Nat2

Summary

Gene Symbol: Nat2
Description: N-acetyltransferase 2
Alias: Nat2a, arylamine N-acetyltransferase 2, AT-2, N-Acetyltransferase-2 (arylamine N-acetyltransferase), N-acetyltransferase 2 (arylamine N-acetyltransferase), N-acetyltransferase type 2, NAT-2, arylamide acetylase 2
Species: rat
Products:     Nat2

Top Publications

  1. Jiao L, Doll M, Hein D, Bondy M, Hassan M, Hixson J, et al. Haplotype of N-acetyltransferase 1 and 2 and risk of pancreatic cancer. Cancer Epidemiol Biomarkers Prev. 2007;16:2379-86 pubmed
    We examined the association between N-acetyltransferase 1 and 2 (NAT1 and NAT2) haplotype and risk of pancreatic cancer by genotyping eight NAT1 and seven NAT2 single nucleotide polymorphisms in 532 patients and in 581 healthy controls (..
  2. Hein D, Grant D, Sim E. Update on consensus arylamine N-acetyltransferase gene nomenclature. Pharmacogenetics. 2000;10:291-2 pubmed
  3. Kelly S, Sim E. Arylamine N-acetyltransferase in Balb/c mice: identification of a novel mouse isoenzyme by cloning and expression in vitro. Biochem J. 1994;302 ( Pt 2):347-53 pubmed
    ..The products of all three genes are demonstrated to catalyse acetylation of aminofluorene and anisidine following expression in Escherichia coli. ..
  4. Cornish V, Pinter K, Boukouvala S, Johnson N, Labrousse C, Payton M, et al. Generation and analysis of mice with a targeted disruption of the arylamine N-acetyltransferase type 2 gene. Pharmacogenomics J. 2003;3:169-77 pubmed
    ..represent inbuilt redundancy or whether they have unique roles, we have generated mice with a null allele of Nat2 by gene targeting...
  5. Doll M, Hein D. Cloning, sequencing and expression of NAT1 and NAT2 encoding genes from rapid and slow acetylator inbred rats. Pharmacogenetics. 1995;5:247-51 pubmed
  6. Hein D, Bendaly J, Neale J, Doll M. Systemic functional expression of N-acetyltransferase polymorphism in the F344 Nat2 congenic rat. Drug Metab Dispos. 2008;36:2452-9 pubmed publisher
    Rat lines congenic for the rat N-acetyltransferase 2 [(RAT)Nat2] gene were constructed and characterized. F344 (homozygous Nat2 rapid) males were mated to Wistar Kyoto (homozygous Nat2 slow) females to produce heterozygous F1...
  7. Bandmann O, Vaughan J, Holmans P, Marsden C, Wood N. Association of slow acetylator genotype for N-acetyltransferase 2 with familial Parkinson's disease. Lancet. 1997;350:1136-9 pubmed
    ..Further studies are needed to investigate the biological relevance of these findings, but slow acetylation could lead to impaired ability of patients with familial PD to handle neurotoxic substances. ..
  8. Sobti R, Kaur P, Kaur S, Janmeja A, Jindal S, Kishan J, et al. Impact of interaction of polymorphic forms of p53 codon 72 and N-acetylation gene (NAT2) on the risk of lung cancer in the North Indian population. DNA Cell Biol. 2009;28:443-9 pubmed publisher
    ..We studied the influence of NAT2 and codon 72 p53 polymorphisms on 151 patients with lung cancer and an equal number of matched population controls...
  9. Nacak M, Erbagci Z, Aynacioglu A. Human arylamine N-acetyltransferase 2 polymorphism and susceptibility to allergic contact dermatitis. Int J Dermatol. 2006;45:323-6 pubmed
    N-acetyltransferase 2 (NAT2) polymorphism may be involved in the pathogenesis of allergic contact dermatitis...
  10. Rothman N, Garcia Closas M, Chatterjee N, Malats N, Wu X, Figueroa J, et al. A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. Nat Genet. 2010;42:978-84 pubmed publisher
    ..3, validated previous candidate associations for the GSTM1 deletion (P = 4 × 10?¹¹) and a tag SNP for NAT2 acetylation status (P = 4 × 10?¹¹), and found interactions with smoking in both regions...

Detail Information

Publications63

  1. Jiao L, Doll M, Hein D, Bondy M, Hassan M, Hixson J, et al. Haplotype of N-acetyltransferase 1 and 2 and risk of pancreatic cancer. Cancer Epidemiol Biomarkers Prev. 2007;16:2379-86 pubmed
    We examined the association between N-acetyltransferase 1 and 2 (NAT1 and NAT2) haplotype and risk of pancreatic cancer by genotyping eight NAT1 and seven NAT2 single nucleotide polymorphisms in 532 patients and in 581 healthy controls (..
  2. Hein D, Grant D, Sim E. Update on consensus arylamine N-acetyltransferase gene nomenclature. Pharmacogenetics. 2000;10:291-2 pubmed
  3. Kelly S, Sim E. Arylamine N-acetyltransferase in Balb/c mice: identification of a novel mouse isoenzyme by cloning and expression in vitro. Biochem J. 1994;302 ( Pt 2):347-53 pubmed
    ..The products of all three genes are demonstrated to catalyse acetylation of aminofluorene and anisidine following expression in Escherichia coli. ..
  4. Cornish V, Pinter K, Boukouvala S, Johnson N, Labrousse C, Payton M, et al. Generation and analysis of mice with a targeted disruption of the arylamine N-acetyltransferase type 2 gene. Pharmacogenomics J. 2003;3:169-77 pubmed
    ..represent inbuilt redundancy or whether they have unique roles, we have generated mice with a null allele of Nat2 by gene targeting...
  5. Doll M, Hein D. Cloning, sequencing and expression of NAT1 and NAT2 encoding genes from rapid and slow acetylator inbred rats. Pharmacogenetics. 1995;5:247-51 pubmed
  6. Hein D, Bendaly J, Neale J, Doll M. Systemic functional expression of N-acetyltransferase polymorphism in the F344 Nat2 congenic rat. Drug Metab Dispos. 2008;36:2452-9 pubmed publisher
    Rat lines congenic for the rat N-acetyltransferase 2 [(RAT)Nat2] gene were constructed and characterized. F344 (homozygous Nat2 rapid) males were mated to Wistar Kyoto (homozygous Nat2 slow) females to produce heterozygous F1...
  7. Bandmann O, Vaughan J, Holmans P, Marsden C, Wood N. Association of slow acetylator genotype for N-acetyltransferase 2 with familial Parkinson's disease. Lancet. 1997;350:1136-9 pubmed
    ..Further studies are needed to investigate the biological relevance of these findings, but slow acetylation could lead to impaired ability of patients with familial PD to handle neurotoxic substances. ..
  8. Sobti R, Kaur P, Kaur S, Janmeja A, Jindal S, Kishan J, et al. Impact of interaction of polymorphic forms of p53 codon 72 and N-acetylation gene (NAT2) on the risk of lung cancer in the North Indian population. DNA Cell Biol. 2009;28:443-9 pubmed publisher
    ..We studied the influence of NAT2 and codon 72 p53 polymorphisms on 151 patients with lung cancer and an equal number of matched population controls...
  9. Nacak M, Erbagci Z, Aynacioglu A. Human arylamine N-acetyltransferase 2 polymorphism and susceptibility to allergic contact dermatitis. Int J Dermatol. 2006;45:323-6 pubmed
    N-acetyltransferase 2 (NAT2) polymorphism may be involved in the pathogenesis of allergic contact dermatitis...
  10. Rothman N, Garcia Closas M, Chatterjee N, Malats N, Wu X, Figueroa J, et al. A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. Nat Genet. 2010;42:978-84 pubmed publisher
    ..3, validated previous candidate associations for the GSTM1 deletion (P = 4 × 10?¹¹) and a tag SNP for NAT2 acetylation status (P = 4 × 10?¹¹), and found interactions with smoking in both regions...
  11. Gra O, Kozhekbaeva Z, Litvinov V. [Analysis of genetic predisposition to pulmonary tuberculosis in native Russians]. Genetika. 2010;46:262-71 pubmed
    ..of TB development, the frequencies of polymorphisms of genes CYP1A1, CYP2D6, CYP2C9, CYP2C 19, GSTT1, GSTM1, NAT2, MDR1, and NRAMP1 in 73 TB patients and 352 healthy individuals were determined by allele-specific hybridization ..
  12. von Schmiedeberg S, Fritsche E, Rönnau A, Specker C, Golka K, Richter Hintz D, et al. Polymorphisms of the xenobiotic-metabolizing enzymes CYP1A1 and NAT-2 in systemic sclerosis and lupus erythematosus. Adv Exp Med Biol. 1999;455:147-52 pubmed
    ..Thus, enhanced formation of reactive metabolites could alter self-proteins presented to the immune system thus stimulating autoreactive T cells which induce autoimmunity. ..
  13. Wadelius M, Stjernberg E, Wiholm B, Rane A. Polymorphisms of NAT2 in relation to sulphasalazine-induced agranulocytosis. Pharmacogenetics. 2000;10:35-41 pubmed
    ..The polymorphic enzyme N-acetyltransferase 2 (NAT2) plays an important role in the metabolism of sulphasalazine...
  14. Viktorova T, Korytina G, Makarova O, Ianbaeva D, Iakupova E, Khusnutdinova E. [Analysis of the N-acetyltransferase 2 gene polymorphism in the patients with chronic obstructive pulmonary disease and in populations of the Volga-Ural region]. Genetika. 2003;39:855-7 pubmed
    Restriction fragment-length polymorphism of the gene coding for N-acetyltransferase 2 (NAT2) was typed in populations of the Volga-Ural region (Bashkirs, Tatars, Chuvashes, Udmurts, and Russians) as well as in patients with chronic ..
  15. Majumder M, Sikdar N, Ghosh S, Roy B. Polymorphisms at XPD and XRCC1 DNA repair loci and increased risk of oral leukoplakia and cancer among NAT2 slow acetylators. Int J Cancer. 2007;120:2148-56 pubmed
    Polymorphisms at N-acetyl transferase 2 locus (NAT2) lead to slow, intermediate and rapid acetylation properties of the enzyme. Improper acetylation of heterocyclic and aromatic amines, present in tobacco, might cause DNA adduct formation...
  16. Walraven J, Barker D, Doll M, Hein D. Tissue expression and genomic sequences of rat N-acetyltransferases rNat1, rNat2, rNat3, and Functional characterization of a novel rNat3*2 genetic variant. Toxicol Sci. 2007;99:413-21 pubmed
    Human arylamine N-acetyltransferases NAT1 and NAT2 are highly polymorphic genes that modify individual susceptibility to cancers caused by exposure to arylamine procarcinogens...
  17. Unal M, Tamer L, Dogruer Z, Yildirim H, Vayisoglu Y, Camdeviren H. N-acetyltransferase 2 gene polymorphism and presbycusis. Laryngoscope. 2005;115:2238-41 pubmed
    ..The effect of aging shows a wide interindividual range; we aimed to investigate whether profiles of NAT2 genotypes may be associated with the risk of presbycusis.
  18. Hirvonen A, Saarikoski S, Linnainmaa K, Koskinen K, Husgafvel Pursiainen K, Mattson K, et al. Glutathione S-transferase and N-acetyltransferase genotypes and asbestos-associated pulmonary disorders. J Natl Cancer Inst. 1996;88:1853-6 pubmed
    ..e., both copies lost) of these genes can be detected. Polymorphism of the NAT2 gene results in slow and fast acetylators of potentially toxic substances...
  19. Tamer L, Yilmaz A, Yildirim H, Ayaz L, Ates N, Karakas S, et al. N-acetyltransferase 2 phenotype may be associated with susceptibility to age-related cataract. Curr Eye Res. 2005;30:835-9 pubmed
    ..Genotyping of NAT2 polymorphisms were detected by using a LightCycler-NAT2 mutation detection kit in real-time PCR...
  20. Brocvielle H, Muret P, Goydadin A, Boone P, Broly F, Kantelip J, et al. N-acetyltransferase 2 acetylation polymorphism: prevalence of slow acetylators does not differ between atopic dermatitis patients and healthy subjects. Skin Pharmacol Appl Skin Physiol. 2003;16:386-92 pubmed
    The genetic polymorphism of human N-acetyltransferase 2 (NAT2) divides the human population into groups with rapid, intermediate and slow acetylator status...
  21. Jefferson F, Xiao G, Hein D. 4-Aminobiphenyl downregulation of NAT2 acetylator genotype-dependent N- and O-acetylation of aromatic and heterocyclic amine carcinogens in primary mammary epithelial cell cultures from rapid and slow acetylator rats. Toxicol Sci. 2009;107:293-7 pubmed publisher
    ..N-acetyltransferase 1 (NAT1) and N-acetyltransferase 2 (NAT2) enzymes have important roles in their metabolic activation and deactivation...
  22. Kamel A, Ebid G, Moussa H. N-Acetyltransferase 2 (NAT2) polymorphism as a risk modifier of susceptibility to pediatric acute lymphoblastic leukemia. Tumour Biol. 2015;36:6341-8 pubmed publisher
    N-Acetyltransferases (NAT) have been known to modify the risk to a variety of solid tumors. However, the role of NAT2 polymorphism in risk susceptibility to childhood acute lymphoblastic leukemia (ALL) is still not well known...
  23. Silveira V, Canalle R, Scrideli C, Queiroz R, Lopes L, Tone L. CYP3A5 and NAT2 gene polymorphisms: role in childhood acute lymphoblastic leukemia risk and treatment outcome. Mol Cell Biochem. 2012;364:217-23 pubmed publisher
    ..This study aimed to evaluate the impact of the CYP3A5 and NAT2 metabolizing enzyme polymorphisms on the risk of childhood acute lymphoblastic leukemia...
  24. Stepp M, Doll M, Samuelson D, Sanders M, States J, Hein D. Congenic rats with higher arylamine N-acetyltransferase 2 activity exhibit greater carcinogen-induced mammary tumor susceptibility independent of carcinogen metabolism. BMC Cancer. 2017;17:233 pubmed publisher
    Recent investigations suggest role(s) of human arylamine N-acetyltransferase 1 (NAT1) in breast cancer. Rat NAT2 is orthologous to human NAT1 and the gene products are functional homologs. We conducted in vivo studies using F344...
  25. Lu C, Chung M, Huang C, Ko Y. Interaction effect in bladder cancer between N-acetyltransferase 2 genotype and alcohol drinking. Urol Int. 2005;75:360-4 pubmed
    Cigarette smoking, aromatic amines and ionizing radiation are known carcinogens of bladder cancer. NAT2 genotype might play a role in bladder cancer carcinogenesis...
  26. Li X, Wang X, Li Y, Yuan M, Zhu J, Su X, et al. Effect of exposure to acute and chronic high-altitude hypoxia on the activity and expression of CYP1A2, CYP2D6, CYP2C9, CYP2C19 and NAT2 in rats. Pharmacology. 2014;93:76-83 pubmed publisher
    ..chronic high-altitude hypoxia (AHH and CHH) on the activity and expression of CYP1A2, CYP2D6, CYP2C9, CYP2C19 and NAT2 in rats...
  27. Tamer L, Tursen U, Eskandari G, Ates N, Ercan B, Yildirim H, et al. N-acetyltransferase 2 polymorphisms in patients with Behcet's disease. Clin Exp Dermatol. 2005;30:56-60 pubmed
    ..induce an autoimmune mechanism, the aim of the present study was to investigate whether the genetic polymorphism of NAT2 plays a role in susceptibility to Behcet's disease...
  28. Ohtani T, Hiroi A, Sakurane M, Furukawa F. Slow acetylator genotypes as a possible risk factor for infectious mononucleosis-like syndrome induced by salazosulfapyridine. Br J Dermatol. 2003;148:1035-9 pubmed
    ..SASP is known to be mainly metabolized by N-acetyltransferase 2 (NAT2), and acetylation phenotypes (rapid, intermediate and slow acetylator) correlate with NAT2* genotypes...
  29. Ebisawa T, Sasaki Y, Deguchi T. Complementary DNAs for two arylamine N-acetyltransferases with identical 5' non-coding regions from rat pineal gland. Eur J Biochem. 1995;228:129-37 pubmed
  30. Dani M, Boisvert C, Michaud J, Naud J, Lefrancois S, Leblond F, et al. Down-regulation of liver drug-metabolizing enzymes in a murine model of chronic renal failure. Drug Metab Dispos. 2010;38:357-60 pubmed publisher
    ..is related to a decrease in liver cytochrome P450 (P450) and phase II enzymes, particularly N-acetyltransferase 2 (NAT2)...
  31. Kozhekbaeva Z, Gra O, Fadeev V, Goldenkova Pavlova I, Korsunskaia I, Bruskin S, et al. [Association of NAT2 polymorphism with risks to develop psoriasis and various dermatological diseases in Moscow population]. Mol Biol (Mosk). 2009;43:62-76 pubmed
    Ruacetyltransferase 2 (NAT2) is one of key enzymes of the second phase of biotransformation that metabolize genotoxic compounds such as carcinogens and mutagens in different types of cells...
  32. Rollinson S, Roddam P, Willett E, Roman E, Cartwright R, Jack A, et al. NAT2 acetylator genotypes confer no effect on the risk of developing adult acute leukemia: a case-control study. Cancer Epidemiol Biomarkers Prev. 2001;10:567-8 pubmed
  33. Ayaz L, Ercan B, Dirlik M, Atik U, Tamer L. The association between N-acetyltransferase 2 gene polymorphisms and pancreatic cancer. Cell Biochem Funct. 2008;26:329-33 pubmed
    ..N-acetyltransferase 1 (NAT1) and N-acetyltransferase 2 (NAT2) are expressed primarily in extrahepatic and hepatic tissues, respectively...
  34. Hein D, Leff M, Ishibe N, Sinha R, Frazier H, Doll M, et al. Association of prostate cancer with rapid N-acetyltransferase 1 (NAT1*10) in combination with slow N-acetyltransferase 2 acetylator genotypes in a pilot case-control study. Environ Mol Mutagen. 2002;40:161-7 pubmed
    N-acetyltransferase-1 (NAT1) and N-acetyltransferase-2 (NAT2) are important in the metabolism of aromatic and heterocyclic amine carcinogens that induce prostate tumors in the rat...
  35. Vatsis K, Weber W, Bell D, Dupret J, Evans D, Grant D, et al. Nomenclature for N-acetyltransferases. Pharmacogenetics. 1995;5:1-17 pubmed
    ..For designation of genotypes at a single NAT* locus, a slash serves to separate the alleles; in phenotype designations, which are not italicized, alleles are separated by a comma. ..
  36. Lemos M, Cabrita F, Silva H, Vivan M, Placido F, Regateiro F. Genetic polymorphism of CYP2D6, GSTM1 and NAT2 and susceptibility to haematological neoplasias. Carcinogenesis. 1999;20:1225-9 pubmed
    ..polymorphisms of cytochrome P450 2D6 (CYP2D6), glutathione S-transferase M1 (GSTM1) and N-acetyltransferase 2 (NAT2) and an altered risk for haematological neoplasias...
  37. Wakefield L, Cornish V, Broackes Carter F, Sim E. Arylamine N-acetyltransferase 2 expression in the developing heart. J Histochem Cytochem. 2005;53:583-92 pubmed
    Murine arylamine N-acetyltransferase 2 (NAT2) is expressed in the developing heart and in the neural tube at the time of closure...
  38. Barker D, Walraven J, Ristagno E, Doll M, States J, Hein D. Quantitative tissue and gene-specific differences and developmental changes in Nat1, Nat2, and Nat3 mRNA expression in the rat. Drug Metab Dispos. 2008;36:2445-51 pubmed publisher
    Human N-acetyltransferase 1 (NAT1) and 2 (NAT2) are important phase II enzymes involved in the biotransformation of xenobiotics...
  39. Suzuki H, Morris J, Li Y, Doll M, Hein D, Liu J, et al. Interaction of the cytochrome P4501A2, SULT1A1 and NAT gene polymorphisms with smoking and dietary mutagen intake in modification of the risk of pancreatic cancer. Carcinogenesis. 2008;29:1184-91 pubmed publisher
    ..Cytochrome P450 (CYP) 1A2, N-acetyltransferase (NAT) 1, NAT2 and sulfotransferase (SULT) are enzymes involved in the metabolism of these carcinogens...
  40. Potts L, Cambon A, Ross O, Rademakers R, Dickson D, Uitti R, et al. Polymorphic genes of detoxification and mitochondrial enzymes and risk for progressive supranuclear palsy: a case control study. BMC Med Genet. 2012;13:16 pubmed publisher
    ..oxidative stress response, including debrisoquine 4-hydroxylase, paraoxonase 1 and 2, N-acetyltransferase 1 and 2 (NAT2), superoxide dismutase 1 and 2, and PTEN-induced putative kinase are associated with PSP...
  41. Kim J, Park B, Park S, Lee S, Kim M, Jung S, et al. Association analysis of N-acetyl transferase-2 polymorphisms with aspirin intolerance among asthmatics. Pharmacogenomics. 2010;11:951-8 pubmed publisher
    ..In total, 14 polymorphisms of the NAT2 gene were genotyped by a single-base extension method...
  42. Higuchi N, Tahara N, Yanagihara K, Fukushima K, Suyama N, Inoue Y, et al. NAT2 6A, a haplotype of the N-acetyltransferase 2 gene, is an important biomarker for risk of anti-tuberculosis drug-induced hepatotoxicity in Japanese patients with tuberculosis. World J Gastroenterol. 2007;13:6003-8 pubmed
    To investigate an association between N-acetyltransferase 2 (NAT2)-haplotypes/diplotypes and adverse effects in Japanese pulmonary tuberculosis patients. We studied 100 patients with pulmonary TB treated with anti-TB drugs including INH...
  43. Zhang X, Lambert J, Doll M, Walraven J, Arteel G, Hein D. 4,4'-methylenedianiline-induced hepatotoxicity is modified by N-acetyltransferase 2 (NAT2) acetylator polymorphism in the rat. J Pharmacol Exp Ther. 2006;316:289-94 pubmed
    ..MDA undergoes N-acetylation catalyzed by N-acetyltransferase 1 (NAT1) and 2 (NAT2) in the liver...
  44. Belogubova E, Kuligina E, Togo A, Karpova M, Ulibina J, Shutkin V, et al. 'Comparison of extremes' approach provides evidence against the modifying role of NAT2 polymorphism in lung cancer susceptibility. Cancer Lett. 2005;221:177-83 pubmed
    b>NAT2 (arylamine N-acetyltransferase 2) polymorphism, being a key determinant of individual variations in acetylation capacity, is suspected to modify the risk of carcinogen-related malignancies...
  45. Tamer L, Calikoglu M, Aras Ateş N, Yildirim H, Karakas S, Atik U. Relationship between N-acetyl transferase-2 gene polymorphism and risk of bronchial asthma. Tuberk Toraks. 2006;54:137-43 pubmed
    ..The aim of the present study was to investigate further whether the genetic polymorphism of the NAT2 plays a role in susceptibility to bronchial asthma disease...
  46. Yalin S, Hatungil R, Tamer L, Ates N, Dogruer N, Yildirim H, et al. N-acetyltransferase 2 polymorphism in patients with diabetes mellitus. Cell Biochem Funct. 2007;25:407-11 pubmed
    ..06; 95%CI: 10.55-209.77 for NAT 2*5A, OR = 18.48; 95%CI: 3.83-89.11 for NAT2*6A and OR = 18.22; 95%CI: 6.29-52.76 for NAT2*14A)...
  47. Neri M, Filiberti R, Taioli E, Garte S, Paracchini V, Bolognesi C, et al. Pleural malignant mesothelioma, genetic susceptibility and asbestos exposure. Mutat Res. 2005;592:36-44 pubmed
    ..The role of mEH, GSTM1, GSTT1, NAT2, and CYP1A1 genotypes in modulating susceptibility to MM was examined in a case-control study of 80 subjects with a ..
  48. Arif E, Vibhuti A, Alam P, Deepak D, Singh B, Athar M, et al. Association of CYP2E1 and NAT2 gene polymorphisms with chronic obstructive pulmonary disease. Clin Chim Acta. 2007;382:37-42 pubmed
    ..We conducted a case-control study to investigate total 9 polymorphisms of CYP2E1, CYP2D6 and NAT2 genes by PCR-RFLP...
  49. Purewal M, Velasco M, Fretland A, Hein D, Wargovich M. 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine induces a higher number of aberrant crypt foci in Fischer 344 (rapid) than in Wistar Kyoto (slow) acetylator inbred rats. Cancer Epidemiol Biomarkers Prev. 2000;9:529-32 pubmed
    ..N-Acetyltransferase-2 (NAT2) catalyzes the conversion of PhIP and other heterocyclic amines to a DNA-reactive form...
  50. Sabbagh N, Delaporte E, Marez D, Lo Guidice J, Piette F, Broly F. NAT2 genotyping and efficacy of sulfasalazine in patients with chronic discoid lupus erythematosus. Pharmacogenetics. 1997;7:131-5 pubmed
    ..in metabolism of the drug which is extensively acetylated by the polymorphic enzyme N-acetyltransferase 2 (NAT2)...
  51. Pronko P, Järveläinen H, Lindros K. Acinar distribution of rat liver arylamine N-acetyltransferase: effect of chronic ethanol and endotoxin exposure. Pharmacol Toxicol. 2002;90:150-4 pubmed
  52. Zanrosso C, Emerenciano M, Faro A, Gonçalves B, Mansur M, Pombo de Oliveira M. Genetic variability in N-acetyltransferase 2 gene determines susceptibility to childhood lymphoid or myeloid leukemia in Brazil. Leuk Lymphoma. 2012;53:323-7 pubmed publisher
    ..Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals. N-acetyltransferase 2 (NAT2) SNP 341T > C frequency was higher among both leukemia subtypes compared to controls...
  53. Dai Y, Leng S, Li L, Niu Y, Huang H, Liu Q, et al. Effects of genetic polymorphisms of N-Acetyltransferase on trichloroethylene-induced hypersensitivity dermatitis among exposed workers. Ind Health. 2009;47:479-86 pubmed
    ..fragment length polymorphism was used to detect the polymorphic sites of NAT1 at nt 1095 and 1088 and the sites of NAT2 at nt 481, 590, and 857...
  54. Prawan A, Kukongviriyapan V, Tassaneeyakul W, Pairojkul C, Bhudhisawasdi V. Association between genetic polymorphisms of CYP1A2, arylamine N-acetyltransferase 1 and 2 and susceptibility to cholangiocarcinoma. Eur J Cancer Prev. 2005;14:245-50 pubmed
    ..The present study aimed to evaluate the relationship between CYP1A2, NAT1 and NAT2 polymorphisms and cholangiocarcinoma (CCA), the most prevalent cancer in the north-east of Thailand...
  55. Grundmann M, Earl C, Sautter J, Henze C, Oertel W, Bandmann O. Slow N-acetyltransferase 2 status leads to enhanced intrastriatal dopamine depletion in 6-hydroxydopamine-lesioned rats. Exp Neurol. 2004;187:199-202 pubmed
    We previously reported an association between the N-acetyltransferase 2 (NAT2) slow acetylator status and Parkinson's disease (PD)...
  56. Chatzimichalis M, Xenellis J, Tzagaroulakis A, Sarof P, Banis K, Gazouli M, et al. GSTT1, GSTM1, GSTM3 and NAT2 polymorphisms in laryngeal squamous cell carcinoma in a Greek population. J Laryngol Otol. 2010;124:318-23 pubmed publisher
    ..Frequencies of the genotypes GSTT1, GSTM1, GSTM3 and NAT2 were evaluated by polymerase chain reaction restriction fragment polymorphism...
  57. Ozawa S, Katoh T, Inatomi H, Imai H, Kuroda Y, Ichiba M, et al. Association of genotypes of carcinogen-activating enzymes, phenol sulfotransferase SULT1A1 (ST1A3) and arylamine N-acetyltransferase NAT2, with urothelial cancer in a Japanese population. Int J Cancer. 2002;102:418-21 pubmed
    ..and O-acetylation by phenol sulfating sulfotransferase, ST1A3 (SULT1A1), and arylamine N-acetyltransferase, NAT2, respectively...
  58. Zanrosso C, Emerenciano M, Gonçalves B, Faro A, Koifman S, Pombo de Oliveira M. N-acetyltransferase 2 polymorphisms and susceptibility to infant leukemia with maternal exposure to dipyrone during pregnancy. Cancer Epidemiol Biomarkers Prev. 2010;19:3037-43 pubmed publisher
    ..N-Acetyltransferase 2 (NAT2) enzyme acetylates dipyrone, resulting in a detoxified metabolite...
  59. Makarova S, Dodunova E, Ivanova G, Vavilin V, Kaznacheeva L, Lyakhovich V. Polymorphism of arylamine-N-acetyltransferase 2 gene is associated with the risk of atopic dermatitis. Bull Exp Biol Med. 2005;139:662-4 pubmed
    ..Double heterozygote 481C/T and 590G/A in girls is a factor of resistance to atopic dermatitis, especially in the absence of smoking-related effects. ..
  60. Jones R, Land S, King C. Recombinant rat and hamster N-acetyltransferases-1 and -2: relative rates of N-acetylation of arylamines and N,O-acyltransfer with arylhydroxamic acids. Carcinogenesis. 1996;17:1729-33 pubmed
    Genes for the 290 amino acid, 33-34 kDa cytosolic acetyltransferases (NAT1* and NAT2*) from rat and hamster were cloned and expressed in Escherichia coli...
  61. Wakefield L, Long H, Lack N, Sim E. Ocular defects associated with a null mutation in the mouse arylamine N-acetyltransferase 2 gene. Mamm Genome. 2007;18:270-6 pubmed
    The xenobiotic metabolizing enzyme, mouse arylamine N-acetyltransferase type 2 (Nat2), is expressed during embryogenesis from the blastocyst stage and in the developing neural tube and eye...
  62. Korpinen E, Groop P, Rautio A, Madacsy L, Reunanen A, Vaarala O, et al. N-acetyltransferase-2 polymorphism, smoking and type 1 diabetic nephropathy. Pharmacogenetics. 1999;9:627-33 pubmed
    The N-acetyltransferase (NAT2) polymorphism has been suggested to be related to diabetic microvascular complications...
  63. Unal M, Tamer L, Akbas Y, Pata Y, Vayisoglu Y, Degirmenci U, et al. Genetic polymorphism of N-acetyltransferase 2 in the susceptibility to laryngeal squamous cell carcinoma. Head Neck. 2005;27:1056-60 pubmed
    The purpose of this study was to investigate whether polymorphism of N-acetyltransferase 2 (NAT2) genotypes are associated with the risk of laryngeal squamous cell carcinoma (SCC)...