Nos3

Summary

Gene Symbol: Nos3
Description: nitric oxide synthase 3
Alias: eNos, nitric oxide synthase, endothelial, EC-NOS, NOS type III, NOSIII, cNOS, constitutive NOS, endothelial NOS, endothelial nitric oxide synthase 3, nitric oxide synthase 3, endothelial cell
Species: rat
Products:     Nos3

Top Publications

  1. Jiang L, Quarck R, Janssens S, Pokreisz P, Demedts M, Delcroix M. Effect of adenovirus-mediated gene transfer of nitric oxide synthase on vascular reactivity of rat isolated pulmonary arteries. Pflugers Arch. 2006;452:213-21 pubmed
    Aerosol gene transfer of endothelial nitric oxide synthase (eNOS) and inducible NOS (iNOS) to rat lungs increased NOS expression and activity, and prevented hypoxic pulmonary vasoconstriction (HPV) in vivo...
  2. Sakai T, Shikishima K, Matsushima M, Kitahara K. Endothelial nitric oxide synthase gene polymorphisms in non-arteritic anterior ischemic optic neuropathy. Graefes Arch Clin Exp Ophthalmol. 2007;245:288-92 pubmed
    To examine the association between the polymorphisms of the endothelial nitric oxide synthase (eNOS) gene and the occurrence of non-arteritic anterior ischemic optic neuropathy (NAION)...
  3. de Syllos R, Sandrim V, Lisboa H, Tres G, Tanus Santos J. Endothelial nitric oxide synthase genotype and haplotype are not associated with diabetic retinopathy in diabetes type 2 patients. Nitric Oxide. 2006;15:417-22 pubmed
    Polymorphisms in the endothelial nitric oxide synthase (eNOS) gene have been associated with the development of diabetic retinopathy (DR) in patients with type 1 diabetes mellitus (T1DM), but not with T2DM...
  4. Santhanam A, Viswanathan S, Dikshit M. Activation of protein kinase B/Akt and endothelial nitric oxide synthase mediates agmatine-induced endothelium-dependent relaxation. Eur J Pharmacol. 2007;572:189-96 pubmed
    ..increased protein expression of phosphorylated S473-Akt and phosphorylated S1177-endothelial nitric oxide synthase (eNOS), and elevated the levels of cyclic GMP (P<0.01)...
  5. Li Q, Verma A, Han P, Nakagawa T, Johnson R, Grant M, et al. Diabetic eNOS-knockout mice develop accelerated retinopathy. Invest Ophthalmol Vis Sci. 2010;51:5240-6 pubmed publisher
    Dysfunction of endothelial nitric oxide synthase (eNOS) has been implicated in the pathogenesis of diabetic vascular complications...
  6. Kobayashi T, Taguchi K, Nemoto S, Nogami T, Matsumoto T, Kamata K. Activation of the PDK-1/Akt/eNOS pathway involved in aortic endothelial function differs between hyperinsulinemic and insulin-deficient diabetic rats. Am J Physiol Heart Circ Physiol. 2009;297:H1767-75 pubmed publisher
    ..In the diabetic group, various insulin-stimulated levels (nitric oxide production, phosphorylation of endothelial NOS at Ser(1177), of Akt at Thr(308), and of PDK-1 at Ser(241)) were significantly increased, whereas, in the HI-..
  7. Taverna M, Elgrably F, Selmi H, Selam J, Slama G. The T-786C and C774T endothelial nitric oxide synthase gene polymorphisms independently affect the onset pattern of severe diabetic retinopathy. Nitric Oxide. 2005;13:88-92 pubmed
    ..Recently, we reported a strong association between the eNOS4b/a endothelial nitric oxide synthase (eNOS) polymorphism and severe DR...
  8. Kobayashi T, Matsumoto T, Ooishi K, Kamata K. Differential expression of alpha2D-adrenoceptor and eNOS in aortas from early and later stages of diabetes in Goto-Kakizaki rats. Am J Physiol Heart Circ Physiol. 2004;287:H135-43 pubmed
    ..We also evaluated the aortic expression of the alpha(2D)-adrenoceptor and endothelial nitric oxide synthase (eNOS). Vascular reactivity was assessed in thoracic aortas from age-matched control rats and 12- and 36-wk GK rats...
  9. Ayub H, Khan M, Micheal S, Akhtar F, Ajmal M, Shafique S, et al. Association of eNOS and HSP70 gene polymorphisms with glaucoma in Pakistani cohorts. Mol Vis. 2010;16:18-25 pubmed
    To investigate the involvement of stress-regulating genes, endothelial nitric oxide synthase (eNOS) and heat shock protein 70 (HSP70) with primary open angle glaucoma (POAG) and primary closed angle glaucoma (PCAG)...
  10. Herrera M, Hong N, Ortiz P, Garvin J. Endothelin-1 inhibits thick ascending limb transport via Akt-stimulated nitric oxide production. J Biol Chem. 2009;284:1454-60 pubmed publisher
    ..NO production by activating phosphatidylinositol 3-kinase (PI3K), stimulating Akt activity, and phosphorylating NOS3 at Ser1177. This enhances NO production and inhibits sodium transport...

Detail Information

Publications62

  1. Jiang L, Quarck R, Janssens S, Pokreisz P, Demedts M, Delcroix M. Effect of adenovirus-mediated gene transfer of nitric oxide synthase on vascular reactivity of rat isolated pulmonary arteries. Pflugers Arch. 2006;452:213-21 pubmed
    Aerosol gene transfer of endothelial nitric oxide synthase (eNOS) and inducible NOS (iNOS) to rat lungs increased NOS expression and activity, and prevented hypoxic pulmonary vasoconstriction (HPV) in vivo...
  2. Sakai T, Shikishima K, Matsushima M, Kitahara K. Endothelial nitric oxide synthase gene polymorphisms in non-arteritic anterior ischemic optic neuropathy. Graefes Arch Clin Exp Ophthalmol. 2007;245:288-92 pubmed
    To examine the association between the polymorphisms of the endothelial nitric oxide synthase (eNOS) gene and the occurrence of non-arteritic anterior ischemic optic neuropathy (NAION)...
  3. de Syllos R, Sandrim V, Lisboa H, Tres G, Tanus Santos J. Endothelial nitric oxide synthase genotype and haplotype are not associated with diabetic retinopathy in diabetes type 2 patients. Nitric Oxide. 2006;15:417-22 pubmed
    Polymorphisms in the endothelial nitric oxide synthase (eNOS) gene have been associated with the development of diabetic retinopathy (DR) in patients with type 1 diabetes mellitus (T1DM), but not with T2DM...
  4. Santhanam A, Viswanathan S, Dikshit M. Activation of protein kinase B/Akt and endothelial nitric oxide synthase mediates agmatine-induced endothelium-dependent relaxation. Eur J Pharmacol. 2007;572:189-96 pubmed
    ..increased protein expression of phosphorylated S473-Akt and phosphorylated S1177-endothelial nitric oxide synthase (eNOS), and elevated the levels of cyclic GMP (P<0.01)...
  5. Li Q, Verma A, Han P, Nakagawa T, Johnson R, Grant M, et al. Diabetic eNOS-knockout mice develop accelerated retinopathy. Invest Ophthalmol Vis Sci. 2010;51:5240-6 pubmed publisher
    Dysfunction of endothelial nitric oxide synthase (eNOS) has been implicated in the pathogenesis of diabetic vascular complications...
  6. Kobayashi T, Taguchi K, Nemoto S, Nogami T, Matsumoto T, Kamata K. Activation of the PDK-1/Akt/eNOS pathway involved in aortic endothelial function differs between hyperinsulinemic and insulin-deficient diabetic rats. Am J Physiol Heart Circ Physiol. 2009;297:H1767-75 pubmed publisher
    ..In the diabetic group, various insulin-stimulated levels (nitric oxide production, phosphorylation of endothelial NOS at Ser(1177), of Akt at Thr(308), and of PDK-1 at Ser(241)) were significantly increased, whereas, in the HI-..
  7. Taverna M, Elgrably F, Selmi H, Selam J, Slama G. The T-786C and C774T endothelial nitric oxide synthase gene polymorphisms independently affect the onset pattern of severe diabetic retinopathy. Nitric Oxide. 2005;13:88-92 pubmed
    ..Recently, we reported a strong association between the eNOS4b/a endothelial nitric oxide synthase (eNOS) polymorphism and severe DR...
  8. Kobayashi T, Matsumoto T, Ooishi K, Kamata K. Differential expression of alpha2D-adrenoceptor and eNOS in aortas from early and later stages of diabetes in Goto-Kakizaki rats. Am J Physiol Heart Circ Physiol. 2004;287:H135-43 pubmed
    ..We also evaluated the aortic expression of the alpha(2D)-adrenoceptor and endothelial nitric oxide synthase (eNOS). Vascular reactivity was assessed in thoracic aortas from age-matched control rats and 12- and 36-wk GK rats...
  9. Ayub H, Khan M, Micheal S, Akhtar F, Ajmal M, Shafique S, et al. Association of eNOS and HSP70 gene polymorphisms with glaucoma in Pakistani cohorts. Mol Vis. 2010;16:18-25 pubmed
    To investigate the involvement of stress-regulating genes, endothelial nitric oxide synthase (eNOS) and heat shock protein 70 (HSP70) with primary open angle glaucoma (POAG) and primary closed angle glaucoma (PCAG)...
  10. Herrera M, Hong N, Ortiz P, Garvin J. Endothelin-1 inhibits thick ascending limb transport via Akt-stimulated nitric oxide production. J Biol Chem. 2009;284:1454-60 pubmed publisher
    ..NO production by activating phosphatidylinositol 3-kinase (PI3K), stimulating Akt activity, and phosphorylating NOS3 at Ser1177. This enhances NO production and inhibits sodium transport...
  11. Awata T, Neda T, Iizuka H, Kurihara S, Ohkubo T, Takata N, et al. Endothelial nitric oxide synthase gene is associated with diabetic macular edema in type 2 diabetes. Diabetes Care. 2004;27:2184-90 pubmed
    We examined the endothelial nitric oxide (eNOS) gene polymorphisms to assess its possible association with diabetic retinopathy and macular edema. A total of 226 patients with type 2 diabetes and 186 healthy subjects were studied...
  12. Yanamandra K, Boggs P, Thurmon T, Lewis D, Bocchini J, Dhanireddy R. Novel allele of the endothelial nitric oxide synthase gene polymorphism in Caucasian asthmatics. Biochem Biophys Res Commun. 2005;335:545-9 pubmed
    The purpose of the present study was to investigate an association of the endothelial nitric oxide synthase (eNOS) gene polymorphism with asthma...
  13. Logan J, Chakravarthy U, Hughes A, Patterson C, Jackson J, Rankin S. Evidence for association of endothelial nitric oxide synthase gene in subjects with glaucoma and a history of migraine. Invest Ophthalmol Vis Sci. 2005;46:3221-6 pubmed
    ..The candidate genes were the two isoforms of nitric oxide synthase (NOS), NOS3 and -2A, and endothelin (ET)-l. The frequency of the T786C mutation in NOS3 was also examined...
  14. Joshi M, Ferguson T, Johnson F, Johnson R, Parthasarathy S, Lancaster J. Receptor-mediated activation of nitric oxide synthesis by arginine in endothelial cells. Proc Natl Acad Sci U S A. 2007;104:9982-7 pubmed
    ..evidence for binding of arginine to membrane receptor(s), leading to the activation of endothelial NO synthase (eNOS) NO production through a second messenger pathway...
  15. Dumont O, Loufrani L, Henrion D. Key role of the NO-pathway and matrix metalloprotease-9 in high blood flow-induced remodeling of rat resistance arteries. Arterioscler Thromb Vasc Biol. 2007;27:317-24 pubmed
    ..After 14 days, outward hypertrophic remodeling occurred in HF arteries in association with eNOS overexpression. MMP9 activity increased in the early phase (day 4)...
  16. Miyamoto Y, Saito Y, Kajiyama N, Yoshimura M, Shimasaki Y, Nakayama M, et al. Endothelial nitric oxide synthase gene is positively associated with essential hypertension. Hypertension. 1998;32:3-8 pubmed
    ..including findings of elevation of arterial blood pressure in mice lacking the endothelial nitric oxide synthase (eNOS) gene, strongly suggests that alteration in NO metabolism is implicated in hypertension...
  17. Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher A. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature. 1999;399:601-5 pubmed
    Nitric oxide (NO) produced by the endothelial NO synthase (eNOS) is a fundamental determinant of cardiovascular homesotasis: it regulates systemic blood pressure, vascular remodelling and angiogenesis...
  18. Taverna M, Sola A, Guyot Argenton C, Pacher N, Bruzzo F, Chevalier A, et al. eNOS4 polymorphism of the endothelial nitric oxide synthase predicts risk for severe diabetic retinopathy. Diabet Med. 2002;19:240-5 pubmed
    ..n = 42, respectively, OR = 0.4 (95% CI = 0.24-0.79), P = 0.005). We demonstrate in Caucasians with Type 1 diabetes that (i) eNOS4a/a is associated with absent or non-severe DR, and (ii) eNOS4b/b is associated with severe DR. ..
  19. Toporsian M, Govindaraju K, Nagi M, Eidelman D, Thibault G, Ward M. Downregulation of endothelial nitric oxide synthase in rat aorta after prolonged hypoxia in vivo. Circ Res. 2000;86:671-5 pubmed
    The goal of this study was to determine whether hypoxia alters expression of endothelial nitric oxide synthase (eNOS) in the systemic circulation. Rats breathed either air or 10% oxygen for 12 hours, 48 hours, or 7 days...
  20. Kobayashi K, Nishimura Y, Yamashita T, Nishiuma T, Satouchi M, Yokoyama M. The effect of overexpression of endothelial nitric oxide synthase on eosinophilic lung inflammation in a murine model. Int Immunopharmacol. 2006;6:1040-52 pubmed
    ..In particular, the role of endothelial nitric oxide synthase (eNOS) in asthma remains uncertain...
  21. Francis B, Salameh M, Khamisy Farah R, Farah R. Tetrahydrobiopterin (BH4 ): Targeting endothelial nitric oxide synthase as a potential therapy for pulmonary hypertension. Cardiovasc Ther. 2018;36: pubmed publisher
    ..Tetrahydrobiopterin (BH4 ) regulates endothelial nitric oxide synthase (eNOS) to produce nitric oxide rather than superoxide which maintains normal endothelial and cardiac function...
  22. Thil M, Vince V, Veraart C, Delbeke J, Colin I. Nitric oxide synthases II and III and vascular endothelial growth factor are up-regulated in sciatic nerve after spiral cuff electrode implantation. J Neuroimmunol. 2005;166:158-66 pubmed
    ..b>NOSIII as well as VEGF were up-regulated in both epineurial and endoneurial compartments in cuff-implanted animals along ..
  23. An J, Du J, Wei N, Xu H, Pritchard K, Shi Y. Role of tetrahydrobiopterin in resistance to myocardial ischemia in Brown Norway and Dahl S rats. Am J Physiol Heart Circ Physiol. 2009;297:H1783-91 pubmed publisher
    ..generation secondary to increased heat shock protein 90 (HSP90) association with endothelial nitric oxide synthase (NOS3)...
  24. Zhou S, Bai L, Lv L, Chen R, Li C, Liu X, et al. Liraglutide ameliorates renal injury in streptozotocin?induced diabetic rats by activating endothelial nitric oxide synthase activity via the downregulation of the nuclear factor??B pathway. Mol Med Rep. 2014;10:2587-94 pubmed publisher
    ..acid Schiff base staining, and the mRNA levels of nuclear factor ?B (NF??B) and endothelial nitric oxide synthase (eNOS) were assessed by quantitative polymerase chain reaction...
  25. McGown C, Brown N, Hellewell P, Brookes Z. ROCK induced inflammation of the microcirculation during endotoxemia mediated by nitric oxide synthase. Microvasc Res. 2011;81:281-8 pubmed publisher
    ..LPS), which alters levels of nitric oxide (NO), synthesized via endothelial and inducible nitric oxide synthase (eNOS and iNOS)...
  26. Ramachandran R, Ploug K, Hay Schmidt A, Olesen J, Jansen Olesen I, Gupta S. Nitric oxide synthase (NOS) in the trigeminal vascular system and other brain structures related to pain in rats. Neurosci Lett. 2010;484:192-6 pubmed publisher
    ..quantitative real-time PCR and Western blotting to measure the respective levels of mRNA and protein for nNOS and eNOS in peripheral and central tissues involved in migraine pain: dura mater, pial arteries, trigeminal ganglion (TG) ..
  27. Romero M, Jimenez R, Sanchez M, López Sepúlveda R, Zarzuelo M, O Valle F, et al. Quercetin inhibits vascular superoxide production induced by endothelin-1: Role of NADPH oxidase, uncoupled eNOS and PKC. Atherosclerosis. 2009;202:58-67 pubmed publisher
    ..Taken together these results indicate that ET-1-induced NADPH oxidase up-regulation and eNOS uncoupling via PKC leading to endothelial dysfunction and these effects were prevented by quercetin and ..
  28. Kumar S, Jyoti A, Keshari R, Singh M, Barthwal M, Dikshit M. Functional and molecular characterization of NOS isoforms in rat neutrophil precursor cells. Cytometry A. 2010;77:467-77 pubmed publisher
    ..iNOS expression was, however, consistently augmented during maturation, whereas eNOS expression was downregulated with neutrophil maturation...
  29. Ošiņa K, Leonova E, Isajevs S, Baumane L, Rostoka E, Sjakste T, et al. Modifications of expression of genes and proteins involved in DNA repair and nitric oxide metabolism by carbatonides [disodium-2,6-dimethyl-1,4-dihydropyridine- 3,5-bis(carbonyloxyacetate) derivatives] in intact and diabetic rats. Arh Hig Rada Toksikol. 2017;68:212-227 pubmed publisher
    ..Metcarbatone and etcarbatone up-regulated mRNA and protein of eNOS in kidneys of diabetic animals; etcarbatone also in myocardium...
  30. Qiao X, Xu J, Yang Q, Du Y, Lei S, Liu Z, et al. Transient acidosis during early reperfusion attenuates myocardium ischemia reperfusion injury via PI3k-Akt-eNOS signaling pathway. Oxid Med Cell Longev. 2013;2013:126083 pubmed publisher
    In this paper, we concluded that transient acidosis reperfusion conferred cardioprotection against myocardial ischemia reperfusion injury in isolated rat hearts through activating PI3K-Akt-eNOS pathway.
  31. Demirtaş Şahin T, Yazir Y, Utkan T, Gacar G, Furat Rençber S, Göçmez S. TNF-? antagonism with etanercept enhances penile NOS expression, cavernosal reactivity, and testosterone levels in aged rats. Can J Physiol Pharmacol. 2018;96:200-207 pubmed publisher
    ..TNF-?) inhibitor etanercept on penile neuronal nitric oxide synthase (nNOS) and endothelial nitric oxide synthase (eNOS) expressions, testosterone concentrations, neurogenic and endothelium-dependent relaxations of corpus cavernosum (..
  32. Ren Y, Sun L, Shao X, Chen J, Xiong B, Nong L. [Expressions of eNOS and cytochrome P450 in the testis of sexually mature SD rats and their significance]. Zhonghua Nan Ke Xue. 2009;15:911-4 pubmed
    To explore the expressions of endothelial nitric oxide synthase (eNOS) and cytochrome P450 (aromatase) in the testis of sexually mature male SD rats and their significance...
  33. Kim J, Bugaj L, Oh Y, Bivalacqua T, Ryoo S, Soucy K, et al. Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats. J Appl Physiol (1985). 2009;107:1249-57 pubmed publisher
    ..In this study, we demonstrate that arginase upregulation leads to endothelial nitric oxide synthase (eNOS) uncoupling and that in vivo chronic inhibition of arginase restores nitroso-redox balance, improves endothelial ..
  34. Suzuki T, Mori C, Yoshikawa H, Miyazaki Y, Kansaku N, Tanaka K, et al. Changes in nitric oxide production levels and expression of nitric oxide synthase isoforms in the rat uterus during pregnancy. Biosci Biotechnol Biochem. 2009;73:2163-6 pubmed
    ..Thus NOS-2-generated NO in the decidua contributed significantly to uterine NO levels...
  35. Waki H, Murphy D, Yao S, Kasparov S, Paton J. Endothelial NO synthase activity in nucleus tractus solitarii contributes to hypertension in spontaneously hypertensive rats. Hypertension. 2006;48:644-50 pubmed
    ..Based on previous data, we hypothesized that overactivity of endothelial NO synthase (eNOS) within the nucleus tractus solitarii (NTS) could contribute to the hypertension in the spontaneously hypertensive ..
  36. Babu C, Kalaivani P, Ranju V, Sathiya S, Anbarasi C, Mahadevan M, et al. Venthamarai chooranam, a polyherbal Siddha medicine, alleviates hypertension via AT?R and eNOS signaling pathway in 2K1C hypertensive rats. Exp Biol Med (Maywood). 2014;239:758-69 pubmed
    ..Systolic blood pressure (SBP), plasma nitrate/nitrite, carotid endothelial nitric oxide synthetase (eNOS), renal angiotensin type 1 receptor (AT?R), angiotensin type 2 receptor (AT?R), TNF?, IL-6, thioredoxin 1 (TRX1), ..
  37. Yar A, Menevse S, Dogan I, Alp E, Ergin V, Cumaoglu A, et al. Investigation of ocular neovascularization-related genes and oxidative stress in diabetic rat eye tissues after resveratrol treatment. J Med Food. 2012;15:391-8 pubmed publisher
    ..angiotensin-converting enzyme (ACE), matrix metalloproteinase (MMP)-9, and endothelial nitric oxide synthase (eNOS) mRNA expression profiles and oxidative stress in the eye tissue microenviroment may have important roles in ocular ..
  38. Noguchi K, Hamadate N, Matsuzaki T, Sakanashi M, Nakasone J, Uchida T, et al. Increasing dihydrobiopterin causes dysfunction of endothelial nitric oxide synthase in rats in vivo. Am J Physiol Heart Circ Physiol. 2011;301:H721-9 pubmed publisher
    ..of oxidative stress, such as arteriosclerotic/atherosclerotic disorders, where endothelial nitric oxide synthase (eNOS) is dysfunctional, but the role of BH(2) in the regulation of eNOS activity in vivo remains to be evaluated...
  39. Wu Y, Hu Y. [Effect of NOS and PTEN on cardiomyocyte hypertrophy induced by angiotensin II]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2005;21:41-5 pubmed
    ..Total protein content of cardiomyocytes was used as the index of cardiac myocyte hypertrophy. eNOS mRNA, iNOS mRNA and PTEN mRNA expression were assessed using RT-PCR normalized with GAPDH...
  40. Gaafar A, Messiha B, Abdelkafy A. Nicorandil and theophylline can protect experimental rats against complete Freund's adjuvant-induced rheumatoid arthritis through modulation of JAK/STAT/RANKL signaling pathway. Eur J Pharmacol. 2018;822:177-185 pubmed publisher
    ..protein (COMP), together with tissue JAK2, STAT3, RANKL, inducible and endothelial nitric oxide synthases (iNOS and eNOS) as well as macrophage inflammatory protein (MIP1α) were estimated using ELISA, Western blotting and ..
  41. Huang S, Lu Y, Huang J, Wu Y, Day Y, Hung L. The essential role of endothelial nitric oxide synthase activation in insulin-mediated neuroprotection against ischemic stroke in diabetes. J Vasc Surg. 2014;59:483-91 pubmed publisher
    ..membrane-trafficking activity of glucose transporter 1, and reduction of Akt and endothelial nitric oxide synthase (eNOS) phosphorylation in the cerebrum...
  42. Chan Y, Leung F, Wong W, Tian X, Yung L, Lau C, et al. Therapeutically relevant concentrations of raloxifene dilate pressurized rat resistance arteries via calcium-dependent endothelial nitric oxide synthase activation. Arterioscler Thromb Vasc Biol. 2010;30:992-9 pubmed publisher
    ..The present study aimed to examine roles of Ca(2+) influx in endothelium and endothelial nitric oxide synthase (eNOS) activation in dilatations induced by raloxifene, a second-generation SERM in myogenically active arteries...
  43. Patel N, Nandra K, Brines M, Collino M, Wong W, Kapoor A, et al. A nonerythropoietic peptide that mimics the 3D structure of erythropoietin reduces organ injury/dysfunction and inflammation in experimental hemorrhagic shock. Mol Med. 2011;17:883-92 pubmed publisher
  44. Liu F, Xia M, Xu A. Expression of VEGF, iNOS, and eNOS is increased in cochlea of diabetic rat. Acta Otolaryngol. 2008;128:1178-86 pubmed publisher
    ..endothelial growth factor (VEGF), inducible nitric oxide synthase (iNOS), and endothelial nitric oxide synthase (eNOS), which may be involved in the pathogenesis of cochlea functional loss...
  45. Ramseyer V, Garvin J. Angiotensin II decreases nitric oxide synthase 3 expression via nitric oxide and superoxide in the thick ascending limb. Hypertension. 2009;53:313-8 pubmed publisher
    NO produced by NO synthase type 3 (NOS3) in medullary thick ascending limbs (mTHALs) inhibits Cl(-) reabsorption. Acutely, angiotensin II stimulates thick ascending limb NO production. In endothelial cells, NO inhibits NOS3 expression...
  46. Thum T, Fraccarollo D, Schultheiss M, Froese S, Galuppo P, Widder J, et al. Endothelial nitric oxide synthase uncoupling impairs endothelial progenitor cell mobilization and function in diabetes. Diabetes. 2007;56:666-74 pubmed
    Uncoupling of the endothelial nitric oxide synthase (eNOS) resulting in superoxide anion (O(2)(-)) formation instead of nitric oxide (NO) causes diabetic endothelial dysfunction...
  47. Bayazit Y, Yilmaz M, Erdal E, Ciftci T, Ceylan A, Kokturk O, et al. Role of nitric oxide synthase gene intron 4 and exon 7 polymorphisms in obstructive sleep apnea syndrome. Eur Arch Otorhinolaryngol. 2009;266:449-54 pubmed publisher
    ..of our study was to assess the association of eNOS4 and eNOS296 polymorphisms of endothelial nitric oxide synthase (eNOS) gene with obstructive sleep apnea syndrome (OSAS)...
  48. Lam C, Peterson T, Richardson D, Croatt A, d Uscio L, Nath K, et al. Increased blood flow causes coordinated upregulation of arterial eNOS and biosynthesis of tetrahydrobiopterin. Am J Physiol Heart Circ Physiol. 2006;290:H786-93 pubmed
    ..Endothelial NO synthase (eNOS) activity is determined by heat shock protein 90 (HSP90), caveolin-1, and the cofactor tetrahydrobiopterin (BH4)...
  49. Gao L, Yu D. Molecular mechanism of limbs' postischemic revascularization improved by perindopril in diabetic rats. Chin Med J (Engl). 2008;121:2129-33 pubmed
    ..The differences of angiogenesis, the mRNA and protein expression of endothelial nitric oxide synthase (eNOS), vascular endothelial growth factor (VEGF) and basic fibroblast (bFGF), constitutive nitric oxide synthase (cNOS) ..
  50. Sasaki A, Doi S, Mizutani S, Azuma H. Roles of accumulated endogenous nitric oxide synthase inhibitors, enhanced arginase activity, and attenuated nitric oxide synthase activity in endothelial cells for pulmonary hypertension in rats. Am J Physiol Lung Cell Mol Physiol. 2007;292:L1480-7 pubmed
    ..The constitutive NOS activity and protein expression in PAECs were significantly reduced in MCT group, whereas the arginase, which ..
  51. Kim Y, Hwang J, Noh J, Gang G, Kim D, Son H, et al. Activation of NAD(P)H:quinone oxidoreductase ameliorates spontaneous hypertension in an animal model via modulation of eNOS activity. Cardiovasc Res. 2011;91:519-27 pubmed publisher
    ..Nitric oxide (NO) produced by endothelial NO synthase (eNOS) is an important regulator of blood pressure (BP)...
  52. Shafiei M, Lui S, Rockey D. Integrin-linked kinase regulates endothelial cell nitric oxide synthase expression in hepatic sinusoidal endothelial cells. Liver Int. 2015;35:1213-21 pubmed publisher
    ..after liver injury caused in part by abnormal production of endothelial cell derived nitric oxide synthase (eNOS)...
  53. Arrick D, Li C, Mayhan W. Sex-related differences in reactivity of cerebral arterioles during moderate exercise training. Microcirculation. 2016;23:549-557 pubmed publisher
    ..Responses of cerebral arterioles were measured in Sed and MExT adult male and female Sprague-Dawley rats to eNOS-dependent (ADP), nNOS-dependent (NMDA), and NOS-independent (nitroglycerin) agonists before and following L-NMMA...
  54. Jankowski M, Wang D, Mukaddam Daher S, Gutkowska J. Pregnancy alters nitric oxide synthase and natriuretic peptide systems in the rat left ventricle. J Endocrinol. 2005;184:209-17 pubmed
    ..01 +/- 0.15 pmol/g) and day 4 (9.21 +/- 1.79 pmol/g). Changes in endothelial nitric oxide synthase (eNOS), inducible NOS (iNOS), OTR and ERalpha, but not ERbeta, proteins paralleled the pregnancy-related cGMP changes in ..
  55. Couto G, Paula S, Gomes Santos I, Negrão C, Rossoni L. Exercise training induces eNOS coupling and restores relaxation in coronary arteries of heart failure rats. Am J Physiol Heart Circ Physiol. 2018;314:H878-H887 pubmed publisher
    ..Expression levels of endothelial NO synthase (eNOS) and soluble guanylyl cyclase subunits were increased in coronary arteries of UHF rats but reduced in THF rats...
  56. Song W, Kwak H, Kim J, Lawler J. Exercise training modulates the nitric oxide synthase profile in skeletal muscle from old rats. J Gerontol A Biol Sci Med Sci. 2009;64:540-9 pubmed publisher
    ..b>Endothelial NOS (eNOS) protein levels were depressed in WG of old rats but were higher in OE than in OS...
  57. Nishank S, Singh M, Yadav R, Gupta R, Gadge V, Gwal A. Endothelial nitric oxide synthase gene polymorphism is associated with sickle cell disease patients in India. J Hum Genet. 2013;58:775-9 pubmed publisher
    ..In transgenic sickle cell mice, NO synthesized by endothelial nitric oxide synthase (eNOS) enzyme of vascular endothelial cells has been found to protect the mice from vaso-occlusive events...
  58. Wang L, Chen Q, Li G, Ke D. Ghrelin ameliorates impaired angiogenesis of ischemic myocardium through GHSR1a-mediated AMPK/eNOS signal pathway in diabetic rats. Peptides. 2015;73:77-87 pubmed publisher
    ..fetal liver kinase-1 (Flk-1) and fms-like tyrosine kinase-1 (Flt-1), AMPK and endothelial nitric oxide synthase (eNOS) phosphorylation were examined...
  59. Czambel R, Kharlamov A, Jones S. Variations of brain endothelial nitric oxide synthase concentration in rat and mouse cortex. Nitric Oxide. 2010;22:51-7 pubmed publisher
    No information exists on the differences of eNOS concentration in brain tissue, [eNOS](br), between animals during normal and hypotensive blood pressure and both between and within animals during moderate hypotension...
  60. Zhao J, Wecht J, Zhang Y, Wen X, Zeman R, Bauman W, et al. iNOS expression in rat aorta is increased after spinal cord transection: a possible cause of orthostatic hypotension in man. Neurosci Lett. 2007;415:210-4 pubmed
    ..Expression in thoracic aortic of inducible (iNOS), endothelial (eNOS) and neuronal (nNOS) NOS was then determined...
  61. Bonnin P, Leger P, Villapol S, Deroide N, Gressens P, Pocard M, et al. Dual action of NO synthases on blood flow and infarct volume consecutive to neonatal focal cerebral ischemia. Exp Neurol. 2012;236:50-7 pubmed publisher
    ..Conversely, endothelial NOS inhibition increased blood-flows and aggravated volume lesion in males, whereas in females blood-flows did ..
  62. Han F, Shirasaki Y, Fukunaga K. Microsphere embolism-induced endothelial nitric oxide synthase expression mediates disruption of the blood-brain barrier in rat brain. J Neurochem. 2006;99:97-106 pubmed
    Microsphere embolism (ME)-induced up-regulation of endothelial nitric oxide synthase (eNOS) in endothelial cells of brain microvessels was observed 2-48 h after ischemia...