nodal

Summary

Gene Symbol: nodal
Description: nodal growth differentiation factor
Alias: nodal homolog
Species: rat
Products:     nodal

Top Publications

  1. Ma G, Soloveva V, Tzeng S, Lowe L, Pfendler K, Iannaccone P, et al. Nodal regulates trophoblast differentiation and placental development. Dev Biol. 2001;236:124-35 pubmed
    b>Nodal has been thought to be an embryo-specific factor that regulates development, but nodal is also expressed in the mouse placenta beginning at midgestation, specifically in the spongiotrophoblasts...
  2. Yan Y, Liu J, Luo Y, E C, Haltiwanger R, Abate Shen C, et al. Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway. Mol Cell Biol. 2002;22:4439-49 pubmed
    ..that has been implicated in the signaling pathway for the transforming growth factor beta (TGF beta) ligand Nodal. Although recent findings in frog and fish embryos have suggested that EGF-CFC proteins function as coreceptors ..
  3. Hueng D, Lin G, Huang S, Liu L, Ju D, Chen Y, et al. Inhibition of Nodal suppresses angiogenesis and growth of human gliomas. J Neurooncol. 2011;104:21-31 pubmed publisher
    ..We previously reported that expression levels of Nodal, a member of transforming growth factor-? super family, correlate with the malignant invasive behavior of human ..
  4. Kim S, Yoon S, Chuong E, Oyolu C, Wills A, Gupta R, et al. Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs. Dev Biol. 2011;357:492-504 pubmed publisher
    ..Endoderm commitment is controlled by the TGF-? superfamily member, Nodal, which utilizes the transcription factors, SMAD2/3, SMAD4 and FOXH1, to drive target gene expression...
  5. Brennan J, Lu C, Norris D, Rodriguez T, Beddington R, Robertson E. Nodal signalling in the epiblast patterns the early mouse embryo. Nature. 2001;411:965-9 pubmed
    ..The transforming growth factor-beta family member Nodal is known to be required for formation of the anterior-posterior axis...
  6. Brennan J, Norris D, Robertson E. Nodal activity in the node governs left-right asymmetry. Genes Dev. 2002;16:2339-44 pubmed
    b>Nodal is expressed at the lateral edges of the mouse node, but its function in this "organizer" tissue remains unknown due to the early lethality of Nodal mutant embryos...
  7. Lawrence M, Margaryan N, Loessner D, Collins A, Kerr K, Turner M, et al. Reactivation of embryonic nodal signaling is associated with tumor progression and promotes the growth of prostate cancer cells. Prostate. 2011;71:1198-209 pubmed publisher
    b>Nodal is a member of the transforming growth factor ? (TGF?) superfamily that directs embryonic patterning and promotes the plasticity and tumorigenicity of tumor cells, but its role in the prostate is unknown...
  8. Conlon F, Lyons K, Takaesu N, Barth K, Kispert A, Herrmann B, et al. A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse. Development. 1994;120:1919-28 pubmed
    The 413.d insertional mutation arrests mouse development shortly after gastrulation. nodal, a novel TGF beta-related gene, is closely associated with the locus...
  9. Wang H, Jiang J, Zhu C, Peng C, Tsang B. Role and regulation of nodal/activin receptor-like kinase 7 signaling pathway in the control of ovarian follicular atresia. Mol Endocrinol. 2006;20:2469-82 pubmed
    ..In the present study, we have demonstrated for the first time that Nodal, a member of the TGF beta superfamily, is involved in promoting follicular atresia as evidenced by the following: ..

More Information

Publications30

  1. Ware S, Harutyunyan K, Belmont J. Heart defects in X-linked heterotaxy: evidence for a genetic interaction of Zic3 with the nodal signaling pathway. Dev Dyn. 2006;235:1631-7 pubmed
    ..The penetrance of these phenotypes is increased in mice that are also haploinsufficient for Nodal. Zic3(+/-); Nodal (+/-) compound heterozygous mice are born in significantly reduced numbers (P=0...
  2. Jörnvall H, Reissmann E, Andersson O, Mehrkash M, Ibanez C. ALK7, a receptor for nodal, is dispensable for embryogenesis and left-right patterning in the mouse. Mol Cell Biol. 2004;24:9383-9 pubmed
    ..development depend upon selected members of the transforming growth factor beta superfamily, particularly Nodal and Nodal-related ligands...
  3. Lu C, Robertson E. Multiple roles for Nodal in the epiblast of the mouse embryo in the establishment of anterior-posterior patterning. Dev Biol. 2004;273:149-59 pubmed
    The TGFbeta family member Nodal has been shown to be involved in a variety of processes in development, including early axis formation...
  4. Marques S, Borges A, Silva A, Freitas S, Cordenonsi M, Belo J. The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis. Genes Dev. 2004;18:2342-7 pubmed
    ..left/right (L/R) body asymmetry in the mouse embryo requires asymmetric activation of the evolutionarily conserved Nodal signaling cascade in the left lateral plate mesoderm (L-LPM)...
  5. Zhao F, Huang F, Tang M, Li X, Zhang N, Amfilochiadis A, et al. Nodal induces apoptosis through activation of the ALK7 signaling pathway in pancreatic INS-1 ?-cells. Am J Physiol Endocrinol Metab. 2012;303:E132-43 pubmed publisher
    ..Here, we show that Nodal activates ALK7 signaling and regulates ?-cell apoptosis...
  6. Munir S, Xu G, Wu Y, Yang B, Lala P, Peng C. Nodal and ALK7 inhibit proliferation and induce apoptosis in human trophoblast cells. J Biol Chem. 2004;279:31277-86 pubmed
    b>Nodal, a member of the transforming growth factor-beta superfamily, is known to play critical roles in early vertebrate development, but its functions in extraembryonic tissues are unclear. ALK7 is a type I receptor for Nodal...
  7. Vincent S, Dunn N, Hayashi S, Norris D, Robertson E. Cell fate decisions within the mouse organizer are governed by graded Nodal signals. Genes Dev. 2003;17:1646-62 pubmed
    ..Previous studies suggest that signaling pathways activated by Nodal, bone morphogenetic protein (BMP), and Wnt ligands coordinately regulate patterning of the streak and the ..
  8. Yamamoto M, Mine N, Mochida K, Sakai Y, Saijoh Y, Meno C, et al. Nodal signaling induces the midline barrier by activating Nodal expression in the lateral plate. Development. 2003;130:1795-804 pubmed
    The transcription factor Foxh1 mediates Nodal signaling. The role of Foxh1 in left-right (LR) patterning was examined with mutant mice that lack this protein in lateral plate mesoderm (LPM)...
  9. Lowe L, Yamada S, Kuehn M. Genetic dissection of nodal function in patterning the mouse embryo. Development. 2001;128:1831-43 pubmed
    Loss-of-function analysis has shown that the transforming growth factor-like signaling molecule nodal is essential for mouse mesoderm development...
  10. Yamamoto M, Saijoh Y, Perea Gomez A, Shawlot W, Behringer R, Ang S, et al. Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo. Nature. 2004;428:387-92 pubmed
    ..Here we show that Nodal signalling and the regionalization of its antagonists are required for normal migration of the DVE...
  11. Powers S, Taniguchi K, Yen W, Melhuish T, Shen J, Walsh C, et al. Tgif1 and Tgif2 regulate Nodal signaling and are required for gastrulation. Development. 2010;137:249-59 pubmed publisher
    ..TGIF1 are associated with holoprosencephaly, but it is unclear whether this is a result of deregulation of TGFbeta/Nodal signaling, or of effects on other pathways...
  12. Saijoh Y, Oki S, Ohishi S, Hamada H. Left-right patterning of the mouse lateral plate requires nodal produced in the node. Dev Biol. 2003;256:160-72 pubmed
    ..Mice homozygous for a hypomorphic Nodal allele (Nodal(neo)) were generated and found to exhibit L-R defects, including right isomerism...
  13. Huaux F, Liu T, McGarry B, Ullenbruch M, Xing Z, Phan S. Eosinophils and T lymphocytes possess distinct roles in bleomycin-induced lung injury and fibrosis. J Immunol. 2003;171:5470-81 pubmed
  14. Izzi L, Silvestri C, Von Both I, Labbé E, Zakin L, Wrana J, et al. Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development. EMBO J. 2007;26:3132-43 pubmed
    ..Mix/Bix proteins are transcription factors that function in Nodal-like signaling pathways and are themselves regulated by Nodal...
  15. Park C, DeMayo F, Lydon J, Dufort D. NODAL in the uterus is necessary for proper placental development and maintenance of pregnancy. Biol Reprod. 2012;86:194 pubmed publisher
    ..and analysis of a novel conditional knockout of the transforming growth factor beta (TGFB) superfamily member, Nodal, from the maternal reproductive tract of mice...
  16. Camus A, Perea Gomez A, Moreau A, Collignon J. Absence of Nodal signaling promotes precocious neural differentiation in the mouse embryo. Dev Biol. 2006;295:743-55 pubmed
    After implantation, mouse embryos deficient for the activity of the transforming growth factor-beta member Nodal fail to form both the mesoderm and the definitive endoderm...
  17. Nadeem L, Munir S, Fu G, Dunk C, Baczyk D, Caniggia I, et al. Nodal signals through activin receptor-like kinase 7 to inhibit trophoblast migration and invasion: implication in the pathogenesis of preeclampsia. Am J Pathol. 2011;178:1177-89 pubmed publisher
    ..We have reported that Nodal, a member of the transforming growth factor-? superfamily, acts through activin receptor-like kinase 7 (ALK7) to ..
  18. Sirard C, de la Pompa J, Elia A, Itie A, Mirtsos C, Cheung A, et al. The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. Genes Dev. 1998;12:107-19 pubmed
    ..Rescued embryos show severe anterior truncations, indicating a second important role for Smad4 in anterior patterning during embryogenesis. ..
  19. Guzman Ayala M, Ben Haim N, Beck S, Constam D. Nodal protein processing and fibroblast growth factor 4 synergize to maintain a trophoblast stem cell microenvironment. Proc Natl Acad Sci U S A. 2004;101:15656-60 pubmed
    ..Here, we show that Fgf4 expression is induced by the transforming growth factor beta-related protein Nodal. Together with Fgf4, Nodal also acts directly on neighboring ExE to sustain a microenvironment that inhibits ..
  20. Robertson E, Norris D, Brennan J, Bikoff E. Control of early anterior-posterior patterning in the mouse embryo by TGF-beta signalling. Philos Trans R Soc Lond B Biol Sci. 2003;358:1351-7; discussion 1357 pubmed
    ..Signalling pathways controlled by the transforming growth factor-beta ligand nodal are involved in orchestrating the process of axis formation...
  21. Tavares A, Andrade S, Silva A, Belo J. Cerberus is a feedback inhibitor of Nodal asymmetric signaling in the chick embryo. Development. 2007;134:2051-60 pubmed
    The TGF-beta-related molecule Nodal plays an essential and conserved role in left-right patterning of the vertebrate embryo...