Gene Symbol: Nlgn3
Description: neuroligin 3
Alias: neuroligin-3, gliotactin homolog
Species: rat
Products:     Nlgn3

Top Publications

  1. Suckow A, Comoletti D, Waldrop M, Mosedale M, Egodage S, Taylor P, et al. Expression of neurexin, neuroligin, and their cytoplasmic binding partners in the pancreatic beta-cells and the involvement of neuroligin in insulin secretion. Endocrinology. 2008;149:6006-17 pubmed publisher
    ..Analogous to their role in synaptic neurotransmission, neurexin-neuroligin interactions may play a role in the formation of the submembrane insulin secretory apparatus...
  2. Etherton M, Földy C, Sharma M, Tabuchi K, Liu X, Shamloo M, et al. Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function. Proc Natl Acad Sci U S A. 2011;108:13764-9 pubmed publisher
  3. Budreck E, Scheiffele P. Neuroligin-3 is a neuronal adhesion protein at GABAergic and glutamatergic synapses. Eur J Neurosci. 2007;26:1738-48 pubmed
    ..These findings suggest that rodent NL3 is a synaptic adhesion molecule that is a shared component of glutamatergic and GABAergic synapses. ..
  4. Chih B, Engelman H, Scheiffele P. Control of excitatory and inhibitory synapse formation by neuroligins. Science. 2005;307:1324-8 pubmed
    ..Electrophysiological analysis revealed a predominant reduction of inhibitory synaptic function. Thus, neuroligins control the formation and functional balance of excitatory and inhibitory synapses in hippocampal neurons. ..
  5. Chubykin A, Liu X, Comoletti D, Tsigelny I, Taylor P, Sudhof T. Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism. J Biol Chem. 2005;280:22365-74 pubmed
  6. Graf E, Zhang X, Jin S, Linhoff M, Craig A. Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins. Cell. 2004;119:1013-26 pubmed
  7. Varoqueaux F, Aramuni G, Rawson R, Mohrmann R, Missler M, Gottmann K, et al. Neuroligins determine synapse maturation and function. Neuron. 2006;51:741-54 pubmed
    ..Our data show that neuroligins are required for proper synapse maturation and brain function, but not for the initial formation of synaptic contacts. ..
  8. Tabuchi K, Blundell J, Etherton M, Hammer R, Liu X, Powell C, et al. A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice. Science. 2007;318:71-6 pubmed
    ..These data suggest that increased inhibitory synaptic transmission may contribute to human ASDs and that the R451C knockin mice may be a useful model for studying autism-related behaviors. ..
  9. Gobert R, Joubert L, Curchod M, Salvat C, Foucault I, Jorand Lebrun C, et al. Convergent functional genomics of oligodendrocyte differentiation identifies multiple autoinhibitory signaling circuits. Mol Cell Biol. 2009;29:1538-53 pubmed publisher
    ..Oligodendrocytic differentiation feedback loops may therefore yield pharmacological targets to treat disease related to dysfunctional myelin deposition. ..

More Information


  1. Fekete C, Chiou T, Miralles C, Harris R, Fiondella C, LoTurco J, et al. In vivo clonal overexpression of neuroligin 3 and neuroligin 2 in neurons of the rat cerebral cortex: Differential effects on GABAergic synapses and neuronal migration. J Comp Neurol. 2015;523:1359-78 pubmed publisher
    We studied the effect of clonal overexpression of neuroligin 3 (NL3) or neuroligin 2 (NL2) in the adult rat cerebral cortex following in utero electroporation (IUEP) at embryonic stage E14...
  2. Yamakawa H, Oyama S, Mitsuhashi H, Sasagawa N, Uchino S, Kohsaka S, et al. Neuroligins 3 and 4X interact with syntrophin-gamma2, and the interactions are affected by autism-related mutations. Biochem Biophys Res Commun. 2007;355:41-6 pubmed
    ..SNTG2 also bound to NL4X and NL4Y. Interestingly, the binding was influenced by autism-related mutations, implying that the impaired interaction between NLs and SNTG2 contributes to the etiology of autism. ..
  3. Ichtchenko K, Nguyen T, Sudhof T. Structures, alternative splicing, and neurexin binding of multiple neuroligins. J Biol Chem. 1996;271:2676-82 pubmed
    ..Thus, neuroligins constitute a multigene family of brain-specific proteins with distinct isoforms that may have overlapping functions in mediating recognition processes between neurons. ..
  4. Comoletti D, De Jaco A, Jennings L, Flynn R, Gaietta G, Tsigelny I, et al. The Arg451Cys-neuroligin-3 mutation associated with autism reveals a defect in protein processing. J Neurosci. 2004;24:4889-93 pubmed
    ..Our findings reveal a cellular phenotype and loss of function for a congenital mutation associated with autistic spectrum disorders. ..
  5. Ulbrich L, Favaloro F, Trobiani L, Marchetti V, Patel V, Pascucci T, et al. Autism-associated R451C mutation in neuroligin3 leads to activation of the unfolded protein response in a PC12 Tet-On inducible system. Biochem J. 2016;473:423-34 pubmed publisher
    ..Collectively, our data show that mutant R451C neuroligin3 activates the UPR in a novel cell model system, suggesting that this cellular response may have a role in monogenic forms of autism characterized by misfolding mutations. ..
  6. Zelano J, Wallquist W, Hailer N, Cullheim S. Down-regulation of mRNAs for synaptic adhesion molecules neuroligin-2 and -3 and synCAM1 in spinal motoneurons after axotomy. J Comp Neurol. 2007;503:308-18 pubmed
    ..This indicates that down-regulation of synaptic adhesion molecules plays a role in postinjury synapse elimination. ..
  7. Chih B, Afridi S, Clark L, Scheiffele P. Disorder-associated mutations lead to functional inactivation of neuroligins. Hum Mol Genet. 2004;13:1471-7 pubmed
  8. Jamain S, Quach H, Betancur C, Rastam M, Colineaux C, Gillberg I, et al. Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism. Nat Genet. 2003;34:27-9 pubmed
    ..Here we report mutations in two X-linked genes encoding neuroligins NLGN3 and NLGN4 in siblings with autism-spectrum disorders...
  9. Gutierrez R, Hung J, Zhang Y, Kertesz A, Espina F, Colicos M. Altered synchrony and connectivity in neuronal networks expressing an autism-related mutation of neuroligin 3. Neuroscience. 2009;162:208-21 pubmed publisher
    ..Together, these data support the hypothesis that the autism-associated NL3 mutation affects information processing in neuronal networks by altering network architecture and synchrony. ..
  10. Levinson J, Li R, Kang R, Moukhles H, el Husseini A, Bamji S. Postsynaptic scaffolding molecules modulate the localization of neuroligins. Neuroscience. 2010;165:782-93 pubmed publisher
    ..involved in the recruitment of neuroligin 1 to excitatory synapses, the localization of neuroligin 2 (NL2) and neuroligin 3 (NL3) to excitatory and inhibitory synapses is less well defined...
  11. Hamilton S, Green J, Veeraragavan S, Yuva L, McCoy A, Wu Y, et al. Fmr1 and Nlgn3 knockout rats: novel tools for investigating autism spectrum disorders. Behav Neurosci. 2014;128:103-9 pubmed publisher
    ..with heritable disruptions in the genes encoding Fragile X mental retardation protein (FMRP) and Neuroligin3 (NLGN3)...
  12. Poulopoulos A, Soykan T, Tuffy L, Hammer M, Varoqueaux F, Brose N. Homodimerization and isoform-specific heterodimerization of neuroligins. Biochem J. 2012;446:321-30 pubmed publisher
    ..we identified differences in the dimerization capacity of autism-associated neuroligin mutants, and found that neuroligin 3 R471C mutants can form heterodimers with neuroligin 1...
  13. Nguyen Q, Horn M, Nicoll R. Distinct roles for extracellular and intracellular domains in neuroligin function at inhibitory synapses. elife. 2016;5: pubmed publisher
    ..NLGN2 is only at inhibitory synapses while NLGN3 is at both excitatory and inhibitory synapses...
  14. De Jaco A, Lin M, Dubi N, Comoletti D, Miller M, Camp S, et al. Neuroligin trafficking deficiencies arising from mutations in the alpha/beta-hydrolase fold protein family. J Biol Chem. 2010;285:28674-82 pubmed publisher
    ..with autism and the thyroglobulin G2320R (G221R in NLGN) mutation responsible for congenital hypothyroidism into NLGN3, we show that mutations in the alpha/beta-hydrolase fold domain influence folding and biosynthetic processing of ..
  15. Gilbert M, Smith J, Roskams A, Auld V. Neuroligin 3 is a vertebrate gliotactin expressed in the olfactory ensheathing glia, a growth-promoting class of macroglia. Glia. 2001;34:151-64 pubmed
    ..we have isolated a potential vertebrate gliotactin homologue from mice and rat and found that it corresponds to neuroligin 3. Using a combination of RT-PCR and immunohistochemistry, we have found that neuroligin 3 is expressed during ..
  16. Suckow A, Zhang C, Egodage S, Comoletti D, Taylor P, Miller M, et al. Transcellular neuroligin-2 interactions enhance insulin secretion and are integral to pancreatic ? cell function. J Biol Chem. 2012;287:19816-26 pubmed publisher
    ..Together, these results indicate a significant role for transcellular neuroligin-2 interactions in the establishment of ? cell function. ..
  17. Shipman S, Schnell E, Hirai T, Chen B, Roche K, Nicoll R. Functional dependence of neuroligin on a new non-PDZ intracellular domain. Nat Neurosci. 2011;14:718-26 pubmed publisher
    ..Mutation of a single critical residue in this region inhibited neuroligin-mediated excitatory synaptic potentiation. Finally, we found a functional distinction between neuroligins 1 and 3. ..
  18. Ko J, Soler Llavina G, Fuccillo M, Malenka R, Sudhof T. Neuroligins/LRRTMs prevent activity- and Ca2+/calmodulin-dependent synapse elimination in cultured neurons. J Cell Biol. 2011;194:323-34 pubmed publisher
  19. Etherton M, Tabuchi K, Sharma M, Ko J, Sudhof T. An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampus. EMBO J. 2011;30:2908-19 pubmed publisher
    ..Our results suggest that the cytoplasmic tail of neuroligin-3 has a central role in synaptic transmission by modulating the recruitment of AMPA receptors to postsynaptic sites at excitatory synapses. ..