Gene Symbol: Nlrp6
Description: NLR family, pyrin domain containing 6
Alias: Avr, Nalp6, Navr, Navr/Avr, Non-AVR, NACHT, LRR and PYD domains-containing protein 6, NACHT, LRR and PYD domains-containing protein 6-like, NACHT, leucine rich repeat and PYD containing 6, angiotensin II/vasopressin receptor, dual angiotensin II/vasopressin receptor, non-angiotensin-vasopressin receptor
Species: rat
Products:     Nlrp6

Top Publications

  1. Ruiz Opazo N, Akimoto K, Herrera V. Identification of a novel dual angiotensin II/vasopressin receptor on the basis of molecular recognition theory. Nat Med. 1995;1:1074-81 pubmed
    ..This corroborates the dual nature of the receptor and provides direct molecular genetic evidence for the molecular recognition theory. ..
  2. Gonzalez C, Herrera V, Ruiz Opazo N. Renal immunocytochemical distribution and pharmacological properties of the dual angiotensin II/AVP receptor. Hypertension. 1997;29:957-61 pubmed
    ..These data suggest that the Ang II/AVP receptor might provide the molecular basis for the observed similar stimulatory effects of Ang II and AVP on renal tubular sodium and fluid reabsorption at physiological hormone concentrations. ..
  3. Albrecht M, Domingues F, Schreiber S, Lengauer T. Identification of mammalian orthologs associates PYPAF5 with distinct functional roles. FEBS Lett. 2003;538:173-7 pubmed
    ..In particular, based on a comprehensive sequence analysis, we propose a structural model for this hormone receptor that is different from the model suggested previously. ..
  4. Chen G, Liu M, Wang F, Bertin J, Nunez G. A functional role for Nlrp6 in intestinal inflammation and tumorigenesis. J Immunol. 2011;186:7187-94 pubmed publisher
    The nucleotide-binding oligomerization domain-like receptor (NLR) family member, Nlrp6, has been implicated in inflammasome signaling to activate caspase-1, which is essential for the production of mature IL-1? and IL-18...
  5. Normand S, Delanoye Crespin A, Bressenot A, Huot L, Grandjean T, Peyrin Biroulet L, et al. Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury. Proc Natl Acad Sci U S A. 2011;108:9601-6 pubmed publisher
    ..Here, we demonstrate that Nod-like receptor pyrin domain-containing protein 6 (NLRP6) suppresses inflammation and carcinogenesis by regulating tissue repair...
  6. Herrera V, Bagamasbad P, Didishvili T, Decano J, Ruiz Opazo N. Overlapping genes in Nalp6/PYPAF5 locus encode two V2-type vasopressin isoreceptors: angiotensin-vasopressin receptor (AVR) and non-AVR. Physiol Genomics. 2008;34:65-77 pubmed publisher
    ..AVR maps to the Nalp6 locus and overlaps with the larger Nalp6/PYPAF5 reported to be a T cell/granulocyte-specific, cytoplasmic-specific ..
  7. Anand P, Malireddi R, Lukens J, Vogel P, Bertin J, Lamkanfi M, et al. NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens. Nature. 2012;488:389-93 pubmed publisher
    ..Mice lacking the NLR family member NLRP6 were recently shown to be susceptible to colitis and colorectal tumorigenesis, but the role of NLRP6 in microbial ..
  8. Ruiz Opazo N, Lopez L, Herrera V. The dual AngII/AVP receptor gene N119S/C163R variant exhibits sodium-induced dysfunction and cosegregates with salt-sensitive hypertension in the Dahl salt-sensitive hypertensive rat model. Mol Med. 2002;8:24-32 pubmed
  9. Kempster S, Belteki G, Forhead A, Fowden A, Catalano R, Lam B, et al. Developmental control of the Nlrp6 inflammasome and a substrate, IL-18, in mammalian intestine. Am J Physiol Gastrointest Liver Physiol. 2011;300:G253-63 pubmed publisher
    ..profiling and quantitative RT-PCR demonstrated that transcripts of core components of the NOD-like receptor Nlrp6 inflammasome (Nlrp6, Pycard, Caspase-1) and one of its substrates, IL-18, were increased at E20 compared with E16 ..

More Information


  1. Huber S, Gagliani N, Zenewicz L, Huber F, Bosurgi L, Hu B, et al. IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine. Nature. 2012;491:259-63 pubmed publisher
    ..Sensing of intestinal tissue damage via the NLRP3 or NLRP6 inflammasomes led to an IL-18-dependent downregulation of IL-22BP, thereby increasing the ratio of IL-22/IL-22BP...
  2. Hu B, Elinav E, Huber S, Strowig T, Hao L, Hafemann A, et al. Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer. Proc Natl Acad Sci U S A. 2013;110:9862-7 pubmed publisher
    ..critical role in CRC development, where mice deficient in the NOD-like receptor family pyrin domain containing 6 (NLRP6) inflammasome feature enhanced inflammation-induced CRC formation...
  3. Wlodarska M, Thaiss C, Nowarski R, Henao Mejia J, Zhang J, Brown E, et al. NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion. Cell. 2014;156:1045-59 pubmed publisher
    ..Here, we demonstrate that the NLRP6 inflammasome, a recently described regulator of colonic microbiota composition and biogeographical distribution, ..
  4. Herrera V, Bagamasbad P, Decano J, Ruiz Opazo N. AVR/NAVR deficiency lowers blood pressure and differentially affects urinary concentrating ability, cognition, and anxiety-like behavior in male and female mice. Physiol Genomics. 2011;43:32-42 pubmed publisher
    ..They achieve these functions via specific G protein-coupled receptors, respectively. The AVR/NAVR locus encodes two overlapping V2-type vasopressin isoreceptors: angiotensin-vasopressin receptor (AVR) responding ..