neuronal leucine rich repeat protein 3
Gene Symbol: neuronal leucine rich repeat protein 3
Description: leucine rich repeat neuronal 3
Alias: Nlrr3, leucine-rich repeat neuronal protein 3, NLRR-3, leucine rich repeat protein 3, neuronal, neuronal leucine-rich repeat protein 3
Fattoum A, Roustan C, Smyczynski C, Der Terrossian E, Kassab R. Mapping the microtubule binding regions of calponin. Biochemistry. 2003;42:1274-82 pubmed
..Thus, in the living cells, calponin could potentially behave as a cross-linking protein between the two major cytoskeletal filaments. ..
Fukamachi K, Matsuoka Y, Kitanaka C, Kuchino Y, Tsuda H. Rat neuronal leucine-rich repeat protein-3: cloning and regulation of the gene expression. Biochem Biophys Res Commun. 2001;287:257-63 pubmed
..LY294002, a PI3 kinase inhibitor, showed a lesser effect on expression of the gene. These results indicate that rNLRR-3 gene expression is regulated mainly through the Ras-MAPK signaling pathway in fibroblasts. ..
Fukamachi K, Matsuoka Y, Ohno H, Hamaguchi T, Tsuda H. Neuronal leucine-rich repeat protein-3 amplifies MAPK activation by epidermal growth factor through a carboxyl-terminal region containing endocytosis motifs. J Biol Chem. 2002;277:43549-52 pubmed
..We propose that NLRR-3 potentiates Ras-MAPK signaling by facilitating internalization of EGF in clathrin-coated vesicles. ..
Herlan L, Schulz A, Schulte L, Schulz H, HÃ¼bner N, Kreutz R. Novel candidate genes for impaired nephron development in a rat model with inherited nephron deficit and albuminuria. Clin Exp Pharmacol Physiol. 2015;42:1051-8 pubmed publisher
..Thus, we identified several genes that may act as crucial players in nephron development and are responsible for the nephron deficit in the MWF model. ..
Yang J, Li F, Qiu L, Luo X, Huang H. [Role of LRRN3 in the cerebellum postnatal development in rats]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2011;36:424-9 pubmed publisher