Gene Symbol: Nat1
Description: N-acetyltransferase 1
Alias: Nat, arylamine N-acetyltransferase 1, AT-1, N-acetyltransferase (arylamine N-acetyltransferase), N-acetyltransferase 1 (arylamine N-acetyltransferase), N-acetyltransferase type 1, NAT-1, arylamide acetylase 1
Species: rat
Products:     Nat1

Top Publications

  1. Jiao L, Doll M, Hein D, Bondy M, Hassan M, Hixson J, et al. Haplotype of N-acetyltransferase 1 and 2 and risk of pancreatic cancer. Cancer Epidemiol Biomarkers Prev. 2007;16:2379-86 pubmed
    We examined the association between N-acetyltransferase 1 and 2 (NAT1 and NAT2) haplotype and risk of pancreatic cancer by genotyping eight NAT1 and seven NAT2 single nucleotide polymorphisms in 532 patients and in 581 healthy controls (..
  2. Hein D, Grant D, Sim E. Update on consensus arylamine N-acetyltransferase gene nomenclature. Pharmacogenetics. 2000;10:291-2 pubmed
  3. Ebisawa T, Sasaki Y, Deguchi T. Complementary DNAs for two arylamine N-acetyltransferases with identical 5' non-coding regions from rat pineal gland. Eur J Biochem. 1995;228:129-37 pubmed
  4. Ayaz L, Ercan B, Dirlik M, Atik U, Tamer L. The association between N-acetyltransferase 2 gene polymorphisms and pancreatic cancer. Cell Biochem Funct. 2008;26:329-33 pubmed
    ..N-acetyltransferase 1 (NAT1) and N-acetyltransferase 2 (NAT2) are expressed primarily in extrahepatic and hepatic tissues, respectively...
  5. Vatsis K, Weber W, Bell D, Dupret J, Evans D, Grant D, et al. Nomenclature for N-acetyltransferases. Pharmacogenetics. 1995;5:1-17 pubmed
    ..The root symbol (NAT) specifically identifies the genes that code for the N-acetyltransferases, and NAT* loci encoding proteins with ..
  6. Barker D, Walraven J, Ristagno E, Doll M, States J, Hein D. Quantitative tissue and gene-specific differences and developmental changes in Nat1, Nat2, and Nat3 mRNA expression in the rat. Drug Metab Dispos. 2008;36:2445-51 pubmed publisher
    Human N-acetyltransferase 1 (NAT1) and 2 (NAT2) are important phase II enzymes involved in the biotransformation of xenobiotics...
  7. Shah G, Li J, Mooradian A. Novel translational repressor (NAT-1) expression is modified by thyroid state and age in brain and liver. Eur J Endocrinol. 1998;139:649-53 pubmed
    ..Comparison of the sequence to the GenBank data base showed almost 100% homology to mouse translational repressor (NAT-1) mRNA 3'-end...
  8. Wang G, Du Y, Tong J. [Circadian rhythms and light responses of clock gene and arylalkylamine N-acetyltransferase gene expressions in the pineal gland of rats]. Sheng Li Xue Bao. 2005;57:97-102 pubmed
    ..was to investigate the circadian rhythms and light responses of Clock gene and arylalkylamine N-acetyltransferase (NAT) gene expressions in the rat pineal gland under the 12 h-light : 12 h-dark cycle condition (LD) and constant ..
  9. Tamer L, Tursen U, Eskandari G, Ates N, Ercan B, Yildirim H, et al. N-acetyltransferase 2 polymorphisms in patients with Behcet's disease. Clin Exp Dermatol. 2005;30:56-60 pubmed
    ..As N-acetyltransferase (NAT) 2 is an important xenobiotic-metabolizing enzyme and theoretically the nonacetylated xenobiotics may induce an ..

More Information


  1. Hein D, Leff M, Ishibe N, Sinha R, Frazier H, Doll M, et al. Association of prostate cancer with rapid N-acetyltransferase 1 (NAT1*10) in combination with slow N-acetyltransferase 2 acetylator genotypes in a pilot case-control study. Environ Mol Mutagen. 2002;40:161-7 pubmed
    N-acetyltransferase-1 (NAT1) and N-acetyltransferase-2 (NAT2) are important in the metabolism of aromatic and heterocyclic amine carcinogens that induce prostate tumors in the rat...
  2. Kelly S, Sim E. Arylamine N-acetyltransferase in Balb/c mice: identification of a novel mouse isoenzyme by cloning and expression in vitro. Biochem J. 1994;302 ( Pt 2):347-53 pubmed
    ..Two of the genes corresponded to Nat-1 and Nat-2 which have been previously identified in A/J and C57B1/6 strains of mice (Martell et al., 1991)...
  3. Blomeke B, Brans R, Coenraads P, Dickel H, Bruckner T, Hein D, et al. Para-phenylenediamine and allergic sensitization: risk modification by N-acetyltransferase 1 and 2 genotypes. Br J Dermatol. 2009;161:1130-5 pubmed publisher
    ..To investigate whether PPD can be acetylated in vitro by the two N-acetyltransferases 1 (NAT1) and 2 (NAT2)...
  4. Suzuki H, Morris J, Li Y, Doll M, Hein D, Liu J, et al. Interaction of the cytochrome P4501A2, SULT1A1 and NAT gene polymorphisms with smoking and dietary mutagen intake in modification of the risk of pancreatic cancer. Carcinogenesis. 2008;29:1184-91 pubmed publisher
    ..risk of pancreatic cancer (PC), we investigated the effect of single-nucleotide polymorphisms (SNPs) of the CYP1A2, NAT1, NAT2 and SULT1A1 gene on modification of the risk of PC in a hospital-based study of 755 patients with pancreatic ..
  5. Unal M, Tamer L, Dogruer Z, Yildirim H, Vayisoglu Y, Camdeviren H. N-acetyltransferase 2 gene polymorphism and presbycusis. Laryngoscope. 2005;115:2238-41 pubmed
    The enzyme of N-acetyltransferase (NAT) is involved in the metabolism and detoxification of cytotoxic and carcinogenic compounds as well as reactive oxygen species (ROS)...
  6. Omura G. Combination therapy with 5-azacytidine plus beta-2'-deoxythioguanosine in adult acute leukemia. Cancer Treat Rep. 1977;61:915-7 pubmed
  7. Wikman H, Thiel S, Jager B, Schmezer P, Spiegelhalder B, Edler L, et al. Relevance of N-acetyltransferase 1 and 2 (NAT1, NAT2) genetic polymorphisms in non-small cell lung cancer susceptibility. Pharmacogenetics. 2001;11:157-68 pubmed
    The highly polymorphic N-acetyltransferases (NAT1 and NAT2) are involved in both activation and inactivation reactions of numerous carcinogens, such as tobacco derived aromatic amines...
  8. Brocvielle H, Muret P, Goydadin A, Boone P, Broly F, Kantelip J, et al. N-acetyltransferase 2 acetylation polymorphism: prevalence of slow acetylators does not differ between atopic dermatitis patients and healthy subjects. Skin Pharmacol Appl Skin Physiol. 2003;16:386-92 pubmed
    ..The importance attributed to the SA status, which was previously considered a predisposing factor for allergic diseases such as atopic dermatitis, should be reviewed. ..
  9. Bandmann O, Vaughan J, Holmans P, Marsden C, Wood N. Association of slow acetylator genotype for N-acetyltransferase 2 with familial Parkinson's disease. Lancet. 1997;350:1136-9 pubmed
    ..Further studies are needed to investigate the biological relevance of these findings, but slow acetylation could lead to impaired ability of patients with familial PD to handle neurotoxic substances. ..
  10. Walraven J, Barker D, Doll M, Hein D. Tissue expression and genomic sequences of rat N-acetyltransferases rNat1, rNat2, rNat3, and Functional characterization of a novel rNat3*2 genetic variant. Toxicol Sci. 2007;99:413-21 pubmed
    Human arylamine N-acetyltransferases NAT1 and NAT2 are highly polymorphic genes that modify individual susceptibility to cancers caused by exposure to arylamine procarcinogens...
  11. Tamer L, Yilmaz A, Yildirim H, Ayaz L, Ates N, Karakas S, et al. N-acetyltransferase 2 phenotype may be associated with susceptibility to age-related cataract. Curr Eye Res. 2005;30:835-9 pubmed
  12. Varzim G, Monteiro E, Silva R, Pinheiro C, Lopes C. Polymorphisms of arylamine N-acetyltransferase (NAT1 and NAT2) and larynx cancer susceptibility. ORL J Otorhinolaryngol Relat Spec. 2002;64:206-12 pubmed
    Our aim was to examine the role of NAT1 and NAT2 polymorphisms in human larynx cancer susceptibility...
  13. Korpinen E, Groop P, Rautio A, Madacsy L, Reunanen A, Vaarala O, et al. N-acetyltransferase-2 polymorphism, smoking and type 1 diabetic nephropathy. Pharmacogenetics. 1999;9:627-33 pubmed
    ..09]. Smoking is a strong confounding factor in relation to NAT2 analyses and diabetic nephropathy. According to our data, in nonsmoking type 1 diabetic patients fast NAT2 genotype implies an increased risk for diabetic nephropathy. ..
  14. Majumder M, Sikdar N, Ghosh S, Roy B. Polymorphisms at XPD and XRCC1 DNA repair loci and increased risk of oral leukoplakia and cancer among NAT2 slow acetylators. Int J Cancer. 2007;120:2148-56 pubmed
    ..4, respectively) among slow acetylators. Although none of the 3 loci could modulate the risk of the diseases independently but 2 loci in combination, working in 2 different biochemical pathways, could do so in these patient populations...
  15. Prawan A, Kukongviriyapan V, Tassaneeyakul W, Pairojkul C, Bhudhisawasdi V. Association between genetic polymorphisms of CYP1A2, arylamine N-acetyltransferase 1 and 2 and susceptibility to cholangiocarcinoma. Eur J Cancer Prev. 2005;14:245-50 pubmed
    ..The present study aimed to evaluate the relationship between CYP1A2, NAT1 and NAT2 polymorphisms and cholangiocarcinoma (CCA), the most prevalent cancer in the north-east of Thailand...
  16. Ozawa S, Katoh T, Inatomi H, Imai H, Kuroda Y, Ichiba M, et al. Association of genotypes of carcinogen-activating enzymes, phenol sulfotransferase SULT1A1 (ST1A3) and arylamine N-acetyltransferase NAT2, with urothelial cancer in a Japanese population. Int J Cancer. 2002;102:418-21 pubmed
    ..Combined analyses of different alleles of carcinogenic aromatic amine-activating phase II enzymes were applied to urothelial cancer risk for the first time and showed the highest risk combination of ST1A3 and NAT2 alleles. ..
  17. Dai Y, Leng S, Li L, Niu Y, Huang H, Liu Q, et al. Effects of genetic polymorphisms of N-Acetyltransferase on trichloroethylene-induced hypersensitivity dermatitis among exposed workers. Ind Health. 2009;47:479-86 pubmed
    ..Polymerase chain reaction-restriction fragment length polymorphism was used to detect the polymorphic sites of NAT1 at nt 1095 and 1088 and the sites of NAT2 at nt 481, 590, and 857...
  18. Zhang X, Lambert J, Doll M, Walraven J, Arteel G, Hein D. 4,4'-methylenedianiline-induced hepatotoxicity is modified by N-acetyltransferase 2 (NAT2) acetylator polymorphism in the rat. J Pharmacol Exp Ther. 2006;316:289-94 pubmed
    ..MDA undergoes N-acetylation catalyzed by N-acetyltransferase 1 (NAT1) and 2 (NAT2) in the liver...
  19. Yalin S, Hatungil R, Tamer L, Ates N, Dogruer N, Yildirim H, et al. N-acetyltransferase 2 polymorphism in patients with diabetes mellitus. Cell Biochem Funct. 2007;25:407-11 pubmed
    ..Human arylamine NATs are known to exist as two isoenzymes, NAT1 and NAT2...
  20. Jones R, Land S, King C. Recombinant rat and hamster N-acetyltransferases-1 and -2: relative rates of N-acetylation of arylamines and N,O-acyltransfer with arylhydroxamic acids. Carcinogenesis. 1996;17:1729-33 pubmed
    Genes for the 290 amino acid, 33-34 kDa cytosolic acetyltransferases (NAT1* and NAT2*) from rat and hamster were cloned and expressed in Escherichia coli...
  21. Potts L, Cambon A, Ross O, Rademakers R, Dickson D, Uitti R, et al. Polymorphic genes of detoxification and mitochondrial enzymes and risk for progressive supranuclear palsy: a case control study. BMC Med Genet. 2012;13:16 pubmed publisher
    ..Although our results need to be further confirmed in an independent sample, NAT2 acetylation status should be considered in future genetic and epidemiological studies of PSP. ..
  22. Pak B, Pang S. Developmental regulation of the translational repressor NAT1 during cardiac development. J Mol Cell Cardiol. 1999;31:1717-24 pubmed
    ..Here, we report the identification and differential expression of a fundamental translational repressor NAT1, during early postnatal cardiac development...
  23. Abdel Rahman S, El Zein R, Zwischenberger J, Au W. Association of the NAT1*10 genotype with increased chromosome aberrations and higher lung cancer risk in cigarette smokers. Mutat Res. 1998;398:43-54 pubmed
    The NAT1 gene exhibits polymorphisms in the non-coding polyadenylation region with a number of alleles...
  24. Zienolddiny S, Campa D, Lind H, Ryberg D, Skaug V, Stangeland L, et al. A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of non-small cell lung cancer in smokers. Carcinogenesis. 2008;29:1164-9 pubmed publisher
    ..Moreover, significant associations with multiple SNPs in the phase II genes ALDH2, COMT, EPHX1, SOD2, NAT1, NAT2, GSTM3, GSTP1, GSTT2 and MPO were also found...
  25. Liu Y, Meng F, Wang L, Zhang L, Cheng X, Zhou J. Apolipoprotein E influences melatonin biosynthesis by regulating NAT and MAOA expression in C6 cells. J Pineal Res. 2012;52:397-402 pubmed publisher
    ..In addition, we found that N-acetyltransferase (NAT) protein level was up-regulated in ApoE4-C6 cells compared with ApoE3-C6 cells...