Gene Symbol: Nos2
Description: nitric oxide synthase 2
Alias: Nos2a, iNos, nitric oxide synthase, inducible, NOS type II, inducible NO synthase, inducible NOS, inducible nitric oxide synthase, nitric oxide synthase 2, inducible, macrophage, peptidyl-cysteine S-nitrosylase NOS2
Species: rat
Products:     Nos2

Top Publications

  1. Takahashi T, Fujii H, Shimizu H, Omori E, Uehara K, Takeuchi M, et al. Site- and cell-type- specific induction of intestinal inducible nitric oxide synthase in a rat model of endotoxemia. Med Chem. 2005;1:643-7 pubmed
    ..The intestine is one of the major organs that are involved in sepsis. The inducible isoform of nitric oxide synthase (iNOS) is known to play a critical role in the pathogenesis of septic tissue injury by generating excess amount of nitric ..
  2. Jafarian Tehrani M, Louin G, Royo N, Besson V, Bohme G, Plotkine M, et al. 1400W, a potent selective inducible NOS inhibitor, improves histopathological outcome following traumatic brain injury in rats. Nitric Oxide. 2005;12:61-9 pubmed
    There are conflicting data regarding the role of nitric oxide (NO) produced by inducible NO synthase (iNOS) in the pathophysiology of traumatic brain injury (TBI)...
  3. Soliman H, Craig G, Nagareddy P, Yuen V, Lin G, Kumar U, et al. Role of inducible nitric oxide synthase in induction of RhoA expression in hearts from diabetic rats. Cardiovasc Res. 2008;79:322-30 pubmed publisher
    ..of RhoA expression in vascular smooth muscle, and we have previously found that the expression of inducible NO synthase (iNOS) is increased in hearts from STZ-diabetic rats...
  4. Matsui K, Nishizawa M, Ozaki T, Kimura T, Hashimoto I, Yamada M, et al. Natural antisense transcript stabilizes inducible nitric oxide synthase messenger RNA in rat hepatocytes. Hepatology. 2008;47:686-97 pubmed
    During inflammation, inducible nitric oxide synthase (iNOS) is induced to generate the important mediator nitric oxide (NO). Interleukin 1beta (IL-1beta) induces iNOS messenger RNA (mRNA), iNOS protein, and NO in rat hepatocytes...
  5. Ito J, Uchida H, Yokote T, Ohtake K, Kobayashi J. Fasting-induced intestinal apoptosis is mediated by inducible nitric oxide synthase and interferon-{gamma} in rat. Am J Physiol Gastrointest Liver Physiol. 2010;298:G916-26 pubmed publisher
    ..We performed immunohistochemistry for inducible NO synthase (iNOS) expression in the jejunum and measured tissue nitrite levels using HPLC and 8-hydroxydeoxyguanosine ..
  6. Shehata S, Sharma H, Mooi W, Tibboel D. Pulmonary hypertension in human newborns with congenital diaphragmatic hernia is associated with decreased vascular expression of nitric-oxide synthase. Cell Biochem Biophys. 2006;44:147-55 pubmed
    ..the expression pattern of NO-generating enzyme nitric-oxide synthase (NOS) (both endothelial [eNOS] and inducible [iNOS] isoforms) in the lungs of CDH patients with PH and evaluated the influence of ECMO on the expression levels of ..
  7. Jiang L, Quarck R, Janssens S, Pokreisz P, Demedts M, Delcroix M. Effect of adenovirus-mediated gene transfer of nitric oxide synthase on vascular reactivity of rat isolated pulmonary arteries. Pflugers Arch. 2006;452:213-21 pubmed
    Aerosol gene transfer of endothelial nitric oxide synthase (eNOS) and inducible NOS (iNOS) to rat lungs increased NOS expression and activity, and prevented hypoxic pulmonary vasoconstriction (HPV) in vivo...
  8. Chen C, Chuang J, Liu K, Chan J. Nitric oxide triggers delayed anesthetic preconditioning-induced cardiac protection via activation of nuclear factor-kappaB and upregulation of inducible nitric oxide synthase. Shock. 2008;30:241-9 pubmed publisher
    ..activation of nuclear transcription factor-kappaB (NF-kappaB), leading to myocardial adaptation by upregulation of iNOS and increase in production of NO...
  9. Mattace Raso G, Esposito E, Iacono A, Pacilio M, Coppola A, Bianco G, et al. Leptin induces nitric oxide synthase type II in C6 glioma cells. Role for nuclear factor-kappaB in hormone effect. Neurosci Lett. 2006;396:121-6 pubmed
    ..Here we investigated the in vitro effect of leptin on inducible nitric oxide synthase (iNOS) expression in a glioma cell line (C6)...

More Information


  1. Jean Y, Chen W, Duh C, Huang S, Hsu C, Lin C, et al. Inducible nitric oxide synthase and cyclooxygenase-2 participate in anti-inflammatory and analgesic effects of the natural marine compound lemnalol from Formosan soft coral Lemnalia cervicorni. Eur J Pharmacol. 2008;578:323-31 pubmed
    ..demonstrate that lemnalol significantly inhibited the expression of the pro-inflammatory proteins, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), in LPS-stimulated RAW 264.7 cells...
  2. Wakeno Takahashi M, Otani H, Nakao S, Imamura H, Shingu K. Isoflurane induces second window of preconditioning through upregulation of inducible nitric oxide synthase in rat heart. Am J Physiol Heart Circ Physiol. 2005;289:H2585-91 pubmed
    ..We tested the hypothesis that isoflurane-induced SWOP is mediated through upregulation of inducible NOS (iNOS). Rats inhaled 0.75 minimum alveolar concentration (MAC) isoflurane, 1.5 MAC isoflurane, or O2 for 2 h...
  3. Sato N, Moore F, Kone B, Zou L, Smith M, Childs M, et al. Differential induction of PPAR-gamma by luminal glutamine and iNOS by luminal arginine in the rodent postischemic small bowel. Am J Physiol Gastrointest Liver Physiol. 2006;290:G616-23 pubmed
    Using a rodent model of gut ischemia-reperfusion (I/R), we have previously shown that the induction of inducible nitric oxide synthase (iNOS) is harmful, whereas the induction of heme oxygenase 1 (HO-1) and peroxisome proliferator-..
  4. Rafols D, Steiner J, Rafols J, Petrov T. Intracellular coexpression of endothelin-1 and inducible nitric oxide synthase underlies hypoperfusion after traumatic brain injury in the rat. Neurosci Lett. 2004;362:154-7 pubmed
    ..injury to demonstrate colocalization of mRNAs for endothelin-1 (ET-1, a powerful vasoconstrictor) and inducible nitric oxide synthase (iNOS, generator of NO, a vasodilator) in individual cells that form the brain's microvascular wall...
  5. Phillipson M, Henriksnäs J, Holstad M, Sandler S, Holm L. Inducible nitric oxide synthase is involved in acid-induced gastric hyperemia in rats and mice. Am J Physiol Gastrointest Liver Physiol. 2003;285:G154-62 pubmed h-1 iv, in iNOS-deficient (-/-) and nNOS(-/-) mice...
  6. Ahn B, Ohshima H. Suppression of intestinal polyposis in Apc(Min/+) mice by inhibiting nitric oxide production. Cancer Res. 2001;61:8357-60 pubmed
    b>Inducible nitric oxide synthase (iNOS) was shown to be expressed in normal mucosa and adenoma of small and large intestines of Apc(Min/+) mice by reverse transcription-PCR and immunohistochemistry...
  7. Scott D, Hull M, Cartwright E, Lam W, Tisbury A, Poulsom R, et al. Lack of inducible nitric oxide synthase promotes intestinal tumorigenesis in the Apc(Min/+) mouse. Gastroenterology. 2001;121:889-99 pubmed
    The role of the inducible isoform of nitric oxide synthase (Nos2 or iNOS) in intestinal tumorigenesis is unclear...
  8. Bhat N, Feinstein D, Shen Q, Bhat A. p38 MAPK-mediated transcriptional activation of inducible nitric-oxide synthase in glial cells. Roles of nuclear factors, nuclear factor kappa B, cAMP response element-binding protein, CCAAT/enhancer-binding protein-beta, and activating transcription. J Biol Chem. 2002;277:29584-92 pubmed
    ..that mitogen-activated protein kinase (MAPK) cascades signal the induction of inducible nitric-oxide synthase (iNOS) in glial cells (Bhat, N. R., Zhang, P., Lee, J. C., and Hogan E. L. (1998) J. Neurosci. 18, 1633-1641; Bhat, N. R...
  9. Martínez A, Hernández M, Novella S, Martínez M, Pagán R, Hermenegildo C, et al. Diminished neurogenic femoral artery vasoconstrictor response in a Zucker obese rat model: differential regulation of NOS and COX derivatives. PLoS ONE. 2014;9:e106372 pubmed publisher
    ..Neural (nNOS) and inducible NOS (iNOS) were activated and their expression was higher in femoral arteries from OZR...
  10. Lee H, Huang S, Lin Y, Wang H, Jean Y, Wu S, et al. Soft coral-derived lemnalol alleviates monosodium urate-induced gouty arthritis in rats by inhibiting leukocyte infiltration and iNOS, COX-2 and c-Fos protein expression. Mar Drugs. 2013;11:99-113 pubmed publisher
    ..cell infiltration, as well as the elevated expression of c-Fos and pro-inflammatory proteins (inducible nitric oxide synthase and cyclooxygenase-2) observed in synovial tissue, were significantly inhibited by treatment with ..
  11. Park C, Noh J, Kim J, Tanaka T, Zhao Q, Matsumoto K, et al. Evaluation of morroniside, iridoid glycoside from Corni Fructus, on diabetes-induced alterations such as oxidative stress, inflammation, and apoptosis in the liver of type 2 diabetic db/db mice. Biol Pharm Bull. 2011;34:1559-65 pubmed
    ..subunits, NF-E2-related factor 2 (Nrf2), heme oxygenase-1, nuclear factor-kappa B, cyclooxygenase-2, inducible nitric oxide synthase, monocyte chemotactic protein-1, and intracellular adhesion molecule-1 levels in the liver; however, ..
  12. Daneshtalab N, Smeda J. Alterations in the modulation of cerebrovascular tone and blood flow by nitric oxide synthases in SHRsp with stroke. Cardiovasc Res. 2010;86:160-8 pubmed publisher
  13. Jeddi S, Zaman J, Zadeh Vakili A, Zarkesh M, Ghasemi A. Involvement of inducible nitric oxide synthase in the loss of cardioprotection by ischemic postconditioning in hypothyroid rats. Gene. 2016;580:169-76 pubmed publisher
    ..This study aimed at determining whether changes in Bax, Bcl-2, eNOS, and iNOS gene expressions are involved in the negating effects of IPost against ischemia-reperfusion (IR) injury in ..
  14. Igarashi K, Akira S, Imaki J, Takeshita T. Systemic endotoxin induces gene expression of inducible nitric oxide synthase in fetal rat brain. J Nippon Med Sch. 2009;76:232-9 pubmed
    ..Therefore, we investigated the expression of inducible nitric oxide synthase (iNOS) mRNA and the response pattern following lipopolysaccharide (LPS) loading using a rat model of ..
  15. Seimetz M, Parajuli N, Pichl A, Veit F, Kwapiszewska G, Weisel F, et al. Inducible NOS inhibition reverses tobacco-smoke-induced emphysema and pulmonary hypertension in mice. Cell. 2011;147:293-305 pubmed publisher
    ..We provide evidence for a causative role of inducible nitric oxide synthase (iNOS) and peroxynitrite in this context. Mice lacking iNOS were protected against emphysema and PH...
  16. Naura A, Datta R, Hans C, Zerfaoui M, Rezk B, Errami Y, et al. Reciprocal regulation of iNOS and PARP-1 during allergen-induced eosinophilia. Eur Respir J. 2009;33:252-62 pubmed publisher
    b>Inducible nitric oxide synthase (iNOS) inhibition was recently shown to exert no effect on allergen challenge in human asthma, raising serious concerns about the role of the protein in the disease...
  17. Singh D, Kumar V, Singh C. IFN-? regulates xanthine oxidase-mediated iNOS-independent oxidative stress in maneb- and paraquat-treated rat polymorphonuclear leukocytes. Mol Cell Biochem. 2017;427:133-143 pubmed publisher
    ..While inducible NOS (iNOS) is implicated in MB+PQ-induced toxicity in rat polymorphonuclear leukocytes (PMNs), role of XO and its ..
  18. Kan W, Hsu J, Schwacha M, Choudhry M, Raju R, Bland K, et al. Selective inhibition of iNOS attenuates trauma-hemorrhage/resuscitation-induced hepatic injury. J Appl Physiol (1985). 2008;105:1076-82 pubmed publisher
    ..a nonselective NO synthase inhibitor, N(G)-nitro-L-arginine methyl ester (L-NAME), we investigated whether inducible NO synthase plays any role in producing hepatic injury, inflammation, and changes of protein expression following ..
  19. Zhang B, Lakshmanan J, Du Y, Smith J, Harbrecht B. Cell-specific regulation of iNOS by AMP-activated protein kinase in primary rat hepatocytes. J Surg Res. 2018;221:104-112 pubmed publisher an important response to sepsis, inflammation and shock and many of the stimuli that upregulate inducible nitric oxide synthase (iNOS) also activate AMPK...
  20. Zhen J, Lu H, Wang X, Vaziri N, Zhou X. Upregulation of endothelial and inducible nitric oxide synthase expression by reactive oxygen species. Am J Hypertens. 2008;21:28-34 pubmed
    ..In addition, eNOS and inducible NOS (iNOS) expressions were determined in rats treated with either BSO or vehicle for 48 h...
  21. Bae J, Jung K, Ahn W, Bae S, Jang T. Expression of inducible nitric oxide synthase is increased in rat Barrett's esophagus induced by duodenal contents reflux. J Korean Med Sci. 2005;20:56-60 pubmed
    Barrett's esophagus is a premalignant condition of esophageal adenocarcinoma. Inducible nitric oxide synthase (iNOS) is induced by cytokines and can generate locally high concentrations of nitric oxide (NO), whose metabolites can mediate ..
  22. Machida T, Hamaya Y, Izumi S, Hamaya Y, Iizuka K, Igarashi Y, et al. Sphingosine 1-phosphate inhibits nitric oxide production induced by interleukin-1beta in rat vascular smooth muscle cells. J Pharmacol Exp Ther. 2008;325:200-9 pubmed publisher
    ..We investigated the effect of S1P on interleukin (IL)-1beta-induced nitric oxide (NO) production and inducible NO synthase (iNOS) expression in rat vascular smooth muscle cells (VSMCs)...
  23. Zhao P, Zuo Z. Prenatal hypoxia-induced adaptation and neuroprotection that is inducible nitric oxide synthase-dependent. Neurobiol Dis. 2005;20:871-80 pubmed
    ..This neuroprotection was abolished by an inhibitor of inducible nitric oxide synthase (iNOS)...
  24. Tang Q, Svensson C, Fitzsimmons B, Webb M, Yaksh T, Hua X. Inhibition of spinal constitutive NOS-2 by 1400W attenuates tissue injury and inflammation-induced hyperalgesia and spinal p38 activation. Eur J Neurosci. 2007;25:2964-72 pubmed
    Nitric oxide (NO) and its synthesizing enzymes, including NO synthase-2 (NOS-2, also called inducible NOS, iNOS), have been implicated in spinal nociception...
  25. Mei Y, Yamaza T, Atsuta I, Danjo A, Yamashita Y, Kido M, et al. Sequential expression of endothelial nitric oxide synthase, inducible nitric oxide synthase, and nitrotyrosine in odontoblasts and pulp cells during dentin repair after tooth preparation in rat molars. Cell Tissue Res. 2007;328:117-27 pubmed
    ..we investigated the gene expression and/or immunolocalization of endothelial NO synthase (eNOS), inducible NOS (iNOS), and nitrotyrosine (a biomarker for NO-derived peroxinitrite), and alkaline phosphatase (ALP) and ..
  26. Oddi S, Latini L, Viscomi M, Bisicchia E, Molinari M, Maccarrone M. Distinct regulation of nNOS and iNOS by CB2 receptor in remote delayed neurodegeneration. J Mol Med (Berl). 2012;90:371-87 pubmed publisher
    ..JWH-015 prevented the axotomy-induced upregulation of inducible NOS (iNOS) in astrocytes but had no effect on endothelial NOS (eNOS)...
  27. Piazza M, Futrega K, Spratt D, Dieckmann T, Guillemette J. Structure and dynamics of calmodulin (CaM) bound to nitric oxide synthase peptides: effects of a phosphomimetic CaM mutation. Biochemistry. 2012;51:3651-61 pubmed publisher
    ..the dynamic properties of CaM-NOS interactions, we determined the solution structure of CaM bound to the inducible NOS (iNOS) and endothelial NOS (eNOS) CaM binding region peptides...
  28. Paoliello Paschoalato A, Oliveira S, Cunha F. Interleukin 4 induces the expression of inducible nitric oxide synthase in eosinophils. Cytokine. 2005;30:116-24 pubmed
    We investigated the effects of the Th2-like cytokines IL-4 and IL-13 and of IL-10 on the induction of iNOS and NO production in rat eosinophils...
  29. Smirnov A, Tyurenkov I, Shmidt M, Ekova M, Mednikov D, Borodin D. Effect of Combined Stress on Morphological Changes and Expression of NO Synthases in Rat Ventral Hippocampus. Bull Exp Biol Med. 2015;160:96-9 pubmed publisher
    ..the microcirculatory bed, perivascular edema, pronounced degenerative changes, and enhanced expression of inducible NO synthase in CA3 pyramidal neurons in the ventral hippocampus of stressed 12-month-old rats were observed...
  30. Jones R, JOURD HEUIL D, Salerno J, Smith S, Singer H. iNOS regulation by calcium/calmodulin-dependent protein kinase II in vascular smooth muscle. Am J Physiol Heart Circ Physiol. 2007;292:H2634-42 pubmed
    ..the effects of multifunctional calcium/calmodulin-dependent protein kinase II protein kinase (CaMKII) on inducible NOS (iNOS) trafficking in cultured rat aortic vascular smooth muscle cells (VSMCs)...
  31. Shi Y, Guo L, Shi L, Yu J, Song M, Li Y. Caffeic Acid Phenethyl Ester inhibit Hepatic Fibrosis by Nitric Oxide Synthase and Cystathionine Gamma-Lyase in Rats. Med Sci Monit. 2015;21:2774-80 pubmed publisher
    Our aim was to study the effect of caffeic acid phenethyl ester (CAPE) on iNOS and cystathionine gamma-lyase (CSE) of hepatic fibrosis rat, and discuss the anti-hepatic fibrosis mechanism of caffeic acid phenethyl ester...
  32. Aiello S, Cassis P, Cassis L, Tomasoni S, Benigni A, Pezzotta A, et al. DnIKK2-transfected dendritic cells induce a novel population of inducible nitric oxide synthase-expressing CD4+CD25- cells with tolerogenic properties. Transplantation. 2007;83:474-84 pubmed
    ..and expressed interleukin (IL)-10, transforming growth factor-beta, interferon-gamma, IL-2, and inducible nitric oxide synthase (iNOS)...
  33. Portugal Cohen M, Numa R, Yaka R, Kohen R. Cocaine induces oxidative damage to skin via xanthine oxidase and nitric oxide synthase. J Dermatol Sci. 2010;58:105-12 pubmed publisher
    ..Our findings clearly showed that cocaine promoted skin oxidation via the involvement of the enzymes inducible nitric oxide synthase (iNOS) and xanthine oxidase (XO)...
  34. GÄ…dek Michalska A, Tadeusz J, Rachwalska P, Spyrka J, Bugajski J. Effect of repeated restraint on homotypic stress-induced nitric oxide synthases expression in brain structures regulating HPA axis. Pharmacol Rep. 2012;64:1381-90 pubmed
    ..In the present experiment the expression of neuron al and inducible nitric oxide synthase (nNOS and iNOS) were investigated in prefrontal cortex, hippocampus and hypothalamus in response to ..
  35. Horie A, Nagai K, Ohkura S, Ohama T, Komatsu H, Sato K. Proinflammatory cytokines suppress the expression level of protease-activated receptor-2 through the induction of iNOS in rat colon. J Vet Med Sci. 2009;71:1609-15 pubmed
    ..Conversely, in this preparation, mRNA expression levels of iNOS were significantly increased...
  36. Sheng W, Zong Y, Mohammad A, Ajit D, Cui J, Han D, et al. Pro-inflammatory cytokines and lipopolysaccharide induce changes in cell morphology, and upregulation of ERK1/2, iNOS and sPLA?-IIA expression in astrocytes and microglia. J Neuroinflammation. 2011;8:121 pubmed publisher
    ..and release of inflammatory factors, no detailed analysis has been carried out to compare the induction of iNOS and sPLA2-IIA...
  37. Tan S, Xie R, Klein Nulend J, van Rheden R, Bronckers A, Kuijpers Jagtman A, et al. Orthodontic force stimulates eNOS and iNOS in rat osteocytes. J Dent Res. 2009;88:255-60 pubmed publisher osteocytes through the activity of constitutive endothelial nitric oxide synthase (eNOS) or inducible nitric oxide synthase (iNOS)...
  38. Di B, Li X, Song L, Wang Q, Liu S. Association study of ACE and eNOS single nucleotide polymorphisms with Henoch-Schönlein purpura nephritis. Mol Med Rep. 2012;6:1171-7 pubmed publisher
    ..By comparing alleles, genotypes and haplotypes that are associated with lupus nephritis (LN) and HSPN, we found genetic heterogeneity between HSPN and LN. ..
  39. Ranjbaran M, Kadkhodaee M, Seifi B, Adelipour M, Azarian B. Erythropoietin attenuates experimental haemorrhagic shock-induced renal damage through an iNOS- dependent mechanism in male Wistar rats. Injury. 2017;48:262-269 pubmed publisher
    ..were randomized to five groups: 1) Sham, 2) HS 3) EPO 4) L-NAME, a non-specific NOS inhibitor 5) 1400W, a specific iNOS inhibitor. HS was induced by withdrawal of 50% of total blood volume...
  40. Lee J, Zhang Y, Ro J. Involvement of neuronal, inducible and endothelial nitric oxide synthases in capsaicin-induced muscle hypersensitivity. Eur J Pain. 2009;13:924-8 pubmed publisher
    ..Specifically, we examined the contribution of neuronal, inducible and endothelial nitric oxide synthases, nNOS, iNOS and eNOS, respectively, in mediating masseter hypersensitivity under acute inflammatory condition...
  41. Elshiekh M, Kadkhodaee M, Seifi B, Ranjbaran M, Askari H. Up-regulation of nitric oxide synthases by erythropoietin alone or in conjunction with ischemic preconditioning in ischemia reperfusion injury of rat kidneys. Gen Physiol Biophys. 2017;36:281-288 pubmed publisher
    ..attenuates oxidative stress, decreases histological damages, inhibits proinflammatory response, and up-regulates iNOS and eNOS gene expression compared to IR group...
  42. Ohama T, Hori M, Momotani E, Elorza M, Gerthoffer W, Ozaki H. IL-1beta inhibits intestinal smooth muscle proliferation in an organ culture system: involvement of COX-2 and iNOS induction in muscularis resident macrophages. Am J Physiol Gastrointest Liver Physiol. 2007;292:G1315-22 pubmed
    ..Immunostaining revealed that the majority of cyclooxygenase-2 and inducible NO synthase was located in the dense network of macrophages resident in the muscularis, which were immunoreactive to ..
  43. Wu D, Liu J, Pang X, Wang S, Zhao J, Zhang X, et al. Palmitic acid exerts pro-inflammatory effects on vascular smooth muscle cells by inducing the expression of C-reactive protein, inducible nitric oxide synthase and tumor necrosis factor-α. Int J Mol Med. 2014;34:1706-12 pubmed publisher
    ..acid on the expression of C-reactive protein (CRP), tumor necrosis factor α (TNF-α) and inducible nitric oxide synthase (iNOS) in VSMCs...
  44. Niu S, Shingle D, Garbarino Pico E, Kojima S, Gilbert M, Green C. The circadian deadenylase Nocturnin is necessary for stabilization of the iNOS mRNA in mice. PLoS ONE. 2011;6:e26954 pubmed publisher
    ..Mouse embryo fibroblasts (MEFs) lacking Nocturnin exhibit normal patterns of acute induction of TNF? and iNOS mRNAs during the first three hours following LPS treatment, but by 24 hours, while TNF? mRNA levels are ..
  45. Zielińska M, Milewski K, Skowrońska M, Gajos A, Ziemińska E, Beręsewicz A, et al. Induction of inducible nitric oxide synthase expression in ammonia-exposed cultured astrocytes is coupled to increased arginine transport by upregulated y(+)LAT2 transporter. J Neurochem. 2015;135:1272-81 pubmed publisher
    ..Up-regulation of y(+)LAT2 transporter is coupled with increased inducible nitric oxide synthase (iNOS) expression, which leads to increase nitric oxide (NO) synthesis and protein nitration.
  46. Gadek Michalska A, Tadeusz J, Rachwalska P, Bugajski J. Psychosocial stress inhibits additional stress-induced hyperexpression of NO synthases and IL-1? in brain structures. Pharmacol Rep. 2016;68:1178-1196 pubmed publisher
    ..was to compare the expression of interleukin-1? (IL-1?), neuronal nitric oxide synthase (nNOS) and inducible nitric oxide synthase (iNOS) in the prefrontal cortex (PFC), hippocampus (HIP) and hypothalamus (HT) during chronic ..
  47. Gökçek Saraç Ç, Karakurt S, Adali O, Jakubowska Doğru E. Correlation between hippocampal levels of neural, epithelial and inducible NOS and spatial learning skills in rats. Behav Brain Res. 2012;235:326-33 pubmed publisher
    ..isoforms in hippocampus-dependent forms of learning, we examined the expression of neural, endothelial, and inducible NOS in the hippocampus of young-adult rats classified as "poor" and "good" learners on the ..
  48. Villalba N, Sonkusare S, Longden T, Tran T, Sackheim A, Nelson M, et al. Traumatic brain injury disrupts cerebrovascular tone through endothelial inducible nitric oxide synthase expression and nitric oxide gain of function. J Am Heart Assoc. 2014;3:e001474 pubmed publisher
    ..The mechanism of profound cerebral artery vasodilation after TBI is a gain of function in vascular NO production by 60‐fold over controls, resulting from upregulation of the inducible isoform of NO synthase in the endothelium. ..
  49. Viggiano E, Ferrara D, Izzo G, Viggiano A, Minucci S, Monda M, et al. Cortical spreading depression induces the expression of iNOS, HIF-1alpha, and LDH-A. Neuroscience. 2008;153:182-8 pubmed publisher
    ..The effects of CSD on the expression of inducible nitric oxide synthase (iNOS), hypoxia inducible factor-1alpha (HIF-1alpha), and lactate dehydrogenase-A (LDH-A) were ..
  50. Ko S, Ryu G, Kim S, Ahn Y, Yoon K, Kaneto H, et al. Inducible nitric oxide synthase-nitric oxide plays an important role in acute and severe hypoxic injury to pancreatic beta cells. Transplantation. 2008;85:323-30 pubmed publisher
    ..The aim of the present study was to investigate whether acute and severe hypoxic injury could involve inducible nitric oxide synthase (iNOS)-nitric oxide (NO) signaling in beta cells...
  51. Krolick K. Muscle-derived nitric oxide synthase expression, differences associated with muscle fiber-type, and disease susceptibility in a rat model of myasthenia gravis. Clin Immunol. 2006;121:286-93 pubmed
    Reports from this laboratory suggested that expression of skeletal muscle-derived, inducible nitric oxide synthase (iNOS), is associated with resistance of a particular rat strain to the autoimmune model of myasthenia gravis (MG)...
  52. Song D, Yao R, Pang C. Altered vasodilator role of nitric oxide synthase in the pancreas, heart and brain of rats with spontaneous type 2 diabetes. Eur J Pharmacol. 2008;591:177-81 pubmed publisher
    ..We examined the functional role of constitutive and inducible NOS synthase (cNOS and iNOS, respectively) on regional blood flow in thiobutabarbital-anesthetized Zucker diabetic ..
  53. Tuuminen R, Syrjälä S, Krebs R, Keränen M, Koli K, Abo Ramadan U, et al. Donor simvastatin treatment abolishes rat cardiac allograft ischemia/reperfusion injury and chronic rejection through microvascular protection. Circulation. 2011;124:1138-50 pubmed publisher
    ..cell-endothelial cell gap formation; decreased intragraft mRNA levels of hypoxia-inducible factor-1?, inducible nitric oxide synthase, and endothelin-1; and increased heme oxygenase-1...