Nkx2-1

Summary

Gene Symbol: Nkx2-1
Description: NK2 homeobox 1
Alias: TTF1, Titf1, homeobox protein Nkx-2.1, TTF-1, thyroid nuclear factor 1, thyroid transcription factor 1 TTF-1 NK-2, thyroid-specific transcription factor 1
Species: rat
Products:     Nkx2-1

Top Publications

  1. Lee B, Cho G, Norgren R, Junier M, Hill D, Tapia V, et al. TTF-1, a homeodomain gene required for diencephalic morphogenesis, is postnatally expressed in the neuroendocrine brain in a developmentally regulated and cell-specific fashion. Mol Cell Neurosci. 2001;17:107-26 pubmed
    ....
  2. Bruno M, Bohinski R, Huelsman K, Whitsett J, Korfhagen T. Lung cell-specific expression of the murine surfactant protein A (SP-A) gene is mediated by interactions between the SP-A promoter and thyroid transcription factor-1. J Biol Chem. 1995;270:6531-6 pubmed
    ..TTF-1 interacts with complex protein/DNA binding sites located in the 5'-flanking region of the murine SP-A gene enhancing lung epithelial cell-specific expression in vitro. ..
  3. Lee N, Son Y, Kim J, Ha C, Yun C, Lim H, et al. TTF-1 regulates growth hormone and prolactin transcription in the anterior pituitary gland. Biochem Biophys Res Commun. 2007;362:193-9 pubmed
    ..These data suggest that TTF-1 plays a regulatory role in the transcription of growth hormone and prolactin genes and may regulate transdifferentiation of cells expressing these two hormones. ..
  4. Kim M, Hur M, Son Y, Park J, Chun S, D Elia A, et al. Regulation of pituitary adenylate cyclase-activating polypeptide gene transcription by TTF-1, a homeodomain-containing transcription factor. J Biol Chem. 2002;277:36863-71 pubmed
    ..Taken together, these data suggest that TTF-1 plays an important regulatory role in the gene transcription for PACAP, which may be important for the generation of a daily rhythm of hypothalamic PACAP gene expression. ..
  5. Son Y, Hur M, Ryu B, Park S, Damante G, D Elia A, et al. TTF-1, a homeodomain-containing transcription factor, participates in the control of body fluid homeostasis by regulating angiotensinogen gene transcription in the rat subfornical organ. J Biol Chem. 2003;278:27043-52 pubmed
    ..These results demonstrate a novel role for TTF-1 in the regulation of body fluid homeostasis, exerted via the transactivational control of angiotensinogen synthesis in the subfornical organ. ..
  6. Kim J, Son Y, Yun C, Kim Y, Nam Goong I, Park J, et al. Thyroid transcription factor-1 facilitates cerebrospinal fluid formation by regulating aquaporin-1 synthesis in the brain. J Biol Chem. 2007;282:14923-31 pubmed
    ..These results suggest that TTF-1 is physiologically involved in the transcriptional control of AQP-1, which is required for CSF formation. ..
  7. Kim J, Nam Goong I, Yun C, Jeong J, Kim E, Park J, et al. TTF-1, a homeodomain-containing transcription factor, regulates feeding behavior in the rat hypothalamus. Biochem Biophys Res Commun. 2006;349:969-75 pubmed
    ..These results suggest a novel role for TTF-1 in the regulation of feeding behavior in the rat hypothalamus. ..
  8. Ikeda K, Clark J, Shaw White J, Stahlman M, Boutell C, Whitsett J. Gene structure and expression of human thyroid transcription factor-1 in respiratory epithelial cells. J Biol Chem. 1995;270:8108-14 pubmed
    ..The conservation and distribution of TTF-1 in the human respiratory tract support its role in the regulation of lung development and surfactant homeostasis. ..
  9. Dave V, Childs T, Whitsett J. Nuclear factor of activated T cells regulates transcription of the surfactant protein D gene (Sftpd) via direct interaction with thyroid transcription factor-1 in lung epithelial cells. J Biol Chem. 2004;279:34578-88 pubmed
    ..Components of the calcineurin/NFAT pathway were identified in respiratory epithelial cells of the lung that potentially augment rapid assembly of a multiprotein transcription complex on Sftpd promoter inducing SP-D expression. ..
  10. Matagne V, Kim J, Ryu B, Hur M, Kim M, Kim K, et al. Thyroid transcription factor 1, a homeodomain containing transcription factor, contributes to regulating periodic oscillations in GnRH gene expression. J Neuroendocrinol. 2012;24:916-29 pubmed publisher
    Thyroid transcription factor 1 (TTF1), a member of the Nkx family of transcription factors required for basal forebrain morphogenesis, functions in the postnatal hypothalamus as a transcriptional regulator of genes encoding ..

Detail Information

Publications62

  1. Lee B, Cho G, Norgren R, Junier M, Hill D, Tapia V, et al. TTF-1, a homeodomain gene required for diencephalic morphogenesis, is postnatally expressed in the neuroendocrine brain in a developmentally regulated and cell-specific fashion. Mol Cell Neurosci. 2001;17:107-26 pubmed
    ....
  2. Bruno M, Bohinski R, Huelsman K, Whitsett J, Korfhagen T. Lung cell-specific expression of the murine surfactant protein A (SP-A) gene is mediated by interactions between the SP-A promoter and thyroid transcription factor-1. J Biol Chem. 1995;270:6531-6 pubmed
    ..TTF-1 interacts with complex protein/DNA binding sites located in the 5'-flanking region of the murine SP-A gene enhancing lung epithelial cell-specific expression in vitro. ..
  3. Lee N, Son Y, Kim J, Ha C, Yun C, Lim H, et al. TTF-1 regulates growth hormone and prolactin transcription in the anterior pituitary gland. Biochem Biophys Res Commun. 2007;362:193-9 pubmed
    ..These data suggest that TTF-1 plays a regulatory role in the transcription of growth hormone and prolactin genes and may regulate transdifferentiation of cells expressing these two hormones. ..
  4. Kim M, Hur M, Son Y, Park J, Chun S, D Elia A, et al. Regulation of pituitary adenylate cyclase-activating polypeptide gene transcription by TTF-1, a homeodomain-containing transcription factor. J Biol Chem. 2002;277:36863-71 pubmed
    ..Taken together, these data suggest that TTF-1 plays an important regulatory role in the gene transcription for PACAP, which may be important for the generation of a daily rhythm of hypothalamic PACAP gene expression. ..
  5. Son Y, Hur M, Ryu B, Park S, Damante G, D Elia A, et al. TTF-1, a homeodomain-containing transcription factor, participates in the control of body fluid homeostasis by regulating angiotensinogen gene transcription in the rat subfornical organ. J Biol Chem. 2003;278:27043-52 pubmed
    ..These results demonstrate a novel role for TTF-1 in the regulation of body fluid homeostasis, exerted via the transactivational control of angiotensinogen synthesis in the subfornical organ. ..
  6. Kim J, Son Y, Yun C, Kim Y, Nam Goong I, Park J, et al. Thyroid transcription factor-1 facilitates cerebrospinal fluid formation by regulating aquaporin-1 synthesis in the brain. J Biol Chem. 2007;282:14923-31 pubmed
    ..These results suggest that TTF-1 is physiologically involved in the transcriptional control of AQP-1, which is required for CSF formation. ..
  7. Kim J, Nam Goong I, Yun C, Jeong J, Kim E, Park J, et al. TTF-1, a homeodomain-containing transcription factor, regulates feeding behavior in the rat hypothalamus. Biochem Biophys Res Commun. 2006;349:969-75 pubmed
    ..These results suggest a novel role for TTF-1 in the regulation of feeding behavior in the rat hypothalamus. ..
  8. Ikeda K, Clark J, Shaw White J, Stahlman M, Boutell C, Whitsett J. Gene structure and expression of human thyroid transcription factor-1 in respiratory epithelial cells. J Biol Chem. 1995;270:8108-14 pubmed
    ..The conservation and distribution of TTF-1 in the human respiratory tract support its role in the regulation of lung development and surfactant homeostasis. ..
  9. Dave V, Childs T, Whitsett J. Nuclear factor of activated T cells regulates transcription of the surfactant protein D gene (Sftpd) via direct interaction with thyroid transcription factor-1 in lung epithelial cells. J Biol Chem. 2004;279:34578-88 pubmed
    ..Components of the calcineurin/NFAT pathway were identified in respiratory epithelial cells of the lung that potentially augment rapid assembly of a multiprotein transcription complex on Sftpd promoter inducing SP-D expression. ..
  10. Matagne V, Kim J, Ryu B, Hur M, Kim M, Kim K, et al. Thyroid transcription factor 1, a homeodomain containing transcription factor, contributes to regulating periodic oscillations in GnRH gene expression. J Neuroendocrinol. 2012;24:916-29 pubmed publisher
    Thyroid transcription factor 1 (TTF1), a member of the Nkx family of transcription factors required for basal forebrain morphogenesis, functions in the postnatal hypothalamus as a transcriptional regulator of genes encoding ..
  11. Di Palma T, d Andrea B, Liguori G, Liguoro A, De Cristofaro T, Del Prete D, et al. TAZ is a coactivator for Pax8 and TTF-1, two transcription factors involved in thyroid differentiation. Exp Cell Res. 2009;315:162-75 pubmed publisher
    ....
  12. Cao Y, Vo T, Millien G, Tagne J, Kotton D, Mason R, et al. Epigenetic mechanisms modulate thyroid transcription factor 1-mediated transcription of the surfactant protein B gene. J Biol Chem. 2010;285:2152-64 pubmed publisher
    ..Our findings suggest that DNA methylation and chromatin modifications cooperate with Nkx2-1 to regulate Sftpb gene cell specific expression. ..
  13. Yan C, Sever Z, Whitsett J. Upstream enhancer activity in the human surfactant protein B gene is mediated by thyroid transcription factor 1. J Biol Chem. 1995;270:24852-7 pubmed
    ..In summary, TTF-1 interacts with distinct proximal (-80 to -110) and distal (-439 to -331) cis-acting elements than regulate lung epithelial cell-specific transcription of the human SP-B gene. ..
  14. Li J, Zhang R, Wang B, Na R, Li Y, Zhao X, et al. [Effects of supplement of thyroxine for hypothyroid pregnant rat on the expression of homeobox gene Nkx2.1 mRNA in the offspring's cerebrum tissue]. Zhonghua Yu Fang Yi Xue Za Zhi. 2010;44:726-30 pubmed
    ..225, 0.336, 0.345, all P values > 0.05). The difference in the expression of homeobox gene Nkx2.1 mRNA is highly related to the level of thyroid hormone. ..
  15. Takuma N, Sheng H, Furuta Y, Ward J, Sharma K, Hogan B, et al. Formation of Rathke's pouch requires dual induction from the diencephalon. Development. 1998;125:4835-40 pubmed
    Targeted disruption of the homeobox gene T/ebp (Nkx2.1, Ttf1, Titf1) in mice results in ablation of the pituitary...
  16. Saito R, Watabe T, Horiguchi K, Kohyama T, Saitoh M, Nagase T, et al. Thyroid transcription factor-1 inhibits transforming growth factor-beta-mediated epithelial-to-mesenchymal transition in lung adenocarcinoma cells. Cancer Res. 2009;69:2783-91 pubmed publisher
    ....
  17. Guazzi S, Price M, De Felice M, Damante G, Mattei M, Di Lauro R. Thyroid nuclear factor 1 (TTF-1) contains a homeodomain and displays a novel DNA binding specificity. EMBO J. 1990;9:3631-9 pubmed
    ....
  18. Yuan B, Li C, Kimura S, Engelhardt R, Smith B, Minoo P. Inhibition of distal lung morphogenesis in Nkx2.1(-/-) embryos. Dev Dyn. 2000;217:180-90 pubmed
    ..1 independent, while distal lung morphogenesis appears to be strictly dependent on the wild-type activity of Nkx2.1. ..
  19. Aurisicchio L, Di Lauro R, Zannini M. Identification of the thyroid transcription factor-1 as a target for rat MST2 kinase. J Biol Chem. 1998;273:1477-82 pubmed
    ..Thus, TTF-1 represents the first identified target of this class of protein kinases. ..
  20. Endo T, Ohta K, Saito T, Haraguchi K, Nakazato M, Kogai T, et al. Structure of the rat thyroid transcription factor-1 (TTF-1) gene. Biochem Biophys Res Commun. 1994;204:1358-63 pubmed
    ....
  21. Vélez M, Costamagna E, Kimura E, Fozzatti L, Pellizas C, Montesinos M, et al. Bacterial lipopolysaccharide stimulates the thyrotropin-dependent thyroglobulin gene expression at the transcriptional level by involving the transcription factors thyroid transcription factor-1 and paired box domain transcription factor 8. Endocrinology. 2006;147:3260-75 pubmed
    ..The half-lives of TG, Pax8, and TTF-1 are increased in endotoxin-treated cells. Our results reveal the ability of LPS to stimulate the expression of TG, a finding of potential pathophysiological implication. ..
  22. Konishi T, Kono S, Fujimoto M, Terada T, Matsushita K, Ouchi Y, et al. Benign hereditary chorea: dopaminergic brain imaging in patients with a novel intronic NKX2.1 gene mutation. J Neurol. 2013;260:207-13 pubmed publisher
    ..The molecular brain imaging and therapeutic response may help elucidate the pathophysiological mechanism of the motor control in the BHC-associated NKX2.1 mutation. ..
  23. Suzuki M, Katagiri N, Ueda M, Tanaka S. Functional analysis of Nkx2.1 and Pax9 for calcitonin gene transcription. Gen Comp Endocrinol. 2007;152:259-66 pubmed
    ..Pax9 also showed no cooperative effects when it was co-transfected with Nkx2.1. The results suggest that CT gene expression could be directly activated by Nkx2.1, whereas Pax9 is not involved in transcription from the 2kbp CT promoter. ..
  24. Xu Q, Cobos I, De La Cruz E, Rubenstein J, Anderson S. Origins of cortical interneuron subtypes. J Neurosci. 2004;24:2612-22 pubmed
    ..By establishing spatial differences in the origins of interneuron subtypes, these studies lay the groundwork for elucidating the molecular bases for their distinct differentiation pathways. ..
  25. Ferrara A, De Michele G, Salvatore E, Di Maio L, Zampella E, Capuano S, et al. A novel NKX2.1 mutation in a family with hypothyroidism and benign hereditary chorea. Thyroid. 2008;18:1005-9 pubmed publisher
    ..The aim of this study was to establish the genetic defects that cause that phenotype and study the molecular mechanisms of the pathology...
  26. Que J, Okubo T, Goldenring J, Nam K, Kurotani R, Morrisey E, et al. Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm. Development. 2007;134:2521-31 pubmed
    ..By contrast, Nkx2.1 (Titf1) is expressed ventrally, in the future trachea...
  27. Maeda Y, Tsuchiya T, Hao H, Tompkins D, Xu Y, Mucenski M, et al. Kras(G12D) and Nkx2-1 haploinsufficiency induce mucinous adenocarcinoma of the lung. J Clin Invest. 2012;122:4388-400 pubmed publisher
    ..NKX2-1 inhibited both AP-1 activity and tumor colony formation in vitro. These data demonstrate that NKX2-1 functions in a context-dependent manner in lung tumorigenesis and inhibits Kras(G12D)-driven mucinous pulmonary adenocarcinoma. ..
  28. Koht J, Løstegaard S, Wedding I, Vidailhet M, Louha M, Tallaksen C. Benign hereditary chorea, not only chorea: a family case presentation. Cerebellum Ataxias. 2016;3:3 pubmed publisher
    ..This is the first Norwegian family with benign hereditary chorea due to a mutation in the NKX2-1 gene, c.671 T > G (p.Leu224Arg). This family demonstrates well the wide phenotype, including dystonia, myoclonus and ataxia. ..
  29. Rivas M, Mellstrom B, Naranjo J, Santisteban P. Transcriptional repressor DREAM interacts with thyroid transcription factor-1 and regulates thyroglobulin gene expression. J Biol Chem. 2004;279:33114-22 pubmed
    ..Furthermore, chromatin immunoprecipitation experiments in FRTL-5 cells confirmed that Tg is a bona fide target gene for DREAM transrepression in thyroid follicular cells. ..
  30. Parlato R, Rosica A, Rodriguez Mallon A, Affuso A, Postiglione M, Arra C, et al. An integrated regulatory network controlling survival and migration in thyroid organogenesis. Dev Biol. 2004;276:464-75 pubmed
    ..The experiments reported here analyze the expression of the transcription factors Titf1, Hhex, Pax8, and Foxe1 in the thyroid primordium of null mutants of each of them...
  31. Varma S, Cao Y, Tagne J, Lakshminarayanan M, Li J, Friedman T, et al. The transcription factors Grainyhead-like 2 and NK2-homeobox 1 form a regulatory loop that coordinates lung epithelial cell morphogenesis and differentiation. J Biol Chem. 2012;287:37282-95 pubmed publisher
    ..Thus, Grhl2 functions at the nexus of a novel regulatory network, connecting lung epithelial cell identity, migration, and cell-cell interactions. ..
  32. Dentice M, Luongo C, Elefante A, Ambrosio R, Salzano S, Zannini M, et al. Pendrin is a novel in vivo downstream target gene of the TTF-1/Nkx-2.1 homeodomain transcription factor in differentiated thyroid cells. Mol Cell Biol. 2005;25:10171-82 pubmed
    ..In conclusion, we demonstrate that pendrin and thyroglobulin are downstream targets in vivo of TTF-1, whose action is a prime factor in controlling thyroid differentiation in vivo. ..
  33. Marin O, Baker J, Puelles L, Rubenstein J. Patterning of the basal telencephalon and hypothalamus is essential for guidance of cortical projections. Development. 2002;129:761-73 pubmed
    ..Furthermore, analysis of the expression of candidate molecules in the basal telencephalon and hypothalamus of Nkx2-1 mutants suggests that Slit2 contributes to this activity. ..
  34. DeFelice M, Silberschmidt D, DiLauro R, Xu Y, Wert S, Weaver T, et al. TTF-1 phosphorylation is required for peripheral lung morphogenesis, perinatal survival, and tissue-specific gene expression. J Biol Chem. 2003;278:35574-83 pubmed
    ..In contrast to Titf1 null mutant mice, which lack peripheral lung tissues, bronchiolar and peripheral acinar components of the lung ..
  35. Kolla V, Gonzales L, Gonzales J, Wang P, Angampalli S, Feinstein S, et al. Thyroid transcription factor in differentiating type II cells: regulation, isoforms, and target genes. Am J Respir Cell Mol Biol. 2007;36:213-25 pubmed
    ..In addition, knockdown of TTF-1 inhibited 72 of 274 other genes induced by hormones. We conclude that 42-kD TTF-1 is required for induction of a subset of regulated genes during type II cell differentiation. ..
  36. Park K, Korfhagen T, Bruno M, Kitzmiller J, Wan H, Wert S, et al. SPDEF regulates goblet cell hyperplasia in the airway epithelium. J Clin Invest. 2007;117:978-88 pubmed
    ..SPDEF was induced following intratracheal allergen exposure and after Th2 cytokine stimulation and was sufficient to cause goblet cell differentiation of Clara cells in vivo. ..
  37. Butt S, Sousa V, Fuccillo M, Hjerling Leffler J, Miyoshi G, Kimura S, et al. The requirement of Nkx2-1 in the temporal specification of cortical interneuron subtypes. Neuron. 2008;59:722-32 pubmed publisher
    ..Our strategy reveals a causal link between the embryonic genetic specification by Nkx2-1 in progenitors and the functional attributes of their neuronal progeny in the mature nervous system. ..
  38. Pakarinen P, Kimura S, El Gehani F, Pelliniemi L, Huhtaniemi I. Pituitary hormones are not required for sexual differentiation of male mice: phenotype of the T/ebp/Nkx2.1 null mutant mice. Endocrinology. 2002;143:4477-82 pubmed
    ..The endogenous testosterone level in the null mutant testes is 5-10% of the control level, which suggests that there is a considerable safety margin in the amount of testosterone that is needed for the male fetal masculinization. ..
  39. Kusakabe T, Kawaguchi A, Hoshi N, Kawaguchi R, Hoshi S, Kimura S. Thyroid-specific enhancer-binding protein/NKX2.1 is required for the maintenance of ordered architecture and function of the differentiated thyroid. Mol Endocrinol. 2006;20:1796-809 pubmed
    ..Taken together, these results suggest that T/ebp/Nkx2.1 is required for maintenance of the normal architecture and function of differentiated thyroids. ..
  40. Liu C, Glasser S, Wan H, Whitsett J. GATA-6 and thyroid transcription factor-1 directly interact and regulate surfactant protein-C gene expression. J Biol Chem. 2002;277:4519-25 pubmed
    ..GATA-6 influenced the activity of the sp-C promoter, binding and acting synergistically with TTF-1. ..
  41. Tell G, Perrone L, Fabbro D, Pellizzari L, Pucillo C, De Felice M, et al. Structural and functional properties of the N transcriptional activation domain of thyroid transcription factor-1: similarities with the acidic activation domains. Biochem J. 1998;329 ( Pt 2):395-403 pubmed
    ..TTF-1 N domain and acidic domains define a family of proteins whose common property is to activate transcription through the use of mechanisms largely conserved during evolutionary development. ..
  42. Missero C, Pirro M, Di Lauro R. Multiple ras downstream pathways mediate functional repression of the homeobox gene product TTF-1. Mol Cell Biol. 2000;20:2783-93 pubmed
    ..Our data indicate that the Raf/MEK/ERK cascade may act in concert with an as-yet-uncharacterized signaling pathway activated by V12N38 Ras to repress TTF-1 function and ultimately to inhibit thyroid cell differentiation. ..
  43. Zhou L, Lim L, Costa R, Whitsett J. Thyroid transcription factor-1, hepatocyte nuclear factor-3beta, surfactant protein B, C, and Clara cell secretory protein in developing mouse lung. J Histochem Cytochem. 1996;44:1183-93 pubmed
    ..The early expression of TTF-1 and HNF-3beta, preceding and overlapping that of pro-SP-B, mature SP-B, pro-SP-C, and CCSP, supports a regulatory role for TTF-1 and HNF-3beta in lung-specific gene expression. ..
  44. Kimura S, Hara Y, Pineau T, Fernandez Salguero P, Fox C, Ward J, et al. The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary. Genes Dev. 1996;10:60-9 pubmed
    ..These results establish that the expression of T/EBP, a transcription factor known to control thyroid-specific gene transcription, is also essential for organogenesis of the thyroid, lung, ventral forebrain, and pituitary. ..
  45. Chen H, Zhang J, Huang H, Wang Z, Cheng R, Cai W. Leptin promotes fetal lung maturity and upregulates SP-A expression in pulmonary alveoli type-II epithelial cells involving TTF-1 activation. PLoS ONE. 2013;8:e69297 pubmed publisher
    ..These results suggest that leptin may have great therapeutic potential for the treatment of FGR, and leptin-mediated SP-A induction and lung maturity of the fetus are TTF-1 dependent. ..
  46. McMichael G, Haan E, Gardner A, Yap T, Thompson S, Ouvrier R, et al. NKX2-1 mutation in a family diagnosed with ataxic dyskinetic cerebral palsy. Eur J Med Genet. 2013;56:506-9 pubmed publisher
    ..Screening of 60 unrelated individuals with a diagnosis of dyskinetic or ataxic CP did not identify NKX2-1 mutations. BHC can be confused with ataxic and dyskinetic CP. Occasionally these children have a mutation in NKX2-1. ..
  47. Abramowicz M, Vassart G, Christophe D. Functional study of the human thyroid peroxidase gene promoter. Eur J Biochem. 1992;203:467-73 pubmed
    ....
  48. Nettore I, Mirra P, Ferrara A, Sibilio A, Pagliara V, Kay C, et al. Identification and functional characterization of a novel mutation in the NKX2-1 gene: comparison with the data in the literature. Thyroid. 2013;23:675-82 pubmed publisher
    ..NKX2-1 mutations have been described in several patients with primary congenital hypothyroidism, respiratory distress, and benign hereditary chorea, which are classical manifestations of the brain-thyroid-lung syndrome (BTLS)...
  49. Amendola E, Sanges R, Galvan A, Dathan N, Manenti G, Ferrandino G, et al. A locus on mouse chromosome 2 is involved in susceptibility to congenital hypothyroidism and contains an essential gene expressed in thyroid. Endocrinology. 2010;151:1948-58 pubmed publisher
    ..development of congenital hypothyroidism in mice heterozygous for null mutations in genes encoding Nkx2-1/Titf1 and Pax8...
  50. Ngan E, Lang B, Liu T, Shum C, So M, Lau D, et al. A germline mutation (A339V) in thyroid transcription factor-1 (TITF-1/NKX2.1) in patients with multinodular goiter and papillary thyroid carcinoma. J Natl Cancer Inst. 2009;101:162-75 pubmed publisher
    ..This is the first germline mutation identified in MNG/PTC patients. It could contribute to predisposition for MNG and/or PTC and to the pathogenesis of PTC. ..
  51. Yin Z, Gonzales L, Kolla V, Rath N, Zhang Y, Lu M, et al. Hop functions downstream of Nkx2.1 and GATA6 to mediate HDAC-dependent negative regulation of pulmonary gene expression. Am J Physiol Lung Cell Mol Physiol. 2006;291:L191-9 pubmed
    ..Thus Hop represents a novel regulator of pulmonary maturation that is induced by glucocorticoids to mediate functionally important HDAC-dependent negative feedback regulation. ..
  52. Di Palma T, Nitsch R, Mascia A, Nitsch L, Di Lauro R, Zannini M. The paired domain-containing factor Pax8 and the homeodomain-containing factor TTF-1 directly interact and synergistically activate transcription. J Biol Chem. 2003;278:3395-402 pubmed
    ....
  53. Zhang Y, Rath N, Hannenhalli S, Wang Z, Cappola T, Kimura S, et al. GATA and Nkx factors synergistically regulate tissue-specific gene expression and development in vivo. Development. 2007;134:189-98 pubmed
    ..However, the relevance of this synergy has not been demonstrated in vivo. We show that Gata6-Titf1 (Gata6-Nkx2...
  54. Weidenfeld J, Shu W, Zhang L, Millar S, Morrisey E. The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium. J Biol Chem. 2002;277:21061-70 pubmed
    ..Together, these results suggest that WNT7b gene expression in the lung epithelium is regulated in a combinatorial fashion by TTF-1, GATA6, and Foxa2. ..
  55. Zighelboim I, Goodfellow P, Schmidt A, Walls K, Mallon M, Mutch D, et al. Differential methylation hybridization array of endometrial cancers reveals two novel cancer-specific methylation markers. Clin Cancer Res. 2007;13:2882-9 pubmed
    ..DMH and COBRA identified two CpG islands methylated in tumors but not in normal DNAs: SESN3 (PY2B4) and TITF1 (SC77F6/154). Bisulfite sequencing showed dense methylation of the CpG islands and confirmed the COBRA assays...
  56. Xu B, O DONNELL M, O Donnell J, Yu J, Zhang Y, Sartor M, et al. Adipogenic Differentiation of Thyroid Cancer Cells Through the Pax8-PPARγ Fusion Protein Is Regulated by Thyroid Transcription Factor 1 (TTF-1). J Biol Chem. 2016;291:19274-86 pubmed publisher
    ..Our data indicate that TTF-1 interacts with PPFP to inhibit the pro-adipogenic response to pioglitazone, and that the ability of pioglitazone to decrease TTF-1 expression contributes to its pro-adipogenic action. ..
  57. Zhu N, Li C, Xiao J, Minoo P. NKX2.1 regulates transcription of the gene for human bone morphogenetic protein-4 in lung epithelial cells. Gene. 2004;327:25-36 pubmed
    ..1. These findings bear functional implications regarding the regulation of a key signaling molecule by a homeodomain transcriptional regulator of lung epithelial morphogenesis. ..
  58. Serls A, Doherty S, Parvatiyar P, Wells J, Deutsch G. Different thresholds of fibroblast growth factors pattern the ventral foregut into liver and lung. Development. 2005;132:35-47 pubmed
    ..Together, the findings suggest that a concentration threshold of FGFs emanating from the cardiac mesoderm are involved in patterning the foregut endoderm. ..
  59. Uemae Y, Sakamoto J, Hidaka Y, Hiratsuka A, Susa T, Kato Y, et al. Gene expression, function, and diversity of Nkx2-4 in the rainbow trout, Oncorhynchus mykiss. Gen Comp Endocrinol. 2014;206:193-202 pubmed publisher
    ..The results suggest that in the rainbow trout, Nkx2-4a and Nkx2-4b might play a major role in TG gene transcription whereas Nkx2-4c might have some functions in the ovary as well as the thyroid. ..
  60. Acebron A, Aza Blanc P, Rossi D, Lamas L, Santisteban P. Congenital human thyroglobulin defect due to low expression of the thyroid-specific transcription factor TTF-1. J Clin Invest. 1995;96:781-5 pubmed
    ..Moreover, these data suggest that TTF-1 and Pax-8 would be differentially regulating thyroglobulin and thyroperoxidase gene transcription. ..
  61. Stahlman M, Gray M, Whitsett J. Expression of thyroid transcription factor-1(TTF-1) in fetal and neonatal human lung. J Histochem Cytochem. 1996;44:673-8 pubmed
    ....
  62. Reiser H, Schneeberger E. Expression and function of B7-1 and B7-2 in hapten-induced contact sensitivity. Eur J Immunol. 1996;26:880-5 pubmed
    ..Experiments in which mice are injected differentially with anti-B7-2 mAb, either before the afferent or before the efferent phase of the contact sensitivity response, suggest that B7-2 is important for successful antigen priming. ..