Ncstn

Summary

Gene Symbol: Ncstn
Description: nicastrin
Species: rat

Top Publications

  1. ncbi Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch
    Sheu Fen Lee
    Center for Basic Neuroscience and Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Biol Chem 277:45013-9. 2002
  2. ncbi Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria
    Camilla A Hansson
    Karolinska Institutet and Sumitomo Pharmaceuticals Alzheimer Center KASPAC, Neurotec, Novum, SE 141 57 Huddinge, Sweden
    J Biol Chem 279:51654-60. 2004
  3. ncbi Presenilin-1, nicastrin, amyloid precursor protein, and gamma-secretase activity are co-localized in the lysosomal membrane
    Stephen H Pasternak
    Research Institute, The Hospital for Sick Children, University of Toronto, Toronto M5G 1X8, Canada
    J Biol Chem 278:26687-94. 2003
  4. pmc Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-β production by altering Nicastrin maturation and intracellular localization
    Vasiliki Michaki
    Center for Human Genetics and Leuven Institute for Neurodegenerative Diseases, KU Leuven, 3000 Leuven, Belgium
    J Biol Chem 287:1100-11. 2012
  5. pmc Proteomic and metabolomic analyses of mitochondrial complex I-deficient mouse model generated by spontaneous B2 short interspersed nuclear element (SINE) insertion into NADH dehydrogenase (ubiquinone) Fe-S protein 4 (Ndufs4) gene
    Dillon W Leong
    Molecular Medicine Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    J Biol Chem 287:20652-63. 2012
  6. ncbi Rat nicastrin gene: cDNA isolation, mRNA variants and expression pattern analysis
    Annamaria Confaloni
    Department of Cellular Biology and Neuroscience, Istituto Superiore di Sanita, 299 Viale Regina Elena, 00161 Rome, Italy
    Brain Res Mol Brain Res 136:12-22. 2005
  7. pmc Cellular distribution of gamma-secretase subunit nicastrin in the developing and adult rat brains
    A Kodam
    Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada
    Neurobiol Aging 29:724-38. 2008
  8. ncbi Cell and molecular biology of Notch
    Ulla Maj Fiuza
    Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK
    J Endocrinol 194:459-74. 2007
  9. pmc Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes
    Kulandaivelu S Vetrivel
    Department of Neurobiology, Pharmacology and Physiology, The University of Chicago, Illinois 60637, USA
    J Biol Chem 279:44945-54. 2004
  10. ncbi Normal distribution of presenilin-1 and nicastrin in skeletal muscle and the differential responses of these proteins after denervation
    Kunihiro Sakuma
    Health Science Center, Toyohashi University of Technology, 1 1, Hibarigaoka, Tenpaku cho, Toyohashi 441 8580, Japan
    Biochim Biophys Acta 1760:980-7. 2006

Scientific Experts

  • Kunihiro Sakuma
  • Ulla Maj Fiuza
  • Vasiliki Michaki
  • Dillon W Leong
  • A Kodam
  • Annamaria Confaloni
  • Kulandaivelu S Vetrivel
  • Camilla A Hansson
  • Stephen H Pasternak
  • Sheu Fen Lee
  • Kenneth D Tew
  • Hamish S Scott
  • Krist l Vennekens
  • Gordon K Smyth
  • Michael T Ryan
  • Belinda Phipson
  • Chelsee A Hewitt
  • Sebastian Munck
  • Matthew McKenzie
  • Francesc X Guix
  • Carlos G Dotti
  • Gayle M Davey
  • Adrienne Laskowski
  • William R Heath
  • Sarah A Kinkel
  • Albert Sickmann
  • Tina Wahle
  • Estelle Arnaud
  • Roman Chrast
  • Anne K Voss
  • John B Davis
  • David R Thorburn
  • Jasper C Komen
  • Rene P Zahedi
  • Bart De Strooper
  • Colin Dingwall
  • Melanie Bahlo
  • Fabian Feiguin
  • James J Pitt
  • Danyelle M Townsend
  • G Thinakaran
  • S Kar
  • K S Vetrivel
  • Paola Piscopo
  • Marco Tartaglia
  • Diego Albani
  • Lorenzo Malvezzi Campeggi
  • Alessio Crestini
  • Liana Terreni
  • Gianluigi Forloni
  • Mark R Farmery
  • Nobuyuki Nukina
  • Camilla Nilsberth
  • Haipeng Cheng
  • Maria Ankarcrona
  • Bengt Winblad
  • Huaxi Xu
  • Susanne Frykman
  • Tong Li
  • Sharon E Pursglove
  • Philip C Wong
  • Johan Thyberg
  • Takashi Sakurai
  • Gopal Thinakaran
  • Akira Ito
  • Richard F Cowburn
  • William Lin
  • Lars O Tjernberg
  • Brian J Pak
  • Cameron A Ackerley
  • Don J Mahuran
  • John W Callahan
  • Marianne Guiral
  • Sunqu Zhang
  • Richard D Bagshaw
  • Gang Yu
  • Weiping Han
  • Sanjiv Shah
  • Hongqiao Li
  • Cong Yu

Detail Information

Publications10

  1. ncbi Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch
    Sheu Fen Lee
    Center for Basic Neuroscience and Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Biol Chem 277:45013-9. 2002
    ..These data indicate that mAPH-1 is probably a functional component of the gamma-secretase complex required for the intramembrane proteolysis of APP and Notch...
  2. ncbi Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria
    Camilla A Hansson
    Karolinska Institutet and Sumitomo Pharmaceuticals Alzheimer Center KASPAC, Neurotec, Novum, SE 141 57 Huddinge, Sweden
    J Biol Chem 279:51654-60. 2004
    ..This novel localization of NCT, PS1, APH-1, and PEN-2 expands the role and importance of gamma-secretase activity to mitochondria...
  3. ncbi Presenilin-1, nicastrin, amyloid precursor protein, and gamma-secretase activity are co-localized in the lysosomal membrane
    Stephen H Pasternak
    Research Institute, The Hospital for Sick Children, University of Toronto, Toronto M5G 1X8, Canada
    J Biol Chem 278:26687-94. 2003
    ..These data reassert the importance of the lysosomal/endosomal system in the generation of Abeta and suggest a role for lysosomes in the pathophysiology of AD...
  4. pmc Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-β production by altering Nicastrin maturation and intracellular localization
    Vasiliki Michaki
    Center for Human Genetics and Leuven Institute for Neurodegenerative Diseases, KU Leuven, 3000 Leuven, Belgium
    J Biol Chem 287:1100-11. 2012
    ..Reduced Abca2 levels in mammalian cells in vitro, in Drosophila melanogaster and in mice resulted in altered γ-secretase processing of APP, and thus Aβ generation, without affecting Notch cleavage...
  5. pmc Proteomic and metabolomic analyses of mitochondrial complex I-deficient mouse model generated by spontaneous B2 short interspersed nuclear element (SINE) insertion into NADH dehydrogenase (ubiquinone) Fe-S protein 4 (Ndufs4) gene
    Dillon W Leong
    Molecular Medicine Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    J Biol Chem 287:20652-63. 2012
    ..Metabolomic analysis of the blood by tandem mass spectrometry showed increased hydroxyacylcarnitine species, implying that the CI defect leads to an imbalanced NADH/NAD(+) ratio that inhibits mitochondrial fatty acid β-oxidation...
  6. ncbi Rat nicastrin gene: cDNA isolation, mRNA variants and expression pattern analysis
    Annamaria Confaloni
    Department of Cellular Biology and Neuroscience, Istituto Superiore di Sanita, 299 Viale Regina Elena, 00161 Rome, Italy
    Brain Res Mol Brain Res 136:12-22. 2005
    ....
  7. pmc Cellular distribution of gamma-secretase subunit nicastrin in the developing and adult rat brains
    A Kodam
    Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada
    Neurobiol Aging 29:724-38. 2008
    ....
  8. ncbi Cell and molecular biology of Notch
    Ulla Maj Fiuza
    Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK
    J Endocrinol 194:459-74. 2007
    ..In this review, we will describe the multiple roles of Notch and how various factors can regulate Notch signalling...
  9. pmc Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes
    Kulandaivelu S Vetrivel
    Department of Neurobiology, Pharmacology and Physiology, The University of Chicago, Illinois 60637, USA
    J Biol Chem 279:44945-54. 2004
    ..These findings are consistent with the localization of gamma-secretase in lipid raft microdomains of post-Golgi and endosomes, organelles previously implicated in amyloidogenic processing of APP...
  10. ncbi Normal distribution of presenilin-1 and nicastrin in skeletal muscle and the differential responses of these proteins after denervation
    Kunihiro Sakuma
    Health Science Center, Toyohashi University of Technology, 1 1, Hibarigaoka, Tenpaku cho, Toyohashi 441 8580, Japan
    Biochim Biophys Acta 1760:980-7. 2006
    ..These data suggest that enhanced presenilin-1 protein may play a role in the degeneration and regeneration of skeletal muscle...