Gene Symbol: Ncoa4
Description: nuclear receptor coactivator 4
Alias: nuclear receptor coactivator 4
Bogdan A, Miyazawa M, Hashimoto K, Tsuji Y. Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease. Trends Biochem Sci. 2016;41:274-286 pubmed publisher
..39, SLC39, also known as ZRT/IRT-like protein, ZIP; and poly-(rC)-binding protein, PCBP] and a cargo receptor (NCOA4) that is crucial for release of ferritin-bound iron...
Shaw P, Rittenberg P, Brown T. Activation of androgen receptor-associated protein 70 (ARA70) mRNA expression in ovarian cancer. Gynecol Oncol. 2001;80:132-8 pubmed
..These observations indicate that ARA70 expression is activated in invasive ovarian cancer tumor cells, and suggest that amplification of androgen action by ARA70 may be involved in the etiology/progression of this disease. ..
Tai P, Huang Y, Shih C, Chen R, Chen C, Chen W, et al
. Direct regulation of androgen receptor-associated protein 70 by thyroid hormone and its receptors. Endocrinology. 2007;148:3485-95 pubmed
..Therefore, the data indicated that ARA70 suppresses T3 signaling in a TRE-dependent manner. These experimental results suggest that T3 directly up-regulates ARA70 gene expression. Subsequently, ARA70 negatively regulates T3 signaling. ..
Kollara A, Kahn H, Marks A, Brown T. Loss of androgen receptor associated protein 70 (ARA70) expression in a subset of HER2-positive breast cancers. Breast Cancer Res Treat. 2001;67:245-53 pubmed
..This may reflect aberrant splicing in some breast cancers, leading to the emergence of the 35 kDa isoform. ..
Li P, Yu X, Ge K, Melamed J, Roeder R, Wang Z. Heterogeneous expression and functions of androgen receptor co-factors in primary prostate cancer. Am J Pathol. 2002;161:1467-74 pubmed
..Together, these findings indicate that changes in levels of expression of AR co-factors may play important, yet different, roles in prostate tumorigenesis. ..
Hu Y, Yeh S, Yeh S, Sampson E, Huang J, Li P, et al
. Functional domain and motif analyses of androgen receptor coregulator ARA70 and its differential expression in prostate cancer. J Biol Chem. 2004;279:33438-46 pubmed
Lane D, Merlot A, Huang M, Bae D, Jansson P, Sahni S, et al
. Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease. Biochim Biophys Acta. 2015;1853:1130-44 pubmed publisher
..g., Friedreich's ataxia. Increased knowledge of the molecules and their mechanisms of action in iron processing pathways (e.g., ISC biogenesis) will shape the investigation of iron metabolism in human health and disease. ..
Quezada S, Avellaira C, Johnson M, Gabler F, Fuentes A, Vega M. Evaluation of steroid receptors, coregulators, and molecules associated with uterine receptivity in secretory endometria from untreated women with polycystic ovary syndrome. Fertil Steril. 2006;85:1017-26 pubmed
..The higher response to steroid hormones of endometria from untreated PCOS-women induces diminished expression of beta3 integrin, which partially explain implantation failure in PCOS patients. ..