neurturin

Summary

Gene Symbol: neurturin
Description: neurturin
Alias: neurturin
Species: rat
Products:     neurturin

Top Publications

  1. Zihlmann K, Ducray A, Schaller B, Huber A, Krebs S, Andres R, et al. The GDNF family members neurturin, artemin and persephin promote the morphological differentiation of cultured ventral mesencephalic dopaminergic neurons. Brain Res Bull. 2005;68:42-53 pubmed
    b>Neurturin (NRTN), artemin (ARTN), persephin (PSPN) and glial cell line-derived neurotrophic factor (GDNF) form a group of neurotrophic factors, also known as the GDNF family ligands (GFLs)...
  2. Doray B, Salomon R, Amiel J, Pelet A, Touraine R, Billaud M, et al. Mutation of the RET ligand, neurturin, supports multigenic inheritance in Hirschsprung disease. Hum Mol Genet. 1998;7:1449-52 pubmed
    ..neurotrophic factor (GDNF) mutations have been reported in the disease, we regarded the other RET ligand, neurturin (NTN), as an attractive candidate gene, especially as it shares large homologies with GDNF...
  3. Song X, Li D, Farley W, Luo L, Heuckeroth R, Milbrandt J, et al. Neurturin-deficient mice develop dry eye and keratoconjunctivitis sicca. Invest Ophthalmol Vis Sci. 2003;44:4223-9 pubmed
    b>Neurturin has been identified as a neurotrophic factor for parasympathetic neurons. Neurturin-deficient (NRTN(-/-)) mice have defective parasympathetic innervation of their lacrimal glands...
  4. Harada C, Harada T, Quah H, Maekawa F, Yoshida K, Ohno S, et al. Potential role of glial cell line-derived neurotrophic factor receptors in Müller glial cells during light-induced retinal degeneration. Neuroscience. 2003;122:229-35 pubmed
    Glial cell line-derived neurotrophic factor (GDNF), neurturin (NTN) and their receptors (GFRalpha1, GFRalpha2 and Ret) play an important role in the survival of neurons in the central and peripheral nervous system...
  5. Maroldt H, Kaplinovsky T, Cunningham A. Immunohistochemical expression of two members of the GDNF family of growth factors and their receptors in the olfactory system. J Neurocytol. 2005;34:241-55 pubmed
    The glial cell line-derived (GDNF) family of trophic factors, GDNF, neurturin, persephin and artemin, are known to support the survival and regulate differentiation of many neuronal populations, including peripheral autonomic, enteric ..
  6. Baloh R, Gorodinsky A, Golden J, Tansey M, Keck C, Popescu N, et al. GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family. Proc Natl Acad Sci U S A. 1998;95:5801-6 pubmed
    GDNF, neurturin, and persephin are transforming growth factor beta-related neurotrophic factors known collectively as the GDNF family (GF)...
  7. Stover T, Gong T, Cho Y, Altschuler R, Lomax M. Expression of the GDNF family members and their receptors in the mature rat cochlea. Brain Res Mol Brain Res. 2000;76:25-35 pubmed
    The GDNF family comprises glial cell line-derived neurotrophic factor (GDNF) and the related proteins neurturin, artemin and persephin, which form a subgroup of the TGF-beta superfamily of growth factors...
  8. Kawakami T, Wakabayashi Y, Aimi Y, Isono T, Okada Y. Developmental expression of glial cell-line derived neurotrophic factor, neurturin, and their receptor mRNA in the rat urinary bladder. Neurourol Urodyn. 2003;22:83-8 pubmed
    Glial cell-line derived neurotrophic factor (GDNF) and related factors neurturin (NRTN), artemin, and persephin are members of the GDNF family of neurotrophic factors...
  9. Cho J, Kholodilov N, Burke R. Patterns of developmental mRNA expression of neurturin and GFRalpha2 in the rat striatum and substantia nigra do not suggest a role in the regulation of natural cell death in dopamine neurons. Brain Res Dev Brain Res. 2004;148:143-9 pubmed
    We examined the mRNA expression of neurturin (NTN) and its receptor GFRalpha2 in rat substantia nigra (SN) and striatum by northern analysis at ages ranging from postnatal day (PND) 2 to adult...

More Information

Publications16

  1. Yan H, Bergner A, Enomoto H, Milbrandt J, Newgreen D, Young H. Neural cells in the esophagus respond to glial cell line-derived neurotrophic factor and neurturin, and are RET-dependent. Dev Biol. 2004;272:118-33 pubmed
    ..Two other GDNF family members, neurturin and artemin, are also expressed in the developing gut although artemin is only expressed in the esophagus...
  2. Vourc H P, Lacar B, Mignon L, Lucas P, Young H, Chesselet M. Effect of neurturin on multipotent cells isolated from the adult skeletal muscle. Biochem Biophys Res Commun. 2005;332:215-23 pubmed
    ..We examined the action of neurturin on a candidate stem cell population isolated from adult skeletal muscles...
  3. Wanigasekara Y, Airaksinen M, Heuckeroth R, Milbrandt J, Keast J. Neurturin signalling via GFRalpha2 is essential for innervation of glandular but not muscle targets of sacral parasympathetic ganglion neurons. Mol Cell Neurosci. 2004;25:288-300 pubmed
    b>Neurturin, a member of the glial cell-derived neurotrophic factor familys of ligands, is important for development of many cranial parasympathetic ganglion neurons...
  4. Ramaswamy S, McBride J, Herzog C, Brandon E, Gasmi M, Bartus R, et al. Neurturin gene therapy improves motor function and prevents death of striatal neurons in a 3-nitropropionic acid rat model of Huntington's disease. Neurobiol Dis. 2007;26:375-84 pubmed
    ..This study tested the hypothesis that an adenoassociated viral (AAV2) vector encoding for the trophic factor neurturin (NTN) could provide neuroprotection in the rat 3-nitropropionic acid (3NP) model of HD...
  5. Wan G, Zhou L, Lim Q, Wong Y, Too H. Cyclic AMP signalling through PKA but not Epac is essential for neurturin-induced biphasic ERK1/2 activation and neurite outgrowths through GFR?2 isoforms. Cell Signal. 2011;23:1727-37 pubmed publisher
    ..Glial cell line-derived neurotrophic factor (GDNF) and its family member neurturin (NTN) transduce signal through a multi-component receptor complex consisting of GDNF family receptor alpha 2 (..
  6. Heuckeroth R, Enomoto H, Grider J, Golden J, Hanke J, Jackman A, et al. Gene targeting reveals a critical role for neurturin in the development and maintenance of enteric, sensory, and parasympathetic neurons. Neuron. 1999;22:253-63 pubmed
    b>Neurturin (NTN) is a neuronal survival factor that activates the Ret tyrosine kinase in the presence of a GPI-linked coreceptor (either GFR alpha1 or GFR alpha2)...
  7. Oiwa Y, Yoshimura R, Nakai K, Itakura T. Dopaminergic neuroprotection and regeneration by neurturin assessed by using behavioral, biochemical and histochemical measurements in a model of progressive Parkinson's disease. Brain Res. 2002;947:271-83 pubmed
    Trophic effects of neurturin, a member of the glial cell line-derived neurotrophic factor-family, have been demonstrated on mesencephalic dopaminergic neurons, suggesting its therapeutic potential for Parkinson's disease...