Gene Symbol: Nopp140
Description: nucleolar and coiled-body phosphoprotein 1
Alias: Nopp140, nucleolar and coiled-body phosphoprotein 1, 140 kDa nucleolar phosphoprotein, nucleolar 130 kDa protein, nucleolar phosphoprotein 140, nucleolar phosphoprotein p130
Species: rat
Products:     Nopp140

Top Publications

  1. Meier U, Blobel G. Nopp140 shuttles on tracks between nucleolus and cytoplasm. Cell. 1992;70:127-38 pubmed
    b>Nopp140 is a nucleolar phosphoprotein of 140 kd that we originally identified and purified as a nuclear localization signal (NLS)-binding protein...
  2. Yang Y, Meier U. Genetic interaction between a chaperone of small nucleolar ribonucleoprotein particles and cytosolic serine hydroxymethyltransferase. J Biol Chem. 2003;278:23553-60 pubmed
    ..Finally, rat Nopp140 restored growth and stability of box H/ACA snoRNAs after genetic depletion of SRP40 in the synthetic lethal ..
  3. Tyner J, Uchida O, Kajiwara N, Kim E, Patel A, O Sullivan M, et al. CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection. Nat Med. 2005;11:1180-7 pubmed
    ..The antiapoptotic action of chemokine signaling may therefore allow scavengers to finally stop the host cell-to-cell infectious process. ..
  4. Werner A, Iwasaki S, McGourty C, Medina Ruiz S, Teerikorpi N, Fedrigo I, et al. Cell-fate determination by ubiquitin-dependent regulation of translation. Nature. 2015;525:523-7 pubmed publisher
    ..We conclude that ubiquitin-dependent regulation of translation is an important feature of cell-fate determination. ..
  5. Miau L, Chang C, Tsai W, Lee S. Identification and characterization of a nucleolar phosphoprotein, Nopp140, as a transcription factor. Mol Cell Biol. 1997;17:230-9 pubmed
    ..In addition to interacting with AGP/EBP, Nopp140 interacts specifically with TFIIB...
  6. Miau L, Chang C, Shen B, Tsai W, Lee S. Identification of heterogeneous nuclear ribonucleoprotein K (hnRNP K) as a repressor of C/EBPbeta-mediated gene activation. J Biol Chem. 1998;273:10784-91 pubmed
    ..Furthermore, agp gene activation by the synergistic interaction of Nopp140 and C/EBPbeta is abolished by hnRNP K...
  7. Warskulat U, Hammermann R, Haussinger D. Anisoosmotic regulation of the Nopp140 mRNA in H4IIE rat hepatoma cells and primary hepatocytes. FEBS Lett. 1999;452:259-62 pubmed
    ..polymerase chain reaction osmosensitive regulation of mRNA levels of the nucleolar phosphoprotein of 140 kDa (Nopp140) was found in H4IIE rat hepatoma cells...
  8. Yang Y, Isaac C, Wang C, Dragon F, Pogacic V, Meier U. Conserved composition of mammalian box H/ACA and box C/D small nucleolar ribonucleoprotein particles and their interaction with the common factor Nopp140. Mol Biol Cell. 2000;11:567-77 pubmed
    ..Using coimmunoprecipitation experiments, we show that the nucleolar and coiled-body protein Nopp140 interacts with both classes of snoRNPs...
  9. Tucker K, Berciano M, Jacobs E, LePage D, Shpargel K, Rossire J, et al. Residual Cajal bodies in coilin knockout mice fail to recruit Sm snRNPs and SMN, the spinal muscular atrophy gene product. J Cell Biol. 2001;154:293-307 pubmed
    ..are highly enriched in basal transcription and cell cycle factors, the nucleolar proteins fibrillarin (Fb) and Nopp140 (Nopp), the survival motor neuron (SMN) protein complex, and the CB marker protein, p80 coilin...

More Information


  1. Wang C, Query C, Meier U. Immunopurified small nucleolar ribonucleoprotein particles pseudouridylate rRNA independently of their association with phosphorylated Nopp140. Mol Cell Biol. 2002;22:8457-66 pubmed
    ..Additionally, the nucleolar and Cajal body protein Nopp140 (Srp40p) associates with the snoRNPs...
  2. Lee H, Yamanouchi K, Nishihara M. Effects of perinatal exposure to phthalate/adipate esters on hypothalamic gene expression and sexual behavior in rats. J Reprod Dev. 2006;52:343-52 pubmed