Gene Symbol: Nfyb
Description: nuclear transcription factor Y subunit beta
Alias: CBF-B, CBFB, Nfya, nuclear transcription factor Y subunit beta, CAAT box DNA-binding protein subunit B, CBF-A, CCAAT binding transcription factor of CBF-B/NFY-B, CCAAT-binding transcription factor subunit A, CCAAT-binding transcription factor subunit B, NF-YB, nuclear transcription factor - Y beta, nuclear transcription factor Y subunit B, nuclear transcription factor-Y beta
Species: rat
Products:     Nfyb

Top Publications

  1. Chattopadhyay C, Hawke D, Kobayashi R, Maity S. Human p32, interacts with B subunit of the CCAAT-binding factor, CBF/NF-Y, and inhibits CBF-mediated transcription activation in vitro. Nucleic Acids Res. 2004;32:3632-41 pubmed
    ..Altogether, our study identified p32 as a novel and specific corepressor of CBF-mediated transcription activation in vitro. ..
  2. Kabe Y, Yamada J, Uga H, Yamaguchi Y, Wada T, Handa H. NF-Y is essential for the recruitment of RNA polymerase II and inducible transcription of several CCAAT box-containing genes. Mol Cell Biol. 2005;25:512-22 pubmed
  3. Hooft van Huijsduijnen R, Li X, Black D, Matthes H, Benoist C, Mathis D. Co-evolution from yeast to mouse: cDNA cloning of the two NF-Y (CP-1/CBF) subunits. EMBO J. 1990;9:3119-27 pubmed
    ..We hypothesize that in the case of NF-Y, DNA binding and dimerization both rely on residues within the homology domains, which include rather suggestive 'half-finger' motifs. ..
  4. Sunyakumthorn P, Boonsaen T, Boonsaeng V, Wallace J, Jitrapakdee S. Involvement of specific proteins (Sp1/Sp3) and nuclear factor Y in basal transcription of the distal promoter of the rat pyruvate carboxylase gene in beta-cells. Biochem Biophys Res Commun. 2005;329:188-96 pubmed
  5. Niimi T, Hayashi Y, Futaki S, Sekiguchi K. SOX7 and SOX17 regulate the parietal endoderm-specific enhancer activity of mouse laminin alpha1 gene. J Biol Chem. 2004;279:38055-61 pubmed
  6. Freed Pastor W, Prives C. Mutant p53: one name, many proteins. Genes Dev. 2012;26:1268-86 pubmed publisher
    ..Here we review mechanisms by which mutant p53 exerts its cellular effects, with a particular focus on the burgeoning mutant p53 transcriptome, and discuss the biological and clinical consequences of mutant p53 gain of function. ..
  7. Sinha S, Maity S, Lu J, de Crombrugghe B. Recombinant rat CBF-C, the third subunit of CBF/NFY, allows formation of a protein-DNA complex with CBF-A and CBF-B and with yeast HAP2 and HAP3. Proc Natl Acad Sci U S A. 1995;92:1624-8 pubmed
    ..Our results indicate that CBF is a unique evolutionarily conserved DNA binding protein. ..
  8. Huang C, Wu S, Choo K. Transcriptional modulation of the pre-implantation embryo-specific Rnf35 gene by the Y-box protein NF-Y/CBF. Biochem J. 2005;387:367-75 pubmed
    ..We suggest that the NF-Y, targeting at a Y-box sequence, may function as an important activator in transcriptional regulation of the Rnf35 gene in the pre-implantation embryo. ..
  9. vanWert J, Wolfe S, Grimes S. Binding of RFX2 and NF-Y to the testis-specific histone H1t promoter may be required for transcriptional activation in primary spermatocytes. J Cell Biochem. 2008;104:1087-101 pubmed publisher
    ..Furthermore, we show that both the X-box and CCAAT-box are required for promoter activity and that co-expression of RFX2 greatly enhances testis histone H1t promoter activity in the GC-1spg germinal cell line. ..

Scientific Experts

More Information


  1. Vuorio T, Maity S, de Crombrugghe B. Purification and molecular cloning of the "A" chain of a rat heteromeric CCAAT-binding protein. Sequence identity with the yeast HAP3 transcription factor. J Biol Chem. 1990;265:22480-6 pubmed
    ..The deduced amino acid sequence of the A chain showed a remarkable identity over a length of 90-amino acid residues with a sequence of the Hap3 polypeptide, a component of a heteromeric multisubunit yeast transcription factor. ..
  2. Kahle J, Baake M, Doenecke D, Albig W. Subunits of the heterotrimeric transcription factor NF-Y are imported into the nucleus by distinct pathways involving importin beta and importin 13. Mol Cell Biol. 2005;25:5339-54 pubmed
    ..Importin 13 competes with NF-YA for binding to the NF-YB/NF-YC dimer. Our data suggest that a distinct binding platform derived from the HFM of both subunits, NF-YB/NF-YC, mediates those interactions. ..
  3. Stros M, Polansk√° E, Struncov√° S, Pospisilova S. HMGB1 and HMGB2 proteins up-regulate cellular expression of human topoisomerase IIalpha. Nucleic Acids Res. 2009;37:2070-86 pubmed publisher
  4. Haze K, Okada T, Yoshida H, Yanagi H, Yura T, Negishi M, et al. Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response. Biochem J. 2001;355:19-28 pubmed
    ..We thus concluded that the two related bZIP proteins are crucial transcriptional regulators of the mammalian UPR, and propose calling the ATF6 gene product ATF6alpha and the G13 gene product ATF6beta. ..
  5. Muller P, Vousden K. p53 mutations in cancer. Nat Cell Biol. 2013;15:2-8 pubmed publisher
    ..Here we highlight some of the emerging molecular mechanisms through which mutant p53 proteins can exert these oncogenic functions. ..
  6. Chang M, Jin W, Sun S. Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production. Nat Immunol. 2009;10:1089-95 pubmed publisher
    ..Our findings suggest that Peli1 is a ubiquitin ligase needed for the transmission of TRIF-dependent TLR signals. ..