleophosmin (NPM) joined to the entire cytoplasmic portion of the receptor tyrosine kinase ALK (anaplastic lymphoma kinase)..
  39. Zou T, Rao J, Liu L, Marasa B, Keledjian K, Zhang A, et al. Polyamine depletion induces nucleophosmin modulating stability and transcriptional activity of p53 in intestinal epithelial cells. Am J Physiol Cell Physiol. 2005;289:C686-96 pubmed
    ..b>Nucleophosmin (NPM) is a multifunctional protein that recently has been shown to regulate p53 activity...
  40. Grisendi S, Pandolfi P. NPM mutations in acute myelogenous leukemia. N Engl J Med. 2005;352:291-2 pubmed
  41. Szebeni A, Hingorani K, Negi S, Olson M. Role of protein kinase CK2 phosphorylation in the molecular chaperone activity of nucleolar protein b23. J Biol Chem. 2003;278:9107-15 pubmed
    ..These studies suggest that unlike many molecular chaperones, which directly hydrolyze ATP, substrate release by protein B23 is dependent on its phosphorylation by CK2. ..
  42. Nawa Y, Kawahara K, Tancharoen S, Meng X, Sameshima H, Ito T, et al. Nucleophosmin may act as an alarmin: implications for severe sepsis. J Leukoc Biol. 2009;86:645-53 pubmed publisher
    b>NPM is a major nucleolar multifunctional protein involved in ribosome biogenesis, centrosome duplication, cell-cycle progression, apoptosis, cell differentiation, and sensing cellular stress...
  43. Savkur R, Olson M. Preferential cleavage in pre-ribosomal RNA byprotein B23 endoribonuclease. Nucleic Acids Res. 1998;26:4508-15 pubmed
    ..These results, in conjunction with the sub-nucleolar localization of the protein with elements of the processing machinery, suggest that the protein B23 endoribonuclease could play a role in pre-rRNA processing in ITS2. ..
  44. Meder V, Boeglin M, de Murcia G, Schreiber V. PARP-1 and PARP-2 interact with nucleophosmin/B23 and accumulate in transcriptionally active nucleoli. J Cell Sci. 2005;118:211-22 pubmed
    ..PARP-2 is enriched within the whole nucleolus and partially colocalizes with the nucleolar factor nucleophosmin/B23...
  45. Biggiogera M, Burki K, Kaufmann S, Shaper J, Gas N, Amalric F, et al. Nucleolar distribution of proteins B23 and nucleolin in mouse preimplantation embryos as visualized by immunoelectron microscopy. Development. 1990;110:1263-70 pubmed
    ..Moreover, neither the localization of the two above proteins nor silver staining are unequivocally related to the nucleolar activity. ..
  46. Romanova L, Anger M, Zatsepina O, Schultz R. Implication of nucleolar protein SURF6 in ribosome biogenesis and preimplantation mouse development. Biol Reprod. 2006;75:690-6 pubmed
    ..analyses revealed that the localization of SURF6 was similar but not identical to those of fibrillarin and B23/nucleophosmin 1, which are involved in rRNA processing and ribosome biogenesis in mammalian somatic cells...
  47. Dhar S, Lynn B, Daosukho C, St Clair D. Identification of nucleophosmin as an NF-kappaB co-activator for the induction of the human SOD2 gene. J Biol Chem. 2004;279:28209-19 pubmed
    ..b>Nucleophosmin (NPM), a nucleolar phosphoprotein, is the most abundant single protein identified...
  48. Suzuki T, Shiratori M, Furuichi Y, Matsumoto T. Diverged nuclear localization of Werner helicase in human and mouse cells. Oncogene. 2001;20:2551-8 pubmed
    ..In addition, mouse cells cannot recognize the NoLS of hWRNp. Our study suggests that defect in nucleolar function of hWRNp may be linked to the premature aging which is not observed in mWRN(-/-) mice. ..
  49. Gale R, Green C, Allen C, Mead A, Burnett A, Hills R, et al. The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia. Blood. 2008;111:2776-84 pubmed
    ..poor prognosis in acute myeloid leukemia (AML), but the impact of mutant level, size, and interaction with nucleophosmin 1 (NPM1) mutations remains controversial...
  50. Lorenzen J, Bonacci B, Palmer R, Wells C, Zhang J, Haber D, et al. Rbm19 is a nucleolar protein expressed in crypt/progenitor cells of the intestinal epithelium. Gene Expr Patterns. 2005;6:45-56 pubmed
    ..Interestingly, the loss of nucleolar rbm19, nucleolin/C23, and nucleophosmin/B23 in confluent Caco-2 cells did not signify loss of nucleoli as detected by electron microscopy...
  51. Yu Y, Maggi L, Brady S, Apicelli A, Dai M, Lu H, et al. Nucleophosmin is essential for ribosomal protein L5 nuclear export. Mol Cell Biol. 2006;26:3798-809 pubmed
    b>Nucleophosmin (NPM/B23) is a key regulator in the regulation of a number of processes including centrosome duplication, maintenance of genomic integrity, and ribosome biogenesis...
  52. Zou T, Mazan Mamczarz K, Rao J, Liu L, Marasa B, Zhang A, et al. Polyamine depletion increases cytoplasmic levels of RNA-binding protein HuR leading to stabilization of nucleophosmin and p53 mRNAs. J Biol Chem. 2006;281:19387-94 pubmed
    ..epithelial integrity, an effect that relies, at least in part, on their ability to keep low levels of nucleophosmin (NPM) and p53 mRNAs...
  53. Milochau A, Lagr e V, Benassy M, Chaignepain S, Papin J, Garcia Arcos I, et al. Synaptotagmin 11 interacts with components of the RNA-induced silencing complex RISC in clonal pancreatic ?-cells. FEBS Lett. 2014;588:2217-22 pubmed publisher
    ..Binding to SND was direct via its N-terminal tandem repeats. Our data indicate that syt11 may provide a link between gene regulation by microRNAs and membrane traffic...