Nfkb1

Summary

Gene Symbol: Nfkb1
Description: nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Alias: EBP-1, NF-kB, DNA-binding factor KBF1, nuclear factor NF-kappa-B p105 subunit, nuclear factor of kappa light chain gene enhancer in B-cells 1, p105, nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105
Species: rat

Top Publications

  1. ncbi Dehydroepiandrosterone modulates nuclear factor-kappaB activation in hippocampus of diabetic rats
    Manuela Aragno
    Department of Experimental Medicine and Oncology, General Pathology Section, University of Turin, Turin 10126, Italy
    Endocrinology 143:3250-8. 2002
  2. ncbi Clinorotation prevents differentiation of rat myoblastic L6 cells in association with reduced NF-kappa B signaling
    Katsuya Hirasaka
    Department of Nutrition, The University of Tokushima School of Medicine, Tokushima, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    Biochim Biophys Acta 1743:130-40. 2005
  3. ncbi Dramatic co-activation of WWOX/WOX1 with CREB and NF-kappaB in delayed loss of small dorsal root ganglion neurons upon sciatic nerve transection in rats
    Meng Yen Li
    Department of Cell Biology and Anatomy, National Cheng Kung University Medical College, Tainan, Taiwan
    PLoS ONE 4:e7820. 2009
  4. ncbi Distinct patterns of intracerebral hemorrhage-induced alterations in NF-kappaB subunit, iNOS, and COX-2 expression
    Xiurong Zhao
    Department of Neurology, Stroke Program, University of Texas Houston Medical School, Houston, Texas 77030, USA
    J Neurochem 101:652-63. 2007
  5. ncbi Regulation of multidrug resistance protein 1 by tumor necrosis factor alpha in cultured glial cells: involvement of nuclear factor-kappaB and c-Jun N-terminal kinase signaling pathways
    Patrick T Ronaldson
    Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, ON, Canada
    Mol Pharmacol 77:644-59. 2010
  6. ncbi Neuroinflammation activates Mdr1b efflux transport through NFkappaB: promoter analysis in BBB endothelia
    Chuanhui Yu
    Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Cell Physiol Biochem 22:745-56. 2008
  7. ncbi Strong neuroprotection by inhibition of NF-kappaB after neonatal hypoxia-ischemia involves apoptotic mechanisms but is independent of cytokines
    Cora H A Nijboer
    University Medical Center Utrecht, Laboratory of Psychoneuroimmunology, Lundlaan 6, KC 03 068 0, 3584 EA Utrecht, The Netherlands
    Stroke 39:2129-37. 2008
  8. ncbi Cross-talk between cytokines and renin-angiotensin in hypothalamic paraventricular nucleus in heart failure: role of nuclear factor-kappaB
    Yu Ming Kang
    Shanxi Medical University, Taiyuan 030001, People s Republic of China
    Cardiovasc Res 79:671-8. 2008
  9. ncbi Serum levels of NFkappaB and pro-inflammatory cytokines following administration of mucotoxic drugs
    Richard M Logan
    Oral Pathology, School of Dentistry, Faculty of Health Sciences, The University of Adelaide, South Australia, Australia
    Cancer Biol Ther 7:1139-45. 2008
  10. ncbi NF-kappaB inhibits sodium transport via down-regulation of SGK1 in renal collecting duct principal cells
    Sophie de Seigneux
    Service de Nephrologie, Fondation pour Recherches Medicales, 64 Avenue de la Roseraie, 1211 Geneva 4, Switzerland
    J Biol Chem 283:25671-81. 2008

Research Grants

  1. LIVER-LUNG INTERACTIONS DURING GRAM-NEGATIVE ENDOTOXEMIA
    George Matuschak; Fiscal Year: 1993
  2. LIVER/LUNG INTERACTIONS DURING GRAM NEGATIVE ENDOTOXEMIA
    George Matuschak; Fiscal Year: 2003
  3. Gender Differences in Experimental Aortic Aneurysms
    Gilbert Upchurch; Fiscal Year: 2007
  4. Gender Differences in Experimental Aortic Aneurysms
    Gilbert Upchurch; Fiscal Year: 2009
  5. MMP-9-Dependent Vessel Wall Remodeling is NO-Dependent
    Gilbert Upchurch; Fiscal Year: 2005
  6. Chronic Alcohol Consumption Induces Tumor Angiogenesis
    Jian Wei Gu; Fiscal Year: 2006
  7. Role of CCK Receptor in Acute Pancreatitis Pathogenesis
    Isaac Samuel; Fiscal Year: 2007
  8. Gender Differences in Experimental Aortic Aneurysms
    GILBERT RIVERS UPCHURCH; Fiscal Year: 2010
  9. Gallstone Pancreatitis: Pathogenesis and Treatment
    Isaac Samuel; Fiscal Year: 2010
  10. LIVER LUNG INTERACTIONS DURING GRAM NEGATIVE ENDOTOXEMIA
    George Matuschak; Fiscal Year: 1999

Scientific Experts

Detail Information

Publications96

  1. ncbi Dehydroepiandrosterone modulates nuclear factor-kappaB activation in hippocampus of diabetic rats
    Manuela Aragno
    Department of Experimental Medicine and Oncology, General Pathology Section, University of Turin, Turin 10126, Italy
    Endocrinology 143:3250-8. 2002
    ..Results indicate that DHEA might protect hippocampus from chronic activation of NF-kappaB-dependent genes by reducing NF-kappaB nuclear translocation. This could result in protection from diabetes-dependent brain damage...
  2. ncbi Clinorotation prevents differentiation of rat myoblastic L6 cells in association with reduced NF-kappa B signaling
    Katsuya Hirasaka
    Department of Nutrition, The University of Tokushima School of Medicine, Tokushima, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    Biochim Biophys Acta 1743:130-40. 2005
    ..Our present results suggest that simulated microgravity such as the 3D-clinorotation may disturb skeletal muscle cell differentiation, at least in part, by inhibiting the NF-kappa B pathway...
  3. ncbi Dramatic co-activation of WWOX/WOX1 with CREB and NF-kappaB in delayed loss of small dorsal root ganglion neurons upon sciatic nerve transection in rats
    Meng Yen Li
    Department of Cell Biology and Anatomy, National Cheng Kung University Medical College, Tainan, Taiwan
    PLoS ONE 4:e7820. 2009
    ..Here, we investigated the functional role of WOX1 and transcription factors in the delayed loss of axotomized neurons in dorsal root ganglia (DRG) in rats...
  4. ncbi Distinct patterns of intracerebral hemorrhage-induced alterations in NF-kappaB subunit, iNOS, and COX-2 expression
    Xiurong Zhao
    Department of Neurology, Stroke Program, University of Texas Houston Medical School, Houston, Texas 77030, USA
    J Neurochem 101:652-63. 2007
    ..In summary, NF-kappaB activation occurs within minutes and persists for at least a week in response to ICH. This reaction utilizes different NF-kappaB regulatory subunits and is associated with the expression of selected target genes...
  5. ncbi Regulation of multidrug resistance protein 1 by tumor necrosis factor alpha in cultured glial cells: involvement of nuclear factor-kappaB and c-Jun N-terminal kinase signaling pathways
    Patrick T Ronaldson
    Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, ON, Canada
    Mol Pharmacol 77:644-59. 2010
    ..Furthermore, our results imply that both NF-kappaB and JNK signaling are involved in Mrp1 regulation during an HIV-1 associated inflammatory response...
  6. ncbi Neuroinflammation activates Mdr1b efflux transport through NFkappaB: promoter analysis in BBB endothelia
    Chuanhui Yu
    Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Cell Physiol Biochem 22:745-56. 2008
    ..This study further determines the mechanisms by which TNF activates mdr1b promoter activity...
  7. ncbi Strong neuroprotection by inhibition of NF-kappaB after neonatal hypoxia-ischemia involves apoptotic mechanisms but is independent of cytokines
    Cora H A Nijboer
    University Medical Center Utrecht, Laboratory of Psychoneuroimmunology, Lundlaan 6, KC 03 068 0, 3584 EA Utrecht, The Netherlands
    Stroke 39:2129-37. 2008
    ....
  8. ncbi Cross-talk between cytokines and renin-angiotensin in hypothalamic paraventricular nucleus in heart failure: role of nuclear factor-kappaB
    Yu Ming Kang
    Shanxi Medical University, Taiyuan 030001, People s Republic of China
    Cardiovasc Res 79:671-8. 2008
    ....
  9. ncbi Serum levels of NFkappaB and pro-inflammatory cytokines following administration of mucotoxic drugs
    Richard M Logan
    Oral Pathology, School of Dentistry, Faculty of Health Sciences, The University of Adelaide, South Australia, Australia
    Cancer Biol Ther 7:1139-45. 2008
    ..The aims of this study were to determine whether changes in serum levels of NFkappaB, TNF, IL-1beta and IL-6 following administration of different drugs predicted histological evidence of tissue damage...
  10. ncbi NF-kappaB inhibits sodium transport via down-regulation of SGK1 in renal collecting duct principal cells
    Sophie de Seigneux
    Service de Nephrologie, Fondation pour Recherches Medicales, 64 Avenue de la Roseraie, 1211 Geneva 4, Switzerland
    J Biol Chem 283:25671-81. 2008
    ..In conclusion, we show that activation of the NF-kappaB pathway down-regulates SGK1 expression, which might lead to decreased ENaC alpha-subunit expression, ultimately resulting in decreased Na(+) transport...
  11. ncbi Pregabalin and gabapentin inhibit substance P-induced NF-kappaB activation in neuroblastoma and glioma cells
    Seyeon Park
    Dongduk Women s University, Department of Applied Chemistry, Seoul, Korea
    J Cell Biochem 105:414-23. 2008
    ..These results suggest a previously undefined role of pregabalin and gabapentin in the regulation of inflammation-related intracellular signaling in both neuronal and glial cells...
  12. ncbi Age-related differences in NFkappaB translocation and Bcl-2/Bax ratio caused by TNFalpha and Abeta42 promote survival in middle-age neurons and death in old neurons
    Jigisha R Patel
    Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University, School of Medicine, Springfield, IL, USA
    Exp Neurol 213:93-100. 2008
    ..In the setting of old neurons, these results suggest that overactivated nuclear translocation of NFkappaB and lower Bcl-2 levels promote death that is reduced by inhibition of either TNFR1 or R2...
  13. ncbi Diabetes-induced atrophy is associated with a muscle-specific alteration in NF-kappaB activation and expression
    Bruce C Frier
    School of Kinesiology, Faculty of Health Sciences, Research Institute, University of Western Ontario, London, Ontario, Canada
    Cell Stress Chaperones 13:287-96. 2008
    ..These results indicate that diabetes may alter NF-kappaB activity and expression in a muscle-specific manner...
  14. ncbi Relationship between carbachol hyperstimulation-induced pancreatic intracellular trypsinogen and NF-kappa B activation in rats in vitro
    Chunfang Jiang
    Department of Emergency Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    J Huazhong Univ Sci Technolog Med Sci 28:69-72. 2008
    ..NF-kappa B activation is likely not necessary for high concentrations of carbachol-induced trypsinogen activation in pancreatic acinar cells in vitro...
  15. ncbi Progesterone prevents traumatic brain injury-induced intestinal nuclear factor kappa B activation and proinflammatory cytokines expression in male rats
    Gang Chen
    Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province 210002, China
    Mediators Inflamm 2007:93431. 2007
    ..The results of the present study suggest that the therapeutic benefit of post-TBI progesterone injections might be due to its inhibitory effects on intestinal NF-kappaB activation and proinflammatory cytokines expression...
  16. ncbi Transcriptional regulation of intronic calcium-activated potassium channel SK2 promoters by nuclear factor-kappa B and glucocorticoids
    Min Jeong Kye
    Department of Molecular Neuroendocrinology, Max Planck Institute for Experimental Medicine, Goettingen, Germany
    Mol Cell Biochem 300:9-17. 2007
    ..These findings suggest a possible transcriptional cross talk between GRs and NF-kappaB in the intronic promoter regulation of SK2-S channel gene transcription...
  17. ncbi Differential expression of genes involved with apoptosis, cell cycle, connective tissue proteins, fuel substrate utilization, inflammation and mitochondrial biogenesis in copper-deficient rat hearts: implication of a role for Nfkappab1
    Darcey Klaahsen
    Department of Human Nutrition, Kansas State University, Manhattan, KS 66506, USA
    J Nutr Biochem 18:719-26. 2007
    ..The results of this study merit the further investigation of the role of reactive oxidative species with regard to Nfkappab1 in the copper deficient rat heart...
  18. ncbi Inhibition of GSK-3beta decreases NF-kappaB-dependent gene expression and impairs the rat liver regeneration
    Huan Chen
    Clinical Research Center, Changhai Hospital, Shanghai 200433, China
    J Cell Biochem 102:1281-9. 2007
    ..GSK-3beta plays an important role in rat liver regeneration. We conclude it may partially result from the inhibition of the NF-kappaB pathway and enhancement of p21 (WAF1/Cip1) expression...
  19. ncbi Arginine vasopressin increases iNOS-NO system activity in cardiac fibroblasts through NF-kappaB activation and its relation with myocardial fibrosis
    Yan Hong Fan
    Department of Cardiology, Xijing Hospital, The Fourth Military Medical University, 17 Changlexi Street, Xi an 710032, PR China
    Life Sci 81:327-35. 2007
    ..NO production induced by AVP may counteract the profibrotic effects of AVP, thus the development of MF perhaps depends on the balance between profibrotic AVP and antifibrotic NO effects on MF...
  20. ncbi HB-EGF induces delayed STAT3 activation via NF-kappaB mediated IL-6 secretion in vascular smooth muscle cell
    Kuy Sook Lee
    Center for Biomedical Sciences, Division of Cardiovascular Diseases, National Institute of Health, Seoul, Korea
    Biochim Biophys Acta 1773:1637-44. 2007
    ..In conclusion, IL-6 plays an important role in the delayed activation of STAT3 and VSMC proliferation induced by HB-EGF...
  21. ncbi The classical and a non-classical pathways associated with NF-kappaB are involved in estrogen-mediated regulation of calbindin-D9k gene in rat pituitary cells
    Geun Shik Lee
    Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 361 763, Republic of Korea
    Mol Cell Endocrinol 277:42-50. 2007
    ..Taken together, these results suggest that in GH3 cells, both the classical ERalpha-ERE pathway and a non-classical pathway involving NF-kappaB are involved in E2-mediatd regulation of CaBP-9k expression in the pituitary gland...
  22. ncbi Biomechanical signals inhibit IKK activity to attenuate NF-kappaB transcription activity in inflamed chondrocytes
    Anar Dossumbekova
    The Ohio State University, Columbus, OH 43210, USA
    Arthritis Rheum 56:3284-96. 2007
    ..This study was undertaken to examine the intracellular mechanisms by which biomechanical signals suppress proinflammatory gene induction by the interleukin-1-beta (IL-1beta)-induced NF-kappaB signaling cascade in articular chondrocytes...
  23. ncbi Flavonoids protect against cytokine-induced pancreatic beta-cell damage through suppression of nuclear factor kappaB activation
    Eun Kyung Kim
    Department of Biochemistry, Chonbuk National University Medical School, Jeonju, South Korea
    Pancreas 35:e1-9. 2007
    ..Our current study focuses on the preventive effects of quercetin, apigenin, and luteolin on cytokine-induced beta-cell damage...
  24. ncbi Hemolysate-induced expression of intercellular adhesion molecule-1 and monocyte chemoattractant protein-1 expression in cultured brain microvascular endothelial cells via through ROS-dependent NF-kappaB pathways
    Hua Lu
    Department of Neurosurgery, Jinling Hospital, Clinical School of Nanjing University, Nanjing, China
    Cell Mol Neurobiol 29:87-95. 2009
    ..Taken together, our results indicate that hemolysate can induce inflammatory responses that increase expression of ICAM-1 and MCP-1, through ROS-dependent NF-kappaB activation in BMECs...
  25. ncbi Insulin suppresses LPS-induced iNOS and COX-2 expression and NF-kappaB activation in alveolar macrophages
    Joilson O Martins
    Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, SP, Brazil
    Cell Physiol Biochem 22:279-86. 2008
    ....
  26. ncbi ReLA/P65-serine 536 nuclear factor-kappa B phosphorylation is related to vulnerability to status epilepticus in the rat hippocampus
    H J Ryu
    Department of Anatomy and Neurobiology, College of Medicine, Hallym University, Chunchon, Kangwon Do 200 702, South Korea
    Neuroscience 187:93-102. 2011
    ....
  27. ncbi NF-κB activation in organs from STZ-treated rats
    Marius Locke
    Faculty of Physical Education and Health, University of Toronto, 55 Harbord Street, Toronto, ON M5S 2W6, Canada
    Appl Physiol Nutr Metab 36:121-7. 2011
    ..These findings support the idea that a diabetic state may induce specific changes in NF-κB subunit composition in certain tissues...
  28. ncbi [Regulation of inflammatory pain by NF-κB and CX3CR1 at the spinal cord of rats]
    Bei Peng
    Department of Anesthesiology, Xiangya Hospital, Central South University, Changsha 410008, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 35:1167-73. 2010
    ....
  29. ncbi Fenofibrate attenuates tubulointerstitial fibrosis and inflammation through suppression of nuclear factor-κB and transforming growth factor-β1/Smad3 in diabetic nephropathy
    Lingyun Li
    Department of Physiology, Atlanta, GA 30310, USA
    Exp Biol Med (Maywood) 235:383-91. 2010
    ..Taken together, fenofibrate suppressed NF-kappaB and TGF-beta1/Smad3 signaling pathways and reduced renal inflammation and tubulointerstitial fibrosis in diabetic ZD animals...
  30. ncbi [Delayed neuroprotective effect of sevoflurane on the expression of NF-kappaB following transient focal ischemia-reperfusion in rats]
    Zhi Ye
    Department of Anesthesia, Xiangya Hospital, Central South University, Changsha 410008, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 35:262-6. 2010
    ..To explore the delayed neuroprotective effect of sevoflurane on the expression of NF-kappaB in rat models of transient focal ischemia-reperfusion...
  31. ncbi Transcriptional upregulation of nitric oxide synthase II by nuclear factor-kappaB promotes apoptotic neuronal cell death in the hippocampus following experimental status epilepticus
    Yao Chung Chuang
    Department of Neurology, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung County, Taiwan, Republic of China
    J Neurosci Res 88:1898-907. 2010
    ..We conclude that activation of NF-kappaB in hippocampal CA3 neurons upregulates NOS II gene expression following experimental temporal lobe status epilepticus, leading to apoptotic neuronal cell death in the hippocampus...
  32. ncbi Inflammation induces lymphangiogenesis through up-regulation of VEGFR-3 mediated by NF-kappaB and Prox1
    Michael J Flister
    Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL 62794 9626, USA
    Blood 115:418-29. 2010
    ..This, in turn, enhances the responsiveness of preexisting lymphatic endothelium to VEGFR-3 binding factors, VEGF-C and VEGF-D, ultimately resulting in robust lymphangiogenesis...
  33. ncbi IL-18 overexpression promotes vascular inflammation and remodeling in a rat model of metabolic syndrome
    Hong Wei Tan
    Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Jinan, 250012, China
    Atherosclerosis 208:350-7. 2010
    ..Targeting expression of IL-18 or its specific downstream mediators may retard the progression of MetS and its complications...
  34. ncbi Cyclic AMP inhibits IL-1beta plus IFNgamma-induced NF-kappaB translocation in hepatocytes by a PKA independent mechanism
    Guiying Hong
    Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    J Surg Res 159:565-71. 2010
    ..We demonstrated that cAMP inhibits IL-1beta plus IFNgamma-induced NF-kappaB binding due to its blockade of the upstream signal(s) leading to IkappaB phosphorylation and degradation, and is mediated by PKA-independent signaling pathways...
  35. ncbi MyD88-dependent nuclear factor-kappaB activation is involved in fibrinogen-induced hypertrophic response of cardiomyocytes
    Ting Li
    Department of Pathophysiology, Nanjing Medical University, Jiangsu Province, 210029, China
    J Hypertens 27:1084-93. 2009
    ..The present study aimed to investigate whether fibrinogen will stimulate the hypertrophic response of cardiac myocytes and to examine the role of the TLR4/MyD88/NF-kappaB pathway in fibrinogen-induced cardiac hypertrophy...
  36. ncbi Candida albicans induces cyclo-oxygenase 2 expression and prostaglandin E2 production in synovial fibroblasts through an extracellular-regulated kinase 1/2 dependent pathway
    Herng Sheng Lee
    Department of Pathology, Tri Service General Hospital and National Defense Medical Center, Neihu District, Taipei City, Taiwan
    Arthritis Res Ther 11:R48. 2009
    ..Synovial cells are potential sources of inflammatory mediators in bacterial-induced arthritis but their involvement in the inflammatory response to Candida albicans-induced septic arthritis is largely unknown...
  37. ncbi Ferritin functions as a proinflammatory cytokine via iron-independent protein kinase C zeta/nuclear factor kappaB-regulated signaling in rat hepatic stellate cells
    Richard G Ruddell
    The Hepatic Fibrosis Group, Queensland Institute of Medical Research and the University of Queensland, P Royal Brisbane and Women s Hospital, Brisbane, Australia
    Hepatology 49:887-900. 2009
    ....
  38. ncbi Soy phosphatidylcholine inhibited TLR4-mediated MCP-1 expression in vascular cells
    Atsushi Ishikado
    Department of Medicine, Shiga University of Medical Science, Japan
    Atherosclerosis 205:404-12. 2009
    ..Moreover, we propose that SPC can be useful as a selective inhibitor to suppress the TLR4-mediated inflammatory signaling...
  39. ncbi Extent of liver resection modulates the activation of transcription factors and the production of cytokines involved in liver regeneration
    Jan Peter Sowa
    Department of Gastroenterology and Hepatology, University Hospital of Essen, Hufelandstr 55, 45122 Essen, Germany
    World J Gastroenterol 14:7093-100. 2008
    ..To investigate the molecular events involved in liver regeneration following subtotal hepatectomy (SH) as previous studies have largely focused on partial hepatectomy (PH)...
  40. ncbi Sulforaphane protects against cytokine- and streptozotocin-induced beta-cell damage by suppressing the NF-kappaB pathway
    Mi Young Song
    Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk, 561 756, Republic of Korea
    Toxicol Appl Pharmacol 235:57-67. 2009
    ..Furthermore, pretreatment with SFN blocked the development of type 1 diabetes in streptozotocin-treated mice...
  41. ncbi [Dynamic expression and quantitative analysis of hepatic nuclear factor-kappa B and its gene during the development of hepatocellular carcinoma]
    Zhi Zhen Dong
    Affiliated Hospital of Nantong University, Nantong 226001, China
    Zhonghua Gan Zang Bing Za Zhi 16:669-73. 2008
    ..To investigate the kinetic expression and alteration of nuclear transcription factor-kappa B (NF-kappaB) and its gene in hepatocellular carcinoma (HCC) development...
  42. ncbi The inflammatory response to double stranded DNA in endothelial cells is mediated by NFκB and TNFα
    Suraj J Patel
    Center for Engineering in Medicine and the Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 6:e19910. 2011
    ....
  43. ncbi Hypoosmolarity influences the activity of transcription factor NF-kappaB in rat H4IIE hepatoma cells
    M Michalke
    Department of Gastroenterology, Hepatology and Infectiology, Heinrich Heine University, Moorenstr 5, D 40225, D usseldorf, Germany
    FEBS Lett 465:64-8. 2000
    ..Transforming growth factor beta-induced apoptosis was diminished by hypoosmolarity. However, this anti-apoptotic effect was probably not related to NF-kappaB activation...
  44. ncbi Inflammatory cytokines induce production of CHI3L1 by articular chondrocytes
    Anneliese D Recklies
    Joint Diseases Laboratory, Shriners Hospital for Children, McGill University, Montreal, Quebec, Canada
    J Biol Chem 280:41213-21. 2005
    ....
  45. ncbi In vivo heat shock protein assembles with septic liver NF-kappaB/I-kappaB complex regulating NF-kappaB activity
    Hsiang Wen Chen
    Department of Microbiology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung City, Taiwan
    Shock 24:232-8. 2005
    ..HSP72 appears to play a crucial protective role in modulating the gene expression controlled by NF-kappaB in sepsis...
  46. ncbi The effect of hindlimb immobilization on acid phosphatase, metalloproteinases and nuclear factor-kappaB in muscles of young and old rats
    Marina Bar-Shai
    Department of Anatomy and Cell Biology, Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, P O Box 9649, Haifa 31096, Israel
    Mech Ageing Dev 126:289-97. 2005
    ..In conclusion, it seems that the kinetics of activation of extracellular hydrolytic and proteolytic systems differ in muscles of old animals compared to young animals...
  47. ncbi Role of NF-kappaB and DNA repair protein Ku on apoptosis in pancreatic acinar cells
    Ji Yeon Song
    Department of Pharmacology and Institute of Gastroenterology, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 120 752, Korea
    Ann N Y Acad Sci 1010:259-63. 2003
    ..The novel finding is that nuclear translocation of Ku proteins may be mediated by NF-kappaB...
  48. ncbi Alpha-melanocyte stimulating hormone protects against H2O2-induced inhibition of wound restitution in IEC-6 cells via a Syk kinase- and NF-kappabeta-dependent mechanism
    Lei Zou
    Department of Internal Medicine, Trauma Research Center, University of Texas Medical School at Houston, Houston, Texas, USA
    Shock 22:453-9. 2004
    ..The data also disclose that the beneficial effects of alpha-MSH on gut ischemia/reperfusion injury may relate to its acceleration of epithelial restitution...
  49. ncbi Prolongation of liver allograft survival by dendritic cells modified with NF-kappaB decoy oligodeoxynucleotides
    Ming Qing Xu
    Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
    World J Gastroenterol 10:2361-8. 2004
    ..To induce the tolerance of rat liver allograft by dendritic cells (DCs) modified with NF-kappaB decoy oligodeoxynucleotides (ODNs)...
  50. ncbi Hypoxic suppression of E. coli-induced NF-kappa B and AP-1 transactivation by oxyradical signaling
    George M Matuschak
    Division of Pulmonary, Critical Care, and Occupational Medicine, Department of Internal Medicine, St Louis University School of Medicine, and Department of Critical Care Medicine, St John s Mercy Medical Center, St Louis, Missouri, USA
    Am J Physiol Regul Integr Comp Physiol 287:R437-45. 2004
    ..These results suggest a novel multifunctionality of oxyradicals in decoupling hepatic transcriptional activity and cytokine biosynthesis early in the posttraumatic milieu...
  51. ncbi Kupffer cell stimulation in the isolated perfused rat liver triggers nuclear factor-kappaB DNA binding activity
    Pamela Romanque
    Programa de Farmacología Molecular y Clínica, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    Redox Rep 8:341-6. 2003
    ....
  52. ncbi SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling
    Jennifer Chen
    Gladstone Institute of Neurological Disease, University of California, San Francisco, California 94158, USA
    J Biol Chem 280:40364-74. 2005
    ..They also implicate SIRT1 in this pathway and highlight the therapeutic potential of resveratrol and other sirtuin-activating compounds in Alzheimer disease...
  53. ncbi Inhibition of experimental abdominal aortic aneurysm in the rat by use of decoy oligodeoxynucleotides suppressing activity of nuclear factor kappaB and ets transcription factors
    Hideki Nakashima
    Division of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Circulation 109:132-8. 2004
    ..Thus, we developed a novel strategy to treat AAA by simultaneous inhibition of both NF-kappaB and ets by using chimeric decoy oligodeoxynucleotides (ODN)...
  54. ncbi Induction of myofibroblast MMP-9 transcription in three-dimensional collagen I gel cultures: regulation by NF-kappaB, AP-1 and Sp1
    Terumi Takahra
    Third Department of Internal Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, 930 0194, Toyama, Japan
    Int J Biochem Cell Biol 36:353-63. 2004
    ..It is concluded that 3D contact of activated HSC with collagen I stimulates MMP-9 expression by elevating NF-kappaB and AP-1 activities which are able to overcome the repressive influence of Sp1/Sp3 on MMP-9 gene transcription...
  55. ncbi Temporal control of NF-kappaB activation by ERK differentially regulates interleukin-1beta-induced gene expression
    Bingbing Jiang
    Whitaker Cardiovascular Institute, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 279:1323-9. 2004
    ..These results reveal a novel functional role for ERK as an important temporal regulator of NF-kappaB activation and NF-kappaB-dependent gene expression...
  56. ncbi [Effects of moderate hypothermia on expression of nuclear factor-KappaB in rats with acute pancreatitis]
    Xue min Wang
    Shanghai Sixth People s Hospital, Medical College of Shanghai Jiao Tong University, Shanghai 200233, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 17:658-61. 2005
    ....
  57. ncbi Peroxynitrite induces an alternative NF-kappaB activation pathway in L8 rat myoblasts
    Marina Bar-Shai
    Department of Anatomy and Cell Biology, Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Antioxid Redox Signal 8:639-52. 2006
    ..This resulted in prolonged iNOS expression. Hence, peroxynitrite may exacerbate inflammatory responses mediated by NF-kappaB...
  58. ncbi Hypoxia/reoxygenation differentially modulates NF-kappaB activation and iNOS expression in astrocytes and microglia
    Guiwen Guo
    Department of Neurology, Medical University of South Carolina, Charleston, 29425, USA
    Antioxid Redox Signal 8:911-8. 2006
    ..Lastly, the two cell types displayed differential vulnerabilities to hypoxia-induced cell death, the astrocytes being relatively more resistant than microglia...
  59. ncbi Ethanol sensitizes NF-kappaB activation in pancreatic acinar cells through effects on protein kinase C-epsilon
    Akihiko Satoh
    VA Greater L A Healthcare System, West L A Healthcare Center, Bldg 258, RM 340, 11301 Wilshire Blvd, Los Angeles, CA 90073, USA
    Am J Physiol Gastrointest Liver Physiol 291:G432-8. 2006
    ..These results suggest that ethanol enhances the CCK-8-induced NF-kappaB activation at least in part through its effects on PKC-epsilon...
  60. ncbi [Relationship between nuclear factor-kappaB activity and kidney injury in rats with postburn sepsis]
    Feng hua Yao
    Department of Nephrology, 304 th Hospital Affiliated to General Hospital of PLA, Beijing 100037, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 17:722-5. 2005
    ..To investigate the relationship between nuclear factor-KappaB (NF-KappaB) activity and kidney injury in rats with postburn sepsis...
  61. ncbi Effect of nuclear factor kappa B on intercellular adhesion molecule-1 expression and neutrophil infiltration in lung injury induced by intestinal ischemia/reperfusion in rats
    Xiao Feng Tian
    Department of General Surgery, Second Affiliated Hospital, Dalian Medical University, Dalian 116027, Liaoning Province, China
    World J Gastroenterol 12:388-92. 2006
    ....
  62. ncbi Angiotensin II and Aldosterone stimulating NF-kappaB and AP-1 activation in hepatic fibrosis of rat
    Xu Li
    Department of Emergency, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China
    Regul Pept 138:15-25. 2007
    ..The present study aims to investigate the signal transduction mechanism underlying effects of Ang II and Aldo on NF-kappaB and AP-1 pathway during hepatic fibrogenesis...
  63. ncbi Action of NF-kappaB on the delta opioid receptor gene promoter
    Yulong L Chen
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Biochem Biophys Res Commun 352:818-22. 2007
    ..Together, the results show that direct association of p65 with the promoter is important in NGF-induced dor promoter activity...
  64. ncbi Hippocampal region-specific regulation of NF-kappaB may contribute to learning-associated synaptic reorganisation
    Niamh C O'Sullivan
    Applied Neurotherapeutics Research Group, UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Brain Res Bull 81:385-90. 2010
    ..These results suggest that NF-kappaB activity following hippocampal learning may contribute to consolidation-associated synaptic reorganisation...
  65. ncbi Peroxisome proliferator-activated receptor gamma agonist reduces the severity of post-ERCP pancreatitis in rats
    Emma Folch-Puy
    Department of Experimental Pathology, IIBB CSIC, IDIBAPS, Barcelona, Spain
    World J Gastroenterol 12:6458-63. 2006
    ..To determine the effects of prophylactic peroxi-some proliferator-activated receptor (PPARgamma) agonist administration in an experimental model of post-endoscopic retrograde cholangiopancreatography (post-ERCP) acute pancreatitis...
  66. ncbi Neointimal smooth muscle cells display a proinflammatory phenotype resulting in increased leukocyte recruitment mediated by P-selectin and chemokines
    Ute Zeiffer
    Department of Molecular Cardiovascular Research, University of Technology, Aachen, Germany
    Circ Res 94:776-84. 2004
    ..In conclusion, we have identified a NF-kappaB-mediated proinflammatory phenotype of niSMCs that is characterized by increased P-selectin and chemokine expression and thereby effectively supports leukocyte recruitment...
  67. ncbi The role of [beta]-transducin repeat-containing protein ([beta]-TrCP) in the regulation of NF-[kappa]B in vascular smooth muscle cells
    Xiaohong Wang
    Lillehei Heart Institute, Division of Cardiology, Department of Medicine, University of Minnesota, Minneapolis 55455, USA
    Arterioscler Thromb Vasc Biol 24:85-90. 2004
    ..We hypothesized that the E3-ligase, beta-transducin repeat-containing protein 1 (beta-TrCP1), was a rate-determining mediator that regulates the ubiquitin-mediated degradation of IkappaBalpha (in VSMC)...
  68. ncbi Effects of extracts from Paederia scandens (LOUR.) MERRILL (Rubiaceae) on MSU crystal-induced rats gouty arthritis
    Ying Ma
    Department of Pharmacology, Anhui Medical University, Hefei 230032, China
    Am J Chin Med 37:669-83. 2009
    ....
  69. ncbi Variable effects of cyclophosphamide in rodent models of experimental allergic encephalomyelitis
    K Mangano
    Department of Biomedical Sciences, School of Medicine, Via Androne n 83, 95124 Catania, Italy
    Clin Exp Immunol 159:159-68. 2010
    ....
  70. ncbi Inhibition of NF-kappaB signaling by fasudil as a potential therapeutic strategy for rheumatoid arthritis
    Hiroshi Okamoto
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    Arthritis Rheum 62:82-92. 2010
    ....
  71. ncbi Oxidative stress causes renal dopamine D1 receptor dysfunction and hypertension via mechanisms that involve nuclear factor-kappaB and protein kinase C
    Anees Ahmad Banday
    Heart and Kidney Institute, College of Pharmacy, University of Houston, Houston, Texas, USA
    J Am Soc Nephrol 18:1446-57. 2007
    ..Tempol reduced oxidative stress and thereby restored D1 receptor function and normalized BP...
  72. ncbi Thyroid hormone-induced oxidative stress triggers nuclear factor-kappaB activation and cytokine gene expression in rat liver
    Gladys Tapia
    Programa de Farmacologíca Molecular y Clínica, Instituto de Ciencias Biomedicas, Universidad de Chile, Santiago, Chile
    Free Radic Biol Med 35:257-65. 2003
    ..It is concluded that T(3)-induced oxidative stress enhances the DNA-binding activity of NF-kappaB and the NF-kappaB-dependent expression of TNF-alpha and IL-10 genes...
  73. ncbi Suppression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor-kappaB, cyclooxygenase 2, and matrix metalloprotease 9
    Sanjeev Banerjee
    Cytokine Research Laboratory, Department of Bioimmunotherapy, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 62:4945-54. 2002
    ..Overall, our results suggest that resveratrol suppresses DMBA-induced mammary carcinogenesis, which correlates with down-regulation of NF-kappaB, cyclooxygenase-2, and matrix metalloprotease-9 expression...
  74. ncbi Redox regulation of pro-inflammatory cytokines and IkappaB-alpha/NF-kappaB nuclear translocation and activation
    John J Haddad
    Oxygen Signaling Group, Center for Research into Human Development, Tayside Institute of Child Health, Faculty of Medicine, Ninewells Hospital and Medical School, University of Dundee, Scotland, UK corrected
    Biochem Biophys Res Commun 296:847-56. 2002
    ....
  75. ncbi Synergistic activation of NF-kappaB by tumor necrosis factor alpha and gamma interferon via enhanced I kappaB alpha degradation and de novo I kappaBbeta degradation
    J L Cheshire
    Lineberger Comprehensive Cancer Center, Department of Biology and Curriculum in Genetics and Molecular Biology, University of North Carolina School of Medicine, Chapel Hill 27599, USA
    Mol Cell Biol 17:6746-54. 1997
    ....
  76. ncbi IL-17 stimulates migration of carotid artery vascular smooth muscle cells in an MMP-9 dependent manner via p38 MAPK and ERK1/2-dependent NF-kappaB and AP-1 activation
    Gao Cheng
    Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China
    Cell Mol Neurobiol 29:1161-8. 2009
    ..The present results demonstrated that IL-17 may play a role in vascular remodeling and targeting IL-17 or its specific downstream mediators is a potentially novel therapeutic pathway for attenuating the post-angioplastic restenosis...
  77. ncbi Role of nuclear factor kappaB in ovarian hormone-mediated stress hypersensitivity in female mice
    Quincey LaPlant
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Biol Psychiatry 65:874-80. 2009
    ..The molecular mechanisms of stress-induced depressive behaviors have been characterized extensively in male rodents; however, much less is known about female subjects, despite the fact that human depression is far more prevalent in women...
  78. ncbi The differential NF-kB modulation by S-adenosyl-L-methionine, N-acetylcysteine and quercetin on the promotion stage of chemical hepatocarcinogenesis
    Rebeca García-Román
    Departamento de Biologia Celular, Centro de Investigacion y de Estudios Avanzados del IPN, Mexico D F, Mexico
    Free Radic Res 42:331-43. 2008
    ..The mechanisms exerted by SAM in the reduction of foci makes this compound a potential liver cancer therapeutic agent...
  79. ncbi Taxifolin ameliorates cerebral ischemia-reperfusion injury in rats through its anti-oxidative effect and modulation of NF-kappa B activation
    Yea Hwey Wang
    Institute of Pharmacology, National Yang Ming University, Taipei, Taiwan
    J Biomed Sci 13:127-41. 2006
    ..These data suggest that amelioration of CI/R injury by taxifolin may be attributed to its anti-oxidative effect, which in turn modulates NF-kappaB activation that mediates CI/R injury...
  80. ncbi Cloning of rat Sertoli cell follicle-stimulating hormone primary response complementary deoxyribonucleic acid: regulation of TSC-22 gene expression
    K G Hamil
    Laboratories for Reproductive Biology, University of North Carolina, Chapel Hill 27599
    Endocrinology 134:1205-12. 1994
    ..A 5-kb transcript became detectable by 30 days and decreased after 50 days of age. Ovarian 1.8-kb TSC-22 transcript levels increased about 2-fold during the same maturation period...
  81. ncbi Rapid communication: protective effect of a nuclear factor kappaB inhibitor, pyrolidium dithiocarbamate, in the kidney of rats with nephrolithiasis induced by ethylene glycol
    Volkan Tugcu
    Department of Urology, Bakirkoy Research and Training Hospital, Istanbul, Turkey
    J Endourol 21:1097-106. 2007
    ....
  82. ncbi Inhibition of NF-kappaB induces regression of cardiac hypertrophy, independent of blood pressure control, in spontaneously hypertensive rats
    Sudhiranjan Gupta
    Dept of Molecular Cardiology, NB 50, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Am J Physiol Heart Circ Physiol 289:H20-9. 2005
    ..The relationship between NF-kappaB activity and cardiac remodeling is causal, not coincidental...
  83. ncbi Hepatitis B virus HBx protein localizes to mitochondria in primary rat hepatocytes and modulates mitochondrial membrane potential
    AMY J CLIPPINGER
    Graduate Program in Molecular and Cellular Biology and Genetics, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA
    J Virol 82:6798-811. 2008
    ....
  84. ncbi Hydrogen sulfide potentiates interleukin-1beta-induced nitric oxide production via enhancement of extracellular signal-regulated kinase activation in rat vascular smooth muscle cells
    Sun Oh Jeong
    Medicinal Resources Research Institute, Wonkwang University, Department of Microbiology and Immunology, Wonkwang University School of Medicine, Chonbug 570 749, Republic of Korea
    Biochem Biophys Res Commun 345:938-44. 2006
    ..Our findings suggest that H(2)S enhances NO production and iNOS expression by potentiating IL-1beta-induced NF-kappaB activation through a mechanism involving ERK1/2 signaling cascade in rat VSMCs...
  85. ncbi Acetylation of nuclear factor-kappaB in rat amygdala improves long-term but not short-term retention of fear memory
    Shiu Hwa Yeh
    Institute of Basic Medical Sciences, Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan
    Mol Pharmacol 65:1286-92. 2004
    ..This study provides evidence that HDAC-mediated deacetylation functions as an intranuclear molecular switch culminating in the termination of NF-kappaB transcriptional response that is involved in the formation of fear memory...
  86. ncbi In vivo preconditioning with normobaric hyperoxia induces ischemic tolerance partly by triggering tumor necrosis factor-alpha converting enzyme/tumor necrosis factor-alpha/nuclear factor-kappaB
    M R Bigdeli
    Faculty of Biological Sciences, Shahid Beheshti University, Tehran, Iran
    Neuroscience 153:671-8. 2008
    ..Although further studies are needed to clarify the mechanisms of brain ischemic tolerance, InHO and PrHO may partly exert their effects via triggering TACE/TNF-alpha/NF-kappaB...
  87. ncbi NF-kappaB blockade upregulates Bax, TSP-1, and TSP-2 expression in rat granulation tissue
    Daniela De Stefano
    Dipartimento di Farmacologia Sperimentale, Facolta di Scienze Biotecnologiche, Universita degli Studi di Napoli Federico II, via D Montesano, 49, 80131, Naples, Italy
    J Mol Med (Berl) 87:481-92. 2009
    ..Our findings show that the blockade of NF-kappaB activation by WT ODN decoy prevents the development of granulation tissue induced by lambda-carrageenin-soaked sponge implant upregulating Bax as well as TSP-1 and TSP-2 expression...
  88. ncbi Fibronectin prevents endotoxin shock after partial hepatectomy in rats via inhibition of nuclear factor-kappaB and apoptosis
    A Hon Kwon
    Department of Surgery, Kansai Medical University, Moriguchi, Osaka, Japan
    Exp Biol Med (Maywood) 232:895-903. 2007
    ....
  89. ncbi Effects of gut barrier dysfunction and NF-kappaB activation on aggravating mechanism of severe acute pancreatitis
    Yi Lin Wang
    Department of Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    J Dig Dis 10:30-40. 2009
    ..To study the effects of gut-derived endotoxin translocation and NF-kappaB activation on the aggravating mechanism of severe acute pancreatitis (SAP) and of treatment with pyrrolidine dithiocarbamate (PDTC) on rats with SAP...
  90. ncbi Variants of neural nitric oxide synthase in the spinal cord of neuropathic rats and their effects on nuclear factor-kappaB (NF-kappaB) activity in PC12 cells
    Xiao Gao Jin
    Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China
    J Pain 10:80-9. 2009
    ..Considering the importance of spinal NF-kappaB signaling in neuropathic rat, it could be concluded that changes in spinal nNOS variants and quantity after peripheral nerve injury implicate nNOS in the generation of neuropathic pain...
  91. ncbi Apoptosis of dedifferentiated hepatoma cells is independent of NF-kappaB activation in response to LPS
    M Ryan Reidy
    Department of Biological Sciences, Eastern Illinois University, Charleston, IL 61920, USA
    Biosci Rep 27:235-46. 2007
    ..Importantly, this pro-apoptotic function of LPS appears to be a function of loss of hepatic gene expression, as the parental hepatoma cells resist LPS-mediated apoptosis in the presence of protein synthesis inhibitors...
  92. ncbi Angiotensin II stimulates transcription of insulin-like growth factor I receptor in vascular smooth muscle cells: role of nuclear factor-kappaB
    Yewei Ma
    Department of Medicine, One Baylor Plaza, N520, Baylor College of Medicine, Houston, Texas 77030, USA
    Endocrinology 147:1256-63. 2006
    ..Because IGF-IR is a major factor associated with thickening of mesenteric vessels, our results provide potential therapeutic targets...
  93. ncbi P2Y6 nucleotide receptors activate NF-kappaB and increase survival of osteoclasts
    Jasminka Korcok
    Canadian Institutes of Health Research Group in Skeletal Development and Remodeling, Department of Physiology and Pharmacology and Division of Oral Biology, Faculty of Medicine and Dentistry, The University of Western Ontario, London, Canada
    J Biol Chem 280:16909-15. 2005
    ..Thus, nucleotides, following their release at sites of inflammation and mechanical stimulation, can act through P2Y6 receptors to initiate NF-kappaB signaling and enhance osteoclast survival...
  94. ncbi Increased mitochondrial H2O2 production promotes endothelial NF-kappaB activation in aged rat arteries
    Zoltan Ungvari
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 293:H37-47. 2007
    ..g., calorie restriction mimetics) will exert significant anti-inflammatory and vasoprotective effects...
  95. ncbi Estrus cycle: influence on cardiac function following trauma-hemorrhage
    Shaolong Yang
    Department of Surgery, University of Alabama at Birmingham, AL 35294 0019, USA
    Am J Physiol Heart Circ Physiol 291:H2807-15. 2006
    ..These data collectively suggest that the estrus cycle plays an important role in cardiac function following TH. The salutary effect seen in PE following TH is likely due to a decrease in NF-kappaB-dependent cardiac IL-6 pathway...
  96. ncbi CCK-A receptor induction and P38 and NF-kappaB activation in acute pancreatitis
    Isaac Samuel
    Department of Surgery, University of Iowa Roy J and Lucille A Carver College of Medicine, and the Veterans Affairs Medical Center, Iowa City, Iowa 52242, USA
    Pancreatology 4:49-56. 2004
    ..These findings may have significance in the mechanism of disease pathogenesis in this experimental model...

Research Grants27

  1. LIVER-LUNG INTERACTIONS DURING GRAM-NEGATIVE ENDOTOXEMIA
    George Matuschak; Fiscal Year: 1993
    ..This will enable a synthesis integrating the signal transduction of peptide and non-peptide mediators with organ system interactions, and provide further insight into potential therapeutic interventions to ameliorate ARDS with MSOF...
  2. LIVER/LUNG INTERACTIONS DURING GRAM NEGATIVE ENDOTOXEMIA
    George Matuschak; Fiscal Year: 2003
    ....
  3. Gender Differences in Experimental Aortic Aneurysms
    Gilbert Upchurch; Fiscal Year: 2007
    ....
  4. Gender Differences in Experimental Aortic Aneurysms
    Gilbert Upchurch; Fiscal Year: 2009
    ..abstract_text> ..
  5. MMP-9-Dependent Vessel Wall Remodeling is NO-Dependent
    Gilbert Upchurch; Fiscal Year: 2005
    ....
  6. Chronic Alcohol Consumption Induces Tumor Angiogenesis
    Jian Wei Gu; Fiscal Year: 2006
    ..The new information will promote cancer prevention and treatment. ..
  7. Role of CCK Receptor in Acute Pancreatitis Pathogenesis
    Isaac Samuel; Fiscal Year: 2007
    ..James W. Maher, MD, Director, Division of Gastrointestinal Surgery, University of Iowa College of Medicine, Iowa City. [] PHS 398/2590 (Rev. 05/01) Page__ 26 Continuation Format Page [] ..
  8. Gender Differences in Experimental Aortic Aneurysms
    GILBERT RIVERS UPCHURCH; Fiscal Year: 2010
    ....
  9. Gallstone Pancreatitis: Pathogenesis and Treatment
    Isaac Samuel; Fiscal Year: 2010
    ..A better understanding of these processes will help to improve the treatment of this potentially fatal condition. ..
  10. LIVER LUNG INTERACTIONS DURING GRAM NEGATIVE ENDOTOXEMIA
    George Matuschak; Fiscal Year: 1999
    ..This should provide novel insights into the regulation of cytokine expression during gram negative sepsis while identifying mechanistic therapies to ameliorate acute lung injury and multiple organ failure. ..
  11. Gallstone Pancreatitis: Pathogenesis and Treatment
    Isaac Samuel; Fiscal Year: 2009
    ..A better understanding of these processes will help to improve the treatment of this potentially fatal condition. ..