Ngf

Summary

Gene Symbol: Ngf
Description: nerve growth factor
Alias: Ngfb, beta-NGF, beta-nerve growth factor, nerve growth factor (beta polypeptide)
Species: rat
Products:     Ngf

Top Publications

  1. Hallbook F, Ebendal T, Persson H. Production and characterization of biologically active recombinant beta nerve growth factor. Mol Cell Biol. 1988;8:452-6 pubmed
    DNA fragments encoding either rat or chicken beta nerve growth factor (NGF) were inserted in the expression vector p91023(B) for transient expression in COS cells...
  2. Xuan Nguyen T, Choi J, Lee S, Ye K, Woo S, Lee K, et al. Akt phosphorylation is essential for nuclear translocation and retention in NGF-stimulated PC12 cells. Biochem Biophys Res Commun. 2006;349:789-98 pubmed
    Nerve growth factor (NGF) elicits Akt translocation into the nucleus, where it phosphorylates nuclear targets...
  3. Lujan H, Chen Y, DiCarlo S. Paraplegia increased cardiac NGF content, sympathetic tonus, and the susceptibility to ischemia-induced ventricular tachycardia in conscious rats. Am J Physiol Heart Circ Physiol. 2009;296:H1364-72 pubmed publisher
    ..Furthermore, it is well known that sympathetic neurons have a lifelong requirement for nerve growth factor (NGF)...
  4. Li W, Sabsovich I, Guo T, Zhao R, Kingery W, Clark J. The role of enhanced cutaneous IL-1beta signaling in a rat tibia fracture model of complex regional pain syndrome. Pain. 2009;144:303-13 pubmed publisher
    ..the modulation of nociceptive information and it acts as an intermediate inflammatory mediator via up-regulation of NGF. We hypothesized that IL-1beta signaling might mediate the development of the CRPS-like changes after tibial ..
  5. Chung C, Zhang Q, Qiao L. Endogenous nerve growth factor regulates collagen expression and bladder hypertrophy through Akt and MAPK pathways during cystitis. J Biol Chem. 2010;285:4206-12 pubmed publisher
    ..The endogenous nerve growth factor (NGF) in the urinary bladder regulated type I collagen expression because the neutralizing NGF antibody attenuated ..
  6. Nykjaer A, Lee R, Teng K, Jansen P, Madsen P, Nielsen M, et al. Sortilin is essential for proNGF-induced neuronal cell death. Nature. 2004;427:843-8 pubmed
    ..Sortilin is expressed during embryogenesis in areas where nerve growth factor (NGF) and its precursor, proNGF, have well-characterized effects...
  7. Dijkmans T, van Hooijdonk L, Schouten T, Kamphorst J, Fitzsimons C, Vreugdenhil E. Identification of new Nerve Growth Factor-responsive immediate-early genes. Brain Res. 2009;1249:19-33 pubmed publisher
    Stimulation of the PC12 pheochromocytoma cell line with the prototypical neurotrophin Nerve Growth Factor (NGF) induces a cellular response of neuronal differentiation and is therefore a widely used model to gain molecular insight into ..
  8. Cragnolini A, Huang Y, Gokina P, Friedman W. Nerve growth factor attenuates proliferation of astrocytes via the p75 neurotrophin receptor. Glia. 2009;57:1386-92 pubmed publisher
    ..Treatment of hippocampal astrocytes with nerve growth factor (NGF) caused a reduction in cell number, but did not elicit an apoptotic response, in contrast to hippocampal neurons...
  9. Orita S, Ohtori S, Nagata M, Horii M, Yamashita M, Yamauchi K, et al. Inhibiting nerve growth factor or its receptors downregulates calcitonin gene-related peptide expression in rat lumbar dorsal root ganglia innervating injured intervertebral discs. J Orthop Res. 2010;28:1614-20 pubmed publisher
    Nerve growth factor (NGF) and its dual structurally unrelated receptors, tropomyosin-related kinase A (TrkA) or p75 neurotrophin receptor (p75(NTR)), cause the pathogenesis of discogenic pain...

More Information

Publications93

  1. Allard S, Leon W, Pakavathkumar P, Bruno M, Ribeiro Da Silva A, Cuello A. Impact of the NGF maturation and degradation pathway on the cortical cholinergic system phenotype. J Neurosci. 2012;32:2002-12 pubmed publisher
    ..Nerve growth factor (NGF) is the neurotrophin responsible for the phenotypic maintenance of basal forebrain cholinergic neurons in the ..
  2. Chaldakov G, Fiore M, Stankulov I, Hristova M, Antonelli A, Manni L, et al. NGF, BDNF, leptin, and mast cells in human coronary atherosclerosis and metabolic syndrome. Arch Physiol Biochem. 2001;109:357-60 pubmed
    ..implicated in cardiovascular tissue development and in lipid and glucose metabolism, the role of the neurotrophins NGF and BDNF and also the adipokine leptin in human coronary atherosclerosis and related disorders, such as metabolic ..
  3. Noga O, Hanf G, Schaper C, O CONNOR A, Kunkel G. The influence of inhalative corticosteroids on circulating Nerve Growth Factor, Brain-Derived Neurotrophic Factor and Neurotrophin-3 in allergic asthmatics. Clin Exp Allergy. 2001;31:1906-12 pubmed
    The neurotrophins Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF) and Neurotrophin (NT)-3 are produced, stored and released by various immunological cells...
  4. D Onofrio M, Paoletti F, Arisi I, Brandi R, Malerba F, Fasulo L, et al. NGF and proNGF regulate functionally distinct mRNAs in PC12 cells: an early gene expression profiling. PLoS ONE. 2011;6:e20839 pubmed publisher
    The biological activities of NGF and of its precursor proNGF are quite distinct, due to different receptor binding profiles, but little is known about how proNGF regulates gene expression...
  5. Perrard M, Durand P. Redundancy of the effect of TGFbeta1 and beta-NGF on the second meiotic division of rat spermatocytes. Microsc Res Tech. 2009;72:596-602 pubmed publisher
    ..in cocultures of late pachytene/diplotene spermatocytes (PS/DS) with Sertoli cells, beta-nerve growth factor (beta-NGF) or transforming growth factor (TGFbeta1) regulates the second meiotic division by blocking secondary spermatocytes ..
  6. Hope Gill B, Hilldrup S, Davies C, Newton R, Harrison N. A study of the cough reflex in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2003;168:995-1002 pubmed
    ..The cough response to inhaled SP in most patients may reflect disrupted respiratory epithelium. The response to corticosteroids demonstrates that the cough is amenable to therapy. ..
  7. Glebova N, Ginty D. Heterogeneous requirement of NGF for sympathetic target innervation in vivo. J Neurosci. 2004;24:743-51 pubmed
    The neurotrophin nerve growth factor (NGF) plays a crucial role in the development of the sympathetic nervous system...
  8. Zhang L, Wang H, Yang Y, Liu H, Zhang Q, Xiang Q, et al. NGF induces adult stem Leydig cells to proliferate and differentiate during Leydig cell regeneration. Biochem Biophys Res Commun. 2013;436:300-5 pubmed publisher
    Nerve growth factor (NGF) has been reported to be involved in male reproductive physiology. However, few reports have described the activity of NGF during Leydig cell development...
  9. Guerios S, Wang Z, Boldon K, Bushman W, Bjorling D. Blockade of NGF and trk receptors inhibits increased peripheral mechanical sensitivity accompanying cystitis in rats. Am J Physiol Regul Integr Comp Physiol. 2008;295:R111-22 pubmed publisher
    ..may induce transient or persistent plastic changes mediated by neurotrophins, particularly nerve growth factor (NGF), which contribute to increased nociceptive input...
  10. Perrard M, Vigier M, Damestoy A, Chapat C, Silandre D, Rudkin B, et al. beta-Nerve growth factor participates in an auto/paracrine pathway of regulation of the meiotic differentiation of rat spermatocytes. J Cell Physiol. 2007;210:51-62 pubmed
    b>NGF appears to be involved in spermatogenesis. However, mice lacking NGF or TrkA genes do not survive more than a few days whereas p75(NTR) knockout mice are viable and fertile...
  11. Frampton J, Guo C, Pierchala B. Expression of axonal protein degradation machinery in sympathetic neurons is regulated by nerve growth factor. J Neurosci Res. 2012;90:1533-46 pubmed publisher
    ..the expression of proteins associated with lysosomes and proteasomes were upregulated selectively in axons by NGF stimulation of the distal axons of sympathetic neurons, suggesting that axonal growth and maintenance requires ..
  12. Perovic M, Tesic V, Mladenovic Djordjevic A, Smiljanic K, Loncarevic Vasiljkovic N, Ruzdijic S, et al. BDNF transcripts, proBDNF and proNGF, in the cortex and hippocampus throughout the life span of the rat. Age (Dordr). 2013;35:2057-70 pubmed publisher
    ..We analyzed the impact of aging on brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) protein isoforms, their receptors, and on the expression patterns of multiple 5' exon-specific BDNF transcripts in ..
  13. Martinelli P, Camargos E, Azevedo A, Chiari E, Morel G, Machado C. Cardiac NGF and GDNF expression during Trypanosoma cruzi infection in rats. Auton Neurosci. 2006;130:32-40 pubmed
    ..work shows the cardiac levels of glial cell line-derived neurotrophic factor (GDNF) and nerve growth factor (NGF), and their cellular sources during T. cruzi infection in rats...
  14. Matsuoka Y, Yokoyama M, Kobayashi H, Omori M, Itano Y, Morita K, et al. Expression profiles of BDNF splice variants in cultured DRG neurons stimulated with NGF. Biochem Biophys Res Commun. 2007;362:682-8 pubmed
    ..Nerve growth factor (NGF) from inflammatory tissue is thought to induce expression of BDNF...
  15. Yu S, Xia C, Kay J, Qiao L. Activation of extracellular signal-regulated protein kinase 5 is essential for cystitis- and nerve growth factor-induced calcitonin gene-related peptide expression in sensory neurons. Mol Pain. 2012;8:48 pubmed publisher
    ..The molecular mechanism and signal transduction underlying cross talk between the inflamed urinary bladder and sensory sensitization has not been investigated...
  16. Crowley C, Spencer S, Nishimura M, Chen K, Pitts Meek S, Armanini M, et al. Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons. Cell. 1994;76:1001-11 pubmed
    ..recombination was utilized to generate mice with a deletion in the coding sequence of the nerve growth factor (NGF) gene...
  17. Ricci A, Mariotta S, Saltini C, Falasca C, Giovagnoli M, Mannino F, et al. Neurotrophin system activation in bronchoalveolar lavage fluid immune cells in pulmonary sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis. 2005;22:186-94 pubmed
    ..We hypothesize that neurotrophins (NTs), nerve growth factor (NGF), brain derived neurotrophic factor (BDNF) and NT-3, besides their importance in immune system activities, ..
  18. Shirazi Fard S, Kele J, Vilar M, Paratcha G, Ledda F. Tiam1 as a signaling mediator of nerve growth factor-dependent neurite outgrowth. PLoS ONE. 2010;5:e9647 pubmed publisher
    Nerve Growth Factor (NGF)-induced neuronal differentiation requires the activation of members of the Rho family of small GTPases...
  19. Kimura K, Kanazawa H, Ieda M, Kawaguchi Manabe H, Miyake Y, Yagi T, et al. Norepinephrine-induced nerve growth factor depletion causes cardiac sympathetic denervation in severe heart failure. Auton Neurosci. 2010;156:27-35 pubmed publisher
    ..of circulating norepinephrine (NE) concentration, we investigated the temporal association of nerve growth factor (NGF) expression in the heart and cardiac sympathetic nerve density during the development of CHF in the continuous NE-..
  20. Manni L, Antonelli A, Costa N, Aloe L. Stress alters vascular-endothelial growth factor expression in rat arteries: role of nerve growth factor. Basic Res Cardiol. 2005;100:121-30 pubmed
    The aim of this study was to investigate the role of stress and nerve growth factor (NGF) on the expression of vascular-endothelial growth factor (VEGF) and NGF high-affinity receptor (tyrosine kinase A, TrKA) in the ascending and ..
  21. Wilder R, Griffiths M, Remmers E, Cannon G, Caspi R, Kawahito Y, et al. Localization in rats of genetic loci regulating susceptibility to experimental erosive arthritis and related autoimmune diseases. Transplant Proc. 1999;31:1585-8 pubmed
  22. Zhang Y, Wang Y, Zhang Q, Liu X, Liu X, Jiao L, et al. Interaction of Mint2 with TrkA is involved in regulation of nerve growth factor-induced neurite outgrowth. J Biol Chem. 2009;284:12469-79 pubmed publisher
    TrkA receptor signaling is essential for nerve growth factor (NGF)-induced survival and differentiation of sensory neurons...
  23. Kim I, Piao S, Lee J, Hong S, Hwang T, Kim S, et al. Effect of an adipose-derived stem cell and nerve growth factor-incorporated hydrogel on recovery of erectile function in a rat model of cavernous nerve injury. Tissue Eng Part A. 2013;19:14-23 pubmed publisher
    ..of human adipose-derived stem cell (hADSC) and nerve growth factor-incorporated hyaluronic acid-based hydrogel (NGF-hydrogel) application on the CN in a rat model of bilateral cavernous nerve crush injury...
  24. Badowska Szalewska E, Ludkiewicz B, Krawczyk R, Morys J. Age-Related (Aged vs. Adult) Comparison of the Effect of Two Mild Stressors on the Nerve Growth Factor (NGF) in the Rat Hypothalamic Supraoptic Nucleus (SON) - Immunohistochemical Study. Folia Biol (Praha). 2016;62:212-219 pubmed
    The ontogenetic period of life and stress can have different effects on the nerve growth factor (NGF) in the hypothalamus...
  25. Qiao L, Yu S, Kay J, Xia C. In vivo regulation of brain-derived neurotrophic factor in dorsal root ganglia is mediated by nerve growth factor-triggered Akt activation during cystitis. PLoS ONE. 2013;8:e81547 pubmed publisher
    ..BDNF up-regulation in the L6 DRG was triggered by endogenous nerve growth factor (NGF) because neutralization of NGF with a specific NGF antibody reduced BDNF levels during cystitis...
  26. Li Y, Yang C, Lei L, Wu K, Yang P, Xiao W. Serum nerve grow factor and brain-derived neurotrophic factor profiles in Sjögren's syndrome concomitant with interstitial lung disease. Clin Rheumatol. 2014;33:1161-4 pubmed publisher
    The aim of this study is to investigate the serum levels and clinical significance of nerve grow factor (NGF) and brain-derived neurotrophic factor (BDNF) in Sjogren's syndrome (SS) with interstitial lung disease (ILD)...
  27. Qu L, Liang X, Wu Q, Sun L, Zhao L, Chen X, et al. [Effects of Jinmaitong capsule on nerve growth factor in diabetic rats]. Zhongguo Zhong Yao Za Zhi. 2008;33:2539-44 pubmed
    To study the effects of Jinmaitong Capsule (JMT) on the expression of NGF and NGF mRNA in STZ-induced diabetic rats...
  28. Conner J, Franks K, Titterness A, Russell K, Merrill D, Christie B, et al. NGF is essential for hippocampal plasticity and learning. J Neurosci. 2009;29:10883-9 pubmed publisher
    Nerve growth factor (NGF) is produced in the hippocampus throughout life and is retrogradely trafficked to septal cholinergic neurons, providing a potential mechanism for modulating cholinergic inputs and, thereby, hippocampal plasticity...
  29. Sivilia S, Paradisi M, D Intino G, Fernandez M, Pirondi S, Lorenzini L, et al. Skin homeostasis during inflammation: a role for nerve growth factor. Histol Histopathol. 2008;23:1-10 pubmed publisher
    ..In this paper we examined NGF and p75 receptor expression in the skin, during CFA induced inflammation, in a time-course study...
  30. Kim M, Shutov L, Gnanasekaran A, Lin Z, Rysted J, ULRICH J, et al. Nerve growth factor (NGF) regulates activity of nuclear factor of activated T-cells (NFAT) in neurons via the phosphatidylinositol 3-kinase (PI3K)-Akt-glycogen synthase kinase 3β (GSK3β) pathway. J Biol Chem. 2014;289:31349-60 pubmed publisher
    ..Recent data suggest that NFAT and NFAT-dependent functions in neurons can also be potently regulated by NGF and other neurotrophins. However, the mechanisms of NFAT regulation by neurotrophins are not well understood...
  31. Cassano S, Agnese S, D Amato V, Papale M, Garbi C, Castagnola P, et al. Reactive oxygen species, Ki-Ras, and mitochondrial superoxide dismutase cooperate in nerve growth factor-induced differentiation of PC12 cells. J Biol Chem. 2010;285:24141-53 pubmed publisher
    Nerve growth factor (NGF) induces terminal differentiation in PC12, a pheochromocytoma-derived cell line. NGF binds a specific receptor on the membrane and triggers the ERK1/2 cascade, which stimulates the transcription of neural genes...
  32. Urrego F, Scuri M, Auais A, Mohtasham L, Piedimonte G. Combined effects of chronic nicotine and acute virus exposure on neurotrophin expression in rat lung. Pediatr Pulmonol. 2009;44:1075-84 pubmed publisher
    ..Expression of the neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor, of their high-affinity tyrosine kinase receptors (trkA and trkB, ..
  33. Saito M, Ohmasa F, Tsounapi P, Inoue S, Dimitriadis F, Kinoshita Y, et al. Nicorandil ameliorates hypertension-related bladder dysfunction in the rat. Neurourol Urodyn. 2012;31:695-701 pubmed publisher
    ..Tissue levels of nerve growth factor (NGF) were measured by ELISA method...
  34. Al Gayyar M, Matragoon S, Pillai B, Ali T, Abdelsaid M, El Remessy A. Epicatechin blocks pro-nerve growth factor (proNGF)-mediated retinal neurodegeneration via inhibition of p75 neurotrophin receptor expression in a rat model of diabetes [corrected]. Diabetologia. 2011;54:669-80 pubmed publisher
    Accumulation of pro-nerve growth factor (NGF), the pro form of NGF, has been detected in neurodegenerative diseases...
  35. XIAN H, Xian Y, Jiang C, Nie X, Wang X, Cheng H, et al. Decreased expression of ?-nerve growth factor correlated with histological changes in a cryptorchidism rat model. Chin Med J (Engl). 2012;125:713-6 pubmed
    Nerve growth factor (NGF) is well-known for its important role in the development and maintenance of the nervous system...
  36. Tam S, Lilla J, Chen C, Kalesnikoff J, Tsai M. RabGEF1/Rabex-5 Regulates TrkA-Mediated Neurite Outgrowth and NMDA-Induced Signaling Activation in NGF-Differentiated PC12 Cells. PLoS ONE. 2015;10:e0142935 pubmed publisher
    Nerve growth factor (NGF) binds to its cognate receptor TrkA and induces neuronal differentiation by activating distinct downstream signal transduction events...
  37. Bjorling D, Jacobsen H, Blum J, Shih A, Beckman M, Wang Z, et al. Intravesical Escherichia coli lipopolysaccharide stimulates an increase in bladder nerve growth factor. BJU Int. 2001;87:697-702 pubmed
    ..the effects of the intravesical instillation of Escherichia coli lipopolysaccharide (LPS) on nerve growth factor (NGF, which may mediate the pain associated with inflammation) protein and mRNA in the bladders of mice. E...
  38. Van Kanegan M, Strack S. The protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiation. Mol Cell Biol. 2009;29:662-74 pubmed publisher
    Nerve growth factor (NGF) is critical for the differentiation and maintenance of neurons in the peripheral and central nervous system...
  39. Sekino Y, Nakano J, Hamaue Y, Chuganji S, Sakamoto J, Yoshimura T, et al. Sensory hyperinnervation and increase in NGF, TRPV1 and P2X3 expression in the epidermis following cast immobilization in rats. Eur J Pain. 2014;18:639-48 pubmed publisher
    ..methods were used to assess sensory nerve fibre profiles and to examine the expression of the nerve growth factor (NGF), transient receptor potential vanilloid 1 (TRPV1) and P2X3 in the epidermis...
  40. Lu J, Xing J, Li J. Role for NGF in augmented sympathetic nerve response to activation of mechanically and metabolically sensitive muscle afferents in rats with femoral artery occlusion. J Appl Physiol (1985). 2012;113:1311-22 pubmed publisher
    ..Also, the prior findings demonstrate that nerve growth factor (NGF) is increased in sensory neurons-dorsal root ganglion (DRG) neurons of occluded rats...
  41. Hunter D, Carrell Jacks L, Batchelor T, Dey R. Role of nerve growth factor in ozone-induced neural responses in early postnatal airway development. Am J Respir Cell Mol Biol. 2011;45:359-65 pubmed publisher
    ..period of developmental, postnatal day (PD) 6, that may be mediated by the neurotrophin nerve growth factor (NGF), resulting in an enhanced release of inflammatory neuropeptide substance P (SP) from airway nerves...
  42. Staecker H, Van De Water T, Lefebvre P, Liu W, Moghadassi M, Galinovic Schwartz V, et al. NGF, BDNF and NT-3 play unique roles in the in vitro development and patterning of innervation of the mammalian inner ear. Brain Res Dev Brain Res. 1996;92:49-60 pubmed
    ..RT-PCR of E11 through E14 otocyst-CVG RNA extracts have shown that NGF as well as BDNF and NT-3 are expressed in the developing inner ear (in situ RT-PCR on tissue sections of E12 ..
  43. Lee S, Kwon I, Park J, Lee K, Ahn Y, Lee C, et al. Ribosomal protein S3, a new substrate of Akt, serves as a signal mediator between neuronal apoptosis and DNA repair. J Biol Chem. 2010;285:29457-68 pubmed publisher
    ..Here, we show that human RPS3 is a physiological target of Akt kinase and a novel mediator of neuronal apoptosis. NGF stimulation resulted in phosphorylation of threonine 70 of RPS3 by Akt, and this phosphorylation was required for ..
  44. Raap U, Deneka N, Bruder M, Kapp A, Wedi B. Differential up-regulation of neurotrophin receptors and functional activity of neurotrophins on peripheral blood eosinophils of patients with allergic rhinitis, atopic dermatitis and nonatopic subjects. Clin Exp Allergy. 2008;38:1493-8 pubmed publisher
    ..The aim of the study was to assess the functional role of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin (NT)-3 and -4 and the expression of pan-neurotrophin ..
  45. Xing J, Lu J, Li J. Nerve growth factor decreases in sympathetic and sensory nerves of rats with chronic heart failure. Neurochem Res. 2014;39:1564-70 pubmed publisher
    Nerve growth factor (NGF) plays a critical role in the maintenance and survival of both sympathetic and sensory nerves. Also, NGF can regulate receptor expression and neuronal activity in the sympathetic and sensory neurons...
  46. Peng R, Gao Y, Xiao X, Wang D, Chen H, Wu X, et al. [Study on the expressions of basic fibroblast growth factor and nervous growth factor genes in rat cerebral concussion]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2003;15:213-6 pubmed
    To study the expressions of basic fibroblast growth factor (bFGF) and nervous growth factor(NGF) genes in rat cerebral concussion...
  47. Bie B, Wang Y, Cai Y, Zhang Z, Hou Y, Pan Z. Upregulation of nerve growth factor in central amygdala increases sensitivity to opioid reward. Neuropsychopharmacology. 2012;37:2780-8 pubmed publisher
    ..place preference (CPP) with sub-threshold priming morphine, epigenetically upregulated the output activity of Ngf encoding the nerve growth factor (NGF) by increasing histone H4 acetylation in the rat central nucleus of the ..
  48. Zhang D, Marlin M, Liang Z, Ahmad M, Ashpole N, Sonntag W, et al. The Protein Tyrosine Phosphatase MEG2 Regulates the Transport and Signal Transduction of Tropomyosin Receptor Kinase A. J Biol Chem. 2016;291:23895-23905 pubmed
    ..As a result, overexpression of PTP-MEG2 down-regulates NGF/TrkA signaling and blocks neurite outgrowth and differentiation in PC12 cells and cortical neurons.
  49. Jing Y, Wang J, Li X, Wang Z, Pei L, Pan M, et al. Nerve growth factor of red nucleus involvement in pain induced by spared nerve injury of the rat sciatic nerve. Neurochem Res. 2009;34:1612-8 pubmed publisher
    Nerve growth factor (NGF), a member of the neurotrophin family, is essential for the development and maintenance of sensory neurons and for the formation of central pain circuitry...
  50. Pirchl M, Ullrich C, Humpel C. Differential effects of short- and long-term hyperhomocysteinaemia on cholinergic neurons, spatial memory and microbleedings in vivo in rats. Eur J Neurosci. 2010;32:1516-27 pubmed publisher
    ..Nerve growth factor (NGF) was significantly enhanced in the cortex only after 15 months of HHcy...
  51. Kasahara K, Nakagawa T, Kubota T. Neuronal loss and expression of neurotrophic factors in a model of rat chronic compressive spinal cord injury. Spine (Phila Pa 1976). 2006;31:2059-66 pubmed
    ..The expression of neurotrophic factors, including NGF, BDNF, NT-3, GDNF, CNTF, and VEGF, was analyzed using semiquantitative RT-PCR, enzyme immunoassay, and ..
  52. Tamura T, Kimoto N. Efficacy of repeated pretreatment with olopatadine hydrochloride on rhinitis induced by intranasal instillation of toluene-2,4-diisocyanate in rats. Pharmacology. 2009;84:288-93 pubmed publisher
    ..A single administration of olopatadine suppressed sneezing and the increases in histamine, nerve growth factor (NGF) and vascular endothelial growth factor (VEGF) production in nasal lavage fluid...
  53. Muzi S, Colafrancesco V, Sornelli F, Mantelli F, Lambiase A, Aloe L. Nerve growth factor in the developing and adult lacrimal glands of rat with and without inherited retinitis pigmentosa. Cornea. 2010;29:1163-8 pubmed publisher
    In the present study, we investigated lacrimal function and presence of the neurotrophin nerve growth factor (NGF) and its receptors in the lacrimal gland (LG) of normal rats and rats with inherited retinitis pigmentosa (IRP)...
  54. Huagn Y, Xu Y, Zhang J, Ren X, Suo A. [Effects of estrogen on P-Tau, ChAT and nerve growth factor protein expressions in the brain tissue of rats with Alzheimer's disease]. Nan Fang Yi Ke Da Xue Xue Bao. 2010;30:2408-10 pubmed
    To examine the effect of estrogen on the expressions of phosphorylated Tau (P-Tau), ChAT and nerve growth factor (NGF) protein in the brain tissue of rat models of Alzheimer disease (AD)...
  55. Alsina F, Irala D, Fontanet P, Hita F, Ledda F, Paratcha G. Sprouty4 is an endogenous negative modulator of TrkA signaling and neuronal differentiation induced by NGF. PLoS ONE. 2012;7:e32087 pubmed publisher
    ..Using real time PCR, we detect a significant increase in the expression of Spry4 mRNA in response to NGF, indicating that Spry4 could modulate intracellular signaling pathways and biological processes induced by NGF and ..
  56. Sasaki K, Chancellor M, Goins W, Phelan M, Glorioso J, de Groat W, et al. Gene therapy using replication-defective herpes simplex virus vectors expressing nerve growth factor in a rat model of diabetic cystopathy. Diabetes. 2004;53:2723-30 pubmed
    ..replication-defective herpes simplex virus type 1 (HSV-1) vectors to deliver and express the nerve growth factor (NGF) gene (HSV-NGF) on tissue NGF levels and bladder function, were evaluated in streptozotocin (STZ)-induced diabetic ..
  57. Lu X, Shu Y, Qiu C, Chen K, Wang Y. Protective effects and anti-apoptotic role of nerve growth factor on spinal cord neurons in sciatic nerve-injured rats. Neurol Res. 2014;36:814-23 pubmed publisher
    ..the communication with their targets, sciatic nerves, and investigate whether the effects of nerve growth factor (NGF) on the spinal cord neuron apoptosis and surviving through the regulation of nuclear factor-kappa B (NF-kappaB) in ..
  58. Santos F, Silva J, Giardini A, Rocha P, Achermann A, Alves A, et al. Neural mobilization reverses behavioral and cellular changes that characterize neuropathic pain in rats. Mol Pain. 2012;8:57 pubmed publisher
    ..DRG) and spinal cord were analyzed using immunohistochemistry and Western blot assays for neural growth factor (NGF) and glial fibrillary acidic protein (GFAP)...
  59. Pryor S, McCaffrey G, Young L, Grimes M. NGF causes TrkA to specifically attract microtubules to lipid rafts. PLoS ONE. 2012;7:e35163 pubmed publisher
    ..Although the nerve growth factor (NGF) receptors, TrkA and p75(NTR) collaborate with each other at the plasma membrane to bind NGF, these two receptors ..
  60. Ju H, Feng Y, Gao Z, Yang B. The potential role of nerve growth factor in cryoneurolysis-induced neuropathic pain in rats. Cryobiology. 2012;65:132-8 pubmed publisher
    ..The role of nerve growth factor (NGF) was also studied...
  61. Liu W, DeYoung B, Chen X, Evanoff D, Luo Y. RDP58 inhibits T cell-mediated bladder inflammation in an autoimmune cystitis model. J Autoimmun. 2008;30:257-65 pubmed
    ..RDP58-treated bladders showed markedly reduced histopathology and expressions of mRNAs and proteins of TNF-alpha, NGF and substance P...
  62. Ales K, Wraber B, Lipnik Stangelj M. The synergistic effect of histamine and IL-6 on NGF secretion from cultured astrocytes is evoked by histamine stimulation of IL-6 secretion via H1-receptor-PKC-MAPK signalling pathway. Inflamm Res. 2008;57 Suppl 1:S33-4 pubmed publisher
  63. Saygili E, Pekassa M, Saygili E, Rackauskas G, Hommes D, Noor Ebad F, et al. Mechanical stretch of sympathetic neurons induces VEGF expression via a NGF and CNTF signaling pathway. Biochem Biophys Res Commun. 2011;410:62-7 pubmed publisher
    ..Sympathetic neurons (SN) also possess the ability to express and secrete VEGF, which is mediated by the NGF/TrkA signaling pathway...
  64. Zhu Y, Mehta K, Li C, Xu G, Liu L, Colak T, et al. Systemic administration of anti-NGF increases A-type potassium currents and decreases pancreatic nociceptor excitability in a rat model of chronic pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2012;302:G176-81 pubmed publisher
    ..Because of its well known role in somatic hyperalgesia, we hypothesized a role for the nerve growth factor (NGF) in driving these changes. CP was induced by intraductal injection of trinitrobenzene sulfonic acid (TNBS) in rats...
  65. Semra Y, Sherif S, Lincoln J. NGF protects paravertebral but not prevertebral sympathetic neurons against exposure to high glucose in vitro. Brain Res. 2009;1285:164-73 pubmed publisher
    ..Changes in neurotrophic support by NGF occur during postnatal development and are implicated in diabetic neuropathy...
  66. Mesentier Louro L, De Nicoló S, Rosso P, De Vitis L, Castoldi V, Leocani L, et al. Time-Dependent Nerve Growth Factor Signaling Changes in the Rat Retina During Optic Nerve Crush-Induced Degeneration of Retinal Ganglion Cells. Int J Mol Sci. 2017;18: pubmed publisher
    Nerve growth factor (NGF) is suggested to be neuroprotective after nerve injury; however, retinal ganglion cells (RGC) degenerate following optic-nerve crush (ONC), even in the presence of increased levels of endogenous NGF...
  67. Badowska Szalewska E, Ludkiewicz B, Krawczyk R, MoryÅ› J. The impact of two mild stressors on the nerve growth factor (NGF) immunoreactivity in the amygdala in aged rats compared to adult ones. Int J Dev Neurosci. 2016;49:6-13 pubmed publisher
    Nerve growth factor (NGF) seems to play an important role in the ageing limbic system in response to stress...
  68. Navarro Tableros V, Fiordelisio T, Hernandez Cruz A, Hiriart M. Nerve growth factor promotes development of glucose-induced insulin secretion in rat neonate pancreatic beta cells by modulating calcium channels. Channels (Austin). 2007;1:408-16 pubmed
    ..Adult rat beta cells synthesize and secrete nerve growth factor (NGF) and express NGF receptors...
  69. Grills B, Schuijers J. Immunohistochemical localization of nerve growth factor in fractured and unfractured rat bone. Acta Orthop Scand. 1998;69:415-9 pubmed
    We detected nerve growth factor (NGF) by immunohistochemical localization in both fractured and unfractured rat rib...
  70. Wang J, Ding F, Gu Y, Liu J, Gu X. Bone marrow mesenchymal stem cells promote cell proliferation and neurotrophic function of Schwann cells in vitro and in vivo. Brain Res. 2009;1262:7-15 pubmed publisher
    ..Our results help to elucidate the mechanisms by which MSCs function as a cell therapy agent in peripheral nerve repair. ..
  71. Gulko P, Kawahito Y, Remmers E, Reese V, Wang J, Dracheva S, et al. Identification of a new non-major histocompatibility complex genetic locus on chromosome 2 that controls disease severity in collagen-induced arthritis in rats. Arthritis Rheum. 1998;41:2122-31 pubmed
    ..This rat model should facilitate positional cloning and functional characterization of regulatory genes that may play a role in several forms of autoimmune disease, including rheumatoid arthritis. ..
  72. Tannemaat M, Eggers R, Hendriks W, de Ruiter G, van Heerikhuize J, Pool C, et al. Differential effects of lentiviral vector-mediated overexpression of nerve growth factor and glial cell line-derived neurotrophic factor on regenerating sensory and motor axons in the transected peripheral nerve. Eur J Neurosci. 2008;28:1467-79 pubmed publisher
    ..the experiments described here, we examined the effect of LV vector-mediated overexpression of nerve growth factor (NGF) and glial cell line-derived neurotrophic factor (GDNF) on regeneration of the rat peripheral nerve in a ..
  73. Korzeniecka Kozerska A, Porowski T, Michaluk Skutnik J, Wasilewska A, Płoński G. Urinary nerve growth factor level in children with neurogenic bladder due to myelomeningocele. Scand J Urol. 2013;47:411-7 pubmed publisher
    ..Nerve growth factor (NGF) is an important mediator inducing bladder overactivity in many pathological conditions...
  74. Lin M, Yang L, Fu R, Zhao H. Cloning of the eukaryotic expression vector with nerve growth factor in rats and its effects on proliferation and differentiation of mesencephal neural stem cells of fetal rats. J Huazhong Univ Sci Technolog Med Sci. 2008;28:513-6 pubmed publisher
    The eukaryotic expression vector containing full-length cDNA sequence of rate nerve growth factor (NGF) beta subunit was constructed and its effects on proliferation and differentiation of neural stem cells were observed...
  75. De Simone R, Micera A, Tirassa P, Aloe L. mRNA for NGF and p75 in the central nervous system of rats affected by experimental allergic encephalomyelitis. Neuropathol Appl Neurobiol. 1996;22:54-9 pubmed
    In this study we measured the concentration of nerve growth factor (NGF) and the expression of NGF and the low affinity NGF-receptor (NGF-r) mRNA in the central nervous system (CNS) of rats affected by experimental allergic ..
  76. Mullenbrock S, Shah J, Cooper G. Global expression analysis identified a preferentially nerve growth factor-induced transcriptional program regulated by sustained mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) and AP-1 protein activation during PC12 cel. J Biol Chem. 2011;286:45131-45 pubmed publisher
    Neuronal differentiation of PC12 cells in response to NGF is a prototypical model in which signal duration determines a biological response...
  77. Griffiths M, Encinas J, Remmers E, Kuchroo V, Wilder R. Mapping autoimmunity genes. Curr Opin Immunol. 1999;11:689-700 pubmed
    ..Candidate genes are being identified. Polymorphic alleles associated with these chromosomal segments may represent predisposing genetic elements common to a number of human diseases with very different clinical presentations. ..
  78. Maures T, Chen L, Carter Su C. Nucleocytoplasmic shuttling of the adapter protein SH2B1beta (SH2-Bbeta) is required for nerve growth factor (NGF)-dependent neurite outgrowth and enhancement of expression of a subset of NGF-responsive genes. Mol Endocrinol. 2009;23:1077-91 pubmed publisher
    ..recruited to multiple ligand-activated receptor tyrosine kinases, including the receptors for nerve growth factor (NGF), insulin, and IGF-I as well as the cytokine receptor-associated Janus kinase family kinases...
  79. Chae C, Jung S, An S, Jung C, Nam S, Kim H. Treadmill exercise suppresses muscle cell apoptosis by increasing nerve growth factor levels and stimulating p-phosphatidylinositol 3-kinase activation in the soleus of diabetic rats. J Physiol Biochem. 2011;67:235-41 pubmed publisher
    ..the effects of treadmill exercise performed regularly for 6 weeks on the levels of nerve growth factor (NGF), tyrosine kinase A and p75 receptors, phosphatidylinositol 3-kinase (PI3-K), mitogen-activated protein kinase/..
  80. Acosta C, Cortes C, Altaweel K, MacPhee H, Hoogervorst B, Bhullar H, et al. Immune System Induction of Nerve Growth Factor in an Animal Model of Multiple Sclerosis: Implications in Re-Myelination and Myelin Repair. CNS Neurol Disord Drug Targets. 2015;14:1069-78 pubmed
    Nerve growth factor (NGF) expression is augmented during neuroinflammation...
  81. Antonucci M, Bonofiglio R, Papalia T, Caruso F, Caroleo M, Mancuso D, et al. Nerve growth factor and its monocyte receptors are affected in kidney disease. Nephron Clin Pract. 2009;111:c21-8 pubmed publisher
    Nerve growth factor (NGF) plays a critical role in both physiological and pathological conditions. Their biological effects are mediated by two receptors (NGF-R): TrkA and p75...
  82. Evans L, Loescher A, Boissonade F, Whawell S, Robinson P, Andrew D. Temporal mismatch between pain behaviour, skin Nerve Growth factor and intra-epidermal nerve fibre density in trigeminal neuropathic pain. BMC Neurosci. 2014;15:1 pubmed publisher
    The neurotrophin Nerve Growth factor (NGF) is known to influence the phenotype of mature nociceptors, for example by altering synthesis of neuropeptides, and changes in NGF levels have been implicated in the pathophysiology of chronic ..
  83. Yan Q, Yin Y, Li B. Use new PLGL-RGD-NGF nerve conduits for promoting peripheral nerve regeneration. Biomed Eng Online. 2012;11:36 pubmed publisher
    ..acid)-alt-(L-lysine)]} (PLGL) was modified by grafting Gly-Arg-Gly-Asp-Gly (RGD peptide) and nerve growth factor (NGF) for fabricating new PLGL-RGD-NGF nerve conduits to promote nerve regeneration and functional recovery...
  84. Marler K, Becker Barroso E, MARTINEZ A, Llovera M, Wentzel C, Poopalasundaram S, et al. A TrkB/EphrinA interaction controls retinal axon branching and synaptogenesis. J Neurosci. 2008;28:12700-12 pubmed publisher
    ..In addition, our data suggest that growth factors and the EphA-ephrinA system interact in a way that affects axon branching and synapse development. ..