Gene Symbol: Nop53
Description: NOP53 ribosome biogenesis factor
Alias: Gltscr2, glioma tumor suppressor candidate region gene 2 protein, preS1 binding protein
Species: rat
Products:     Nop53

Top Publications

  1. Kim J, Seok K, Kim Y, Bae W, Lee S, Park J. Involvement of GLTSCR2 in the DNA Damage Response. Am J Pathol. 2011;179:1257-64 pubmed publisher
    ..b>GLTSCR2 is a nucleolar protein believed to function as a tumor suppressor, although its exact molecular mechanisms have ..
  2. Sasaki M, Kawahara K, Nishio M, Mimori K, Kogo R, Hamada K, et al. Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11. Nat Med. 2011;17:944-51 pubmed publisher
    PICT1 (also known as GLTSCR2) is considered a tumor suppressor because it stabilizes phosphatase and tensin homolog (PTEN), but individuals with oligodendrogliomas lacking chromosome 19q13, where PICT1 is located, have better prognoses ..
  3. Lee S, Kim J, Kim Y, Seok K, Kim J, Chang Y, et al. Nucleolar protein GLTSCR2 stabilizes p53 in response to ribosomal stresses. Cell Death Differ. 2012;19:1613-22 pubmed publisher
    ..In this work, we show that nucleolar protein glioma tumor-suppressor candidate region gene 2 (GLTSCR2) translocates to the nucleoplasm under ribosomal stress, where it interacts with and stabilizes p53 and inhibits ..
  4. Kim J, Cho Y, An Y, Kim S, Lee Y, Park J, et al. GLTSCR2 is an upstream negative regulator of nucleophosmin in cervical cancer. J Cell Mol Med. 2015;19:1245-52 pubmed publisher
    ..In this study, we showed that nucleolar protein GLTSCR2/Pict-1 induced nucleoplasmic translocation and enhanced the degradation of NPM via the proteasomal ..
  5. YOON J, Ling A, Isik M, Lee D, Steinbaugh M, Sack L, et al. GLTSCR2/PICT1 links mitochondrial stress and Myc signaling. Proc Natl Acad Sci U S A. 2014;111:3781-6 pubmed publisher
    ..The screen identified 94 candidate mitochondrial regulators including the nuclear protein GLTSCR2, also known as PICT1...
  6. Chen H, Han L, Tsai H, Wang Z, Wu Y, Duo Y, et al. PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway. Oncotarget. 2016;7:83241-83257 pubmed publisher
    ..These data indicate that PICT-1 is a major nucleolar sensor of the DNA damage repair response and an important upstream regulator of p53 via the RPL11-MDM2-p53 pathway. ..
  7. Kim J, Cho Y, Park J. The Nucleolar Protein GLTSCR2 Is an Upstream Negative Regulator of the Oncogenic Nucleophosmin-MYC Axis. Am J Pathol. 2015;185:2061-8 pubmed publisher
    ..we describe a novel function of the nucleolar protein glioblastoma tumor-suppressive candidate region gene 2 (GLTSCR2) in regulating the transcriptional activity of MYC through an NPM-dependent pathway in SK-BR3 breast cancer cells...
  8. Chen H, Mei L, Zhou L, Zhang X, Guo C, Li J, et al. Moesin-ezrin-radixin-like protein (merlin) mediates protein interacting with the carboxyl terminus-1 (PICT-1)-induced growth inhibition of glioblastoma cells in the nucleus. Int J Biochem Cell Biol. 2011;43:545-55 pubmed publisher
    ..Knockdown of merlin expression by siRNA attenuates the inhibitory effects induced by PICT-1 over-expression. We propose that merlin mediates PICT-1-induced growth inhibition by translocating to the nucleolus and binding PICT-1. ..
  9. Maehama T, Kawahara K, Nishio M, Suzuki A, Hanada K. Nucleolar stress induces ubiquitination-independent proteasomal degradation of PICT1 protein. J Biol Chem. 2014;289:20802-12 pubmed
    ..These results suggest that PICT1 employs atypical proteasome-mediated degradation machinery to sense nucleolar stress within the nucleolus. ..

More Information


  1. Chen H, Duo Y, Hu B, Wang Z, Zhang F, Tsai H, et al. PICT-1 triggers a pro-death autophagy through inhibiting rRNA transcription and AKT/mTOR/p70S6K signaling pathway. Oncotarget. 2016;7:78747-78763 pubmed publisher
    ..Our data show that PICT-1 triggers pro-death autophagy through inhibition of rRNA transcription and the inactivation of AKT/mTOR/p70S6K pathway, independent of nucleolar disruption and p53 activation. ..
  2. Wang P, Meng W, Han S, Li C, Wang X, Wang X. The nucleolar protein GLTSCR2 is required for efficient viral replication. Sci Rep. 2016;6:36226 pubmed publisher
    b>Glioma tumor suppressor candidate region gene 2 protein (GLTSCR2) is a nucleolar protein...
  3. Sloan K, Bohnsack M, Watkins N. The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress. Cell Rep. 2013;5:237-47 pubmed publisher
    ..The 5S RNP therefore emerges as the critical coordinator of signaling pathways that couple cell proliferation with ribosome production. ..
  4. Okahara F, Ikawa H, Kanaho Y, Maehama T. Regulation of PTEN phosphorylation and stability by a tumor suppressor candidate protein. J Biol Chem. 2004;279:45300-3 pubmed
    ..These findings suggest a novel molecular mechanism underlying the turnover of PTEN, which also provides an explanation for the loss of PTEN function due to C-terminal mutations. ..
  5. Borodianskiy Shteinberg T, Kalt I, Kipper S, Nachum N, Katz S, Pauker M, et al. The nucleolar PICT-1/GLTSCR2 protein forms homo-oligomers. J Mol Biol. 2014;426:2363-78 pubmed publisher
    ..carboxyl terminus 1" (PICT-1), also designated as the "glioma tumor suppressor candidate region 2 gene product", GLTSCR2, is a nucleolar protein whose activity is, as yet, unknown...
  6. Kalt I, Borodianskiy Shteinberg T, Schachor A, Sarid R. GLTSCR2/PICT-1, a putative tumor suppressor gene product, induces the nucleolar targeting of the Kaposi's sarcoma-associated herpesvirus KS-Bcl-2 protein. J Virol. 2010;84:2935-45 pubmed publisher as protein interacting with carboxyl terminus 1 (PICT-1), encoded by a candidate tumor suppressor gene, GLTSCR2. Confocal laser scanning microscopy revealed nucleolar localization of PICT-1, whereas KS-Bcl-2 was located ..
  7. Lee S, Cho Y, Kim S, Kim Y, Park J. GLTSCR2 promotes the nucleoplasmic translocation and subsequent degradation of nucleolar ARF. Oncotarget. 2017;8:16293-16302 pubmed publisher
    ..b>GLTSCR2 (also known as PICT-1) is a nucleolar protein involved in both tumor suppression and oncogenesis in concert with ..
  8. Okahara F, Itoh K, Nakagawara A, Murakami M, Kanaho Y, Maehama T. Critical role of PICT-1, a tumor suppressor candidate, in phosphatidylinositol 3,4,5-trisphosphate signals and tumorigenic transformation. Mol Biol Cell. 2006;17:4888-95 pubmed
    ..Recent study revealed that PICT-1/GLTSCR2 bound to and stabilized PTEN protein in cells, implicating its roles in PTEN-governed PIP(3) signals...