Nat2

Summary

Gene Symbol: Nat2
Description: N-acetyltransferase 2
Alias: Nat2a, AT-2, N-Acetyltransferase-2 (arylamine N-acetyltransferase), N-acetyltransferase 2 (arylamine N-acetyltransferase), N-acetyltransferase type 2, NAT-2, arylamide acetylase 2, arylamine N-acetyltransferase 2
Species: rat

Top Publications

  1. ncbi Association of prostate cancer with rapid N-acetyltransferase 1 (NAT1*10) in combination with slow N-acetyltransferase 2 acetylator genotypes in a pilot case-control study
    David W Hein
    Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    Environ Mol Mutagen 40:161-7. 2002
  2. pmc Haplotype of N-acetyltransferase 1 and 2 and risk of pancreatic cancer
    Li Jiao
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 16:2379-86. 2007
  3. ncbi Relationship between N-acetyl transferase-2 gene polymorphism and risk of bronchial asthma
    Lulufer Tamer
    Department of Biochemistry, Faculty of Medicine, Mersin University, Mersin, Turkey
    Tuberk Toraks 54:137-43. 2006
  4. ncbi Association of CYP2E1 and NAT2 gene polymorphisms with chronic obstructive pulmonary disease
    Ehtesham Arif
    Functional Genomics Unit, Institute of Genomics and Integrative Biology, Delhi, India
    Clin Chim Acta 382:37-42. 2007
  5. pmc Tissue expression and genomic sequences of rat N-acetyltransferases rNat1, rNat2, rNat3, and Functional characterization of a novel rNat3*2 genetic variant
    Jason M Walraven
    Department of Pharmacology and Toxicology and James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    Toxicol Sci 99:413-21. 2007
  6. pmc Interaction of the cytochrome P4501A2, SULT1A1 and NAT gene polymorphisms with smoking and dietary mutagen intake in modification of the risk of pancreatic cancer
    Hideo Suzuki
    Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Carcinogenesis 29:1184-91. 2008
  7. ncbi Nomenclature for N-acetyltransferases
    K P Vatsis
    Department of Pharmacology, Medical School, University of Michigan, Ann Arbor 48109 0632, USA
    Pharmacogenetics 5:1-17. 1995
  8. pmc Systemic functional expression of N-acetyltransferase polymorphism in the F344 Nat2 congenic rat
    David W Hein
    Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Drug Metab Dispos 36:2452-9. 2008
  9. pmc Quantitative tissue and gene-specific differences and developmental changes in Nat1, Nat2, and Nat3 mRNA expression in the rat
    David F Barker
    Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Drug Metab Dispos 36:2445-51. 2008
  10. pmc 4-Aminobiphenyl downregulation of NAT2 acetylator genotype-dependent N- and O-acetylation of aromatic and heterocyclic amine carcinogens in primary mammary epithelial cell cultures from rapid and slow acetylator rats
    Felicia A Jefferson
    Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    Toxicol Sci 107:293-7. 2009

Scientific Experts

  • D W Hein
  • Lulufer Tamer
  • Ranbir C Sobti
  • M Unal
  • E Korpinen
  • S Yalin
  • L B Zavodnik
  • Mark A Doll
  • Jason M Walraven
  • David F Barker
  • Li Jiao
  • M Chatzimichalis
  • Jin Moo Kim
  • Felicia A Jefferson
  • Hideo Suzuki
  • Melissa L Bondy
  • Manal M Hassan
  • Donghui Li
  • James L Abbruzzese
  • Ehtesham Arif
  • Xiaoyan Zhang
  • Evgeniya V Belogubova
  • Monica Neri
  • M Grundmann
  • T V Viktorova
  • Pavel S Pronko
  • Byung Lae Park
  • Choon Sik Park
  • J Xenellis
  • Inseon S Choi
  • Se Min Park
  • Soo Taek Uh
  • Myung Ok Kim
  • Shin Hwa Lee
  • A Bibas
  • Sang Heon Cho
  • Hae Sim Park
  • A Tzagaroulakis
  • Yong Hoon Kim
  • M Purewal
  • P Sarof
  • K Banis
  • Mi Kyeong Kim
  • Byoung Whui Choi
  • M Gazouli
  • Eun Hee Lee
  • Hyoung Doo Shin
  • Jong Sook Park
  • Seok Jung
  • Hun Soo Chang
  • Jae Sung Choi
  • Gong H Xiao
  • Jun Liu
  • Elizabeth H Ristagno
  • Yanan Li
  • J Christopher States
  • Rena S Day
  • Jeffrey S Morris
  • Mohammad Athar
  • Bhawani Singh
  • Arpana Vibhuti
  • James E Hixson
  • Desh Deepak
  • Pervez Alam
  • M A Qadar Pasha
  • Jason C Lambert
  • Gavin E Arteel
  • Evgeny N Imyanitov
  • Pier Aldo Canessa
  • Riccardo Puntoni
  • Stefano Bonassi
  • Julia M Ulibina
  • Ingolf Cascorbi
  • Seymour Garte
  • Emanuela Taioli
  • Giovanni Paolo Ivaldi
  • Vladimir A Shutkin
  • Anna Verna
  • Katrin Popowski
  • Maria B Karpova
  • Igor Mosyagin
  • Rosangela Filiberti
  • Claudia Bolognesi
  • Ari Hirvonen
  • Ekatherina Sh Kuligina
  • Alexandr V Togo
  • Kaido P Hanson
  • Valentina Paracchini
  • Vincenzo Fontana
  • O Bandmann

Detail Information

Publications29

  1. ncbi Association of prostate cancer with rapid N-acetyltransferase 1 (NAT1*10) in combination with slow N-acetyltransferase 2 acetylator genotypes in a pilot case-control study
    David W Hein
    Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    Environ Mol Mutagen 40:161-7. 2002
    N-acetyltransferase-1 (NAT1) and N-acetyltransferase-2 (NAT2) are important in the metabolism of aromatic and heterocyclic amine carcinogens that induce prostate tumors in the rat...
  2. pmc Haplotype of N-acetyltransferase 1 and 2 and risk of pancreatic cancer
    Li Jiao
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 16:2379-86. 2007
    We examined the association between N-acetyltransferase 1 and 2 (NAT1 and NAT2) haplotype and risk of pancreatic cancer by genotyping eight NAT1 and seven NAT2 single nucleotide polymorphisms in 532 patients and in 581 healthy controls (..
  3. ncbi Relationship between N-acetyl transferase-2 gene polymorphism and risk of bronchial asthma
    Lulufer Tamer
    Department of Biochemistry, Faculty of Medicine, Mersin University, Mersin, Turkey
    Tuberk Toraks 54:137-43. 2006
    ..The aim of the present study was to investigate further whether the genetic polymorphism of the NAT2 plays a role in susceptibility to bronchial asthma disease...
  4. ncbi Association of CYP2E1 and NAT2 gene polymorphisms with chronic obstructive pulmonary disease
    Ehtesham Arif
    Functional Genomics Unit, Institute of Genomics and Integrative Biology, Delhi, India
    Clin Chim Acta 382:37-42. 2007
    ..Detoxification genes are potential candidates in the susceptibility of patients with chronic obstructive pulmonary disease. Polymorphisms in these genes alter the metabolism of xenobiotics such as present in cigarette smoke...
  5. pmc Tissue expression and genomic sequences of rat N-acetyltransferases rNat1, rNat2, rNat3, and Functional characterization of a novel rNat3*2 genetic variant
    Jason M Walraven
    Department of Pharmacology and Toxicology and James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    Toxicol Sci 99:413-21. 2007
    Human arylamine N-acetyltransferases NAT1 and NAT2 are highly polymorphic genes that modify individual susceptibility to cancers caused by exposure to arylamine procarcinogens...
  6. pmc Interaction of the cytochrome P4501A2, SULT1A1 and NAT gene polymorphisms with smoking and dietary mutagen intake in modification of the risk of pancreatic cancer
    Hideo Suzuki
    Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Carcinogenesis 29:1184-91. 2008
    ..Cytochrome P450 (CYP) 1A2, N-acetyltransferase (NAT) 1, NAT2 and sulfotransferase (SULT) are enzymes involved in the metabolism of these carcinogens...
  7. ncbi Nomenclature for N-acetyltransferases
    K P Vatsis
    Department of Pharmacology, Medical School, University of Michigan, Ann Arbor 48109 0632, USA
    Pharmacogenetics 5:1-17. 1995
    ..For designation of genotypes at a single NAT* locus, a slash serves to separate the alleles; in phenotype designations, which are not italicized, alleles are separated by a comma...
  8. pmc Systemic functional expression of N-acetyltransferase polymorphism in the F344 Nat2 congenic rat
    David W Hein
    Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Drug Metab Dispos 36:2452-9. 2008
    Rat lines congenic for the rat N-acetyltransferase 2 [(RAT)Nat2] gene were constructed and characterized. F344 (homozygous Nat2 rapid) males were mated to Wistar Kyoto (homozygous Nat2 slow) females to produce heterozygous F1...
  9. pmc Quantitative tissue and gene-specific differences and developmental changes in Nat1, Nat2, and Nat3 mRNA expression in the rat
    David F Barker
    Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Drug Metab Dispos 36:2445-51. 2008
    Human N-acetyltransferase 1 (NAT1) and 2 (NAT2) are important phase II enzymes involved in the biotransformation of xenobiotics...
  10. pmc 4-Aminobiphenyl downregulation of NAT2 acetylator genotype-dependent N- and O-acetylation of aromatic and heterocyclic amine carcinogens in primary mammary epithelial cell cultures from rapid and slow acetylator rats
    Felicia A Jefferson
    Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    Toxicol Sci 107:293-7. 2009
    ..N-acetyltransferase 1 (NAT1) and N-acetyltransferase 2 (NAT2) enzymes have important roles in their metabolic activation and deactivation...
  11. doi Impact of interaction of polymorphic forms of p53 codon 72 and N-acetylation gene (NAT2) on the risk of lung cancer in the North Indian population
    Ranbir C Sobti
    Department of Biotechnology, Panjab University, Chandigarh, India
    DNA Cell Biol 28:443-9. 2009
    ..We studied the influence of NAT2 and codon 72 p53 polymorphisms on 151 patients with lung cancer and an equal number of matched population controls...
  12. doi GSTT1, GSTM1, GSTM3 and NAT2 polymorphisms in laryngeal squamous cell carcinoma in a Greek population
    M Chatzimichalis
    Department of Otolaryngology Head and Neck Surgery, METAXA Anticancer Hospital, Piraeus, Greece
    J Laryngol Otol 124:318-23. 2010
    ..Accumulating evidence suggests that alterations of detoxification enzymes, such as glutathione S-transferases and N-acetyltransferases, influence the risk of cancers associated with tobacco smoke and alcohol...
  13. ncbi N-acetyltransferase 2 polymorphism in patients with diabetes mellitus
    Serap Yalin
    Mersin University Pharmacy School, Department of Biochemistry, Mersin, Turkey
    Cell Biochem Funct 25:407-11. 2007
    ..06; 95%CI: 10.55-209.77 for NAT 2*5A, OR = 18.48; 95%CI: 3.83-89.11 for NAT2*6A and OR = 18.22; 95%CI: 6.29-52.76 for NAT2*14A)...
  14. pmc 4,4'-methylenedianiline-induced hepatotoxicity is modified by N-acetyltransferase 2 (NAT2) acetylator polymorphism in the rat
    Xiaoyan Zhang
    Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    J Pharmacol Exp Ther 316:289-94. 2006
    ..MDA undergoes N-acetylation catalyzed by N-acetyltransferase 1 (NAT1) and 2 (NAT2) in the liver...
  15. ncbi Genetic polymorphism of N-acetyltransferase 2 in the susceptibility to laryngeal squamous cell carcinoma
    Murat Unal
    Mersin Universitesi Tip Fakultesi Hastanesi, KBB Anabilim Dali, Zeytinlibahce Cad, 33079, Mersin, Turkey
    Head Neck 27:1056-60. 2005
    The purpose of this study was to investigate whether polymorphism of N-acetyltransferase 2 (NAT2) genotypes are associated with the risk of laryngeal squamous cell carcinoma (SCC).
  16. ncbi Complementary DNAs for two arylamine N-acetyltransferases with identical 5' non-coding regions from rat pineal gland
    T Ebisawa
    Department of Molecular Neurobiology, Tokyo Metropolitan Institute for Neuroscience, Japan
    Eur J Biochem 228:129-37. 1995
    ....
  17. ncbi Cloning, sequencing and expression of NAT1 and NAT2 encoding genes from rapid and slow acetylator inbred rats
    M A Doll
    Department of Pharmacology and Toxicology, University of North Dakota School of Medicine, Grand Forks 58202 9037, USA
    Pharmacogenetics 5:247-51. 1995
  18. ncbi Recombinant rat and hamster N-acetyltransferases-1 and -2: relative rates of N-acetylation of arylamines and N,O-acyltransfer with arylhydroxamic acids
    R F Jones
    Molecular and Chemical Carcinogenesis Program, Karmanos Cancer Institute, Wayne State University College of Medicine, Detroit, MI 48201, USA
    Carcinogenesis 17:1729-33. 1996
    Genes for the 290 amino acid, 33-34 kDa cytosolic acetyltransferases (NAT1* and NAT2*) from rat and hamster were cloned and expressed in Escherichia coli...
  19. ncbi Glutathione S-transferase and N-acetyltransferase genotypes and asbestos-associated pulmonary disorders
    A Hirvonen
    Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Helsinki, Finland
    J Natl Cancer Inst 88:1853-6. 1996
    ..e., both copies lost) of these genes can be detected. Polymorphism of the NAT2 gene results in slow and fast acetylators of potentially toxic substances...
  20. ncbi N-acetyltransferase-2 polymorphism, smoking and type 1 diabetic nephropathy
    E Korpinen
    Hospital for Children and Adolescents, University of Helsinki, Finland
    Pharmacogenetics 9:627-33. 1999
    The N-acetyltransferase (NAT2) polymorphism has been suggested to be related to diabetic microvascular complications...
  21. ncbi 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine induces a higher number of aberrant crypt foci in Fischer 344 (rapid) than in Wistar Kyoto (slow) acetylator inbred rats
    M Purewal
    Department of Gastrointestinal Medical Oncology and Digestive Diseases, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Cancer Epidemiol Biomarkers Prev 9:529-32. 2000
    ..N-Acetyltransferase-2 (NAT2) catalyzes the conversion of PhIP and other heterocyclic amines to a DNA-reactive form...
  22. ncbi Acinar distribution of rat liver arylamine N-acetyltransferase: effect of chronic ethanol and endotoxin exposure
    Pavel S Pronko
    Institute of Biochemistry, National Academy of Sciences of Belarus, Grodno
    Pharmacol Toxicol 90:150-4. 2002
    ....
  23. ncbi [Analysis of the N-acetyltransferase 2 gene polymorphism in the patients with chronic obstructive pulmonary disease and in populations of the Volga-Ural region]
    T V Viktorova
    Institute of Biochemistry and Genetics, Russian Academy of Sciences, Ufa, 450054 Bashkortostan, Russia
    Genetika 39:855-7. 2003
    Restriction fragment-length polymorphism of the gene coding for N-acetyltransferase 2 (NAT2) was typed in populations of the Volga-Ural region (Bashkirs, Tatars, Chuvashes, Udmurts, and Russians) as well as in patients with chronic ..
  24. ncbi Slow N-acetyltransferase 2 status leads to enhanced intrastriatal dopamine depletion in 6-hydroxydopamine-lesioned rats
    M Grundmann
    Department of Neurology, Philipps University, Marburg, Germany
    Exp Neurol 187:199-202. 2004
    We previously reported an association between the N-acetyltransferase 2 (NAT2) slow acetylator status and Parkinson's disease (PD)...
  25. ncbi 'Comparison of extremes' approach provides evidence against the modifying role of NAT2 polymorphism in lung cancer susceptibility
    Evgeniya V Belogubova
    Group of Molecular Diagnostics, N N Petrov Institute of Oncology, Pesochny 2, St Petersburg 197758, Russian Federation
    Cancer Lett 221:177-83. 2005
    b>NAT2 (arylamine N-acetyltransferase 2) polymorphism, being a key determinant of individual variations in acetylation capacity, is suspected to modify the risk of carcinogen-related malignancies...
  26. ncbi Pleural malignant mesothelioma, genetic susceptibility and asbestos exposure
    Monica Neri
    Unit of Epidemiology and Biostatistics, National Cancer Research Institute, Largo Rosanna Benzi 10, 16132 Genoa, Italy
    Mutat Res 592:36-44. 2005
    ..The role of mEH, GSTM1, GSTT1, NAT2, and CYP1A1 genotypes in modulating susceptibility to MM was examined in a case-control study of 80 subjects with a ..
  27. doi Association analysis of N-acetyl transferase-2 polymorphisms with aspirin intolerance among asthmatics
    Jin Moo Kim
    Genome Research Center for Allergy and Respiratory disease, Soonchunhyang University Bucheon Hospital, 1174 Jung dong, Wonmi gu, Bucheon, Gyeonggi do 420 767, Republic of Korea
    Pharmacogenomics 11:951-8. 2010
    ..Cysteinyl leukotrienes are inactivated by acetyl coenzyme A-dependent N-acetyltransferase (NAT). Thus, functional alterations of the NAT gene may contribute to the risk of aspirin-intolerant asthma...

Research Grants20

  1. UofL Environmental Health Sciences Training Program
    David Hein; Fiscal Year: 2007
    ..The University of Louisville has increased its commitment to health science research and infrastructure, graduate education, and minority recruitment, making this training program particularly timely. ..
  2. PHARMACOGENETICS OF DRUG AND CARCINOGEN METABOLISM
    David Hein; Fiscal Year: 2007
    ..breast cancer in those individuals with rapid and/or slow acetylator N-acetyltransferase- 1 (NAT1) and - 2 (NAT2) acetylator genotypes...
  3. PHARMACOGENETICS OF DRUG AND CARCINOGEN METABOLISM
    David Hein; Fiscal Year: 2001
    ..characterized over the previous project period to test the hypothesis that rapid acetylator genotype (NAT1 and/or NAT2) is a risk factor for cancers of the breast, colon, and prostate...
  4. PHARMACOGENETICS OF DRUG AND CARCINOGEN METABOLISM
    David Hein; Fiscal Year: 2009
    ..breast cancer in those individuals with rapid and/or slow acetylator N-acetyltransferase- 1 (NAT1) and - 2 (NAT2) acetylator genotypes...