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Genomes and Genes | Nat2SummaryGene Symbol: Nat2 Description: N-acetyltransferase 2 Alias: Nat2a, AT-2, N-Acetyltransferase-2 (arylamine N-acetyltransferase), N-acetyltransferase 2 (arylamine N-acetyltransferase), N-acetyltransferase type 2, NAT-2, arylamide acetylase 2, arylamine N-acetyltransferase 2 Species: rat Top Publications
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Publications
Association of prostate cancer with rapid N-acetyltransferase 1 (NAT1*10) in combination with slow N-acetyltransferase 2 acetylator genotypes in a pilot case-control studyDavid W Hein
Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
Environ Mol Mutagen 40:161-7. 2002N-acetyltransferase-1 (NAT1) and N-acetyltransferase-2 (NAT2) are important in the metabolism of aromatic and heterocyclic amine carcinogens that induce prostate tumors in the rat...
Haplotype of N-acetyltransferase 1 and 2 and risk of pancreatic cancerLi Jiao
Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Cancer Epidemiol Biomarkers Prev 16:2379-86. 2007We examined the association between N-acetyltransferase 1 and 2 (NAT1 and NAT2) haplotype and risk of pancreatic cancer by genotyping eight NAT1 and seven NAT2 single nucleotide polymorphisms in 532 patients and in 581 healthy controls (..- Relationship between N-acetyl transferase-2 gene polymorphism and risk of bronchial asthmaLulufer Tamer
Department of Biochemistry, Faculty of Medicine, Mersin University, Mersin, Turkey
Tuberk Toraks 54:137-43. 2006..The aim of the present study was to investigate further whether the genetic polymorphism of the NAT2 plays a role in susceptibility to bronchial asthma disease... - Association of CYP2E1 and NAT2 gene polymorphisms with chronic obstructive pulmonary diseaseEhtesham Arif
Functional Genomics Unit, Institute of Genomics and Integrative Biology, Delhi, India
Clin Chim Acta 382:37-42. 2007..Detoxification genes are potential candidates in the susceptibility of patients with chronic obstructive pulmonary disease. Polymorphisms in these genes alter the metabolism of xenobiotics such as present in cigarette smoke... - Tissue expression and genomic sequences of rat N-acetyltransferases rNat1, rNat2, rNat3, and Functional characterization of a novel rNat3*2 genetic variantJason M Walraven
Department of Pharmacology and Toxicology and James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
Toxicol Sci 99:413-21. 2007Human arylamine N-acetyltransferases NAT1 and NAT2 are highly polymorphic genes that modify individual susceptibility to cancers caused by exposure to arylamine procarcinogens... - Interaction of the cytochrome P4501A2, SULT1A1 and NAT gene polymorphisms with smoking and dietary mutagen intake in modification of the risk of pancreatic cancerHideo Suzuki
Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Carcinogenesis 29:1184-91. 2008..Cytochrome P450 (CYP) 1A2, N-acetyltransferase (NAT) 1, NAT2 and sulfotransferase (SULT) are enzymes involved in the metabolism of these carcinogens... - Nomenclature for N-acetyltransferasesK P Vatsis
Department of Pharmacology, Medical School, University of Michigan, Ann Arbor 48109 0632, USA
Pharmacogenetics 5:1-17. 1995..For designation of genotypes at a single NAT* locus, a slash serves to separate the alleles; in phenotype designations, which are not italicized, alleles are separated by a comma... - Systemic functional expression of N-acetyltransferase polymorphism in the F344 Nat2 congenic ratDavid W Hein
Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40292, USA
Drug Metab Dispos 36:2452-9. 2008Rat lines congenic for the rat N-acetyltransferase 2 [(RAT)Nat2] gene were constructed and characterized. F344 (homozygous Nat2 rapid) males were mated to Wistar Kyoto (homozygous Nat2 slow) females to produce heterozygous F1... - Quantitative tissue and gene-specific differences and developmental changes in Nat1, Nat2, and Nat3 mRNA expression in the ratDavid F Barker
Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40292, USA
Drug Metab Dispos 36:2445-51. 2008Human N-acetyltransferase 1 (NAT1) and 2 (NAT2) are important phase II enzymes involved in the biotransformation of xenobiotics... - 4-Aminobiphenyl downregulation of NAT2 acetylator genotype-dependent N- and O-acetylation of aromatic and heterocyclic amine carcinogens in primary mammary epithelial cell cultures from rapid and slow acetylator ratsFelicia A Jefferson
Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
Toxicol Sci 107:293-7. 2009..N-acetyltransferase 1 (NAT1) and N-acetyltransferase 2 (NAT2) enzymes have important roles in their metabolic activation and deactivation... 
Impact of interaction of polymorphic forms of p53 codon 72 and N-acetylation gene (NAT2) on the risk of lung cancer in the North Indian populationRanbir C Sobti
Department of Biotechnology, Panjab University, Chandigarh, India
DNA Cell Biol 28:443-9. 2009..We studied the influence of NAT2 and codon 72 p53 polymorphisms on 151 patients with lung cancer and an equal number of matched population controls...- GSTT1, GSTM1, GSTM3 and NAT2 polymorphisms in laryngeal squamous cell carcinoma in a Greek populationM Chatzimichalis
Department of Otolaryngology Head and Neck Surgery, METAXA Anticancer Hospital, Piraeus, Greece
J Laryngol Otol 124:318-23. 2010..Accumulating evidence suggests that alterations of detoxification enzymes, such as glutathione S-transferases and N-acetyltransferases, influence the risk of cancers associated with tobacco smoke and alcohol... - N-acetyltransferase 2 polymorphism in patients with diabetes mellitusSerap Yalin
Mersin University Pharmacy School, Department of Biochemistry, Mersin, Turkey
Cell Biochem Funct 25:407-11. 2007..06; 95%CI: 10.55-209.77 for NAT 2*5A, OR = 18.48; 95%CI: 3.83-89.11 for NAT2*6A and OR = 18.22; 95%CI: 6.29-52.76 for NAT2*14A)... - 4,4'-methylenedianiline-induced hepatotoxicity is modified by N-acetyltransferase 2 (NAT2) acetylator polymorphism in the ratXiaoyan Zhang
Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40292, USA
J Pharmacol Exp Ther 316:289-94. 2006..MDA undergoes N-acetylation catalyzed by N-acetyltransferase 1 (NAT1) and 2 (NAT2) in the liver... - Genetic polymorphism of N-acetyltransferase 2 in the susceptibility to laryngeal squamous cell carcinomaMurat Unal
Mersin Universitesi Tip Fakultesi Hastanesi, KBB Anabilim Dali, Zeytinlibahce Cad, 33079, Mersin, Turkey
Head Neck 27:1056-60. 2005The purpose of this study was to investigate whether polymorphism of N-acetyltransferase 2 (NAT2) genotypes are associated with the risk of laryngeal squamous cell carcinoma (SCC). - Complementary DNAs for two arylamine N-acetyltransferases with identical 5' non-coding regions from rat pineal glandT Ebisawa
Department of Molecular Neurobiology, Tokyo Metropolitan Institute for Neuroscience, Japan
Eur J Biochem 228:129-37. 1995.... - Cloning, sequencing and expression of NAT1 and NAT2 encoding genes from rapid and slow acetylator inbred ratsM A Doll
Department of Pharmacology and Toxicology, University of North Dakota School of Medicine, Grand Forks 58202-9037, USA
Pharmacogenetics 5:247-51. 1995 - Recombinant rat and hamster N-acetyltransferases-1 and -2: relative rates of N-acetylation of arylamines and N,O-acyltransfer with arylhydroxamic acidsR F Jones
Molecular and Chemical Carcinogenesis Program, Karmanos Cancer Institute, Wayne State University College of Medicine, Detroit, MI 48201, USA
Carcinogenesis 17:1729-33. 1996Genes for the 290 amino acid, 33-34 kDa cytosolic acetyltransferases (NAT1* and NAT2*) from rat and hamster were cloned and expressed in Escherichia coli... - Glutathione S-transferase and N-acetyltransferase genotypes and asbestos-associated pulmonary disordersA Hirvonen
Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Helsinki, Finland
J Natl Cancer Inst 88:1853-6. 1996..e., both copies lost) of these genes can be detected. Polymorphism of the NAT2 gene results in slow and fast acetylators of potentially toxic substances... - N-acetyltransferase-2 polymorphism, smoking and type 1 diabetic nephropathyE Korpinen
Hospital for Children and Adolescents, University of Helsinki, Finland
Pharmacogenetics 9:627-33. 1999The N-acetyltransferase (NAT2) polymorphism has been suggested to be related to diabetic microvascular complications... - 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine induces a higher number of aberrant crypt foci in Fischer 344 (rapid) than in Wistar Kyoto (slow) acetylator inbred ratsM Purewal
Department of Gastrointestinal Medical Oncology and Digestive Diseases, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
Cancer Epidemiol Biomarkers Prev 9:529-32. 2000..N-Acetyltransferase-2 (NAT2) catalyzes the conversion of PhIP and other heterocyclic amines to a DNA-reactive form... - Acinar distribution of rat liver arylamine N-acetyltransferase: effect of chronic ethanol and endotoxin exposurePavel S Pronko
Institute of Biochemistry, National Academy of Sciences of Belarus, Grodno
Pharmacol Toxicol 90:150-4. 2002.... - [Analysis of the N-acetyltransferase 2 gene polymorphism in the patients with chronic obstructive pulmonary disease and in populations of the Volga-Ural region]T V Viktorova
Institute of Biochemistry and Genetics, Russian Academy of Sciences, Ufa, 450054 Bashkortostan, Russia
Genetika 39:855-7. 2003Restriction fragment-length polymorphism of the gene coding for N-acetyltransferase 2 (NAT2) was typed in populations of the Volga-Ural region (Bashkirs, Tatars, Chuvashes, Udmurts, and Russians) as well as in patients with chronic .. - Slow N-acetyltransferase 2 status leads to enhanced intrastriatal dopamine depletion in 6-hydroxydopamine-lesioned ratsM Grundmann
Department of Neurology, Philipps University, Marburg, Germany
Exp Neurol 187:199-202. 2004We previously reported an association between the N-acetyltransferase 2 (NAT2) slow acetylator status and Parkinson's disease (PD)... - 'Comparison of extremes' approach provides evidence against the modifying role of NAT2 polymorphism in lung cancer susceptibilityEvgeniya V Belogubova
Group of Molecular Diagnostics, N N Petrov Institute of Oncology, Pesochny 2, St Petersburg 197758, Russian Federation
Cancer Lett 221:177-83. 2005b>NAT2 (arylamine N-acetyltransferase 2) polymorphism, being a key determinant of individual variations in acetylation capacity, is suspected to modify the risk of carcinogen-related malignancies... - Pleural malignant mesothelioma, genetic susceptibility and asbestos exposureMonica Neri
Unit of Epidemiology and Biostatistics, National Cancer Research Institute, Largo Rosanna Benzi 10, 16132 Genoa, Italy
Mutat Res 592:36-44. 2005..The role of mEH, GSTM1, GSTT1, NAT2, and CYP1A1 genotypes in modulating susceptibility to MM was examined in a case-control study of 80 subjects with a .. - Association analysis of N-acetyl transferase-2 polymorphisms with aspirin intolerance among asthmaticsJin Moo Kim
Genome Research Center for Allergy and Respiratory disease, Soonchunhyang University Bucheon Hospital, 1174 Jung dong, Wonmi gu, Bucheon, Gyeonggi do 420 767, Republic of Korea
Pharmacogenomics 11:951-8. 2010..Cysteinyl leukotrienes are inactivated by acetyl coenzyme A-dependent N-acetyltransferase (NAT). Thus, functional alterations of the NAT gene may contribute to the risk of aspirin-intolerant asthma...
Research Grants
- UofL Environmental Health Sciences Training ProgramDavid Hein; Fiscal Year: 2007..The University of Louisville has increased its commitment to health science research and infrastructure, graduate education, and minority recruitment, making this training program particularly timely. ..
- PHARMACOGENETICS OF DRUG AND CARCINOGEN METABOLISMDavid Hein; Fiscal Year: 2007..breast cancer in those individuals with rapid and/or slow acetylator N-acetyltransferase- 1 (NAT1) and - 2 (NAT2) acetylator genotypes...
- PHARMACOGENETICS OF DRUG AND CARCINOGEN METABOLISMDavid Hein; Fiscal Year: 2001..characterized over the previous project period to test the hypothesis that rapid acetylator genotype (NAT1 and/or NAT2) is a risk factor for cancers of the breast, colon, and prostate...
- PHARMACOGENETICS OF DRUG AND CARCINOGEN METABOLISMDavid Hein; Fiscal Year: 2009..breast cancer in those individuals with rapid and/or slow acetylator N-acetyltransferase- 1 (NAT1) and - 2 (NAT2) acetylator genotypes...