Gene Symbol: Nlrp1b
Description: NLR family, pyrin domain containing 1B
Alias: NACHT, LRR and PYD domains-containing protein 1b allele 3-like, NLR family, pyrin domain containing 1B
Bouchier Hayes L, Conroy H, Egan H, Adrain C, Creagh E, MacFarlane M, et al
. CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways. J Biol Chem. 2001;276:44069-77 pubmed
..Thus, CARDINAL is a novel regulator of NF-kappaB activation in the context of pro-inflammatory signals. ..
Chavarria Smith J, Vance R. Direct proteolytic cleavage of NLRP1B is necessary and sufficient for inflammasome activation by anthrax lethal factor. PLoS Pathog. 2013;9:e1003452 pubmed publisher
..Here we determine the mechanism of activation of the NLRP1B inflammasome in mice...
Razmara M, Srinivasula S, Wang L, Poyet J, Geddes B, DiStefano P, et al
. CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis. J Biol Chem. 2002;277:13952-8 pubmed
..Overexpression of CARD-8 can also induce apoptosis in transfected cells. The results suggest that CARD-8 represents a new signaling molecule involved in the regulation of caspase-1 and NF-kappaB activation. ..
Stilo R, Leonardi A, Formisano L, Di Jeso B, Vito P, Liguoro D. TUCAN/CARDINAL and DRAL participate in a common pathway for modulation of NF-kappaB activation. FEBS Lett. 2002;521:165-9 pubmed
..Thus, our observations suggest that DRAL and TUCAN/CARDINAL may participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappaB transcription factor. ..
Agostini L, Martinon F, Burns K, McDermott M, Hawkins P, Tschopp J. NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity. 2004;20:319-25 pubmed
..Macrophages from Muckle-Wells patients spontaneously secrete active IL-1beta. Increased inflammasome activity is therefore likely to be the molecular basis of the symptoms associated with NALP3-dependent autoinflammatory disorders. ..