Nos1

Summary

Gene Symbol: Nos1
Description: nitric oxide synthase 1
Alias: bNOS, nitric oxide synthase, brain, N-NOS, NC-NOS, NOS type I, constitutive NOS, nNOS, neuronal NOS, nitric oxidase synthase, nitric oxide synthase 1, neuronal, peptidyl-cysteine S-nitrosylase NOS1
Species: rat
Products:     Nos1

Top Publications

  1. Tiso M, Konas D, Panda K, Garcin E, Sharma M, Getzoff E, et al. C-terminal tail residue Arg1400 enables NADPH to regulate electron transfer in neuronal nitric-oxide synthase. J Biol Chem. 2005;280:39208-19 pubmed
    The neuronal nitric-oxide synthase (nNOS) flavoprotein domain (nNOSr) contains regulatory elements that repress its electron flux in the absence of bound calmodulin (CaM)...
  2. Cheng W, Lu P, Ho W, Tung C, Cheng P, Hsiao M, et al. Angiotensin II inhibits neuronal nitric oxide synthase activation through the ERK1/2-RSK signaling pathway to modulate central control of blood pressure. Circ Res. 2010;106:788-95 pubmed publisher
    ..signal-regulated kinase (ERK)1/2, ribosomal protein S6 kinase (RSK), and also increased neuronal NO synthase (nNOS) phosphorylation. RSK was also found to bind directly to nNOS and induce phosphorylation at the Ser1416 position...
  3. Park J, Park S, Park S, Kim K, Chung J, Chun M, et al. Up-regulated expression of neuronal nitric oxide synthase in experimental diabetic retina. Neurobiol Dis. 2006;21:43-9 pubmed
    ..This study investigated the differential expression of neuronal nitric oxide synthase (nNOS) in the streptozotocin-induced diabetic rat retina to clarify the involvement of NO produced from neurons in the ..
  4. Li H, Shimizu H, Flinspach M, Jamal J, Yang W, Xian M, et al. The novel binding mode of N-alkyl-N'-hydroxyguanidine to neuronal nitric oxide synthase provides mechanistic insights into NO biosynthesis. Biochemistry. 2002;41:13868-75 pubmed
    ..Crystal structures of the nNOS heme domain complexed with either N-isopropyl-N'-hydroxyguanidine or N-butyl-N'-hydroxyguanidine reveal two ..
  5. Ollerstam A, Skøtt O, Ek J, Persson A, Thorup C. Effects of long-term inhibition of neuronal nitric oxide synthase on blood pressure and renin release. Acta Physiol Scand. 2001;173:351-8 pubmed
    Nitric oxide (NO) produced by neuronal NO-synthase (nNOS) in macula densa cells may be involved in the control of renin release...
  6. Xu K, Huso D, Dawson T, Bredt D, Becker L. Nitric oxide synthase in cardiac sarcoplasmic reticulum. Proc Natl Acad Sci U S A. 1999;96:657-62 pubmed
    ..Immunoelectron microscopy demonstrated labeling of cardiac SR vesicles by using anti-neuronal NOS (nNOS), but not anti-endothelial NOS (eNOS) or anti-inducible NOS (iNOS) antibodies, whereas skeletal muscle SR ..
  7. Fang M, Jaffrey S, Sawa A, Ye K, Luo X, Snyder S. Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON. Neuron. 2000;28:183-93 pubmed
    ..NO signaling may be enhanced by adaptor proteins that couple neuronal NO synthase (nNOS) to specific target proteins...
  8. Rameau G, Chiu L, Ziff E. Bidirectional regulation of neuronal nitric-oxide synthase phosphorylation at serine 847 by the N-methyl-D-aspartate receptor. J Biol Chem. 2004;279:14307-14 pubmed
    At glutamatergic synapses, the scaffolding protein PSD95 links the neuronal isoform of nitric-oxide synthase (nNOS) to the N-methyl-d-aspartate (NMDA) receptor...
  9. Talman W, Dragon D. Transmission of arterial baroreflex signals depends on neuronal nitric oxide synthase. Hypertension. 2004;43:820-4 pubmed
    ..These data support the hypothesis and suggest that neuronal nitric oxide synthase is critical to transmission of baroreflex signals through the nucleus tractus solitarii. ..

More Information

Publications62

  1. Saitoh F, Tian Q, Okano A, Sakagami H, Kondo H, Suzuki T. NIDD, a novel DHHC-containing protein, targets neuronal nitric-oxide synthase (nNOS) to the synaptic membrane through a PDZ-dependent interaction and regulates nNOS activity. J Biol Chem. 2004;279:29461-8 pubmed
    Targeting of neuronal nitric-oxide synthase (nNOS) to appropriate sites in a cell is mediated by interactions with its PDZ domain and plays an important role in specifying the sites of reaction of nitric oxide (NO) in the central nervous ..
  2. Jaffrey S, Snowman A, Eliasson M, Cohen N, Snyder S. CAPON: a protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD95. Neuron. 1998;20:115-24 pubmed
    Nitric oxide (NO) produced by neuronal nitric oxide synthase (nNOS) is important for N-methyl-D-aspartate (NMDA) receptor-dependent neurotransmitter release, neurotoxicity, and cyclic GMP elevations...
  3. Brenman J, Chao D, Xia H, Aldape K, Bredt D. Nitric oxide synthase complexed with dystrophin and absent from skeletal muscle sarcolemma in Duchenne muscular dystrophy. Cell. 1995;82:743-52 pubmed
    Nitric oxide (NO) is synthesized in skeletal muscle by neuronal-type NO synthase (nNOS), which is localized to sarcolemma of fast-twitch fibers. Synthesis of NO in active muscle opposes contractile force...
  4. Venema V, Ju H, Zou R, Venema R. Interaction of neuronal nitric-oxide synthase with caveolin-3 in skeletal muscle. Identification of a novel caveolin scaffolding/inhibitory domain. J Biol Chem. 1997;272:28187-90 pubmed
    Neuronal nitric-oxide synthase (nNOS) has been shown previously to interact with alpha1-syntrophin in the dystrophin complex of skeletal muscle...
  5. Yen D, Chen L, Shen Y, Chiu Y, Ho I, Lou Y, et al. Protein kinase A-dependent neuronal nitric oxide synthase activation mediates the enhancement of baroreflex response by adrenomedullin in the nucleus tractus solitarii of rats. J Biomed Sci. 2011;18:32 pubmed publisher
    ..the receptor-mediated enzymatic mechanisms that involve protein kinase A (PKA), or neuronal nitric oxide synthase (nNOS)...
  6. Shang T, Kotamraju S, Kalivendi S, Hillard C, Kalyanaraman B. 1-Methyl-4-phenylpyridinium-induced apoptosis in cerebellar granule neurons is mediated by transferrin receptor iron-dependent depletion of tetrahydrobiopterin and neuronal nitric-oxide synthase-derived superoxide. J Biol Chem. 2004;279:19099-112 pubmed
    ..Depletion of BH(4) decreased the active, dimeric form of neuronal nitric-oxide synthase (nNOS). MPP(+)-mediated "uncoupling" of nNOS decreased *NO and increased superoxide formation...
  7. Lin L, Talman W. Soluble guanylate cyclase and neuronal nitric oxide synthase colocalize in rat nucleus tractus solitarii. J Chem Neuroanat. 2005;29:127-36 pubmed
    ..In this study, we tested the hypothesis that neurons and fibers containing neuronal nitric oxide synthase (nNOS) lie in close proximity to those containing sGC and the two enzymes colocalize in some neurons and fibers in the ..
  8. Osuka K, Watanabe Y, Usuda N, Nakazawa A, Fukunaga K, Miyamoto E, et al. Phosphorylation of neuronal nitric oxide synthase at Ser847 by CaM-KII in the hippocampus of rat brain after transient forebrain ischemia. J Cereb Blood Flow Metab. 2002;22:1098-106 pubmed
    ..CaM)-dependent protein kinase IIalpha (CaM-KIIalpha) can phosphorylate neuronal nitric oxide synthase (nNOS) at Ser847 and attenuate NOS activity in neuronal cells...
  9. Socodato R, Santiago F, Portugal C, Domingues A, Santiago A, Relvas J, et al. Calcium-permeable ?-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors trigger neuronal nitric-oxide synthase activation to promote nerve cell death in an Src kinase-dependent fashion. J Biol Chem. 2012;287:38680-94 pubmed publisher
    ..Interestingly, experiments confirmed that neuronal NOS was activated in response to calcium-permeable AMPA receptor stimulation...
  10. Bredt D, Hwang P, Glatt C, Lowenstein C, Reed R, Snyder S. Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase. Nature. 1991;351:714-8 pubmed
    ..The only known mammalian enzyme with close homology is cytochrome P-450 reductase. ..
  11. Hillier B, Christopherson K, Prehoda K, Bredt D, Lim W. Unexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complex. Science. 1999;284:812-5 pubmed
    The PDZ protein interaction domain of neuronal nitric oxide synthase (nNOS) can heterodimerize with the PDZ domains of postsynaptic density protein 95 and syntrophin through interactions that are not mediated by recognition of a typical ..
  12. Hirai D, Copp S, Holdsworth C, Ferguson S, Musch T, Poole D. Effects of neuronal nitric oxide synthase inhibition on microvascular and contractile function in skeletal muscle of aged rats. Am J Physiol Heart Circ Physiol. 2012;303:H1076-84 pubmed publisher
    ..that, contrary to what was reported previously in young rats, selective neuronal nitric oxide (NO) synthase (nNOS) inhibition would result in attenuated or absent alterations in skeletal muscle microvascular oxygenation (Po(2)(mv)..
  13. Xiu li S, Jia hui L, Yi xue X. [The subgroup change of nitric oxide synthase in earlier period with cerebral ischemia/reperfusion in rats]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2010;26:144-6 pubmed
    To observe the expression of endothelial nitric oxide synthase (eNOS)and nervous nitric oxide synthase (nNOS) in rats during cerebral ischemia/reperfusion (CI/R) and study if change will be happen in subgroup between eNOS and nNOS during ..
  14. Long C, Hsu C, Shao P, Liu C, Su J, Tsai E. Effect of ovariectomy on the gene expression of detrusor muscarinic receptors in female rats. Fertil Steril. 2009;92:1147-9 pubmed publisher
    ..Two months later, the expression of muscarinic receptors, neuronal nitric oxide synthase (nNOS), and estrogen receptor (R) at the mRNA level were assessed by reverse-transcription polymerase chain reaction...
  15. Ma S, Kang J, Bae E, Choi C, Lee J, Kim S, et al. Effects of volume depletion and NaHCO3 loading on the expression of Na+/H+ exchanger isoform 3, Na+: HCO3- cotransporter type 1 and nitric oxide synthase in rat kidney. Clin Exp Pharmacol Physiol. 2008;35:262-7 pubmed
    ..The expression of NHE3, NBC1, nNOS and iNOS proteins was determined in the cortex of the kidney by immunoblotting and immunohistochemistry...
  16. Walkowska A, Sadowski J, Kompanowska Jezierska E. Oxidative stress and neuronal NOS activity: putative determinants of rapid blood pressure increase after renal denervation in anesthetized rats. Physiol Res. 2013;62:257-66 pubmed
    ..or pre-treated with tempol, a superoxide scavenger, or N(omega)-propyl-L-arginine (L-NPA), an inhibitor of neuronal NOS (nNOS)...
  17. Shao C, Suzuki Y, Kamada F, Kanno K, Tamari M, Hasegawa K, et al. Linkage and association of childhood asthma with the chromosome 12 genes. J Hum Genet. 2004;49:115-22 pubmed
    ..the signal transducer and activator of transcription 6 gene ( STAT6), the nitrogen oxide synthetase 1 gene ( NOS1), the interferon gamma gene ( IFNG), and the activation-induced cytidine deaminase gene ( AICDA)...
  18. Parkash J, d Anglemont de Tassigny X, Bellefontaine N, Campagne C, Mazure D, Buee Scherrer V, et al. Phosphorylation of N-methyl-D-aspartic acid receptor-associated neuronal nitric oxide synthase depends on estrogens and modulates hypothalamic nitric oxide production during the ovarian cycle. Endocrinology. 2010;151:2723-35 pubmed publisher
    ..b>Neuronal NOS Ser1412 phosphorylation is maximal on the afternoon of proestrus when both the levels of estrogens and the ..
  19. Yu W. Spatial and temporal correlation of nitric oxide synthase expression with CuZn-superoxide dismutase reduction in motor neurons following axotomy. Ann N Y Acad Sci. 2002;962:111-21 pubmed
    Axotomized neurons expressing neuronal nitric oxide synthase (nNOS) may use nitric oxide (NO), known for its antioxidant activities and ability to scavenge free radicals, to protect against oxidative stress...
  20. Huang Y, Chin C, Chen C, Shindel A, Ho D, Lin C, et al. Chronic Cigarette Smoking Impairs Erectile Function through Increased Oxidative Stress and Apoptosis, Decreased nNOS, Endothelial and Smooth Muscle Contents in a Rat Model. PLoS ONE. 2015;10:e0140728 pubmed publisher
    ..Corporal tissue was assessed by Western blot for neuronal nitric oxide synthase (nNOS). Penile tissues were subjected to immunohistochemistry for endothelial, smooth muscle, and apoptotic content...
  21. Sullivan J, Smart E, Pollock D, Pollock J. Influence of salt on subcellular localization of nitric oxide synthase activity and expression in the renal inner medulla. Clin Exp Pharmacol Physiol. 2008;35:120-5 pubmed
    ..and intracellular membrane subcellular fractions of the renal inner medulla of rats; and (ii) to determine whether NOS1 and NOS3 activity and expression in subcellular fractions of the renal inner medulla are regulated by dietary salt ..
  22. Slyvka Y, Malgor R, Inman S, Ding J, Heh V, Nowak F. Antioxidant diet and sex interact to regulate NOS isoform expression and glomerular mesangium proliferation in Zucker diabetic rat kidney. Acta Histochem. 2016;118:183-93 pubmed publisher
    ..eNOS was observed in glomeruli and tubules. nNOS predominantly localized to tubular epithelium in both cortex and medulla...
  23. Davidova A, Schreiberova A, Kolesar D, Capková L, Krizanová O, Lukacova N. Spinal cord transection significantly influences nNOS-IR in neuronal circuitry that underlies the tail-flick reflex activity. Cell Mol Neurobiol. 2009;29:879-86 pubmed publisher
    ..cord transection performed at low thoracic level on changes in (i) neuronal nitric oxide synthase immunoreactivity (nNOS-IR), and (ii) the level of neuronal nitric oxide synthase (nNOS) protein in the neuronal circuitry that underlies ..
  24. Gao S, Fei M, Cheng C, Yu X, Chen M, Shi S, et al. Spatiotemporal expression of PSD-95 and nNOS after rat sciatic nerve injury. Neurochem Res. 2008;33:1090-100 pubmed
    Neuronal nitric oxide synthase (nNOS) has been implicated to influence peripheral nerve lesion and regeneration...
  25. Talman W, Nitschke Dragon D. Neuronal nitric oxide mediates cerebral vasodilatation during acute hypertension. Brain Res. 2007;1139:126-32 pubmed
    ..of cerebral vessels during hypertension, that hypothesis has not been tested with selective local inhibition of neuronal NOS (nNOS)...
  26. Patterson M, Mullins J, Mitchell K. Renoprotective effects of neuronal NOS-derived nitric oxide and cyclooxygenase-2 metabolites in transgenic rats with inducible malignant hypertension. Am J Physiol Renal Physiol. 2008;294:F205-11 pubmed
    The present study was performed to determine the effects of neuronal nitric oxide synthase (nNOS) and cyclooxygenase-2 (COX-2) inhibition on blood pressure and renal hemodynamics in transgenic rats with inducible ANG II-dependent ..
  27. Uvarov VYu -, Lyashenko A. The identification of the pterin-binding domain in the nitric oxide synthase's sequence. Biochem Biophys Res Commun. 1995;206:736-41 pubmed
    ..Pairwise alignment of amino acids sequences of NOS from rat brain and rat xantine dehydrogenase revealed that the two proteins are 39.7% identical. ..
  28. Siow T, Chen C, Wan N, Chow K, Chang C. In vivo evidence of increased nNOS activity in acute MPTP neurotoxicity: a functional pharmacological MRI study. Biomed Res Int. 2013;2013:964034 pubmed publisher
    ..Previous studies have suggested a critical role for neuronal nitric oxide (NO) synthase- (nNOS-) derived NO in the pathogenesis of MPTP...
  29. Liang Z, Zhang L, Wang X, Gao F, Wang X, Zhou S, et al. Distribution and neurochemical features of neuronal nitric oxide synthase-expressing interneurons in the rat dentate gyrus. Brain Res. 2013;1505:11-21 pubmed publisher
    Neuronal nitric oxide synthase (nNOS)-expressing interneurons are abundant in the dentate gyrus (DG) of rodents...
  30. Morishita T, Tsutsui M, Shimokawa H, Horiuchi M, Tanimoto A, Suda O, et al. Vasculoprotective roles of neuronal nitric oxide synthase. FASEB J. 2002;16:1994-6 pubmed
    ..NOS (iNOS) on the development of atherosclerosis have been described, little is known about the role of neuronal NOS (nNOS). Here, we show that nNOS also exerts important vasculoprotective effects in vivo...
  31. Huang S, Wei F, Hung L. Ischemic preconditioning attenuates postischemic leukocyte--endothelial cell interactions: role of nitric oxide and protein kinase C. Circ J. 2006;70:1070-5 pubmed
    ..It was also observed that IPC upregulated nNOS, iNOS, and eNOS mRNA in I/R injured tissue, but this effect was not blocked by chelerythrine...
  32. Qi C, Zhang J, Tian Y, Chen X, Zhang P, Xiao X, et al. [Effect of ligustrazine on cell proliferation in subventricular zone in rat brain with focal cerebral ischemia-reperfusion injury]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2007;32:396-400 pubmed
    ..The total number of BrdU positive cells in the SVZ was measured. The expression of neuro nitric oxide synthase (nNOS) was detected with Western blot method...
  33. Nava Ruíz C, Alcaraz Zubeldia M, Mendez Armenta M, Vergara P, Diaz Ruiz A, Rios C. Nitric oxide synthase immunolocalization and expression in the rat hippocampus after sub-acute lead acetate exposure in rats. Exp Toxicol Pathol. 2010;62:311-6 pubmed publisher
    ..We found diminished expression and immunoreactivity of nNOS and eNOS at 500ppm as compared to the control group...
  34. Chertok V, Kotsuba A. [The distribution of NADPH-diaphorase and neuronal no synthase in rat medulla oblongata nuclei]. Morfologiia. 2013;144:9-14 pubmed
    ..NADPH-diaphorase) and using immunohistochemistry with an antiserum against neuronal form of nitric oxide synthase (nNOS). NADPH-diaphorase activity was found in large and small neurons of the sensory, autonomic and motor nuclei...
  35. d Anglemont de Tassigny X, Campagne C, Steculorum S, Prevot V. Estradiol induces physical association of neuronal nitric oxide synthase with NMDA receptor and promotes nitric oxide formation via estrogen receptor activation in primary neuronal cultures. J Neurochem. 2009;109:214-24 pubmed publisher
    ..regulation of NO production may reside in the differential coupling of the calcium-activated neuronal NO synthase (nNOS) to glutamate NMDA receptor channels harboring NR2B subunits by the scaffolding protein post-synaptic density-95 (..
  36. Fellet A, Balaszczuk A, Arranz C, López Costa J, Boveris A, Bustamante J. Autonomic regulation of pacemaker activity: role of heart nitric oxide synthases. Am J Physiol Heart Circ Physiol. 2006;291:H1246-54 pubmed
    ..The observations suggest that NO-mediated pathways contribute to pacemaker heart activity, likely through the NO steady-state levels in the right atrium and the whole heart. ..
  37. Copp S, Hirai D, Ferguson S, Holdsworth C, Musch T, Poole D. Effects of chronic heart failure on neuronal nitric oxide synthase-mediated control of microvascular O2 pressure in contracting rat skeletal muscle. J Physiol. 2012;590:3585-96 pubmed publisher
    ..It is unknown whether nNOS-mediated PO(2)mv regulation is altered in CHF...
  38. Di J, Li C, Yu H, Zheng J, Zhang G. nNOS downregulation attenuates neuronal apoptosis by inhibiting nNOS-GluR6 interaction and GluR6 nitrosylation in cerebral ischemic reperfusion. Biochem Biophys Res Commun. 2012;420:594-9 pubmed publisher
    ..NO (Nitric Oxide) is mainly generated from neuronal nitric oxide synthase (nNOS) in cerebral neurons during the early stages of reperfusion...
  39. Richmonds C, Kaminski H. Nitric oxide synthase expression and effects of nitric oxide modulation on contractility of rat extraocular muscle. FASEB J. 2001;15:1764-70 pubmed
    ..nNOS activity was highest in EOM compared with diaphragm, extensor digitorum longus, and soleus. Neuronal NOS was concentrated to the sarcolemma of orbital and global singly innervated fibers, but not evident in the multi-..
  40. Premaratne S, Xue C, McCarty J, Zaki M, McCuen R, Johns R, et al. Neuronal nitric oxide synthase: expression in rat parietal cells. Am J Physiol Gastrointest Liver Physiol. 2001;280:G308-13 pubmed
    ..At least three isoforms of NOS have been identified: neuronal NOS (nNOS or NOS I), inducible NOS (iNOS or NOS II), and endothelial NOS (eNOS or NOS II)...
  41. Sanae R, Kurokawa F, Oda M, Ishijima S, Sagami I. Thermodynamic analysis of interactions between cofactor and neuronal nitric oxide synthase. Biochemistry. 2011;50:1714-22 pubmed publisher
    The thermodynamics of cofactor binding to the isolated reductase domain (Red) of nNOS and its mutants have been studied by isothermal titration calorimetry...
  42. Cunningham M, Sasser J, West C, Baylis C. Renal redox response to normal pregnancy in the rat. Am J Physiol Regul Integr Comp Physiol. 2013;304:R443-9 pubmed publisher
    ..Protein abundance of endothelial NOS (eNOS) was unchanged and neuronal NOS (nNOS)? fell at LP in the kidney cortex. Kidney cortex nNOS? was elevated at MP, LP, and PP...
  43. Zhang J, He Y, Ding Y, Zhou H, Tang Y, Chen L, et al. Nitric oxide synthase expression in the medullary respiratory related nuclei and its involvement in CO-mediated central respiratory effects in neonatal rats. Brain Res Bull. 2011;84:258-63 pubmed publisher
    ..The results suggest that nitric oxide synthase-NO pathway might be involved in the CO-mediated central regulation of respiration at the level of medulla oblongata in neonatal rats. ..
  44. Sato Y, Sagami I, Shimizu T. Identification of caveolin-1-interacting sites in neuronal nitric-oxide synthase. Molecular mechanism for inhibition of NO formation. J Biol Chem. 2004;279:8827-36 pubmed
    Caveolin is known to down-regulate both neuronal (nNOS) and endothelial nitric-oxide synthase (eNOS)...
  45. Silva S, Silva S, Meireles M, Leal S. nNOS is involved in cardiac remodeling induced by chronic ethanol consumption. Toxicology. 2015;329:98-105 pubmed publisher
    ..Moreover, nitric oxide (NO) derived from neuronal NO synthase (nNOS) seems to be important to balance the harmful effects of ethanol consumption, because it influences several aspects ..
  46. Wang M, Jiang C, Wang C, Yao Q. Role of brain angiotensin AT1 receptor in the carbachol-induced natriuresis and expression of nNOS in the locus coeruleus and proximal convoluted tubule. Physiol Res. 2007;56:383-91 pubmed
    ..angiotensin AT(1) receptor in the carbachol-induced natriuresis and expression of neuronal nitric oxide synthase (nNOS) in the locus coeruleus (LC) and proximal convoluted tubule (PCT)...
  47. Fricks Gleason A, Keefe K. Evaluating the role of neuronal nitric oxide synthase-containing striatal interneurons in methamphetamine-induced dopamine neurotoxicity. Neurotox Res. 2013;24:288-97 pubmed publisher
    ..clearly delineated, but recent evidence suggests that it arises from activation of neuronal nitric oxide synthase (nNOS), which is selectively expressed in a subpopulation of striatal interneurons...
  48. Panda K, Adak S, Aulak K, Santolini J, McDonald J, Stuehr D. Distinct influence of N-terminal elements on neuronal nitric-oxide synthase structure and catalysis. J Biol Chem. 2003;278:37122-31 pubmed
    ..Of these, only NOS I (neuronal nitric-oxide synthase; nNOS) is expressed as catalytically active N-terminally truncated forms that are missing either an N-terminal leader ..
  49. Cattano D, Valleggi S, Abramo A, Forfori F, Maze M, Giunta F. Nitrous oxide discretely up-regulates nNOS and p53 in neonatal rat brain. Minerva Anestesiol. 2010;76:420-4 pubmed
    ..by a compensatory increase in intracellular free calcium, a potent activator of neuronal nitric oxide synthase (nNOS)...
  50. Palomba L, Persichini T, Mazzone V, Colasanti M, Cantoni O. Inhibition of nitric-oxide synthase-I (NOS-I)-dependent nitric oxide production by lipopolysaccharide plus interferon-gamma is mediated by arachidonic acid. Effects on NFkappaB activation and late inducible NOS expression. J Biol Chem. 2004;279:29895-901 pubmed
    ..These responses were promptly reestablished by addition of exogenous AA. Finally, we have demonstrated that the LPS/IFNgamma-dependent tyrosine phosphorylation of NOS-I and inhibition of its activity are mediated by endogenous AA. ..
  51. Kim K, Kim J, Han J, Choe M, Ahn J. Upregulation of neuronal nitric oxide synthase in the periphery promotes pain hypersensitivity after peripheral nerve injury. Neuroscience. 2011;190:367-78 pubmed publisher
    ..Several studies suggest a functional role for neuronal nitric oxide synthase (nNOS) in the development or maintenance of neuropathic pain, but such a contribution remains unclear...
  52. Pignataro G, Esposito E, Sirabella R, Vinciguerra A, Cuomo O, di Renzo G, et al. nNOS and p-ERK involvement in the neuroprotection exerted by remote postconditioning in rats subjected to transient middle cerebral artery occlusion. Neurobiol Dis. 2013;54:105-14 pubmed publisher
    ..The use of in vivo silencing strategy allowed to demonstrate that NO production through nNOS mediates part of the neuroprotection...
  53. Kemuriyama T, Tandai Hiruma M, Kato K, Ohta H, Maruyama S, Sato Y, et al. Endogenous angiotensin II has fewer effects but neuronal nitric oxide synthase has excitatory effects on renal sympathetic nerve activity in salt-sensitive hypertension-induced heart failure. J Physiol Sci. 2009;59:275-81 pubmed publisher
    The effects of endogenous angiotensin II (Ang II) and neuronal nitric oxide synthase (nNOS) on tonic sympathetic activity were studied in salt-sensitive hypertension-induced heart failure...