Ngfr

Summary

Gene Symbol: Ngfr
Description: nerve growth factor receptor
Alias: LNGFR, RNNGFRR, Tnfrsf16, p75, p75NTR, tumor necrosis factor receptor superfamily member 16, NGF receptor, gp80-LNGFR, low affinity nerve growth factor receptor, low affinity neurotrophin receptor p75NTR, nerve growth factor receptor (TNFR superfamily, member 16), nerve growth factor receptor, fast, p75 ICD
Species: rat
Products:     Ngfr

Top Publications

  1. Feng D, Kim T, Ozkan E, Light M, Torkin R, Teng K, et al. Molecular and structural insight into proNGF engagement of p75NTR and sortilin. J Mol Biol. 2010;396:967-84 pubmed publisher
    ..In this study, we carried out structural and biochemical characterization of proNGF interactions with p75NTR and sortilin. We crystallized proNGF complexed to p75NTR and present the structure at 3.75-A resolution...
  2. Gong Y, Cao P, Yu H, Jiang T. Crystal structure of the neurotrophin-3 and p75NTR symmetrical complex. Nature. 2008;454:789-93 pubmed publisher
    ..NTs bind to two distinct classes of glycosylated receptor: the p75 neurotrophin receptor (p75(NTR)) and tyrosine kinase receptors (Trks)...
  3. Nykjaer A, Lee R, Teng K, Jansen P, Madsen P, Nielsen M, et al. Sortilin is essential for proNGF-induced neuronal cell death. Nature. 2004;427:843-8 pubmed
    ..NGF regulates cell survival and cell death via binding to two different receptors, TrkA and p75NTR (ref. 10). In contrast, proNGF selectively induces apoptosis through p75NTR but not TrkA...
  4. Mukai J, Hachiya T, Shoji Hoshino S, Kimura M, Nadano D, Suvanto P, et al. NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR. J Biol Chem. 2000;275:17566-70 pubmed
    The low affinity neurotrophin receptor p75NTR can mediate cell survival as well as cell death of neural cells by NGF and other neurotrophins...
  5. Coassin M, Lambiase A, Sposato V, Micera A, Bonini S, Aloe L. Retinal p75 and bax overexpression is associated with retinal ganglion cells apoptosis in a rat model of glaucoma. Graefes Arch Clin Exp Ophthalmol. 2008;246:1743-9 pubmed publisher
    ..Therefore, this study sought to address whether timely changes in NGF and its receptors, trkA(NGFR) and p75(NTR), might explain the progression of retinal damage during experimental glaucoma...
  6. Brandoli C, Shi B, Pflug B, Andrews P, Wrathall J, Mocchetti I. Dexamethasone reduces the expression of p75 neurotrophin receptor and apoptosis in contused spinal cord. Brain Res Mol Brain Res. 2001;87:61-70 pubmed
    ..SCI induces the expression of the low affinity neurotrophin receptor p75 (p75NTR), that in the absence of the high affinity component, TrkA, can promote cell death by apoptosis...
  7. Park J, Lee J, Sato T, Koh J. Co-induction of p75NTR and p75NTR-associated death executor in neurons after zinc exposure in cortical culture or transient ischemia in the rat. J Neurosci. 2000;20:9096-103 pubmed
    Recently, a 22 kDa protein termed p75(NTR)-associated death executor (NADE) was discovered to be a necessary factor for p75(NTR)-mediated apoptosis in certain cells...
  8. Xu F, Wei Y, Lu Q, Zheng D, Zhang F, Gao E, et al. Immunohistochemical localization of sortilin and p75(NTR) in normal and ischemic rat retina. Neurosci Lett. 2009;454:81-5 pubmed publisher
    In our previous study, we found the increased expression of p75(NTR) and sortilin by Western blotting in ischemic retina induced by elevated intraocular pressure (IOP)...
  9. Ye X, Mehlen P, Rabizadeh S, VanArsdale T, Zhang H, Shin H, et al. TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction. J Biol Chem. 1999;274:30202-8 pubmed
    The common neurotrophin receptor, p75(NTR), has been shown to signal in the absence of Trk tyrosine kinase receptors, including induction of neural apoptosis and activation of NF-kappaB...

More Information

Publications62

  1. Vilar M, Charalampopoulos I, Kenchappa R, Simi A, Karaca E, Reversi A, et al. Activation of the p75 neurotrophin receptor through conformational rearrangement of disulphide-linked receptor dimers. Neuron. 2009;62:72-83 pubmed publisher
    ..Neurotrophins interact with dimers of the p75 neurotrophin receptor (p75(NTR)), but the mechanism of receptor activation has remained elusive...
  2. von Schack D, Casademunt E, Schweigreiter R, Meyer M, Bibel M, Dechant G. Complete ablation of the neurotrophin receptor p75NTR causes defects both in the nervous and the vascular system. Nat Neurosci. 2001;4:977-8 pubmed
  3. Mi Z, Rogers D, Mirnics Z, Schor N. p75NTR-dependent modulation of cellular handling of reactive oxygen species. J Neurochem. 2009;110:295-306 pubmed publisher
    Our previous studies demonstrated that p75NTR confers protection against oxidative stress-induced apoptosis upon PC12 cells; however, the mechanisms responsible for this effect are not known...
  4. Lebrun Julien F, Morquette B, Douillette A, Saragovi H, Di Polo A. Inhibition of p75(NTR) in glia potentiates TrkA-mediated survival of injured retinal ganglion cells. Mol Cell Neurosci. 2009;40:410-20 pubmed publisher
    ..In the adult retina, nerve growth factor (NGF) binds to TrkA (expressed by neurons) and p75(NTR) (expressed by Müller glia), but fails to promote the survival of axotomized retinal ganglion cells (RGCs)...
  5. Beattie M, Harrington A, Lee R, Kim J, Boyce S, Longo F, et al. ProNGF induces p75-mediated death of oligodendrocytes following spinal cord injury. Neuron. 2002;36:375-86 pubmed
    The neurotrophin receptor p75 is induced by various injuries to the nervous system, but its role after injury has remained unclear...
  6. Hartmann M, Brigadski T, Erdmann K, Holtmann B, Sendtner M, Narz F, et al. Truncated TrkB receptor-induced outgrowth of dendritic filopodia involves the p75 neurotrophin receptor. J Cell Sci. 2004;117:5803-14 pubmed
    The Trk family of receptor tyrosine kinases and the p75 receptor (p75NTR) mediate the effects of neurotrophins on neuronal survival, differentiation and synaptic plasticity...
  7. Epa W, Markovska K, Barrett G. The p75 neurotrophin receptor enhances TrkA signalling by binding to Shc and augmenting its phosphorylation. J Neurochem. 2004;89:344-53 pubmed
    ..Whilst providing evidence that p75(NTR) augments TrkA signal transduction, these results do not preclude the presence of a p75(NTR)-TrkA high-affinity NGF receptor.
  8. Lee K, Li E, Huber L, Landis S, Sharpe A, Chao M, et al. Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system. Cell. 1992;69:737-49 pubmed
    We have generated mice carrying a mutation of the gene encoding the low affinity NGF receptor p75NGFR by targeted mutation in embryonic stem cells. Mice homozygous for the mutation were viable and fertile...
  9. Dubreuil C, Winton M, McKerracher L. Rho activation patterns after spinal cord injury and the role of activated Rho in apoptosis in the central nervous system. J Cell Biol. 2003;162:233-43 pubmed
    ..Next, we examined the role of the p75 neurotrophin receptor (p75NTR) in Rho signaling...
  10. Wang K, Kim J, Sivasankaran R, Segal R, He Z. P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp. Nature. 2002;420:74-8 pubmed
    ..Here, we demonstrate that p75, a transmembrane protein known to be a receptor for the neurotrophin family of growth factors, specifically ..
  11. Cosgaya J, Chan J, Shooter E. The neurotrophin receptor p75NTR as a positive modulator of myelination. Science. 2002;298:1245-8 pubmed
    Schwann cells in developing and regenerating peripheral nerves express elevated levels of the neurotrophin receptor p75NTR. Neurotrophins are key mediators of peripheral nervous system myelination...
  12. Salehi A, Roux P, Kubu C, Zeindler C, Bhakar A, Tannis L, et al. NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis. Neuron. 2000;27:279-88 pubmed
    The mechanisms employed by the p75 neurotrophin receptor (p75NTR) to mediate neurotrophin-dependent apoptosis are poorly defined...
  13. Cozza A, Melissari E, Iacopetti P, Mariotti V, Tedde A, Nacmias B, et al. SNPs in neurotrophin system genes and Alzheimer's disease in an Italian population. J Alzheimers Dis. 2008;15:61-70 pubmed
    ..growth factor (NGFB), brain-derived neurotrophic factor (BDNF), and their receptors, nerve growth factor receptor (NGFR), and neurotrophin tyrosine kinase receptors 1 and 2 (NTRK1 and NTRK2), in Alzheimer's disease (AD)...
  14. Li S, Saragovi H, Nedev H, Zhao C, Racine R, Fahnestock M. Differential actions of nerve growth factor receptors TrkA and p75NTR in a rat model of epileptogenesis. Mol Cell Neurosci. 2005;29:162-72 pubmed
    ..factor (NGF), but whether NGF acts via its high-affinity receptor TrkA and/or the common neurotrophin receptor p75NTR is unknown...
  15. Chittka A, Chao M. Identification of a zinc finger protein whose subcellular distribution is regulated by serum and nerve growth factor. Proc Natl Acad Sci U S A. 1999;96:10705-10 pubmed
    ..First, SC-1 interacts with the p75 neurotrophin receptor and is redistributed from the cytoplasm to the nucleus after nerve growth factor (NGF) ..
  16. Liepinsh E, Ilag L, Otting G, Ibanez C. NMR structure of the death domain of the p75 neurotrophin receptor. EMBO J. 1997;16:4999-5005 pubmed
    The intracellular domain of the p75 neurotrophin receptor (p75ICD) lacks catalytic activity but contains a motif similar to death domains found in the cytoplasmic regions of members of the tumor necrosis factor receptor family and their ..
  17. Lazaridis I, Charalampopoulos I, Alexaki V, Avlonitis N, Pediaditakis I, Efstathopoulos P, et al. Neurosteroid dehydroepiandrosterone interacts with nerve growth factor (NGF) receptors, preventing neuronal apoptosis. PLoS Biol. 2011;9:e1001051 pubmed publisher
    ..down recombinant and naturally expressed TrkA and p75(NTR) receptors; (4) DHEA induced TrkA phosphorylation and NGF receptor-mediated signaling; Shc, Akt, and ERK1/2 kinases down-stream to TrkA receptors and TRAF6, RIP2, and RhoGDI ..
  18. Wang T, Luo S, Lin C, Chang P, Chen M. Modulation of p75 neurotrophin receptor under hypoxic conditions induces migration and invasion of C6 glioma cells. Clin Exp Metastasis. 2015;32:73-81 pubmed publisher
    p75 neurotrophin receptor (p75NTR) has been reported to play important roles in various cancer types. However, the exact mechanism of tumorigenesis involving p75NTR is unknown...
  19. Ohrt T, Mancini A, Tamura T, Niedenthal R. c-Cbl binds to tyrosine-phosphorylated neurotrophin receptor p75 and induces its ubiquitination. Cell Signal. 2004;16:1291-8 pubmed
    The p75 neurotrophin receptor (p75NTR) has dual functions in cell survival and cell death but its intracellular signalling pathways are not understood...
  20. Ravasi M, Scuteri A, Pasini S, Bossi M, Menendez V, Maggioni D, et al. Undifferentiated MSCs are able to myelinate DRG neuron processes through p75. Exp Cell Res. 2013;319:2989-99 pubmed publisher
    ..In this process a pivotal role is performed by the p75 receptor.
  21. Qu Q, Chen J, Wang Y, Gui W, Wang L, Fan Z, et al. Structural characterization of the self-association of the death domain of p75(NTR.). PLoS ONE. 2013;8:e57839 pubmed publisher
    The neurotrophin receptor p75(NTR) conveys multiple signals via its intracellular death domain. However, how the death domain is activated and interacts with downstream adaptors remains unclear...
  22. Wilson Gerwing T, Johnston J, Verge V. p75 neurotrophin receptor is implicated in the ability of neurotrophin-3 to negatively modulate activated ERK1/2 signaling in TrkA-expressing adult sensory neurons. J Comp Neurol. 2009;516:49-58 pubmed publisher
    ..in trkA- versus trkC-mRNA-positive subpopulations of neurons and the role that the common neurotrophin receptor, p75NTR, plays in this response was assessed by examining alterations in the levels of phospho-ERK1/2 immunofluorescence ..
  23. Shi J, Longo F, Massa S. A small molecule p75(NTR) ligand protects neurogenesis after traumatic brain injury. Stem Cells. 2013;31:2561-74 pubmed publisher
    The p75 neurotrophin receptor (p75(NTR)) influences the proliferation, survival, and differentiation of neuronal precursors and its expression is induced in injured brain, where it regulates cell survival...
  24. Frånberg J, Karlstrom H, Winblad B, Tjernberg L, Frykman S. gamma-Secretase dependent production of intracellular domains is reduced in adult compared to embryonic rat brain membranes. PLoS ONE. 2010;5:e9772 pubmed publisher
    ..Here, we investigated gamma-secretase cleavage of five substrates; APP, Notch1, N-cadherin, ephrinB and p75 neurotrophin receptor (p75-NTR) in membranes isolated from embryonic, young or old adult rat brain by analyzing the ..
  25. Tang Y, Wang P, Du B, Zhou B, DU B. [Expressions of neurotrophin factor receptor in spiral ganglion cell of cisplatin-induced ototoxicity]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2008;43:950-5 pubmed
    ..the effects of high-affinity tyrosine kinase receptors TrkB, TrkC and the low-affinity neurotrophin receptor p75 in spiral ganglion cell (SGC) of cisplatin-induced ototoxicity...
  26. Kobayashi H, Hirakawa H, O Briain D, Puri P. Nerve growth factor receptor staining of suction biopsies in the diagnosis of Hirschsprung's disease. J Pediatr Surg. 1994;29:1224-7 pubmed
    ..The 60 cases were stained with a monoclonal antibody to the nerve growth factor receptor (NGFR) using immunohistochemistry on fresh frozen biopsy tissue...
  27. Breiderhoff T, Christiansen G, Pallesen L, Vaegter C, Nykjaer A, Holm M, et al. Sortilin-related receptor SORCS3 is a postsynaptic modulator of synaptic depression and fear extinction. PLoS ONE. 2013;8:e75006 pubmed publisher
    ..In conclusion, our studies have identified a novel function for VPS10P domain receptors in control of synaptic depression and suggest SORCS3 as a novel factor modulating aversive memory extinction. ..
  28. Egashira Y, Tanaka T, Soni P, Sakuragi S, Tominaga Yoshino K, Ogura A. Involvement of the p75(NTR) signaling pathway in persistent synaptic suppression coupled with synapse elimination following repeated long-term depression induction. J Neurosci Res. 2010;88:3433-46 pubmed publisher
    ..Recently, proneurotrophin-activated p75(NTR) signaling has been gaining attention as a possible pathway for the regulation of both neuronal apoptosis and ..
  29. Sotthibundhu A, Sykes A, Fox B, Underwood C, Thangnipon W, Coulson E. Beta-amyloid(1-42) induces neuronal death through the p75 neurotrophin receptor. J Neurosci. 2008;28:3941-6 pubmed publisher
    ..Abeta is a ligand for the p75 neurotrophin receptor (p75(NTR)), which is best known for mediating neuronal death and has been consistently linked ..
  30. Young H, Ciampoli D, Hsuan J, Canty A. Expression of Ret-, p75(NTR)-, Phox2a-, Phox2b-, and tyrosine hydroxylase-immunoreactivity by undifferentiated neural crest-derived cells and different classes of enteric neurons in the embryonic mouse gut. Dev Dyn. 1999;216:137-52 pubmed
    ..In this study the distribution of p75(NTR)-immunoreactivity was compared with that of Ret-, Phox2a-, Phox2b-, and tyrosine hydroxylase (TH) in ..
  31. Butowt R, von Bartheld C. Anterograde axonal transport of BDNF and NT-3 by retinal ganglion cells: roles of neurotrophin receptors. Mol Cell Neurosci. 2005;29:11-25 pubmed
    ..RT-PCR and Western blot analysis of purified murine RGCs showed that adult RGCs express the p75 receptor...
  32. Cowen T, Woodhoo A, Sullivan C, Jolly R, Crutcher K, Wyatt S, et al. Reduced age-related plasticity of neurotrophin receptor expression in selected sympathetic neurons of the rat. Aging Cell. 2003;2:59-69 pubmed
    ..RT-PCR for the principal NT receptors, trkA and p75, in SCG showed increased message during early postnatal life...
  33. Pappas T, Decorti F, Macdonald N, Neet K, Taglialatela G. Tumour necrosis factor-alpha- vs. growth factor deprivation-promoted cell death: different receptor requirements for mediating nerve growth factor-promoted rescue. Aging Cell. 2003;2:83-92 pubmed
    ..TrkA), while NGF rescue from TNFalpha-promoted cell death requires NGF signalling through the low-affinity p75NTR receptor...
  34. Sinha R, Pathak A, Kumar A, Tiwari M, Shrivastava A, Godbole M. Enhanced neuronal loss under perinatal hypothyroidism involves impaired neurotrophic signaling and increased proteolysis of p75(NTR). Mol Cell Neurosci. 2009;40:354-64 pubmed publisher
    ..neuronal loss involve down regulation of neurotrophic survival signaling and increased truncation of the receptor p75(NTR)...
  35. Ross G, Shamovsky I, Lawrance G, Solc M, Dostaler S, Weaver D, et al. Reciprocal modulation of TrkA and p75NTR affinity states is mediated by direct receptor interactions. Eur J Neurosci. 1998;10:890-8 pubmed
    ..factor (125I-NGF) to cells coexpressing the tyrosine kinase receptor A (TrkA) and common neurotrophin receptor (p75NTR), cells coexpressing both receptors where p75NTR is occupied, and cells expressing only p75NTR, revealed ..
  36. Chaldakov G, Stankulov I, Fiore M, Ghenev P, Aloe L. Nerve growth factor levels and mast cell distribution in human coronary atherosclerosis. Atherosclerosis. 2001;159:57-66 pubmed
    ..The aim of the present study was to determine the NGF levels and the distribution of NGF and low-affinity NGF receptor (p75NGFR) and mast cells (MC) in human atherosclerotic coronary arteries...
  37. Piiper A, Dikic I, Lutz M, Leser J, Kronenberger B, Elez R, et al. Cyclic AMP induces transactivation of the receptors for epidermal growth factor and nerve growth factor, thereby modulating activation of MAP kinase, Akt, and neurite outgrowth in PC12 cells. J Biol Chem. 2002;277:43623-30 pubmed
    ..It occurs also in Panc-1, but not in human mesangial cells. cAMP-induced tyrosine phosphorylation of the NGF receptor is slower and correlates with Akt activation...
  38. Mamidipudi V, Li X, Wooten M. Identification of interleukin 1 receptor-associated kinase as a conserved component in the p75-neurotrophin receptor activation of nuclear factor-kappa B. J Biol Chem. 2002;277:28010-8 pubmed
    ..Our results reveal that IRAK is recruited to the p75-NGF receptor leading to formation of a complex between IRAK, atypical protein kinase C interacting protein, p62, and TRAF6...
  39. Sykes A, Palstra N, Abankwa D, Hill J, Skeldal S, Matusica D, et al. The effects of transmembrane sequence and dimerization on cleavage of the p75 neurotrophin receptor by ?-secretase. J Biol Chem. 2012;287:43810-24 pubmed publisher
    ..Here we show that the transmembrane domain of the pan-neurotrophin receptor p75(NTR), best known for regulating neuronal death, is sufficient for its homodimerization...
  40. Echarte M, Bruno L, Arndt Jovin D, Jovin T, Pietrasanta L. Quantitative single particle tracking of NGF-receptor complexes: transport is bidirectional but biased by longer retrograde run lengths. FEBS Lett. 2007;581:2905-13 pubmed
    ..15 microm/s at room temperature, and the run times were exponentially distributed. The photostability and brightness of QDs permit extended real-time analysis of individual QDbNGF- receptor complexes trafficking within neurites. ..
  41. Qiu D, Mao L, Kikuchi S, Tomita M. Sustained MAPK activation is dependent on continual NGF receptor regeneration. Dev Growth Differ. 2004;46:393-403 pubmed
  42. Andrews J, Newell K, Matosin N, Huang X, Fernandez Enright F. Alterations of p75 neurotrophin receptor and Myelin transcription factor 1 in the hippocampus of perinatal phencyclidine treated rats. Prog Neuropsychopharmacol Biol Psychiatry. 2015;63:91-7 pubmed publisher
    ..findings using a postmortem human brain cohort showed that Lingo-1 signaling partners in the Nogo receptor (NgR)/p75/TNF receptor orphan Y (TROY) signaling complex, and downstream signaling partners With No Lysine (K) (WNK1) and ..
  43. Pišlar A, Kos J. C-terminal peptide of ?-enolase impairs amyloid-?-induced apoptosis through p75(NTR) signaling. Neuromolecular Med. 2013;15:623-35 pubmed publisher
    ..Exposure to A? increased surface expression of p75 neurotrophin receptor (p75(NTR)), and the increase was abolished in the presence of ?-Eno peptide...
  44. Hermes B, Zuberbier T, Haas N, Henz B. Decreased cutaneous expression of stem cell factor and of the p75NGF receptor in urticaria. Br J Dermatol. 2003;148:411-7 pubmed
    ..In contrast, expression of the NGF receptor tyrosine kinase and of the SCF and GM-CSF receptors was unchanged...
  45. Provenzano M, Minner S, Zander K, Clark J, Kane C, Green S, et al. p75(NTR) expression and nuclear localization of p75(NTR) intracellular domain in spiral ganglion Schwann cells following deafness correlate with cell proliferation. Mol Cell Neurosci. 2011;47:306-15 pubmed publisher
    ..Here we investigate the role of p75(NTR) in SGSC responses to gradual denervation...
  46. Tcherpakov M, Bronfman F, Conticello S, Vaskovsky A, Levy Z, Niinobe M, et al. The p75 neurotrophin receptor interacts with multiple MAGE proteins. J Biol Chem. 2002;277:49101-4 pubmed
    The p75 neurotrophin receptor has been implicated in diverse aspects of neurotrophin signaling, but the mechanisms by which its effects are mediated are not well understood...
  47. Bourikas D, Mir A, Walmsley A. LINGO-1-mediated inhibition of oligodendrocyte differentiation does not require the leucine-rich repeats and is reversed by p75(NTR) antagonists. Mol Cell Neurosci. 2010;45:363-9 pubmed publisher
    ..As in neurons, LINGO-1 physically associated with endogenous p75(NTR) in MO3...
  48. Yi J, Lee S, Sato T, Koh J. Co-induction of p75(NTR) and the associated death executor NADE in degenerating hippocampal neurons after kainate-induced seizures in the rat. Neurosci Lett. 2003;347:126-30 pubmed
    Zinc induces in cultured cortical neurons both p75(NTR) and p75(NTR)-associated death executor (NADE), which together contribute to caspase-dependent neuronal apoptosis...
  49. Frade J. Nuclear translocation of the p75 neurotrophin receptor cytoplasmic domain in response to neurotrophin binding. J Neurosci. 2005;25:1407-11 pubmed
    The intracellular domain of the p75 neurotrophin receptor (p75ICD) can be released by gamma-secretase in response to the previous activation of alpha-secretase by phorbol esters...
  50. Xuan A, Luo M, Ji W, Long D. Effects of engrafted neural stem cells in Alzheimer's disease rats. Neurosci Lett. 2009;450:167-71 pubmed publisher
    ..Immunohistochemical detection of p75(NGFR) showed that the number of cholinergic neurons of the NSCs-transplanted group was significant higher than that of ..
  51. Yan Y, Li T, Liu L, Zhou H. Effect of tonifying liver and kidney-essence herbs on expression of Nogo-A and p75(NTR) in cerebral ischemic stroke rats model. J Tradit Chin Med. 2012;32:664-8 pubmed
    ..inhibitor, Nogo for neuron A (Nogo-A), and its associated signaling molecule, low-affinity neurotrophin receptor p75 (p75(NTR)), in rats with cerebral ischemic stroke (CIS), with the aim of exploring the possible mechanism of ..
  52. Dang C, Zhang Y, Ma Q, Shimahara Y. Expression of nerve growth factor receptors is correlated with progression and prognosis of human pancreatic cancer. J Gastroenterol Hepatol. 2006;21:850-8 pubmed
    ..aim of the present study was to investigate the prognostic value of the two types of nerve growth factor receptors (NGFR), namely high-affinity receptor TrkA and low-affinity receptor p75NGFR, in pancreatic cancer...
  53. Formaggio E, Cantù C, Chiamulera C, Fumagalli G. p75 neurotrophin receptor distribution and transport in cultured neurons. Neurosci Res. 2008;62:32-42 pubmed publisher
    In this work, we define a GFP-tagged version of the p75 neurotrophin receptor (p75GFP) as a useful molecular tool for studying its distribution and cellular dynamics...