Gene Symbol: Nanos2
Description: nanos C2HC-type zinc finger 2
Alias: RGD1562436, nanos homolog 2
Tsuda M, Sasaoka Y, Kiso M, Abe K, Haraguchi S, Kobayashi S, et al
. Conserved role of nanos proteins in germ cell development. Science. 2003;301:1239-41 pubmed
..We report the cloning and the functional analyses of nanos2 and nanos3 in mice. These genes are differentially expressed in mouse PGCs...
Sada A, Suzuki A, Suzuki H, Saga Y. The RNA-binding protein NANOS2 is required to maintain murine spermatogonial stem cells. Science. 2009;325:1394-8 pubmed publisher
..With the use of transgenic mice, we found that the RNA-binding protein NANOS2 is essential for maintaining spermatogonial stem cells...
Suzuki A, Igarashi K, Aisaki K, Kanno J, Saga Y. NANOS2 interacts with the CCR4-NOT deadenylation complex and leads to suppression of specific RNAs. Proc Natl Acad Sci U S A. 2010;107:3594-9 pubmed publisher
..We have previously shown that NANOS2 plays an important role in both the maintenance and sexual development of germ cells...
Bhandari D, Raisch T, Weichenrieder O, Jonas S, Izaurralde E. Structural basis for the Nanos-mediated recruitment of the CCR4-NOT complex and translational repression. Genes Dev. 2014;28:888-901 pubmed publisher
Suzuki A, Saga Y. Nanos2 suppresses meiosis and promotes male germ cell differentiation. Genes Dev. 2008;22:430-5 pubmed publisher
..We show here that Nanos2 plays critical roles in the differentiation of male germ cells...
Kusz K, Tomczyk L, Sajek M, Spik A, Latos Bielenska A, Jedrzejczak P, et al
. The highly conserved NANOS2 protein: testis-specific expression and significance for the human male reproduction. Mol Hum Reprod. 2009;15:165-71 pubmed publisher
..The mammalian homologue, Nanos2, was recently found to be expressed in the mouse germ cells...
Geyer C, Saba R, Kato Y, Anderson A, Chappell V, Saga Y, et al
. Rhox13 is translated in premeiotic germ cells in male and female mice and is regulated by NANOS2 in the male. Biol Reprod. 2012;86:127 pubmed publisher
..gonads in vivo but occurs precociously in neonatal testes exposed to RA in vitro or in fetal male germ cells when NANOS2 is absent in vivo...
Jørgensen A, Nielsen J, Blomberg Jensen M, Græm N, Rajpert De Meyts E. Analysis of meiosis regulators in human gonads: a sexually dimorphic spatio-temporal expression pattern suggests involvement of DMRT1 in meiotic entry. Mol Hum Reprod. 2012;18:523-34 pubmed publisher
..The expression pattern of DMRT1, STRA8, SCP3, DMC1, NANOS3, CYP26B1 and NANOS2 was investigated by RT-PCR and immunohistochemistry in a series of human testis samples from fetal life to ..